脯氨酸内肽酶研究进展
|
摘要
脯氨酸内肽酶是一类能够特异性水解多肽链中脯氨酸残基羧基端的内切酶,是丝氨酸蛋白酶家族成员之一,其能有效降解小于30个含有脯氨酸残基的多肽链,在对PEP的研究中发现它能特异性地水解许多含脯氨酸的多肽类神经递质和激素,如促甲状腺激素释放激素、P物质(Substance P)等,因此研究认为PEP可能参与一些神经类疾病的发生,如老年性记忆障碍等。本研究经过阅读相关期刊文献,对脯氨酸内肽酶的分布情况、基本理化和酶学性质、分子结构、作用机理以及在食品、医药领域的最新研究和应用进行了综合性评述,以期能对脯氨酸内肽酶相关性质、机理的后续研究以及在食品、医药领域更广泛的应用提供一定的参考。
Proline endopeptidase is one of the members of serine protease family, which can specifically hydrolyze endonucleases on the carboxyl side of proline residues in polypeptide chains and effectively degrade less than 30 polypeptide chains containing proline residues. The study on PEP found that it could specifically hydrolyze many of the proline-containing peptide neurotransmitters and hormones, such as thyrotropin-releasing hormone, substance P., etc., thus, the study indicated that PEP might be involved in the occurrence of some neurological diseases, such as senile memory impairment. In this study, the distribution, basic physicochemical and enzymatic properties,molecular structure, mechanism of action and the latest research and application of proline endopeptidase in food and medicine fields were comprehensively reviewed by reading relevant periodical literature, which could provide some reference for the follow-up study of the properties and mechanism of proline endopeptidase and its wider application in food and medicine fields.
Proline endopeptidase is one of the members of serine protease family, which can specifically hydrolyze endonucleases on the carboxyl side of proline residues in polypeptide chains and effectively degrade less than 30 polypeptide chains containing proline residues. The study on PEP found that it could specifically hydrolyze many of the proline-containing peptide neurotransmitters and hormones, such as thyrotropin-releasing hormone, substance P., etc., thus, the study indicated that PEP might be involved in the occurrence of some neurological diseases, such as senile memory impairment. In this study, the distribution, basic physicochemical and enzymatic properties,molecular structure, mechanism of action and the latest research and application of proline endopeptidase in food and medicine fields were comprehensively reviewed by reading relevant periodical literature, which could provide some reference for the follow-up study of the properties and mechanism of proline endopeptidase and its wider application in food and medicine fields.
引文
Agirregoitia N.,Casis L.,Gil J.,Ruiz F.,and Irazusta J.,2007,Ontogeny of prolyl endopeptidase and pyroglutamyl peptidase i in rat tissues,Regulatory peptides,139(1):52-58
Aron P.M.,and Shellhammer T.H.,2010,A Discussion of Polyphenols in Beer Physical and Flavour Stability,Journal of the Institute of Brewing,116(4):369-380
Besedin D.V.,and Rudenskaya G.N.,2003,Proline-specific endopeptidases,Russian Journal of Bioorganic Chemistry,29(1):1-17
Besteiro S.,Williams R.A.,Coombs G.H.,and Mottram J.C.,2007,Protein turnover and differentiation in leishmania,International Journal for Parasitology,37(10):1063-1075
Carvalho K.M.,and Camargo A.C.,1981,Purification of rabbit brain endooligopeptidases and preparation of antienzyme antibodies,Biochemistry,20(25):7082-7088
Cong P.J.,2000,Some contributing factors on non-bio-stability of beer,Niangjiu Keji(Liquor-Making Science and Technology),(5):62-63(丛培江,2000,啤酒非生物稳定性的几种影响因素,酿酒科技,(5):62-63)
Cunningham D.F.,and O'Connor B.,1997,Proline specific peptidases,Biochimica Et Biophysica Acta,1343(2):160-186
Fulop V.,Bocskei Z.,and Polgar L.,1998,Prolyl oligopeptidase:an unusual beta-propeller domain regulates proteolysis,Cell,94(2):161-170
Fulop V.,Szeltner Z.,and Polgar L.,2000,Catalysis of serine oligopeptidases is controlled by a gating filter mechanism,EMBO Reports,1(3):277-281
Fuxreiter M.,Magyar C.,Juhasz T.,Szeltner Z.,Polgar L.,and Simon I.,2005,Flexibility of prolyl oligopeptidase:molecular dynamics and molecular framework analysis of the potential substrate pathways,Proteins Structure Function and Bioinformatics,60(3):504-512
Garcia-Horsman J.A.,Mannisto P.T.,and Venalainen J.I.,2007,On the role of prolyl oligopeptidase in health and disease,Neuropeptides,41:1-24
Gass J.,and Khosla C.,2007,Prolyl endopeptidases,Cellular and Molecular Life Sciences,64(3):345-355
Habibi-Najafi M.B.,and Lee B.H.,1994,Proline-specific peptidases of Lactobacillus casei subspecies,Journal of Dairy Science,77(2):385-392
Harwood V.J.,Denson J.D.,Robinson-Bidle K.A.,and Schreier H.J,1997,Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic archaeon pyrococcus furiosus,Journal of Bacteriology,179(11):3613-3618
Harwood V.J.,and Schreier H.J.,2001,Prolyl oligopeptidase from Pyrococcus furiosus,Methods in Enzymol,330:445-454
Heredia-Sandoval N.G.,de la Barca A.M.C.,and Islas-Rubio A.R.,2016,Gluten degradation in wheat flour with Aspergillus niger,prolyl-endopeptidase to prepare a gluten-reduced bread supplemented with an amaranth blend,Journal of Cereal Science,71:73-77
Irazusta J.,Larrinaga G.,González-Maeso J.,Gil J.,Meana J.J.,and Casis L.,2002,Distribution of prolyl endopeptidase activities in rat and human brain,Neurochemistry International,40(4):337-345
Jaeken J.,Martens K.,Franois I.,Eyskens F.,Lecointre C.,Derua R.,Meulemans S.,Slootstra J.W.,Waelkens E.,Zegher F.D.,Creemers J.W.M.,and Matthijs G.,2006,Deletion of PREPL,a gene encoding a putative serine oligopeptidase,in patients with hypotonia-cystinuria syndrome,American Journal of Human Genetics,78(1):38-51
Jalkanen A.J.,Hakkarainen J.J.,Lehtonen M.,Venalainen T.,Kaariainen T.M.,Jarho E.,Suhonen M.,and Forsberg M.M.,2011,Brain pharmacokinetics of two prolyl oligopeptidase inhibitors,JTP-4819 and KYP-2047,in the rat,Basic and Clinical Pharmacology and Toxicology,109(6):443-451
Kabashima T.,Fujii M.,Meng Y.,Ito K.,and Yoshimoto T.,1998,Prolyl endopeptidase from sphingomonas capsulata:isolation and characterization of the enzyme and nucleotide sequence of the gene,Archives of Biochemistry and Biophysics,358(1):141-148
Kalwant S.,and Porter A.G.,1991,Purification and characterization of human brain prolyl endopeptidase,Biochemical Journal,276(1):237-244
Kang C.,Yu X.W.,and Xu Y.,2015,Cloning and expression of a novel prolyl endopeptidase from Aspergillus oryzae and its application in beer stabilization,Journal of Industrial Microbiology and Biotechnology,42(2):263-272
Kusuhara M.,Hachisuka H.,Nakano S.,and Sasai Y.,1993,Purification and characterization of prolyl endopeptidase from rat skin,Journal of Dermatological Science,6(2):138-145
Kuwabara T.,1992,Characterization of a prolyl endopeptidase from spinach thylakoids,FEBS Letters,300(2):127-130
Larrinaga G.,Perez I.,Blanco L.,López J.I.,Andrés L.,and Etxezarraga C.,2010,Santaolalla F.,Zabala A.,Varona A.,I-razusta J.,Increased prolyl endopeptidase activity in human neoplasia,Regulatory Peptides,163(1):102-106
Li M.,amd Chen C.Q.,2000,Progress in the studies of prolyl endopeptidase,Shengwuhuaxue Yu Shengwuwuli Jingzhan(Prog Biochem Biophys),27(2):171-174(李民,陈常庆,2000,脯氨酰内肽酶研究进展,生物化学与生物物理进展,27(2):171-174)
Luoto S.,Jiang Z.,Brinck O.,Sontag-Strohm T.,Kanerva P.,Bruins M.,Edens L.,Salovaara H.,and Loponen J.,2012,Malt hydrolysates for gluten-free applications:autolytic and proline endopeptidase assisted removal of prolamins from wheat,barley and rye,Journal of Cereal Science,56(2):504-509
Maes M.,Goossens F.,Scharpe S.,Meltzer H.Y.,D'Hondt P.,and Cosyns P.,1994,Lower serum prolyl endopeptidase enzyme activity in major depression:further evidence that peptidases play a role in the pathophysiology of depression,Biological Psychiatry,35(8):545-552
Mantle D.,Falkous G.,Ishiura S.,Blanchard P.J.,and Perry E.K.,1996,Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease,lewy body dementia,parkinson's disease and huntington's disease,Clinica Chimica Acta,249(1-2):129
Min L.,Chen C.Q.,Davies D.R.,and Chiu T.K,2010,Induced-fit mechanism for prolyl endopeptidase,Journal of Biological Chemistry,285(28):21487-21495
O'Leary R.M.,and O'Connor B.,1995,Identification and localisation of a synaptosomal membrane prolyl endopeptidase from bovine brain,Febs Journal,227(1-2):277-283
Oyama H.,Aoki H.,Amano M.,Mizuki E.,Yoshimoto T.,Tsuru D.,and Murao S.,1997,Purification and characterization of a prolyl endopeptidase from pseudomonas,sp.ku-22,Journal of Fermentation and Bioengineering,84(6):538-542
Polgar L.,1991,PH dependent mechanism in the catalysis of prolyl endopeptidase from pig muscle,European Journal of Biochemistry,197(2):441-447
Polgar L.,1992,Prolyl endopeptidase catalysis,A physical rather than a chemical step is rate-limiting,Biochemical Journal,283(3):647-648
Polgar L.,1994,Prolyl oligopeptidases,Methods Enzymol.,244:188-200
Racys D.T.,Fulop R.V.,and Wills M.,2010,Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide,.Bioorganic and Medicinal Chemistry,18(13):4775-4782
Rampon C.,Jiang C.H.,Dong H.,Tang Y.P.,Lockhart D.J.,Schultz P.G.,and Tsien J.Z.,2000,Effects of environmental enrichment on gene expression in the brain,Proceedings of the National Academy of Sciences of the United States of America,97(23):12880-12884
Rea D.,and Fulop V.,2006,Structure-function properties of prolyl oligopeptidase family enzymes,Cell Biochemistry and Biophysics,44(3):349-365
Rosenblum J.S.,and Kozarich J.W.,2003,Prolyl peptidases:a serine protease subfamily with high potential for drug dis covery,Current Opinion in Chemical Biology,7(4):496-504
Sattar A.K.,Yamamoto N.,Yoshimoto T.,and Tsuru D.,1990,Purification and characterization of an extracellular prolyl endopeptidase from agaricus bisporus,Journal of Biochemistry,107(2):256-261
Savolainen M.H.,Richie C.T.,Harvey B.K.,Mannist P.T.,Maguire-Zeiss K.A.,and Myohanen T.T.,2014,The beneficial effect of a prolyl oligopeptidase inhibitor,KYP-2047,on alpha-synuclein clearance and autophagy in a30p transgenic mouse,Neurobiology of Disease,68:1-15
Schneider J.S.,Giardiniere M.,and Morain P.,2002,Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys,Neuropsychopharmacology,26:176-182
Shan L.,Mathews I.I.,and Khosla C.,2005,Structural and mechanistic analysis of two prolyl endopeptidases:role of interdomain dynamics in catalysis and specificity,Proceedings of the National Academy of Sciences of the United States of America,102(10):3599-3604
Shen G.X.,and Shi J.P.,1999,Cloning and nucleotide sequencing of prolyl endopeptidase gene from Aeromonas punctata subsp.Punctata,Shengwuhuaxue Yu Shengwuwuli Xuebao(Acta Biochimica et Biophysica Sinica),31(5):567-571(沈国祥,史济平,1999,点状产气单胞菌脯氨酰内肽酶基因的克隆与序列测定,生物化学与生物物理学报,31(5):567-571)
Shirasawa Y.,Osawa T.,and Hirashima A.,1994,Molecular cloning and characterization of prolyl endopeptidase from human T cells,Journal of Biochemistry,115(4):724-729
Storey E.,and Cappai R.,1999,The amyloid precursor protein of Alzheimer's disease and the Abeta peptide,Neuropathology and applied neurobiology,25(2):81-97
Szeltner Z.,Rea D.,Juhasz T.,Renner V.,Fulop V.,and Polgar L.,2004,Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding,Journal of Molecular Biology,340(3):627-637
Szwajcer-Dey E.,Rasmussen J.,and Meldal M.,1992,Proline-specific endopeptidases from microbial sources:isolation of an enzyme from a Xanthomonas sp.,Journal of Bacteriology,174(8):2454-2459
Tang J.,Yan L.J.,Weng L.,Sun L.C.,Liu G.M.,and Cao M.J.,2016,Purification and characterization of a prolyl endopeptidase from the skeletal muscle of blue scad(Decapterus marudsi)and its possible role in collagen degradation,Xiandai Shiping Keji(Modern Food Science and Technology),32(6):122-129(唐俊,颜龙杰,翁凌,孙乐常,刘光明,曹敏杰,2016,蓝圆鲹骨骼肌脯氨酸内肽酶的分离纯化及其对胶原肽的作用,现代食品科技,32(6):122-129)
Toide K.,Iwamoto Y.,Fujiwara T.,and Abe H.,1995,JTP-4819:a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer,Journal of Pharmacology and Experimental Therapeutics,274(3):1370-1378
Walter R.,Shlank H.,Glass J.D.,Schwartz I.L.,and Kerenyi T.D.,1971,Leucylglycinamide released from oxytocin by human uterine enzyme,Science,173(3999):827-829
Walter R.,Simmons W.H.,and Yoshimoto T.,1980,Proline specific endo and exopeptidases,Molecular and Cellular Biochemistry,30(2):111-127
Walter T.,and Wieser H.,2014,Degradation of gluten in wheat bran and bread drink by means of a proline-specific peptidase,Journal of Nutrition and Food Sciences,4(5):293
Walter T.,Wieser H.,and Koehler P.,2014,Production of gluten-free wheat starch by peptidase treatment,Journal of Cereal Science,60(1):202-209
Wang M.X.,2015,Purification and characterizaition of a prolyl endopeptidase from the skeletal muscle of common carp(Cyprinus carpio),Thesis for M.S.,Jimei Daxue(Jimei University),Supervisor:Cao M J.,pp.23-40(王梦想,2015,鲤鱼肌肉脯氨酸内肽酶的分离纯化及性质分析,硕士学位论文,集美大学,导师:曹敏杰,pp.23-40)
Weng L.,Lin Y.,Zhang L.,Zhang L.J.,Yan L.J.,Liu G.M.and Cao M.J.,2015,Study on a prolyl endopeptidase from the Skeletal Muscle of Grass Carp,Zhongguo Shiping Xuebao(Ctenopharyngodon idellus),Zhongguo Shipin Xuebao(Journal of Chinese Institute of Food Science and Technology),15(9):23-31(翁凌,林韵,张玲,张凌晶,颜龙杰,刘光明,曹敏杰,2015,草鱼肌肉脯氨酸内肽酶的研究,中国食品学报,15(9):23-31)
Yoshimoto T.,Ogita K.,Walter R.,Koida M,and Tsuru D.,1979,Post-proline cleaving enzyme synthesis of a new fluorogenic substrate and distribution of the endopeptidase in rat tissues and body fluids of man,Biochim Biophys Acta.,569(2):184-192
Yoshimoto T.,Sattar A.K.M.A.,Hirose W.,and Tsuru D.,1987,Studies on prolyl endopeptidase from carrot(Daucus carota):purification and enzymatic properties,Biochimica et Bio physica Acta(BBA)-Protein Structure and Molecular Enzymology,916(1):29-37
Yoshimoto T.,Oyama H.,Koriyama N.,and Tsuru D.,1988,Prolyl endopeptidase from bovine testis:purification,characterization and comparison with the enzymes from other tis-sues,Chemical and Pharmaceutical Bulletin,36(4):1456-1462
Zhou L.N.,Zhang L.,Lu.F.P.,Yang D.,and Xiang C.X.,2008,Study on hydrolysis of the protein in beer by prolyl endopeptidase,Shiping Yu Fajiao Gongye(Food and Fermentation Industries),34(2):113-116(周丽娜,张鹭,路福平,杨迪,向先长,2008,脯氨酰内肽酶水解啤酒蛋白的研究,食品与发酵工业,34(2):113-116)
Aron P.M.,and Shellhammer T.H.,2010,A Discussion of Polyphenols in Beer Physical and Flavour Stability,Journal of the Institute of Brewing,116(4):369-380
Besedin D.V.,and Rudenskaya G.N.,2003,Proline-specific endopeptidases,Russian Journal of Bioorganic Chemistry,29(1):1-17
Besteiro S.,Williams R.A.,Coombs G.H.,and Mottram J.C.,2007,Protein turnover and differentiation in leishmania,International Journal for Parasitology,37(10):1063-1075
Carvalho K.M.,and Camargo A.C.,1981,Purification of rabbit brain endooligopeptidases and preparation of antienzyme antibodies,Biochemistry,20(25):7082-7088
Cong P.J.,2000,Some contributing factors on non-bio-stability of beer,Niangjiu Keji(Liquor-Making Science and Technology),(5):62-63(丛培江,2000,啤酒非生物稳定性的几种影响因素,酿酒科技,(5):62-63)
Cunningham D.F.,and O'Connor B.,1997,Proline specific peptidases,Biochimica Et Biophysica Acta,1343(2):160-186
Fulop V.,Bocskei Z.,and Polgar L.,1998,Prolyl oligopeptidase:an unusual beta-propeller domain regulates proteolysis,Cell,94(2):161-170
Fulop V.,Szeltner Z.,and Polgar L.,2000,Catalysis of serine oligopeptidases is controlled by a gating filter mechanism,EMBO Reports,1(3):277-281
Fuxreiter M.,Magyar C.,Juhasz T.,Szeltner Z.,Polgar L.,and Simon I.,2005,Flexibility of prolyl oligopeptidase:molecular dynamics and molecular framework analysis of the potential substrate pathways,Proteins Structure Function and Bioinformatics,60(3):504-512
Garcia-Horsman J.A.,Mannisto P.T.,and Venalainen J.I.,2007,On the role of prolyl oligopeptidase in health and disease,Neuropeptides,41:1-24
Gass J.,and Khosla C.,2007,Prolyl endopeptidases,Cellular and Molecular Life Sciences,64(3):345-355
Habibi-Najafi M.B.,and Lee B.H.,1994,Proline-specific peptidases of Lactobacillus casei subspecies,Journal of Dairy Science,77(2):385-392
Harwood V.J.,Denson J.D.,Robinson-Bidle K.A.,and Schreier H.J,1997,Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic archaeon pyrococcus furiosus,Journal of Bacteriology,179(11):3613-3618
Harwood V.J.,and Schreier H.J.,2001,Prolyl oligopeptidase from Pyrococcus furiosus,Methods in Enzymol,330:445-454
Heredia-Sandoval N.G.,de la Barca A.M.C.,and Islas-Rubio A.R.,2016,Gluten degradation in wheat flour with Aspergillus niger,prolyl-endopeptidase to prepare a gluten-reduced bread supplemented with an amaranth blend,Journal of Cereal Science,71:73-77
Irazusta J.,Larrinaga G.,González-Maeso J.,Gil J.,Meana J.J.,and Casis L.,2002,Distribution of prolyl endopeptidase activities in rat and human brain,Neurochemistry International,40(4):337-345
Jaeken J.,Martens K.,Franois I.,Eyskens F.,Lecointre C.,Derua R.,Meulemans S.,Slootstra J.W.,Waelkens E.,Zegher F.D.,Creemers J.W.M.,and Matthijs G.,2006,Deletion of PREPL,a gene encoding a putative serine oligopeptidase,in patients with hypotonia-cystinuria syndrome,American Journal of Human Genetics,78(1):38-51
Jalkanen A.J.,Hakkarainen J.J.,Lehtonen M.,Venalainen T.,Kaariainen T.M.,Jarho E.,Suhonen M.,and Forsberg M.M.,2011,Brain pharmacokinetics of two prolyl oligopeptidase inhibitors,JTP-4819 and KYP-2047,in the rat,Basic and Clinical Pharmacology and Toxicology,109(6):443-451
Kabashima T.,Fujii M.,Meng Y.,Ito K.,and Yoshimoto T.,1998,Prolyl endopeptidase from sphingomonas capsulata:isolation and characterization of the enzyme and nucleotide sequence of the gene,Archives of Biochemistry and Biophysics,358(1):141-148
Kalwant S.,and Porter A.G.,1991,Purification and characterization of human brain prolyl endopeptidase,Biochemical Journal,276(1):237-244
Kang C.,Yu X.W.,and Xu Y.,2015,Cloning and expression of a novel prolyl endopeptidase from Aspergillus oryzae and its application in beer stabilization,Journal of Industrial Microbiology and Biotechnology,42(2):263-272
Kusuhara M.,Hachisuka H.,Nakano S.,and Sasai Y.,1993,Purification and characterization of prolyl endopeptidase from rat skin,Journal of Dermatological Science,6(2):138-145
Kuwabara T.,1992,Characterization of a prolyl endopeptidase from spinach thylakoids,FEBS Letters,300(2):127-130
Larrinaga G.,Perez I.,Blanco L.,López J.I.,Andrés L.,and Etxezarraga C.,2010,Santaolalla F.,Zabala A.,Varona A.,I-razusta J.,Increased prolyl endopeptidase activity in human neoplasia,Regulatory Peptides,163(1):102-106
Li M.,amd Chen C.Q.,2000,Progress in the studies of prolyl endopeptidase,Shengwuhuaxue Yu Shengwuwuli Jingzhan(Prog Biochem Biophys),27(2):171-174(李民,陈常庆,2000,脯氨酰内肽酶研究进展,生物化学与生物物理进展,27(2):171-174)
Luoto S.,Jiang Z.,Brinck O.,Sontag-Strohm T.,Kanerva P.,Bruins M.,Edens L.,Salovaara H.,and Loponen J.,2012,Malt hydrolysates for gluten-free applications:autolytic and proline endopeptidase assisted removal of prolamins from wheat,barley and rye,Journal of Cereal Science,56(2):504-509
Maes M.,Goossens F.,Scharpe S.,Meltzer H.Y.,D'Hondt P.,and Cosyns P.,1994,Lower serum prolyl endopeptidase enzyme activity in major depression:further evidence that peptidases play a role in the pathophysiology of depression,Biological Psychiatry,35(8):545-552
Mantle D.,Falkous G.,Ishiura S.,Blanchard P.J.,and Perry E.K.,1996,Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease,lewy body dementia,parkinson's disease and huntington's disease,Clinica Chimica Acta,249(1-2):129
Min L.,Chen C.Q.,Davies D.R.,and Chiu T.K,2010,Induced-fit mechanism for prolyl endopeptidase,Journal of Biological Chemistry,285(28):21487-21495
O'Leary R.M.,and O'Connor B.,1995,Identification and localisation of a synaptosomal membrane prolyl endopeptidase from bovine brain,Febs Journal,227(1-2):277-283
Oyama H.,Aoki H.,Amano M.,Mizuki E.,Yoshimoto T.,Tsuru D.,and Murao S.,1997,Purification and characterization of a prolyl endopeptidase from pseudomonas,sp.ku-22,Journal of Fermentation and Bioengineering,84(6):538-542
Polgar L.,1991,PH dependent mechanism in the catalysis of prolyl endopeptidase from pig muscle,European Journal of Biochemistry,197(2):441-447
Polgar L.,1992,Prolyl endopeptidase catalysis,A physical rather than a chemical step is rate-limiting,Biochemical Journal,283(3):647-648
Polgar L.,1994,Prolyl oligopeptidases,Methods Enzymol.,244:188-200
Racys D.T.,Fulop R.V.,and Wills M.,2010,Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide,.Bioorganic and Medicinal Chemistry,18(13):4775-4782
Rampon C.,Jiang C.H.,Dong H.,Tang Y.P.,Lockhart D.J.,Schultz P.G.,and Tsien J.Z.,2000,Effects of environmental enrichment on gene expression in the brain,Proceedings of the National Academy of Sciences of the United States of America,97(23):12880-12884
Rea D.,and Fulop V.,2006,Structure-function properties of prolyl oligopeptidase family enzymes,Cell Biochemistry and Biophysics,44(3):349-365
Rosenblum J.S.,and Kozarich J.W.,2003,Prolyl peptidases:a serine protease subfamily with high potential for drug dis covery,Current Opinion in Chemical Biology,7(4):496-504
Sattar A.K.,Yamamoto N.,Yoshimoto T.,and Tsuru D.,1990,Purification and characterization of an extracellular prolyl endopeptidase from agaricus bisporus,Journal of Biochemistry,107(2):256-261
Savolainen M.H.,Richie C.T.,Harvey B.K.,Mannist P.T.,Maguire-Zeiss K.A.,and Myohanen T.T.,2014,The beneficial effect of a prolyl oligopeptidase inhibitor,KYP-2047,on alpha-synuclein clearance and autophagy in a30p transgenic mouse,Neurobiology of Disease,68:1-15
Schneider J.S.,Giardiniere M.,and Morain P.,2002,Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys,Neuropsychopharmacology,26:176-182
Shan L.,Mathews I.I.,and Khosla C.,2005,Structural and mechanistic analysis of two prolyl endopeptidases:role of interdomain dynamics in catalysis and specificity,Proceedings of the National Academy of Sciences of the United States of America,102(10):3599-3604
Shen G.X.,and Shi J.P.,1999,Cloning and nucleotide sequencing of prolyl endopeptidase gene from Aeromonas punctata subsp.Punctata,Shengwuhuaxue Yu Shengwuwuli Xuebao(Acta Biochimica et Biophysica Sinica),31(5):567-571(沈国祥,史济平,1999,点状产气单胞菌脯氨酰内肽酶基因的克隆与序列测定,生物化学与生物物理学报,31(5):567-571)
Shirasawa Y.,Osawa T.,and Hirashima A.,1994,Molecular cloning and characterization of prolyl endopeptidase from human T cells,Journal of Biochemistry,115(4):724-729
Storey E.,and Cappai R.,1999,The amyloid precursor protein of Alzheimer's disease and the Abeta peptide,Neuropathology and applied neurobiology,25(2):81-97
Szeltner Z.,Rea D.,Juhasz T.,Renner V.,Fulop V.,and Polgar L.,2004,Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding,Journal of Molecular Biology,340(3):627-637
Szwajcer-Dey E.,Rasmussen J.,and Meldal M.,1992,Proline-specific endopeptidases from microbial sources:isolation of an enzyme from a Xanthomonas sp.,Journal of Bacteriology,174(8):2454-2459
Tang J.,Yan L.J.,Weng L.,Sun L.C.,Liu G.M.,and Cao M.J.,2016,Purification and characterization of a prolyl endopeptidase from the skeletal muscle of blue scad(Decapterus marudsi)and its possible role in collagen degradation,Xiandai Shiping Keji(Modern Food Science and Technology),32(6):122-129(唐俊,颜龙杰,翁凌,孙乐常,刘光明,曹敏杰,2016,蓝圆鲹骨骼肌脯氨酸内肽酶的分离纯化及其对胶原肽的作用,现代食品科技,32(6):122-129)
Toide K.,Iwamoto Y.,Fujiwara T.,and Abe H.,1995,JTP-4819:a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer,Journal of Pharmacology and Experimental Therapeutics,274(3):1370-1378
Walter R.,Shlank H.,Glass J.D.,Schwartz I.L.,and Kerenyi T.D.,1971,Leucylglycinamide released from oxytocin by human uterine enzyme,Science,173(3999):827-829
Walter R.,Simmons W.H.,and Yoshimoto T.,1980,Proline specific endo and exopeptidases,Molecular and Cellular Biochemistry,30(2):111-127
Walter T.,and Wieser H.,2014,Degradation of gluten in wheat bran and bread drink by means of a proline-specific peptidase,Journal of Nutrition and Food Sciences,4(5):293
Walter T.,Wieser H.,and Koehler P.,2014,Production of gluten-free wheat starch by peptidase treatment,Journal of Cereal Science,60(1):202-209
Wang M.X.,2015,Purification and characterizaition of a prolyl endopeptidase from the skeletal muscle of common carp(Cyprinus carpio),Thesis for M.S.,Jimei Daxue(Jimei University),Supervisor:Cao M J.,pp.23-40(王梦想,2015,鲤鱼肌肉脯氨酸内肽酶的分离纯化及性质分析,硕士学位论文,集美大学,导师:曹敏杰,pp.23-40)
Weng L.,Lin Y.,Zhang L.,Zhang L.J.,Yan L.J.,Liu G.M.and Cao M.J.,2015,Study on a prolyl endopeptidase from the Skeletal Muscle of Grass Carp,Zhongguo Shiping Xuebao(Ctenopharyngodon idellus),Zhongguo Shipin Xuebao(Journal of Chinese Institute of Food Science and Technology),15(9):23-31(翁凌,林韵,张玲,张凌晶,颜龙杰,刘光明,曹敏杰,2015,草鱼肌肉脯氨酸内肽酶的研究,中国食品学报,15(9):23-31)
Yoshimoto T.,Ogita K.,Walter R.,Koida M,and Tsuru D.,1979,Post-proline cleaving enzyme synthesis of a new fluorogenic substrate and distribution of the endopeptidase in rat tissues and body fluids of man,Biochim Biophys Acta.,569(2):184-192
Yoshimoto T.,Sattar A.K.M.A.,Hirose W.,and Tsuru D.,1987,Studies on prolyl endopeptidase from carrot(Daucus carota):purification and enzymatic properties,Biochimica et Bio physica Acta(BBA)-Protein Structure and Molecular Enzymology,916(1):29-37
Yoshimoto T.,Oyama H.,Koriyama N.,and Tsuru D.,1988,Prolyl endopeptidase from bovine testis:purification,characterization and comparison with the enzymes from other tis-sues,Chemical and Pharmaceutical Bulletin,36(4):1456-1462
Zhou L.N.,Zhang L.,Lu.F.P.,Yang D.,and Xiang C.X.,2008,Study on hydrolysis of the protein in beer by prolyl endopeptidase,Shiping Yu Fajiao Gongye(Food and Fermentation Industries),34(2):113-116(周丽娜,张鹭,路福平,杨迪,向先长,2008,脯氨酰内肽酶水解啤酒蛋白的研究,食品与发酵工业,34(2):113-116)