弥可保序贯治疗带状疱疹后神经痛临床疗效及安全性研究
摘要
目的探讨弥可保序贯治疗带状疱疹后神经痛的临床疗效及安全性。方法选2016年10月至2018年9月期间收住本院神经内科的带状疱疹后遗神经痛患者128例,采用随机数字表随机分为弥可保序贯组(A组)、弥可保静滴组(B组),弥可保肌注射(C组)和口服组(D组),每组各32例,4组患者治疗疗程均为28天,治疗后观察四组的临床疗效、不良反应情况。结果弥可保序贯组治疗有效率显著高于弥可保肌注组及口服组(P<0.05);而弥可保序贯组治疗有效率与弥可保静滴组比较无统计学差异(P>0.05);弥可保序贯组中1例出现一过性头晕,弥可保静滴组中1例出现一过性恶心,弥可保肌注组中1例出现一过性臀部麻痛,均不影响后续治疗;弥可保序贯组治疗费用低于弥可保静滴组。结论对于带状疱疹后神经痛患者,弥可保序贯治疗疗效好,安全性高,费用低。
引文
[1]Pickering G.Antiepileptics for post-herpetic neuralgia in the elderly:current and future prospects[J].Drugs Aging,2014,31(9):653-60.
[2]Fan H,Yu W,Zhang Q,et al.Efficacy and safety of gabapentin 1800mg treatment for post-herpetic neuralgia:a meta-analysis of randomized controlled trials[J].J Clin Pharm Ther,2014,39(4):334-42.
[3]李玉青.神经营养因子与弥可保联合加巴喷丁治疗带状疱疹后神经痛30例疗效观察[J].中国实用神经疾病杂志,2013,16(10):17-19.
[4]贾巍.弥可保联合更昔洛韦治疗三叉神经带状疱疹性神经痛疗效分析[J].中国社区医师(医学专业),2010,12(5):105-106.
[5]Chen N,Li Q,Yang J,et al.Antiviral treatment for preventing postherpetic neuralgia[J].Cochrane Database Syst Rev,2014,2:CD006866.
[6]Pickering G,Pereira B,Dufour E,et al.Impaired modulation of pain in patients with postherpetic neuralgia[J].Pain research&management:the journal of the Canadian Pain Society=journal de la societe canadienne pour le traitement de la douleur,2014,19(1):e19-23.
[7]Thomas BM,Farquhar-Smith P.Gabapentin enacarbil extended release for the treatment of postherpetic neuralgia in adults[J].Ther Clin Risk Manag2013,9:469-75.
[2]Fan H,Yu W,Zhang Q,et al.Efficacy and safety of gabapentin 1800mg treatment for post-herpetic neuralgia:a meta-analysis of randomized controlled trials[J].J Clin Pharm Ther,2014,39(4):334-42.
[3]李玉青.神经营养因子与弥可保联合加巴喷丁治疗带状疱疹后神经痛30例疗效观察[J].中国实用神经疾病杂志,2013,16(10):17-19.
[4]贾巍.弥可保联合更昔洛韦治疗三叉神经带状疱疹性神经痛疗效分析[J].中国社区医师(医学专业),2010,12(5):105-106.
[5]Chen N,Li Q,Yang J,et al.Antiviral treatment for preventing postherpetic neuralgia[J].Cochrane Database Syst Rev,2014,2:CD006866.
[6]Pickering G,Pereira B,Dufour E,et al.Impaired modulation of pain in patients with postherpetic neuralgia[J].Pain research&management:the journal of the Canadian Pain Society=journal de la societe canadienne pour le traitement de la douleur,2014,19(1):e19-23.
[7]Thomas BM,Farquhar-Smith P.Gabapentin enacarbil extended release for the treatment of postherpetic neuralgia in adults[J].Ther Clin Risk Manag2013,9:469-75.