红细胞分布宽度和D-二聚体联合评估系统性红斑狼疮病情活动程度

详细信息    查看全文 | 推荐本文 |

英文篇名：The Use of Width of Red Blood Cell Distribution and D-dimer in the Assessment of Systemic Lupus Erythematosus Disease Activity 作者：王坤 ; 贾兴旺 ; 颜光涛 英文作者：WANG Kun;JIA Xing-wang;YAN Guang-tao;Department of Clinical Biochemistry,PLA General Hospital;Department of Laboratory ,Qinghe Outpatient Department,Rocket General Hospital; 关键词：红细胞分布宽度 ; D-二聚体 ; 系统性红斑狼疮 英文关键词：Red blood cell distribution width;;D-dimer;;Systemic lupus erythematosus 中文刊名：BJMY 英文刊名：Labeled Immunoassays and Clinical Medicine 机构：解放军总医院生化科;火箭军总医院清河门诊部检验科; 出版日期：2017-02-25 出版单位：标记免疫分析与临床 年：2017 期：v.24;No.124 基金：国家科技支撑计划(2015BAK45B01);; 国家863计划(2014AA022304) 语种：中文; 页：BJMY201702004 页数：4 CN：02 ISSN：11-3294/R 分类号：16-18+35

摘要

目的探讨RDW和DD在SLE病情活动中的监测价值。方法收集2015年10月至2016年9月在我院住院的确诊SLE患者123例,根据SLEDAI-2000评分规则对患者疾病活动程度进行评分,将SLEDAI评分<10分计为病情稳定,将SLEDAI评分≥10计为病情活动。收集同期年龄性别匹配的100例健康体检人员作为对照组,比较各组RDW与DD水平,探讨RDW和DD在SLE病情活动程度上的评估价值。结果 SLE患者RDW与DD水平明显高于健康对照组,病情活动组SLE患者的RDW与DD水平显著高于稳定组,当取RDW≥14.65%,DD≥1.66μg/m L为阳性标准,并且采用RDW和DD并联方式作为诊断标准时可以在评估SLE活动程度上获得最好的评估效能。结论采用RDW、DD并联的标准在监测SLE患者的病情发展上有一定的应用价值。
        Objective To investigate the diagnostic value of width of red blood cell distribution(RDW) and Ddimer(DD) in the disease activity of systemic lupus erythematosus(SLE). Methods A total of 123 patients with SLE diagnosed were enrolled from Chinese PLA General Hospital between October, 2015 and September,2016. According to SLEDAI-2000,the disease activity of SLE patients was scored. SLEDAI score < 10 was considered as stable condition,while SLEDAI score≥10 was considered as active condition,meanw hile we collected 100 age-and sex-matched patients as control. We compared the RDW and DD levels in each group,and evaluated RDW and DD in SLE disease activity. Results RDW and DD levels of SLE patients were significantly higher than those in healthy controls,while RDW and DD levels of active SLE patients were significantly higher than those in stable group. With RDW and DD in parallel as a diagnostic criterion,we can get the best assessment of performance if using the RDW ≥14. 65% and DD ≥1. 66μg/m L as the positive criteria. Conclusion The standard of RDW and DD in parallel has certain value in monitoring the development of SLE patients.

引文

[1]李春先.165例系统性红斑狼疮患者血液系统受累情况分析.山东医药,2013,53(14):40-41.
    [2]Petri M,Orbai A M,Alarcón G S,et al.Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus.Arthritis Rheum,2012,64(8):2677-2686.
    [3]张春燕,吕良敬,鲍春德,等.系统性红斑狼疮与早发动脉粥样硬化及其相关危险因素.中华风湿病学杂志,2007,11(8):458-461.
    [4]Tanindi A,Topal F E,Topal F,et al.Red cell distribution width in patients with prehypertension and hypertension.Blood Press,2012,21(3):177-181.
    [5]Gunebakmaz O,Kaya M G,Duran M,et al.Red blood cell distribution width in‘non-dippers’versus‘dippers’.Cardiology,2012,123(3):154-159.
    [6]Sen-Yu W,Chao X.Assessment of the relationship between red blood cell distribution width and preganecy hypertension disease.J Obstet Gynaecol Res,2016,42(10):1258-1262.
    [7]杨景阳,吕国荣,张东妹,等.系统性红斑狼疮患者颈动脉内中膜厚度与血清高敏CRP的关系.中国超声医学杂志,2015,31(3):265-267.
    [8]Lippi G,Targher G,Montagnana M,et al.Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients.Arch Pathol Lab Med,2009,133(4):628-632.
    [9]彭可君,廖永强,胡建康,等.红细胞分布宽度与系统性红斑狼疮病情活动的相关性研究.中华检验医学杂志,2015,38(3):196-198.
    [10]武伟,张延,韩辉,等.系统性红斑狼疮活动性同凝血与纤溶障碍的关系.现代中西医结合杂志,2012,21(3):233-234.
    [11]李春,穆荣,任立敏,等.D-二聚体水平在系统性红斑狼疮的临床意义.中华内科杂志,2010,49(12):1039-1042.
    [12]周国进.D-二聚体和脂蛋白(a)联合检测在诊断系统性红斑狼疮合并冠心病中的价值.中国医刊,2011,46(6):51-52.
    [13]Wu H,Birmingham D J,Rovin B,et al.D-dimer level and the risk for thrombosis in systemic lupus erythematosus.Clin J Am Soc Nephrol,2008,3(6):1628-1636.
    [14]郭飞波.天门地区152例系统性红斑狼疮患者血清ANA、抗dsD NA抗体和抗ENA抗体联合检测分析.中国医学前沿杂志电子版,2016,8(3):49-52.