甘草解毒现代研究进展
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摘要
甘草具"解百草毒"之功,常在组方中起解毒、调和诸药的作用。中医药现代研究应用中,甘草解毒作用研究显得尤为重要。本文归纳甘草解毒古籍记载,并从解毒作用、解毒机制方面对相关现代研究进行整理,为甘草解毒后续研究及应用提供参考。
Glycyrrhizae Radix et Rhizoma has the function of "detoxification for hundreds of herbs", and often plays the role of detoxification and harmonization of various medicines in the formulated prescriptions. Study on detoxification effect of Glycyrrhizae Radix et Rhizoma has played an increasingly important role in modern research and application of TCM. This article summarized records about detoxification effect of Glycyrrhizae Radix et Rhizoma in ancient books, and combed relevant modern research from the aspects of detoxification effects and mechanism, with a purpose to provide references for further research and application of detoxification effect of Glycyrrhizae Radix et Rhizoma.
Glycyrrhizae Radix et Rhizoma has the function of "detoxification for hundreds of herbs", and often plays the role of detoxification and harmonization of various medicines in the formulated prescriptions. Study on detoxification effect of Glycyrrhizae Radix et Rhizoma has played an increasingly important role in modern research and application of TCM. This article summarized records about detoxification effect of Glycyrrhizae Radix et Rhizoma in ancient books, and combed relevant modern research from the aspects of detoxification effects and mechanism, with a purpose to provide references for further research and application of detoxification effect of Glycyrrhizae Radix et Rhizoma.
引文
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[2]王军,张虹,谢凤杰,等.甘草酸预处理对大鼠心肌缺血再灌注损伤的保护作用及Bcl-2和Bax表达的影响[J].中国实验方剂学杂志,2018,24(6):126-132.
[3]FUJISAWAY,SAKAMOTOM,MATSUSHITAM,etal.Glycyrrhizin inhibits the lytic pathway of complement-possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis[J].Microbiology&Immunology,2013,44(9):799-804.
[4]JUNGEH,LEEJH,SANGCK,etal.AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor[J]. Eur J Nutr,2017,56(2):635-647.
[5]王颖,韩秀萍.甘草酸苷作用机制的研究进展[J].实用药物与临床,2018,21(1):109-113.
[6]张宇燕,杨洁红.附子甘草配伍对乌头碱、甘草酸、甘草苷的动态影响[J].中国药学杂志,2009,44(1):11-14.
[7]沈红,朱玲英,姚楠,等.甘草与附子配伍对乌头碱、新乌头碱、次乌头碱大鼠药动学的影响[J].中药材,2011,34(6):937-942.
[8]郭玉岩,马文保,肖洪彬,等.基于UPLC-MS技术分析马钱子-甘草药对配伍汤液不同相态中毒效物质的变化规律[J].中草药,2017,48(23):4880-4884.
[9]张敏,邓阳,文雅洁,等.基于HPLC-UV-MS技术的甘草和马钱子大鼠口服入血成分分析[J].中国药学杂志,2017,52(9):731-737.
[10]张敏,王超,温菁,等.甘草提取物对中毒剂量马钱子碱的药代动力学影响[J].中国临床药理学杂志,2017,33(22):2282-2286.
[11]闫雪生,朱建伟,江波,等.马钱子与甘草配伍前后士的宁和马钱子碱的HPLC分析[J].亚太传统医药,2009,5(10):18-19.
[12]闫静,朱海光,刘志强,等.马钱子与甘草配伍前后生物碱成分的变化规律[J].分析化学,2007,35(8):1218-1220.
[13]叶敏,王俊俊,简静,等.马钱子碱体外吸收机制及其与甘草苷的转运相互作用研究[J].中华中医药杂志,2013,28(1):100-103.
[14]王俊俊,廖晓欢,叶敏,等.Caco-2单层细胞模型上士的宁的体外吸收机制及其与甘草苷的转运相互作用[J].药学学报,2010,45(9):1160-1164.
[15]马致洁,章从恩,唐进法,等.雷公藤配伍甘草降低肝毒性的代谢通路探讨[J].药学学报,2017,52(7):1077-1084.
[16]范金晶,华碧春,刘娇,等.甘草减轻黄药子对大鼠肾毒性的实验研究[J].医学研究杂志,2014,43(9):31-33.
[17]闫玉兰,莫永森,张冬梅.异甘草酸镁对化疗药物致初治胃肠道肿瘤患者肝损害的预防作用[J].中华肝脏病杂志,2015,23(3):204-208.
[18]何华,葛志伟,刘雳,等.甘草黄酮对阿霉素细胞毒性的影响及其构效关系研究[J].中草药,2010,41(6):941-945.
[19]何华.甘草提取物及其活性成分抗阿霉素心脏毒性作用及其机制研究[D].杭州:浙江大学,2010.
[20]刘秀英,王翔朴,曾庆善,等.甘草甜素和齐墩果酸对镉中毒肾损害的影响[J].中国公共卫生,2002,18(6):28-30.
[21]刘秀英,王翔朴,贺全仁,等.甘草甜素和齐墩果酸对大鼠镉中毒性肝损伤的防护作用与机理[J].中国公共卫生,2000,16(1):25-28.
[22]陈国杰,郑义,宋彩霞,等.大黄、芒硝及甘草导泻治疗急性百草枯中毒的临床研究[J].临床合理用药杂志,2014,7(35):43-44.
[23]张伟,张剑锋,李浩,等.甘草酸二铵对百草枯中毒大鼠肾组织TOLL样受体4表达的影响[J].中华急诊医学杂志,2015,24(11):1214-1219.
[24]张翔,呼延尧,杨武,等.“甘草绿豆解毒汤”治疗家畜中毒的效果观察[J].养殖技术顾问,2010(9):102-103.
[25]刘建群,刘一文,王雪梅,等.甘草对雷公藤甲素与雷公藤内酯酮体内代谢成分的影响[J].中国实验方剂学杂志,2013,19(13):169-173.
[26]杨明,刘小彬,黄庆德.附子甘草配伍减毒增效机理探析[J].时珍国医国药,2003,14(4):197-198.
[27]卓实,华碧春,何柯利,等.甘草减轻川楝子肝毒性的实验研究[J].临床合理用药杂志,2018,11(4):93-95.
[28]赵小梅,宫嫚,董捷鸣,等.甘草炮制雷公藤降低其肝毒性作用的初步研究[J].中国中药杂志,2017,42(1):119-124.
[29] NEBERT D W, RUSSELL D W. Clinical importance of the cytochromes P450[J]. Lancet,2002,360(9340):1155-1162.
[30] FUJIWARA R, YOKOI T, NAKAJIMA M. Structure and protein-protein interactions of human UDP-glucuronosyltransferases[J]. Frontiers in Pharmacology,2016,7(69):388.
[31] STAUDINGER J L, GOODWIN B, JONES S A, et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity[J]. Proceedings of the National Academy of Sciences of the United States of America,2001,98(6):3369-3374.
[32]戴立波,方平飞,李焕德.药物过量时激活核受体孕烷X受体促进毒物消除的解毒机制[J].中国临床药理学杂志,2018,34(4):454-457.
[33]张靖,胡骞,谭亲友,等.甘草提取物对雷公藤甲素损伤后人肝L-02细胞中UGT1A、MRP2表达的影响[J].中国药房,2018,29(1):65-68.
[34] LU Y, XIE T, ZHANG Y, et al. Triptolide Induces hepatotoxicity viainhibition of CYP450s in Ratliver microsomes[J].BMC Complementary & Alternative Medicine,2017,17(1):15.
[35]谭亲友.甘草酸18H差向异构体及其水解产物对Ⅱ相解毒酶的影响及其机制的研究[D].长沙:中南大学,2012.
[36]苗潇磊,王俊俊,孟沫然,等.次乌头碱、甘草苷单用与合用对大鼠肝脏CYP450酶mRNA表达与活性的影响[J].中华中医药杂志,2016,31(1):313-316.
[37]邢盼盼,吴文华,杜鹏,等.马钱子碱与甘草次酸、甘草苷配伍后对大鼠肝脏CYP450的影响(英文)[J].药学学报,2011,46(5):573-580.
[38]卜晓芬,李骏,朱虹.甘草甜素对体外诱导的酒精性脂肪肝细胞的影响及机制研究[J].重庆医学,2018,47(4):436-438,445.
[39]华碧春,胡娟,王瑞国,等.甘草降低黄药子致小鼠肝毒性的实验研究[J].世界中西医结合杂志,2011,6(1):24-27.
[40]李莹,傅超美,彭伟,等.四逆汤中甘草减附子之毒的代谢组学研究[J].中国中药杂志,2016,41(8):1523-1529.
[41]李莹,傅超美,任波,等.基于MI-RI大鼠心肌细胞代谢组学研究四逆汤中附子配伍甘草解毒增效机制[J].中国中药杂志,2014,39(16):3166-3171.
[42]刘巧云,张宇燕,万海同,等.次乌头碱与甘草苷、甘草次酸配伍的减毒作用[J].中华中医药杂志,2013,28(9):2601-2604.
[2]王军,张虹,谢凤杰,等.甘草酸预处理对大鼠心肌缺血再灌注损伤的保护作用及Bcl-2和Bax表达的影响[J].中国实验方剂学杂志,2018,24(6):126-132.
[3]FUJISAWAY,SAKAMOTOM,MATSUSHITAM,etal.Glycyrrhizin inhibits the lytic pathway of complement-possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis[J].Microbiology&Immunology,2013,44(9):799-804.
[4]JUNGEH,LEEJH,SANGCK,etal.AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor[J]. Eur J Nutr,2017,56(2):635-647.
[5]王颖,韩秀萍.甘草酸苷作用机制的研究进展[J].实用药物与临床,2018,21(1):109-113.
[6]张宇燕,杨洁红.附子甘草配伍对乌头碱、甘草酸、甘草苷的动态影响[J].中国药学杂志,2009,44(1):11-14.
[7]沈红,朱玲英,姚楠,等.甘草与附子配伍对乌头碱、新乌头碱、次乌头碱大鼠药动学的影响[J].中药材,2011,34(6):937-942.
[8]郭玉岩,马文保,肖洪彬,等.基于UPLC-MS技术分析马钱子-甘草药对配伍汤液不同相态中毒效物质的变化规律[J].中草药,2017,48(23):4880-4884.
[9]张敏,邓阳,文雅洁,等.基于HPLC-UV-MS技术的甘草和马钱子大鼠口服入血成分分析[J].中国药学杂志,2017,52(9):731-737.
[10]张敏,王超,温菁,等.甘草提取物对中毒剂量马钱子碱的药代动力学影响[J].中国临床药理学杂志,2017,33(22):2282-2286.
[11]闫雪生,朱建伟,江波,等.马钱子与甘草配伍前后士的宁和马钱子碱的HPLC分析[J].亚太传统医药,2009,5(10):18-19.
[12]闫静,朱海光,刘志强,等.马钱子与甘草配伍前后生物碱成分的变化规律[J].分析化学,2007,35(8):1218-1220.
[13]叶敏,王俊俊,简静,等.马钱子碱体外吸收机制及其与甘草苷的转运相互作用研究[J].中华中医药杂志,2013,28(1):100-103.
[14]王俊俊,廖晓欢,叶敏,等.Caco-2单层细胞模型上士的宁的体外吸收机制及其与甘草苷的转运相互作用[J].药学学报,2010,45(9):1160-1164.
[15]马致洁,章从恩,唐进法,等.雷公藤配伍甘草降低肝毒性的代谢通路探讨[J].药学学报,2017,52(7):1077-1084.
[16]范金晶,华碧春,刘娇,等.甘草减轻黄药子对大鼠肾毒性的实验研究[J].医学研究杂志,2014,43(9):31-33.
[17]闫玉兰,莫永森,张冬梅.异甘草酸镁对化疗药物致初治胃肠道肿瘤患者肝损害的预防作用[J].中华肝脏病杂志,2015,23(3):204-208.
[18]何华,葛志伟,刘雳,等.甘草黄酮对阿霉素细胞毒性的影响及其构效关系研究[J].中草药,2010,41(6):941-945.
[19]何华.甘草提取物及其活性成分抗阿霉素心脏毒性作用及其机制研究[D].杭州:浙江大学,2010.
[20]刘秀英,王翔朴,曾庆善,等.甘草甜素和齐墩果酸对镉中毒肾损害的影响[J].中国公共卫生,2002,18(6):28-30.
[21]刘秀英,王翔朴,贺全仁,等.甘草甜素和齐墩果酸对大鼠镉中毒性肝损伤的防护作用与机理[J].中国公共卫生,2000,16(1):25-28.
[22]陈国杰,郑义,宋彩霞,等.大黄、芒硝及甘草导泻治疗急性百草枯中毒的临床研究[J].临床合理用药杂志,2014,7(35):43-44.
[23]张伟,张剑锋,李浩,等.甘草酸二铵对百草枯中毒大鼠肾组织TOLL样受体4表达的影响[J].中华急诊医学杂志,2015,24(11):1214-1219.
[24]张翔,呼延尧,杨武,等.“甘草绿豆解毒汤”治疗家畜中毒的效果观察[J].养殖技术顾问,2010(9):102-103.
[25]刘建群,刘一文,王雪梅,等.甘草对雷公藤甲素与雷公藤内酯酮体内代谢成分的影响[J].中国实验方剂学杂志,2013,19(13):169-173.
[26]杨明,刘小彬,黄庆德.附子甘草配伍减毒增效机理探析[J].时珍国医国药,2003,14(4):197-198.
[27]卓实,华碧春,何柯利,等.甘草减轻川楝子肝毒性的实验研究[J].临床合理用药杂志,2018,11(4):93-95.
[28]赵小梅,宫嫚,董捷鸣,等.甘草炮制雷公藤降低其肝毒性作用的初步研究[J].中国中药杂志,2017,42(1):119-124.
[29] NEBERT D W, RUSSELL D W. Clinical importance of the cytochromes P450[J]. Lancet,2002,360(9340):1155-1162.
[30] FUJIWARA R, YOKOI T, NAKAJIMA M. Structure and protein-protein interactions of human UDP-glucuronosyltransferases[J]. Frontiers in Pharmacology,2016,7(69):388.
[31] STAUDINGER J L, GOODWIN B, JONES S A, et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity[J]. Proceedings of the National Academy of Sciences of the United States of America,2001,98(6):3369-3374.
[32]戴立波,方平飞,李焕德.药物过量时激活核受体孕烷X受体促进毒物消除的解毒机制[J].中国临床药理学杂志,2018,34(4):454-457.
[33]张靖,胡骞,谭亲友,等.甘草提取物对雷公藤甲素损伤后人肝L-02细胞中UGT1A、MRP2表达的影响[J].中国药房,2018,29(1):65-68.
[34] LU Y, XIE T, ZHANG Y, et al. Triptolide Induces hepatotoxicity viainhibition of CYP450s in Ratliver microsomes[J].BMC Complementary & Alternative Medicine,2017,17(1):15.
[35]谭亲友.甘草酸18H差向异构体及其水解产物对Ⅱ相解毒酶的影响及其机制的研究[D].长沙:中南大学,2012.
[36]苗潇磊,王俊俊,孟沫然,等.次乌头碱、甘草苷单用与合用对大鼠肝脏CYP450酶mRNA表达与活性的影响[J].中华中医药杂志,2016,31(1):313-316.
[37]邢盼盼,吴文华,杜鹏,等.马钱子碱与甘草次酸、甘草苷配伍后对大鼠肝脏CYP450的影响(英文)[J].药学学报,2011,46(5):573-580.
[38]卜晓芬,李骏,朱虹.甘草甜素对体外诱导的酒精性脂肪肝细胞的影响及机制研究[J].重庆医学,2018,47(4):436-438,445.
[39]华碧春,胡娟,王瑞国,等.甘草降低黄药子致小鼠肝毒性的实验研究[J].世界中西医结合杂志,2011,6(1):24-27.
[40]李莹,傅超美,彭伟,等.四逆汤中甘草减附子之毒的代谢组学研究[J].中国中药杂志,2016,41(8):1523-1529.
[41]李莹,傅超美,任波,等.基于MI-RI大鼠心肌细胞代谢组学研究四逆汤中附子配伍甘草解毒增效机制[J].中国中药杂志,2014,39(16):3166-3171.
[42]刘巧云,张宇燕,万海同,等.次乌头碱与甘草苷、甘草次酸配伍的减毒作用[J].中华中医药杂志,2013,28(9):2601-2604.