胞内寄生菌感染巨噬细胞机制的研究进展
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摘要
<正>少数致病菌主要寄生于细胞内,称为胞内寄生菌(intracellular bacteria),简称胞内菌。其中能引起人类疾病的主要有结核分枝杆菌(Mycobacterium tuberculosis,M.tb)、沙门菌(Salmonella)、布鲁菌(Brucella,Bru.)、嗜肺军团菌(Legionella pneumophila,Lp)和单核细胞增多型李斯特菌(Listeria monocytogenes,LM)。胞内菌通过呼吸道
引文
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[7] Shin S.Innate immunity to intracellular pathogens:Lessons learned from Legionella pneumophila[J].Adv Appl Microbiol,2012,79:43-71.
[8] Escoll P,Rolando M,Gomez-Valero L,et al.From amoeba to macrophages:exploring the molecular mechanisms of Legionella pneumophila infection in both hosts[J].Curr Top Microbiol Immunol,2013,376:1-34.
[9] Zhao Y,Hanniffy S,Arce-Gorvel V,et al.Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo[J].Virulence,2018,9(1):465-479.
[10] Gupta A,Kaul A,Tsolaki A G,et al.Mycobacterium tuberculosis:Immune evasion,latency and reactivation[J].Immunobiology,2012,217(3):363-374.
[11] Mishra A K,Driessen N N,Appelmelk B J,et al.Lipoarabinomannan and related glycoconjugates:structure,biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction[J].FEMS Microbiol Rev,2011,35(6):1126-1157.
[12] Ahmed W,Zheng K,Liu Z F.Establishment of chronic infection:Brucella’s stealth strategy[J].Front Cell Infect Microbiol,2016,6:30.
[13] Roset M S,Ibanez A E,de Souza F J,et al.Brucella cyclic beta-1,2-glucan plays a critical role in the induction of splenomegaly in mice[J].PLoS One,2014,9(7):e101279.
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[15] Isaac D T,Isberg R.Master manipulators:an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets[J].Future Microbiol,2014,9(3):343-359.
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[21] Jeschke A,Haas A.Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis[J].Commun Integr Biol,2016,9(3):e1174798.
[22] Mcgourty K,Thurston T L,Matthews S A,et al.Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function[J].Science,2012,338(6109):963-967.
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[25] Cossart P,Toledo-Arana A.Listeria monocytogenes,a unique model in infection biology:an overview[J].Microbes Infect,2008,10(9):1041-1050.
[26] Shaughnessy L M,Hoppe A D,Christensen K A,et al.Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles[J].Cell Microbiol,2006,8(5):781-792.
[27] Ktistakis N T,Tooze S A.Digesting the expanding mechanisms of autophagy[J].Trends Cell Biol,2016,26(8):624-635.
[28] Chico-Calero I,Suarez M,Gonzalez-Zorn B,et al.Hpt,a bacterial homolog of the microsomal glucose-6-phosphate translocase,mediates rapid intracellular proliferation in Listeria[J].Proc Natl Acad Sci U S A,2002,99(1):431-436.
[29] Yoshikawa Y,Ogawa M,Hain T,et al.Listeria monocytogenes ActA-mediated escape from autophagic recognition[J].Nat Cell Biol,2009,11(10):1233-1240.
[30] Tattoli I,Sorbara M T,Yang C,et al.Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures[J].EMBO J,2013,32(23):3066-3078.
[31] Campoy E,Colombo M I.Autophagy in intracellular bacterial infection[J].Biochim Biophys Acta,2009,1793(9):1465-1477.
[32] Dumont A,Boucrot E,Drevensek S,et al.SKIP,the host target of the Salmonella virulence factor SifA,promotes kinesin-1-dependent vacuolar membrane exchanges[J].Traffic,2010,11(7):899-911.
[33] Ouimet M,Koster S,Sakowski E,et al.Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism[J].Nat Immunol,2016,17(6):677-686.
[34] Starr T,Child R,Wehrly T D,et al.Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle[J].Cell Host Microbe,2012,11(1):33-45.
[35] Escoll P,Rolando M,Buchrieser C.Modulation of host autophagy during bacterial infection:sabotaging host munitions for pathogen nutrition[J].Front Immunol,2016,7:81.
[36] Rolando M,Escoll P,Nora T,et al.Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy[J].Proc Natl Acad Sci U S A,2016,113(7):1901-1906.
[37] Choy A,Dancourt J,Mugo B,et al.The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation[J].Science,2012,338(6110):1072-1076.
[38] Arasaki K,Mikami Y,Shames S R,et al.Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17[J].Nat Commun,2017,8:15406.
[39] Wilson B R,Bogdan A R,Miyazawa M,et al.Siderophores in iron metabolism:from mechanism to therapy potential[J].Trends Mol Med,2016,22(12):1077-1090.
[40] Boradia V M,Malhotra H,Thakkar J S,et al.Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin[J].Nat Commun,2014,5:4730.
[41] Skaar E P.The battle for iron between bacterial pathogens and their vertebrate hosts[J].PLoS Pathog,2010,6(8):e1000949.
[42] Cianciotto N P.An update on iron acquisition by Legionella pneumophila:new pathways for siderophore uptake and ferric iron reduction[J].Future Microbiol,2015,10(5):841-851.
[43] Skaar E P,Raffatellu M.Metals in infectious diseases and nutritional immunity[J].Metallomics,2015,7(6):926-928.
[44] Pantopoulos K,Porwal S K,Tartakoff A,et al.Mechanisms of mammalian iron homeostasis[J].Biochemistry,2012,51(29):5705-5724.
[45] Botella H,Stadthagen G,Lugo-Villarino G,et al.Metallobiology of host-pathogen interactions:an intoxicating new insight[J].Trends Microbiol,2012,20(3):106-112.
[46] Speir M,Vogrin A,Seidi A,et al.Legionella pneumophila Strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin[J].Front Cell Infect Microbiol,2017,7:35.
[47] Ge J,Xu H,Li T,et al.A Legionella type Ⅳ effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors[J].Proc Natl Acad Sci U S A,2009,106(33):13725-13730.
[48] Wu H,Jones R M,Neish A S.The Salmonella effector AvrA mediates bacterial intracellular survival during infection in vivo[J].Cell Microbiol,2012,14(1):28-39.
[49] Zhang K,Wang H,Guo F,et al.OMP31 of Brucella melitensis 16M impairs the apoptosis of macrophages triggered by TNF-alpha[J].Exp Ther Med,2016,12(4):2783-2789.
[50] Czuczman M A,Fattouh R,van Rijn J M,et al.Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread[J].Nature,2014,509(7499):230-234.
[51] Aguilo N,Marinova D,Martin C,et al.ESX-1-induced apoptosis during mycobacterial infection:to be or not to be,that is the question[J].Front Cell Infect Microbiol,2013,3:88.
[52] Celli J,Tsolis R M.Bacteria,the endoplasmic reticulum and the unfolded protein response:friends or foes?[J].Nat Rev Microbiol,2015,13(2):71-82.
[2] Wagner C,Hensel M.Adhesive mechanisms of Salmonella enterica[J].Adv Exp Med Biol,2011,715:17-34.
[3] Velge P,Wiedemann A,Rosselin M,et al.Multiplicity of Salmonella entry mechanisms,a new paradigm for Salmonella pathogenesis[J].Microbiologyopen,2012,1(3):243-258.
[4] Burkholder K M,Bhunia A K.Listeria monocytogenes uses Listeria adhesion protein(LAP)to promote bacterial transepithelial translocation and induces expression of LAP receptor Hsp60[J].Infect Immun,2010,78(12):5062-5073.
[5] Osanai A,Li S J,Asano K,et al.Fibronectin-binding protein,FbpA,is the adhesin responsible for pathogenesis of Listeria monocytogenes infection[J].Microbiol Immunol,2013,57(4):253-262.
[6] Bonazzi M,Vasudevan L,Mallet A,et al.Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization[J].J Cell Biol,2011,195(3):525-536.
[7] Shin S.Innate immunity to intracellular pathogens:Lessons learned from Legionella pneumophila[J].Adv Appl Microbiol,2012,79:43-71.
[8] Escoll P,Rolando M,Gomez-Valero L,et al.From amoeba to macrophages:exploring the molecular mechanisms of Legionella pneumophila infection in both hosts[J].Curr Top Microbiol Immunol,2013,376:1-34.
[9] Zhao Y,Hanniffy S,Arce-Gorvel V,et al.Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo[J].Virulence,2018,9(1):465-479.
[10] Gupta A,Kaul A,Tsolaki A G,et al.Mycobacterium tuberculosis:Immune evasion,latency and reactivation[J].Immunobiology,2012,217(3):363-374.
[11] Mishra A K,Driessen N N,Appelmelk B J,et al.Lipoarabinomannan and related glycoconjugates:structure,biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction[J].FEMS Microbiol Rev,2011,35(6):1126-1157.
[12] Ahmed W,Zheng K,Liu Z F.Establishment of chronic infection:Brucella’s stealth strategy[J].Front Cell Infect Microbiol,2016,6:30.
[13] Roset M S,Ibanez A E,de Souza F J,et al.Brucella cyclic beta-1,2-glucan plays a critical role in the induction of splenomegaly in mice[J].PLoS One,2014,9(7):e101279.
[14] Smith E P,Miller C N,Child R,et al.Postreplication roles of the Brucella VirB Type Ⅳ secretion system uncovered via conditional expression of the VirB11 ATPase[J].MBio,2016,7(6).pii:e01730-16.doi:10.1128/mBio.01730-16.
[15] Isaac D T,Isberg R.Master manipulators:an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets[J].Future Microbiol,2014,9(3):343-359.
[16] Murata T,Delprato A,Ingmundson A,et al.The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor[J].Nat Cell Biol,2006,8(9):971-977.
[17] Seto S,Tsujimura K,Koide Y.Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes[J].Traffic,2011,12(4):407-420.
[18] Conrad W H,Osman M M,Shanahan J K,et al.Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions[J].Proc Natl Acad Sci U S A,2017,114(6):1371-1376.
[19] Puri R V,Reddy P V,Tyagi A K.Secreted acid phosphatase(SapM)of Mycobacterium tuberculosis is indispensable for arresting phagosomal maturation and growth of the pathogen in guinea pig tissues[J].PLoS One,2013,8(7):e70514.
[20] Santos J C,Enninga J.At the crossroads:communication of bacteria-containing vacuoles with host organelles[J].Cell Microbiol,2016,18(3):330-339.
[21] Jeschke A,Haas A.Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis[J].Commun Integr Biol,2016,9(3):e1174798.
[22] Mcgourty K,Thurston T L,Matthews S A,et al.Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function[J].Science,2012,338(6109):963-967.
[23] D’Costa V M,Braun V,Landekic M,et al.Salmonella disrupts host rndocytic trafficking by SopD2-mediated inhibition of Rab7[J].Cell Rep,2015,12(9):1508-1518.
[24] Salcedo S P,Holden D W.Sse G.A virulence protein that targets Salmonella to the Golgi network[J].EMBO J,2003,22(19):5003-5014.
[25] Cossart P,Toledo-Arana A.Listeria monocytogenes,a unique model in infection biology:an overview[J].Microbes Infect,2008,10(9):1041-1050.
[26] Shaughnessy L M,Hoppe A D,Christensen K A,et al.Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles[J].Cell Microbiol,2006,8(5):781-792.
[27] Ktistakis N T,Tooze S A.Digesting the expanding mechanisms of autophagy[J].Trends Cell Biol,2016,26(8):624-635.
[28] Chico-Calero I,Suarez M,Gonzalez-Zorn B,et al.Hpt,a bacterial homolog of the microsomal glucose-6-phosphate translocase,mediates rapid intracellular proliferation in Listeria[J].Proc Natl Acad Sci U S A,2002,99(1):431-436.
[29] Yoshikawa Y,Ogawa M,Hain T,et al.Listeria monocytogenes ActA-mediated escape from autophagic recognition[J].Nat Cell Biol,2009,11(10):1233-1240.
[30] Tattoli I,Sorbara M T,Yang C,et al.Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures[J].EMBO J,2013,32(23):3066-3078.
[31] Campoy E,Colombo M I.Autophagy in intracellular bacterial infection[J].Biochim Biophys Acta,2009,1793(9):1465-1477.
[32] Dumont A,Boucrot E,Drevensek S,et al.SKIP,the host target of the Salmonella virulence factor SifA,promotes kinesin-1-dependent vacuolar membrane exchanges[J].Traffic,2010,11(7):899-911.
[33] Ouimet M,Koster S,Sakowski E,et al.Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism[J].Nat Immunol,2016,17(6):677-686.
[34] Starr T,Child R,Wehrly T D,et al.Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle[J].Cell Host Microbe,2012,11(1):33-45.
[35] Escoll P,Rolando M,Buchrieser C.Modulation of host autophagy during bacterial infection:sabotaging host munitions for pathogen nutrition[J].Front Immunol,2016,7:81.
[36] Rolando M,Escoll P,Nora T,et al.Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy[J].Proc Natl Acad Sci U S A,2016,113(7):1901-1906.
[37] Choy A,Dancourt J,Mugo B,et al.The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation[J].Science,2012,338(6110):1072-1076.
[38] Arasaki K,Mikami Y,Shames S R,et al.Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17[J].Nat Commun,2017,8:15406.
[39] Wilson B R,Bogdan A R,Miyazawa M,et al.Siderophores in iron metabolism:from mechanism to therapy potential[J].Trends Mol Med,2016,22(12):1077-1090.
[40] Boradia V M,Malhotra H,Thakkar J S,et al.Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin[J].Nat Commun,2014,5:4730.
[41] Skaar E P.The battle for iron between bacterial pathogens and their vertebrate hosts[J].PLoS Pathog,2010,6(8):e1000949.
[42] Cianciotto N P.An update on iron acquisition by Legionella pneumophila:new pathways for siderophore uptake and ferric iron reduction[J].Future Microbiol,2015,10(5):841-851.
[43] Skaar E P,Raffatellu M.Metals in infectious diseases and nutritional immunity[J].Metallomics,2015,7(6):926-928.
[44] Pantopoulos K,Porwal S K,Tartakoff A,et al.Mechanisms of mammalian iron homeostasis[J].Biochemistry,2012,51(29):5705-5724.
[45] Botella H,Stadthagen G,Lugo-Villarino G,et al.Metallobiology of host-pathogen interactions:an intoxicating new insight[J].Trends Microbiol,2012,20(3):106-112.
[46] Speir M,Vogrin A,Seidi A,et al.Legionella pneumophila Strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin[J].Front Cell Infect Microbiol,2017,7:35.
[47] Ge J,Xu H,Li T,et al.A Legionella type Ⅳ effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors[J].Proc Natl Acad Sci U S A,2009,106(33):13725-13730.
[48] Wu H,Jones R M,Neish A S.The Salmonella effector AvrA mediates bacterial intracellular survival during infection in vivo[J].Cell Microbiol,2012,14(1):28-39.
[49] Zhang K,Wang H,Guo F,et al.OMP31 of Brucella melitensis 16M impairs the apoptosis of macrophages triggered by TNF-alpha[J].Exp Ther Med,2016,12(4):2783-2789.
[50] Czuczman M A,Fattouh R,van Rijn J M,et al.Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread[J].Nature,2014,509(7499):230-234.
[51] Aguilo N,Marinova D,Martin C,et al.ESX-1-induced apoptosis during mycobacterial infection:to be or not to be,that is the question[J].Front Cell Infect Microbiol,2013,3:88.
[52] Celli J,Tsolis R M.Bacteria,the endoplasmic reticulum and the unfolded protein response:friends or foes?[J].Nat Rev Microbiol,2015,13(2):71-82.