微创手术治疗卵巢癌的疗效及对患者血清相关指标及预后的影响
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摘要
目的探讨微创手术治疗卵巢癌的疗效及对患者血清相关指标及预后的影响。方法回顾性分析80例早期卵巢癌患者的临床资料,根据手术治疗方式的不同,分为研究组及对照组(各40例)。研究组采用腹腔镜下卵巢癌手术治疗,对照组采用传统开腹卵巢癌手术治疗,比较2组患者的临床疗效等。结果研究组患者的术中出血量、住院时间、术后排气时间及术后VAS评分均显著优于对照组(P <0. 05);研究组患者的术后并发症率及临床分期上升率均显著低于对照组患者(P <0. 05)。术后2组患者的MMP-9、VEGF及HE4水平均降低,且研究组下降水平显著高于对照组(P <0. 05)。研究组患者术后1年相关生活质量改善情况显著优于对照组(P <0. 05)。结论早期卵巢癌患者采用腹腔镜技术实施治疗可在较大程度保证患者安全的情况下提高疗效,同时可改善患者的短期预后及相关生活质量,值得临床大力推广。
Objective To investigate the clinical efficacy、serum markers and prognosis of laparoscope surgery for early ovarian cancer. Methods To screening 80 cases of patients with early ovarian cancer as research subjects,it will be divided into study group with 40 cases and control group with 40 cases,patients in control group were given open surgery treatment and patients in study group were given the laparoscope surgery,then the two groups were compared in terms of clinical efficacy and so on. Results The relate clinical indexes( such as intraoperative blood loss,hospital stay、postoprative exhaust time and VAS score) in study group were better than the control group( P < 0. 05); The postoperative complications rate and clinical stage rising rate in study group were lower than the control group( P < 0. 05); The serum prognosis indexes( such as MMP-9、VEGF and HE4) were all lower in study group than in the control group after the treatment,and the decline degree in study group was greater than the control group( P < 0. 05); 1-year after operation,the relate living quality indexes in study group were better than the control group( P < 0. 05). Conclusion The laparoscope in the treatment of early ovarian cancer is significant,and it can improve shot-term prognosis and the living quality,Thus worthy of popularization and application.
Objective To investigate the clinical efficacy、serum markers and prognosis of laparoscope surgery for early ovarian cancer. Methods To screening 80 cases of patients with early ovarian cancer as research subjects,it will be divided into study group with 40 cases and control group with 40 cases,patients in control group were given open surgery treatment and patients in study group were given the laparoscope surgery,then the two groups were compared in terms of clinical efficacy and so on. Results The relate clinical indexes( such as intraoperative blood loss,hospital stay、postoprative exhaust time and VAS score) in study group were better than the control group( P < 0. 05); The postoperative complications rate and clinical stage rising rate in study group were lower than the control group( P < 0. 05); The serum prognosis indexes( such as MMP-9、VEGF and HE4) were all lower in study group than in the control group after the treatment,and the decline degree in study group was greater than the control group( P < 0. 05); 1-year after operation,the relate living quality indexes in study group were better than the control group( P < 0. 05). Conclusion The laparoscope in the treatment of early ovarian cancer is significant,and it can improve shot-term prognosis and the living quality,Thus worthy of popularization and application.
引文
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[2]刘永珠,胡庆兰,陈日利,等.腹腔镜与开腹手术治疗早期卵巢癌的比较[J].中国微创外科杂志,2014,14(7):597-599,602.
[3]RL Siegel,KD Miller,SA Fedewa.Colorectal cancer statistics,2017[J].CA Cancer J Clin,2017,67(3):177.
[4]G Bogani,A Cromi,M Serati,et al.Laparoscopic and open abdominal staging for early-stage ovarian cancer:our experience,systematic review,and meta-analysis ofcomparative studies[J].Int J Gynecol Cancer,2014,24(7):1241-1249.
[5]诸一鸣,朱滔.早期卵巢癌腹腔镜手术治疗的安全性和有效性分析[J].中国内镜杂志,2016,22(7):42-45.
[6]YJ Koo,JE Kim,YH Kim,et al.Comparison of laparoscopy and laparotomy for the management of early-stage ovarian cancer:surgical and oncological outcomes[J].J Gynecol Onccl,2014,25(2):111-117.
[7]M Liu,L Li,Y He,et al.Comparison of laparoscopy and laparotomy in the surgical management of early-stage ovarian cancer[J].Int J Gynecol Cancer,2014,24(2):352-357.
[8]Su XL,YF Wang,SJ Li,et al.Hith methylation of the sept9gene in Chinese colorectal cancer patients[J].Genet Mol Res,2014,13(2):2513-2520.
[9]张亮,孟杰.超声联合血清肿瘤标记物CA125、B7同源体4(B7-H4)对卵巢癌的诊断价值[J].实用癌症杂志,2017,32(8):1364-1366.
[10]胡霞,杨华琴.开腹手术在卵巢癌分期手术中的临床应用价值及预后相关因素分析[J].实用癌症杂志,2016,31(5):823-826.