恶性肿瘤化疗所致骨髓抑制的中医药研究进展
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摘要
化疗是恶性肿瘤的主要治疗方法,骨髓抑制是其主要毒副反应,目前,其治疗手段主要由造血细胞集落刺激因子、成分输血和造血干细胞移植组成,效果尚佳,然而费用昂贵,且毒副反应较多。近年来,中医药在治疗化疗后骨髓抑制的理论、临床以及基础研究中都取得了一定进展,特别是在缓解化疗后出现的白细胞减少症、脾胃功能损伤、骨髓造血功能差等方面具有一定优势,值得推广。
Chemotherapy is the main treatment for malignant tumors,and myelosuppression is its main toxic and side effects.At present,the treatment methods are mainly composed of hematopoietic cell colony stimulating factor,component blood transfusion and hematopoietic stem cell transplantation.The effect is still good,but the cost is expensive and has many side effects.In recent years,Chinese medicine has made some progress in the theoretical,clinical and basic research of bone marrow suppression after chemotherapy,especially in relieving the aspects of leukopenia,spleen and stomach function damage,poor bone marrow hematopoietic function,etc.after clinical chemotherapy.So it is worth promoting.
Chemotherapy is the main treatment for malignant tumors,and myelosuppression is its main toxic and side effects.At present,the treatment methods are mainly composed of hematopoietic cell colony stimulating factor,component blood transfusion and hematopoietic stem cell transplantation.The effect is still good,but the cost is expensive and has many side effects.In recent years,Chinese medicine has made some progress in the theoretical,clinical and basic research of bone marrow suppression after chemotherapy,especially in relieving the aspects of leukopenia,spleen and stomach function damage,poor bone marrow hematopoietic function,etc.after clinical chemotherapy.So it is worth promoting.
引文
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[15]郑华.探析黄芪注射液对乳腺癌患者辅助化疗后胃肠道不良反应和营养状态的影响[J].中国医药指南,2018,16(2):173-174.
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[18]王芳,吴文通,方军.加味人参养荣汤对肺癌化疗骨髓抑制的疗效研究[J].中华中医药学刊,2018,36(10):2558-2560.
[19]王理槐,彭昭文,孙银辉.八珍汤加减联合rhGM-CSF治疗非小细胞肺癌化疗所致骨髓抑制效果及对中性粒细胞增殖的影响[J].现代中西医结合杂志,2018,27(33):3653-3659.
[20]陈皎皎,胡陵静,张国铎,等.四君子汤加味对肺癌化疗骨髓抑制的作用机制[J].中国实验方剂学杂志,2018,24(2):180-185.
[21]陆程洁,高静东,刘敏,等.自拟益气温阳方对中晚期非小细胞肺癌患者化疗后骨髓抑制的影响[J].南京中医药大学学报,2018,34(5):465-469.
[22]黄金.益髓汤对恶性血液病化疗49例造血功能的影响[J].中国民族民间医药,2018,17(18):111-112.
[23]张勇,马丽娜.通腑理气方治疗老年结直肠癌临床观察[J].光明中医,2017,32(23):3399-3401.
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[26]陈波,吴文杰.芪胶升白胶囊对肺癌放疗患者白细胞减少的效果和对生存质量的影响分析[J].中国当代医药,2017,24(32):53-55.
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[28]林婉冰,周洁莹,蒋蓓,等.隔姜灸治疗多发性骨髓瘤化疗所致骨髓抑制疗效观察[J].上海针灸杂志,2017,36(7):816-820.
[29]张斌.扶阳强壮灸对晚期NSCLC患者的T淋巴细胞亚群及生存质量的临床观察[D].太原:山西中医药大学,2017.
[30]谢壁元.麦粒灸对晚期非小细胞肺癌化疗相关癌因性疲乏的临床观察[D].广州:广州中医药大学,2017.
[31]张去飞,李丽霞,樊杜英.直接灸四花穴防治肺癌化疗骨髓抑制的疗效观察[J].中医临床研究,2017,9(7):24-27.
[32]刘锦芮.艾灸治疗乳腺癌化疗后骨髓抑制的临床疗效评价研究[D].哈尔滨:黑龙江中医药大学,2016.
[33]熊永爱,邹娅,张德华,等.地榆皂苷Ⅰ基于自噬升高白细胞作用研究[J].中草药,2018,49(14):3350-3356.
[34]丁磊.泰山磐石散对骨髓抑制小鼠造血调控的影响及机制探讨[D].成都:成都中医药大学,2017.
[35]陈义萍.补中益气丸对骨髓抑制小鼠造血调控的影响及机制研究[D].成都:成都中医药大学,2017.
[36]于波涛,王玲洁,刘天亮,等.扶正生血胶囊对化疗致小鼠骨髓抑制的保护作用[J].华西药学杂志,2017,32(6):575-578.
[37]张济周,邵琪琦,周斌,等.验方归芪增血合剂对肺腺癌患者培美曲赛化疗后骨髓抑制干预作用的临床研究[J].中华中医药学刊,2018,36(6):1493-1496.
[38]罗桂芳,唐娅辉,吴莉峰,等.强骨生血口服液对小鼠化疗后骨髓抑制的保护作用及机制研究[J].中国新药杂志,2017,26(22):2664-2671.
[39]白鸽,付槟梵,徐鑫,等.精元康胶囊对齐多夫定致骨髓抑制小鼠骨髓Notch信号通路的影响[J].中医学报,2017,32(228):697-703.
[40]路玫,杜雪源,滕迎春,等.针灸对环磷酰胺化疗小鼠骨髓造血细胞中Notch信号传导通路相关差异基因Numb1、Numb2的影响[J].中华中医药学刊,2018,36(9):2055-2058.
[41]于冬冬,付雪鸽,路玫,等.针灸对环磷酰胺小鼠骨髓细胞DNA核苷酸切除修复基因ERCC1和RRM1的影响[J].时珍国医国药,2018,29(4):1008-1010.
[42]WANG L F,XU Z Y,WANG Z Q,et al.Clinical observation of Shuanghuang Shengbai Granule on prevention and treatment of myelosuppression caused by chemotherapy in cancer patients[J].Chin J Integr Med,2017,23(2):105-109.
[2]HIRSCH F R,SCAGLIOTTI G V,MULSHINE J L,et al.Lung cancer:current therapies and new targeted treatments[J].Lancet,2017,389(10066):299-311.
[3]BRENET F,KERMANI P,SPEKTOR R,et al.TGF-βrestores hematopoietic homeostasis after myelosuppressive chemotherapy[J].J Exp Med,2013,210(3):623-639.
[4]贾英杰,于建春,杨佩颖,等.中医药防治化疗后骨髓抑制的临床研究概况[J].辽宁中医杂志,2014,41(10):2253-2255.
[5]贾英杰.试论癌瘤“正气内虚,毒瘀并存”的病机观点[J].新中医,2014,45(6):9-11.
[6]张福鹏,赵晓燕,周永明.周永明治疗恶性肿瘤化疗后骨髓抑制的经验[J].世界中西医结合杂志,2014,9(7):697-699.
[7]白凤鸣,吴美鲜,牛俊瑞.中药治疗放化疗所致骨髓抑制的疗效观察[J].内蒙古医学院院报,2007,29(3):207-209.
[8]贾英杰,于建春,杨佩颖,等.扶正解毒祛瘀法防治化疗后骨髓抑制的探讨[J].中医杂志,2014,55(3):198-201.
[9]刘学,赵林林.归脾汤合六味地黄丸加减治疗晚期肺癌化疗骨髓抑制[J].吉林中医药,2014,34(7):705-706,727.
[10]唐丽雯,林丽珠.健脾补肾膏方治疗化疗后骨髓抑制的临床疗效观察[J].广州中医药大学学报,2014,30(5):628-631.
[11]贾英杰,吴咸中.中西医结合肿瘤学[M].武汉:华中科技大学出版社,2009:244.
[12]王敏,金军,张力苹,等.探讨中药治疗肿瘤化疗骨髓抑制用药规律[J].辽宁中医药大学学报,2014,16(3):147-149.
[13]葛龙,毛蕾田,金徽,等.食管癌放疗过程中如何选择中药注射剂的网状Meta分析[J].中国中药杂志,2015,40(18):3674-3681.
[14]WANG S F,WANG Q,JIAO L J,et al.Astragaluscontaining Traditional Chinese Medicine,with and without prescription based on syndrome differentiation,combined with chemotherapy for advanced non-small-cell lung cancer:a systemic review and meta-analysis[J].Curr Oncol,2016,23(3):188-195.
[15]郑华.探析黄芪注射液对乳腺癌患者辅助化疗后胃肠道不良反应和营养状态的影响[J].中国医药指南,2018,16(2):173-174.
[16]袁选举,邓守恒.黄芪联合丹参注射液在同步放化疗治疗宫颈癌中的作用观察[J].时珍国医国药,2018,29(9):2133-2135.
[17]HONG J,CHEN X,HUANG J,et al.Danggui buxue decoction,a classical formula of traditional Chinese medicine,fails to prevent myelosuppression in breast cancer patients treated with adjuvant chemotherapy:a prospective study[J].Integr Cancer Ther,2017,16(3):406-413.
[18]王芳,吴文通,方军.加味人参养荣汤对肺癌化疗骨髓抑制的疗效研究[J].中华中医药学刊,2018,36(10):2558-2560.
[19]王理槐,彭昭文,孙银辉.八珍汤加减联合rhGM-CSF治疗非小细胞肺癌化疗所致骨髓抑制效果及对中性粒细胞增殖的影响[J].现代中西医结合杂志,2018,27(33):3653-3659.
[20]陈皎皎,胡陵静,张国铎,等.四君子汤加味对肺癌化疗骨髓抑制的作用机制[J].中国实验方剂学杂志,2018,24(2):180-185.
[21]陆程洁,高静东,刘敏,等.自拟益气温阳方对中晚期非小细胞肺癌患者化疗后骨髓抑制的影响[J].南京中医药大学学报,2018,34(5):465-469.
[22]黄金.益髓汤对恶性血液病化疗49例造血功能的影响[J].中国民族民间医药,2018,17(18):111-112.
[23]张勇,马丽娜.通腑理气方治疗老年结直肠癌临床观察[J].光明中医,2017,32(23):3399-3401.
[24]乔丽莉.扶正解毒饮防治乳腺癌术后围化疗期骨髓抑制临床观察[J].新中医,2018,50(1):101-104.
[25]耿翠翠,孙立哲,张杨,等.养正消积胶囊改善宫颈癌术后放化疗骨髓抑制55例[J].陕西中医药大学学报,2018,41(5):96-99.
[26]陈波,吴文杰.芪胶升白胶囊对肺癌放疗患者白细胞减少的效果和对生存质量的影响分析[J].中国当代医药,2017,24(32):53-55.
[27]刘猛,沈卫东,程少丹.针刺治疗对大肠癌化疗患者骨髓抑制及生存质量的影响[J].上海中医药大学学报,2018,32(2):23-26.
[28]林婉冰,周洁莹,蒋蓓,等.隔姜灸治疗多发性骨髓瘤化疗所致骨髓抑制疗效观察[J].上海针灸杂志,2017,36(7):816-820.
[29]张斌.扶阳强壮灸对晚期NSCLC患者的T淋巴细胞亚群及生存质量的临床观察[D].太原:山西中医药大学,2017.
[30]谢壁元.麦粒灸对晚期非小细胞肺癌化疗相关癌因性疲乏的临床观察[D].广州:广州中医药大学,2017.
[31]张去飞,李丽霞,樊杜英.直接灸四花穴防治肺癌化疗骨髓抑制的疗效观察[J].中医临床研究,2017,9(7):24-27.
[32]刘锦芮.艾灸治疗乳腺癌化疗后骨髓抑制的临床疗效评价研究[D].哈尔滨:黑龙江中医药大学,2016.
[33]熊永爱,邹娅,张德华,等.地榆皂苷Ⅰ基于自噬升高白细胞作用研究[J].中草药,2018,49(14):3350-3356.
[34]丁磊.泰山磐石散对骨髓抑制小鼠造血调控的影响及机制探讨[D].成都:成都中医药大学,2017.
[35]陈义萍.补中益气丸对骨髓抑制小鼠造血调控的影响及机制研究[D].成都:成都中医药大学,2017.
[36]于波涛,王玲洁,刘天亮,等.扶正生血胶囊对化疗致小鼠骨髓抑制的保护作用[J].华西药学杂志,2017,32(6):575-578.
[37]张济周,邵琪琦,周斌,等.验方归芪增血合剂对肺腺癌患者培美曲赛化疗后骨髓抑制干预作用的临床研究[J].中华中医药学刊,2018,36(6):1493-1496.
[38]罗桂芳,唐娅辉,吴莉峰,等.强骨生血口服液对小鼠化疗后骨髓抑制的保护作用及机制研究[J].中国新药杂志,2017,26(22):2664-2671.
[39]白鸽,付槟梵,徐鑫,等.精元康胶囊对齐多夫定致骨髓抑制小鼠骨髓Notch信号通路的影响[J].中医学报,2017,32(228):697-703.
[40]路玫,杜雪源,滕迎春,等.针灸对环磷酰胺化疗小鼠骨髓造血细胞中Notch信号传导通路相关差异基因Numb1、Numb2的影响[J].中华中医药学刊,2018,36(9):2055-2058.
[41]于冬冬,付雪鸽,路玫,等.针灸对环磷酰胺小鼠骨髓细胞DNA核苷酸切除修复基因ERCC1和RRM1的影响[J].时珍国医国药,2018,29(4):1008-1010.
[42]WANG L F,XU Z Y,WANG Z Q,et al.Clinical observation of Shuanghuang Shengbai Granule on prevention and treatment of myelosuppression caused by chemotherapy in cancer patients[J].Chin J Integr Med,2017,23(2):105-109.