强脉冲光联合石膏倒模治疗面部痤疮疗效研究
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摘要
目的:研究强脉冲光联合石膏倒模治疗面部痤疮的美容效果和安全性。方法:选取2016年6月-2018年6月笔者医院收治的120例面部痤疮患者,按抽签随机方法分为两组,每组各60例。其中对照组予以单纯石膏倒模治疗,观察组实施强脉冲光联合石膏倒模治疗,均持续治疗1个月。对比两组临床疗效,分析两组治疗前后皮损计数及不良反应发生情况。结果:观察组总有效率为96.67%,明显高于对照组的85.00%,差异有统计学意义(P<0.05)。两组治疗后炎性皮损、非炎性皮损、总皮损计数均显著低于治疗前(P<0.05),观察组治疗后炎性皮损、总皮损计数均显著低于对照组(P<0.05)。观察组治疗期间不良反应发生率为3.33%,对照组治疗期间未见明显不良反应发生,差异无统计学意义(P>0.05)。结论:强脉冲光联合石膏倒模治疗面部痤疮临床疗效确切,能明显改善患者皮损,安全性较好。
Objective To study the cosmetic effect and safety of intense pulsed light combined with plaster inversion in the treatment of facial acne. Methods 120 patients with facial acne were enrolled in our hospital from June 2016 to June 2018. They were randomly divided into two groups, 60 cases each. The controlgroup was treated with plaster inversion alone, while the observation group wastreated with intense pulsed light combined with plaster inversion for 1 month.The clinical effects of the two groups were compared, and the skin lesion countsand adverse reactions before and after treatment were analyzed. Results The total effective rate in the observation group was 96.67%, significantly higher than that in the control group(85.00%), and the difference was statistically significant(P<0.05). After treatment, the counts of inflammatory, non-inflammatory and total skin lesions in the two groups were significantly lower than those before treatment(P<0.05), and the counts of inflammatory and total skin lesions in the observation group were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions during treatment in the observation group was 3.33%, while no significant adverse reactions were observed in the control group(P>0.05). Conclusion Intensive pulsed light combined with plaster inverted model treatment of facial acne has definite clinical efficacy, can significantly improve the skin lesions of patients, and has good safety.
Objective To study the cosmetic effect and safety of intense pulsed light combined with plaster inversion in the treatment of facial acne. Methods 120 patients with facial acne were enrolled in our hospital from June 2016 to June 2018. They were randomly divided into two groups, 60 cases each. The controlgroup was treated with plaster inversion alone, while the observation group wastreated with intense pulsed light combined with plaster inversion for 1 month.The clinical effects of the two groups were compared, and the skin lesion countsand adverse reactions before and after treatment were analyzed. Results The total effective rate in the observation group was 96.67%, significantly higher than that in the control group(85.00%), and the difference was statistically significant(P<0.05). After treatment, the counts of inflammatory, non-inflammatory and total skin lesions in the two groups were significantly lower than those before treatment(P<0.05), and the counts of inflammatory and total skin lesions in the observation group were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions during treatment in the observation group was 3.33%, while no significant adverse reactions were observed in the control group(P>0.05). Conclusion Intensive pulsed light combined with plaster inverted model treatment of facial acne has definite clinical efficacy, can significantly improve the skin lesions of patients, and has good safety.
引文
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[8]Park JH,Kim JI,Kim WS.Treatment of persistent facial postinflammatory hyperpigmentation with novel pulse-in-pulse mode intense pulsed light[J].Dermatol Surg,2016,42(2):218-224.
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[11]彭勇,罗瑞静,刘杰,等.基于现代文献的痤疮中药面膜用药规律分析[J].中医药导报, 2018,308(10):32-34,39.
[12]吴亚梅,华桦,黄志芳.复方白蔹面膜对兔耳痤疮模型治疗作用的实验研究[J].四川中医,2016,34(8):43-46.
[13]徐萍,赵小兴.当归苦参丸联合红蓝光和维A酸乳膏治疗中度痤疮疗效评价[J].中国麻风皮肤病杂志,2016,32(1):18-19.
[14]何亚丽.胶原贴联合粉刺挤压术及中药石膏倒模术治疗面部寻常性痤疮的疗效观察及意义分析[J].中国药物与临床,2015,15(3):416-417.
[15]Liu L,Fan X,An Y,et al.Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients[J].Photodermatol Photoimmunol Photomed,2015,30(5):246-253.
[2]Aslam I,Fleischer A,Feldman S.Emerging drugs for the treatment of acne[J].Expert Opin Emerg Drugs,2015,20(1):91-101.
[3]何娟.超脉冲二氧化碳激光联合强脉冲光治疗面部寻常性痤疮临床分析[J].中国美容医学,2016,25(10):94-96.
[4]中华医学会.临床诊疗指南·皮肤病与性病分册[M].北京:人民卫生出版社,2006:150.
[5]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:29.
[6]Bremner JD,Fani N,Ashraf A,et al.Functional brain imaging alterations in acne patients treated with isotretinoin[J].Am J Psychiatry,2016,162(5):983-910.
[7]Barakat MT,Moftah NH,El Khayyat MA,et al.Significant reduction of inflammation and sebaceous glands size in acne vulgaris lesions after intense pulsed light treatment[J].Dermatol Ther,2017,30(1):1-5.
[8]Park JH,Kim JI,Kim WS.Treatment of persistent facial postinflammatory hyperpigmentation with novel pulse-in-pulse mode intense pulsed light[J].Dermatol Surg,2016,42(2):218-224.
[9]梁俊芳,王用峰.强脉冲光联合中药倒模治疗面部痤疮红斑及色素沉着的临床疗效[J].现代中医药,2016,36(6):43-44.
[10]Lekwuttikarn R,Tempark T,Chatproedprai S,et al.Randomized,controlled trial split-faced study of 595-nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood[J].Int J Dermatol,2017,56(8):884-888.
[11]彭勇,罗瑞静,刘杰,等.基于现代文献的痤疮中药面膜用药规律分析[J].中医药导报, 2018,308(10):32-34,39.
[12]吴亚梅,华桦,黄志芳.复方白蔹面膜对兔耳痤疮模型治疗作用的实验研究[J].四川中医,2016,34(8):43-46.
[13]徐萍,赵小兴.当归苦参丸联合红蓝光和维A酸乳膏治疗中度痤疮疗效评价[J].中国麻风皮肤病杂志,2016,32(1):18-19.
[14]何亚丽.胶原贴联合粉刺挤压术及中药石膏倒模术治疗面部寻常性痤疮的疗效观察及意义分析[J].中国药物与临床,2015,15(3):416-417.
[15]Liu L,Fan X,An Y,et al.Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients[J].Photodermatol Photoimmunol Photomed,2015,30(5):246-253.