丹参酚酸B对缺血性脑中风保护作用的研究进展
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摘要
丹酚酸B是丹参的水溶性酚酸类成分,具有抗氧化和清除自由基的作用,可改善神经功能缺失症状,减少细胞凋亡,调节内源性物质的释放,影响相关基因表达和细胞信号转导,对脑缺血损伤有神经保护作用。本文对丹参酚酸B治疗缺血性脑中风机制及其临床研究进行综述
Salvianolic acid B is one of the main water-soluble phenolic acid components of Salvia miltiorrhiza. It have been reported to have anti-oxidation and scavenging free radicals. It can improve the symptoms of neurological deficit,reduce apoptosis,regulate the release of endogenous substances,affect the expression of related genes,and signal transduction,and have neuroprotective effects on cerebral ischemic injury. This article will review the mechanism and clinical study of salvianolic acid B in the treatment of ischemic stroke.
Salvianolic acid B is one of the main water-soluble phenolic acid components of Salvia miltiorrhiza. It have been reported to have anti-oxidation and scavenging free radicals. It can improve the symptoms of neurological deficit,reduce apoptosis,regulate the release of endogenous substances,affect the expression of related genes,and signal transduction,and have neuroprotective effects on cerebral ischemic injury. This article will review the mechanism and clinical study of salvianolic acid B in the treatment of ischemic stroke.
引文
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[7]TANG Y,JACOBI A,VATER C,et al.Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/m TOR/4EBP1,p38 MAPK/ATF2,and ERK1/2 signaling pathways[J].Biochem Pharmacol,2014,90(1):34-49.
[8]TANG Y,JACOBI A,VATER C,et al.Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/m TOR/4EBP1,p38 MAPK/ATF2,and ERK1/2 signaling pathways[J].Biochem Pharmacol,2014,90(1):34-49.
[9]SHU T,PANG M,RONG L,et al.Protective effects and mechanisms of salvianolic acid B against H2O2-induced injury in induced pluripotent stem cell-derived neural stem cells[J].Neurochem Res,2015,40(6):1133-1143.
[10]刘鹏,王瑾,苗常青,等.神经营养因子在大鼠局灶性脑缺血-再灌注损伤中的变化及丹参乙酸镁的影响[J].脑与神经疾病杂志,2013,21(4):285-289.
[11]SUN K,FAN J,HAN J.Ameliorating effects of traditional Chinese medicine preparation,Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage[J].Acta Pharm Sin B,2015,5(1):8-24.
[12]HABTEMARIAM S.Molecular pharmacology of rosmarinic and salvianolic acids:potential seeds for alzheimer’s and vascular dementia drugs[J].Int J Mol Sci,2018,19(2):458.
[13]肖文喜,汪红,钟晓明,等.丹酚酸B对小鼠急性局灶性脑缺血的神经保护作用[J].中国实验方剂学杂志,2014,20(17):163-166.
[14]XIONG X Y,LIU L,YANG Q W.Functions and mechanisms of microglia/macrophages in neuro inflammation and neurogenesis after stroke[J].Prog Neurobiol,2016,142(1):23-44.
[15]张义琴,周波,张国锋.丹酚酸B对小鼠创伤性脑损伤的保护作用[J].中华神经外科疾病研究杂志,2014,13(1):27-30.
[16]WANG Y,CHEN G,YU X,et al.Salvianolic acid B ameliorates cerebra ischemia/reperfusion injury through inhibiting TLR4/My D88 signaling pathway[J].Inflammation,2016,39(4):1503-1513.
[17]PUYAL J,GINET V,CLARKE P G.Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage:a challenge for neuroprotection[J].Prog Neurobio,2013,105(1):24-48.
[18]WANG X,ZHU G.Study on protective effect of salvianolic acid Bon glutamate-induced excitotoxicity in pheochromocytoma PC12 cells[J].China J Chin Material Medica,2012,37(3):353-357.
[19]HE Y,JIA K,LI L,et al.Salvianolic acid B attenuates mitochondrial stress against Aβtoxicity in primary cultured mouse neurons[J].Biochem Biophys Res Commun,2018,498(4):1066-1072.
[20]MA X,XU W,ZHANG Z,et al.Salvianolic acid B ameliorates cognitive deficits through IGF-1/Akt pathway in rats with vascular dementia[J].Cell Physiol Biochem,2017,43(4):1381-1391.
[21]HE Y,JIA K,LI L,et al.Salvianolic acid B attenuates mitochondrial stress against Aβtoxicity in primary cultured mouse neurons[J].Biochem Biophys Res Commun,2018,498(4):1066-1072.
[22]MA X,XU W,ZHANG Z,et al.Salvianolic acid B ameliorates cognitive deficits through IGF-1/Akt pathway in rats with vascular dementia[J].Cell Physiol Biochem,2017,43(4):1381-1391.
[23]ZHANG H T,ZHANG P,GAO Y,et al.Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs[J].Mol Med Rep,2017,15(1):57-64.
[24]ZHU H,ZOU L,TIAN J,et al.SMND-309,a novel derivative of salvianolic acid B,protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway[J].Eur J Pharmacol,2013,714(1-3):23-31.
[25]BA J,PENG H,CHEN Y,et al.Effects and mechanism analysis of vascular endothelial growth factor and salvianolic acid B on 125I-low density lipoprotein permeability of the rabbit aortary endothelial cells[J].Cell Biochem Biophys,2014,70(3):1533-1538.
[26]何吉洪,杨海洋,龙江.丹酚酸B对缺糖缺氧/复糖复氧的体外血脑屏障模型的影响[J].重庆医学,2015,44(33):4611-4614.
[27]ZHU H,ZOU L,TIAN J,et al.SMND-309,a novel derivative of salvianolic acid B,protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway[J].Eur J Pharmacol,2013,714(1-3):23-31.
[28]唐浩,张双彦.丹参多酚酸在改善脑缺血再灌注损伤中的机制探究[J].哈尔滨医科大学学报,2018,52(2):118-123.
[29]HU Y,DENG H,XU S,et al.MicroRNAs regulate mitochondrial function in cerebral ischemia-reperfusion injury[J].Int J Mol Sci,2015,16(10):24895-24917.
[30]常慧敏,李常新.注射用丹参多酚酸治疗急性脑梗死的研究进展[J].中西医结合心脑血管病杂志,2018,16(2):183-185.
[31]李富强,王伟,尹金鹏,等.大鼠脑缺血再灌注后线粒体ATP酶活性、形态学变化及丹参多酚酸的保护作用[J].中风与神经疾病杂志,2018,35(3):238-241.
[32]夏杨,张惠军,聂亚莉.丹酚酸B预处理对心肌缺血/再灌注损伤能量代谢的影响[J].药物评价研究,2018,41(12):2210-2213.
[33]周凤,邓幼清,陈小红,等.注射用丹参多酚酸治疗脑梗死恢复期(瘀血阻络型)临床研究[J].实用中西医结合临床,2013,13(8):8-11.
[34]张萌,吴丽娥.注射用丹参多酚酸治疗轻中度缺血性脑卒中的有效性及安全性[J].包头医学院学报,2016,32(9):49-50.
[35]王伟芳.注射用丹参多酚酸治疗进展性脑梗死的疗效观察[J].中国实用神经疾病杂志,2016,19(7):107-108.
[36]房阁.注射用丹参多酚酸治疗缺血性脑卒中的临床效果分析[J].中西医结合心脑血管病杂志,2017,15(6):725-727.
[37]刘媛,彭建伟,孟改,等.丹参多酚酸对急性缺血性脑卒中患者脑灌注影响的临床观察[J].中华老年心脑血管病杂志,2017,19(7):738-744.
[38]郝彦超,苏建.丹参多酚酸对脑梗死患者血液流变学和神经功能的影响[J].中国实用神经疾病杂志,2014,17(16):67-68.
[39]米玉霞.丹参多酚酸盐治疗对急性脑梗死患者血清C反应蛋白和血液流变学的影响[J].医学综述,2012,18(22):3903-3905.
[2]高枫,孙桂波,任小宇,等.丹酚酸B对大鼠离体心脏缺血再灌注损伤的保护作用[J].中国中药杂志,2012,37(3):358-361.
[3]REN Z,WANG X,WANG S,et al.Mechanism of action of salvianolic acid B by module-based network analysis[J].Biomed Mater Eng,2014,24(1):1333-1340.
[4]周林甫,石亚军,焦亚楠,等.红景天苷对大鼠脑缺血再灌注氧化应激损伤的保护作用[J].神经解剖学杂志,2018,34(5):561-566.
[5]HU S,WU Y,ZHAO B,et al.Panax notoginseng saponins protect cerebral microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/Akt/Nrf2 antioxidant signaling pathway[J].Molecules,2018,23(11):2781.
[6]CHEN H M,LUO H,ZENG W B,et al.Salvianolic acid B attenuates oxidized low-density lipoprotein-induced endothelial cell apoptosis through inhibition of oxidative stress,p53,and caspase-3 pathways[J].Chin J Integr Med,2017,24(1):1-7.
[7]TANG Y,JACOBI A,VATER C,et al.Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/m TOR/4EBP1,p38 MAPK/ATF2,and ERK1/2 signaling pathways[J].Biochem Pharmacol,2014,90(1):34-49.
[8]TANG Y,JACOBI A,VATER C,et al.Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/m TOR/4EBP1,p38 MAPK/ATF2,and ERK1/2 signaling pathways[J].Biochem Pharmacol,2014,90(1):34-49.
[9]SHU T,PANG M,RONG L,et al.Protective effects and mechanisms of salvianolic acid B against H2O2-induced injury in induced pluripotent stem cell-derived neural stem cells[J].Neurochem Res,2015,40(6):1133-1143.
[10]刘鹏,王瑾,苗常青,等.神经营养因子在大鼠局灶性脑缺血-再灌注损伤中的变化及丹参乙酸镁的影响[J].脑与神经疾病杂志,2013,21(4):285-289.
[11]SUN K,FAN J,HAN J.Ameliorating effects of traditional Chinese medicine preparation,Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage[J].Acta Pharm Sin B,2015,5(1):8-24.
[12]HABTEMARIAM S.Molecular pharmacology of rosmarinic and salvianolic acids:potential seeds for alzheimer’s and vascular dementia drugs[J].Int J Mol Sci,2018,19(2):458.
[13]肖文喜,汪红,钟晓明,等.丹酚酸B对小鼠急性局灶性脑缺血的神经保护作用[J].中国实验方剂学杂志,2014,20(17):163-166.
[14]XIONG X Y,LIU L,YANG Q W.Functions and mechanisms of microglia/macrophages in neuro inflammation and neurogenesis after stroke[J].Prog Neurobiol,2016,142(1):23-44.
[15]张义琴,周波,张国锋.丹酚酸B对小鼠创伤性脑损伤的保护作用[J].中华神经外科疾病研究杂志,2014,13(1):27-30.
[16]WANG Y,CHEN G,YU X,et al.Salvianolic acid B ameliorates cerebra ischemia/reperfusion injury through inhibiting TLR4/My D88 signaling pathway[J].Inflammation,2016,39(4):1503-1513.
[17]PUYAL J,GINET V,CLARKE P G.Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage:a challenge for neuroprotection[J].Prog Neurobio,2013,105(1):24-48.
[18]WANG X,ZHU G.Study on protective effect of salvianolic acid Bon glutamate-induced excitotoxicity in pheochromocytoma PC12 cells[J].China J Chin Material Medica,2012,37(3):353-357.
[19]HE Y,JIA K,LI L,et al.Salvianolic acid B attenuates mitochondrial stress against Aβtoxicity in primary cultured mouse neurons[J].Biochem Biophys Res Commun,2018,498(4):1066-1072.
[20]MA X,XU W,ZHANG Z,et al.Salvianolic acid B ameliorates cognitive deficits through IGF-1/Akt pathway in rats with vascular dementia[J].Cell Physiol Biochem,2017,43(4):1381-1391.
[21]HE Y,JIA K,LI L,et al.Salvianolic acid B attenuates mitochondrial stress against Aβtoxicity in primary cultured mouse neurons[J].Biochem Biophys Res Commun,2018,498(4):1066-1072.
[22]MA X,XU W,ZHANG Z,et al.Salvianolic acid B ameliorates cognitive deficits through IGF-1/Akt pathway in rats with vascular dementia[J].Cell Physiol Biochem,2017,43(4):1381-1391.
[23]ZHANG H T,ZHANG P,GAO Y,et al.Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs[J].Mol Med Rep,2017,15(1):57-64.
[24]ZHU H,ZOU L,TIAN J,et al.SMND-309,a novel derivative of salvianolic acid B,protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway[J].Eur J Pharmacol,2013,714(1-3):23-31.
[25]BA J,PENG H,CHEN Y,et al.Effects and mechanism analysis of vascular endothelial growth factor and salvianolic acid B on 125I-low density lipoprotein permeability of the rabbit aortary endothelial cells[J].Cell Biochem Biophys,2014,70(3):1533-1538.
[26]何吉洪,杨海洋,龙江.丹酚酸B对缺糖缺氧/复糖复氧的体外血脑屏障模型的影响[J].重庆医学,2015,44(33):4611-4614.
[27]ZHU H,ZOU L,TIAN J,et al.SMND-309,a novel derivative of salvianolic acid B,protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway[J].Eur J Pharmacol,2013,714(1-3):23-31.
[28]唐浩,张双彦.丹参多酚酸在改善脑缺血再灌注损伤中的机制探究[J].哈尔滨医科大学学报,2018,52(2):118-123.
[29]HU Y,DENG H,XU S,et al.MicroRNAs regulate mitochondrial function in cerebral ischemia-reperfusion injury[J].Int J Mol Sci,2015,16(10):24895-24917.
[30]常慧敏,李常新.注射用丹参多酚酸治疗急性脑梗死的研究进展[J].中西医结合心脑血管病杂志,2018,16(2):183-185.
[31]李富强,王伟,尹金鹏,等.大鼠脑缺血再灌注后线粒体ATP酶活性、形态学变化及丹参多酚酸的保护作用[J].中风与神经疾病杂志,2018,35(3):238-241.
[32]夏杨,张惠军,聂亚莉.丹酚酸B预处理对心肌缺血/再灌注损伤能量代谢的影响[J].药物评价研究,2018,41(12):2210-2213.
[33]周凤,邓幼清,陈小红,等.注射用丹参多酚酸治疗脑梗死恢复期(瘀血阻络型)临床研究[J].实用中西医结合临床,2013,13(8):8-11.
[34]张萌,吴丽娥.注射用丹参多酚酸治疗轻中度缺血性脑卒中的有效性及安全性[J].包头医学院学报,2016,32(9):49-50.
[35]王伟芳.注射用丹参多酚酸治疗进展性脑梗死的疗效观察[J].中国实用神经疾病杂志,2016,19(7):107-108.
[36]房阁.注射用丹参多酚酸治疗缺血性脑卒中的临床效果分析[J].中西医结合心脑血管病杂志,2017,15(6):725-727.
[37]刘媛,彭建伟,孟改,等.丹参多酚酸对急性缺血性脑卒中患者脑灌注影响的临床观察[J].中华老年心脑血管病杂志,2017,19(7):738-744.
[38]郝彦超,苏建.丹参多酚酸对脑梗死患者血液流变学和神经功能的影响[J].中国实用神经疾病杂志,2014,17(16):67-68.
[39]米玉霞.丹参多酚酸盐治疗对急性脑梗死患者血清C反应蛋白和血液流变学的影响[J].医学综述,2012,18(22):3903-3905.
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