丙基硫氧嘧啶与甲巯咪唑治疗妊娠合并甲状腺功能亢进的疗效研究
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摘要
目的对比丙基硫氧嘧啶与甲巯咪唑治疗妊娠合并甲状腺功能亢进的临床效果。方法选取94例妊娠合并甲亢患者,采用抽签法将其分为两组,参照组(n=47)采用丙基硫氧嘧啶治疗,实验组(n=47)采用甲巯咪唑治疗,对比二组的甲状腺功能及妊娠结局。结果治疗后,实验组TSH、FT3、FT4、TT3、TT4各指标水平均低于参照组,组间比较P<0.05;两组患者的流产率、早产率、剖宫产率以及新生儿Apgar评分比较均无显著差异,组间比较P>0.05。结论对于妊娠合并甲亢患者,采用丙基硫氧嘧啶与甲巯咪唑治疗均有良好效果,二者对妊娠结局及胎儿的影响性无差异,但甲巯咪唑治在改善甲状腺功能方面稍显优势。
Objective to compare the clinical effects of propyl thiouracil and methimidazole in the treatment of pregnancy complicated with hyperthyroidism. Methods 94 cases of pregnancy complicated with hyperthyroidism were divided into two groups by drawing lots, the reference group(n =47) was treated with propofol, and the experimental group(n =47) was treated with MTX. Then comparing the thyroid function and pregnancy outcome in the two groups. Results after treatment, each index level of the test group TSH, FT3, FT4, TT3, TT4 is lower than the reference group. Comparison in the groups, P <0.05. There was no significant difference in abortion rate, preterm birth rate, cesarean section rate and neonatal Apgar score between the two groups. Comparison in the groups, P >0.05. Conclusion it has good effect on the treatment of patients with hyperthyroidism in pregnancy combined with the use of propyl thiouracil and methimidazole. There was no difference in the effect of the two on pregnancy outcome and fetus, but there was a slight advantage in the improvement of thyroid function by the treatment of metronidazole.
Objective to compare the clinical effects of propyl thiouracil and methimidazole in the treatment of pregnancy complicated with hyperthyroidism. Methods 94 cases of pregnancy complicated with hyperthyroidism were divided into two groups by drawing lots, the reference group(n =47) was treated with propofol, and the experimental group(n =47) was treated with MTX. Then comparing the thyroid function and pregnancy outcome in the two groups. Results after treatment, each index level of the test group TSH, FT3, FT4, TT3, TT4 is lower than the reference group. Comparison in the groups, P <0.05. There was no significant difference in abortion rate, preterm birth rate, cesarean section rate and neonatal Apgar score between the two groups. Comparison in the groups, P >0.05. Conclusion it has good effect on the treatment of patients with hyperthyroidism in pregnancy combined with the use of propyl thiouracil and methimidazole. There was no difference in the effect of the two on pregnancy outcome and fetus, but there was a slight advantage in the improvement of thyroid function by the treatment of metronidazole.
引文
[1]杨静芬.妊娠合并甲状腺功能亢进症对妊娠结局及新生儿的影响分析[J].世界最新医学信息文摘,2015,15(12):21+25.
[2]李淑文.丙基硫氧嘧啶对妊娠合并甲亢患者的影响探讨[J].中国医药指南,2018,16(6):105-106.
[3]高洪伟.抗甲状腺药物在甲状腺疾病中的疗效和安全性评价[J].药品评价,2015(9):35-39.
[4]郝静,杨悦.妊娠女性服用抗甲状腺药物与新生儿出生缺陷的相关性分析及防治策略[J].解放军预防医学杂志,2018,36(2):254-257.
[5]谢开福.丙基硫氧嘧啶治疗妊娠合并甲状腺功能亢进54例临床疗效观察[J].国际医药卫生导报,2013,19(9):1282-1284.
[6]朱代玉,杨永碧,李丽,等.妊娠合并甲亢对母婴代谢指标及预后的影响[J].中国妇幼保健,2017,32(12):2605-2608.
[7]束晓明,周晓燕,吕述彦,等.妊娠合并甲亢的妊娠结局分析[J].现代仪器与医疗,2016,22(2):73-75.
[8]谢爱贤.口服丙硫氧嘧啶对妊娠合并甲状腺功能亢进患者甲状腺激素水平及妊娠结局的影响[J].临床合理用药杂志,2016,9(12):82-83.
[2]李淑文.丙基硫氧嘧啶对妊娠合并甲亢患者的影响探讨[J].中国医药指南,2018,16(6):105-106.
[3]高洪伟.抗甲状腺药物在甲状腺疾病中的疗效和安全性评价[J].药品评价,2015(9):35-39.
[4]郝静,杨悦.妊娠女性服用抗甲状腺药物与新生儿出生缺陷的相关性分析及防治策略[J].解放军预防医学杂志,2018,36(2):254-257.
[5]谢开福.丙基硫氧嘧啶治疗妊娠合并甲状腺功能亢进54例临床疗效观察[J].国际医药卫生导报,2013,19(9):1282-1284.
[6]朱代玉,杨永碧,李丽,等.妊娠合并甲亢对母婴代谢指标及预后的影响[J].中国妇幼保健,2017,32(12):2605-2608.
[7]束晓明,周晓燕,吕述彦,等.妊娠合并甲亢的妊娠结局分析[J].现代仪器与医疗,2016,22(2):73-75.
[8]谢爱贤.口服丙硫氧嘧啶对妊娠合并甲状腺功能亢进患者甲状腺激素水平及妊娠结局的影响[J].临床合理用药杂志,2016,9(12):82-83.
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