干细胞向甲状旁腺细胞的分化及在甲状旁腺功能减退中的研究进展
|
摘要
干细胞是一类能够自我复制、自我更新,具有多向分化潜能,能产生多种分化细胞类型的细胞,由于它的自我复制和多向分化潜能,干细胞技术已经被广泛的应用于细胞移植治疗中。甲状旁腺功能减退作为一种内分泌疾病,目前的治疗方案都不能从根本上治疗该疾病。因此应用干细胞来源的甲状旁腺细胞移植治疗甲状旁腺功能减退越来越受到医学界的重视。目前,已有科研团队报道了应用胚胎干细胞(ESCs)、胸腺上皮细胞和扁桃体间充质细胞向甲状旁腺细胞分化及其在甲状旁腺功能减退中的治疗。本文将干细胞向甲状旁腺细胞的分化及在甲状旁腺功能减退治疗中的研究进展进行综述。
Stem cells are a kind of cells with the ability of self-replication,self-renewal,as well as the potential of multi-directional differentiation,and can produce a variety of differentiated cell types. Stem cells technology has been widely used in cell transplantation because of their potential of self-renewal and multi-directional differentiation. Hypoparathyroidism,as an endocrine disorder,can not be cured by available therapy strategies completely. The transplantation of parathyroid cells derived from stem cell for the treatment of hypothyroidism has attracted more and more attention. Until now,some papers reported that human embryonic stem cells,thymic epithelial cells and tonsil mesenchymal stem cells had been differentiated into parathyroid cells and showed potential prospects in treatment of hypoparathyroidism. This paper explains the differentiation of stem cells to parathyroid cells and summarizes the progress of applying stem cells-derived parathyroid cells in treatment of hypoparathyroidism.
Stem cells are a kind of cells with the ability of self-replication,self-renewal,as well as the potential of multi-directional differentiation,and can produce a variety of differentiated cell types. Stem cells technology has been widely used in cell transplantation because of their potential of self-renewal and multi-directional differentiation. Hypoparathyroidism,as an endocrine disorder,can not be cured by available therapy strategies completely. The transplantation of parathyroid cells derived from stem cell for the treatment of hypothyroidism has attracted more and more attention. Until now,some papers reported that human embryonic stem cells,thymic epithelial cells and tonsil mesenchymal stem cells had been differentiated into parathyroid cells and showed potential prospects in treatment of hypoparathyroidism. This paper explains the differentiation of stem cells to parathyroid cells and summarizes the progress of applying stem cells-derived parathyroid cells in treatment of hypoparathyroidism.
引文
1 Dulak J,Szade K,Szade A,et al.Adult stem cells:hopes and hypes of regenerative medicine[J].Acta Biochim Pol,2015,62(3):329-337.
2李金泰,蓝升,刘毅.3D打印干细胞技术用于组织器官重建的现状与思考[J].器官移植,2017,8(4):267-270.
3 Shi Y,Inoue H,Wu JC,et al.Induced pluripotent stem cell technology:decade of progress[J].Nat Rev Drug Discov,2017,16(2):115-130.
4张维绮,刘光慧.基于人多潜能干细胞的人类疾病研究与治疗[J].生物化学与生物物理进展,2011,38(11):982-987.
5 Clarke BL,Brown EM,Collins MT,et al.Epidemiology and diagnosis of hypoparathyroidism[J].J Clin Endocrinol Metab,2016,101(6):2284-2299.
6 Winer KK,Zhang B,Shrader JA,et al.Synthetic human parathyroid hormone 1-34 replacement therapy:A randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism[J].J Clin Endocrinol Metab,2012,97(2):391-399.
7 Hsu Y,Hung CJ.Intramuscular and subcutaneous forearm parathyroid autograft hyperplasia in renal dialysis patients:a retrospective cohort study[J].Surgery,2015,158(5):1331-1338.
8 Decker GA,Stark JH,Botha JR,et al.Allotransplantation of parathyroid cells[J].Lancet,1995,345(8942):124.
9 Johannesson B,Sui L,Freytes DO,et al.Toward beta cell replacement for diabetes[J].EMBO J,2015,34(7):841-855.
10 Graham A,Okabe M,Quinlan RG.The role of the endoderm in the development and evolution of the pharyngeal arches[J].J Anat,2005,207(5):479-487.
11 Moore-Scott BA,Manley NR.Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs[J].Dev Biol,2005,278(2):323-335.
12 Kelly OG,Pinson KI,Skarnes WC.The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice[J].Development,2004,131(12):2803-2815.
13 Brennan J,Lu CC,Norris DP,et al.Nodal signalling in the epiblast patterns the early mouse embryo[J].Nature,2001,411(6840):965-969.
14 Vincent SD,Dunn NR,Hayashi S,et al.Cell fate decisions within the mouse organizer are governed by graded Nodal signals[J].Genes Dev,2003,17(13):1646-1662.
15 de Caestecker M.The transforming growth factor-beta superfamily of receptors[J].Cytokine Growth Factor Rev,2004,15(1):1-11.
16 Lu CC,Brennan J,Robertson EJ.From fertilization to gastrulation:axis formation in the mouse embryo[J].Curr Opin Genet Dev,2001,11(4):384-392.
17 Sulzbacher S,Schroeder IS,Truong TT,et al.Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions[J].Stem Cell Rev,2009,5(2):159-173.
18 Bingham EL,Cheng SP,Woods Ignatoski KM,et al.Differentiation of Human Embryonic Stem Cells to a Parathyroid-Like Phenotype[J].Stem Cells Dev,2009,18(7):1071-1080.
19 Woods Ignatoski KM,Bingham EL,Frome LK,et al.Differentiation of precursors into parathyroid-like cells for treatment of hypoparathyroidism[J].Surgery,2010,148(6):1186-1190.
20 D'Amour KA,Agulnick AD,Eliazer S,et al.Effi cient differentiation of human embryonic stem cells to defi nitive endoderm[J].Nat Biotechnol,2005,23(12):1534-1541.
21 Woods Ignatoski KM,Bingham EL,Frome LK,et al.Directed TransDifferentiation of Thymus Cells into Parathyroid-Like Cells Without Genetic[J].Tissue Eng Part C Methods,2011,17(11):1051-1059.
22 Mouiseddine M,Mathieu N,Stefani J,et al.Characterization and histological localization of multipotent mesenchymal stromal cells in the human postnatal thymus[J].Stem Cells Dev,2008,17(6):1165-1174.
23 Ryu KH,Cho KA,Park HS,et al.Tonsil-derived mesenchymal stromal cells:evaluation of biologic,immunologic and genetic factors for successful banking[J].Cytotherapy,2012,14(10):1193-1202.
24 Park YS,Kim HS,Jin YM,et al.Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy[J].Biomaterials,2015,65:140-152.
25 Lee Y,Bae JW,Oh DH,et al.In situ forming gelatin-based tissue adhesives and their phenolic content-driven properties[J].J Mater Chem B,2013,1:2407-2414.
26 Park YS,Lee Y,Jin YM,et al.Sustained release of parathyroid hormone via in situ cross-linking gelatin hydrogels improves the therapeutic potential of tonsil-derived mesenchymal stem cells for hypoparathyroidism[J].J Tissue Eng Regen Med,2018,12(3):e1747-e1756.
27 Choi YY,Chung BG,Lee DH,et al.Controlled-size embryoid body formation in concave microwell arrays[J].Biomaterials,2010,31(15):4296-4303.
28 Park JY,Lee DH,Lee EJ,et al.Study of cellular behaviors on concave and convex microstructures fabricated from elastic PDMSmembranes[J].Lab Chip,2009,9(14):2043-2049.
29 Park YS,Hwang JY,Jun Y,et al.Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells[J].Acta Biomater,2016,35:215-227.
30 Zhou Y,Lv BJ,Xu P,etal.Optimising gene therapy of hypoparathyroidism with hematopoietic stem cells[J].Chin Med J,2005,118(3):204-209.
31 ZhaoY,Luo B.Adipose-derived stem cells:A novel source of parathyroid cells for treatment of hypoparathyroidism[J].Med Hypotheses,2016,93:143-145.
2李金泰,蓝升,刘毅.3D打印干细胞技术用于组织器官重建的现状与思考[J].器官移植,2017,8(4):267-270.
3 Shi Y,Inoue H,Wu JC,et al.Induced pluripotent stem cell technology:decade of progress[J].Nat Rev Drug Discov,2017,16(2):115-130.
4张维绮,刘光慧.基于人多潜能干细胞的人类疾病研究与治疗[J].生物化学与生物物理进展,2011,38(11):982-987.
5 Clarke BL,Brown EM,Collins MT,et al.Epidemiology and diagnosis of hypoparathyroidism[J].J Clin Endocrinol Metab,2016,101(6):2284-2299.
6 Winer KK,Zhang B,Shrader JA,et al.Synthetic human parathyroid hormone 1-34 replacement therapy:A randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism[J].J Clin Endocrinol Metab,2012,97(2):391-399.
7 Hsu Y,Hung CJ.Intramuscular and subcutaneous forearm parathyroid autograft hyperplasia in renal dialysis patients:a retrospective cohort study[J].Surgery,2015,158(5):1331-1338.
8 Decker GA,Stark JH,Botha JR,et al.Allotransplantation of parathyroid cells[J].Lancet,1995,345(8942):124.
9 Johannesson B,Sui L,Freytes DO,et al.Toward beta cell replacement for diabetes[J].EMBO J,2015,34(7):841-855.
10 Graham A,Okabe M,Quinlan RG.The role of the endoderm in the development and evolution of the pharyngeal arches[J].J Anat,2005,207(5):479-487.
11 Moore-Scott BA,Manley NR.Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs[J].Dev Biol,2005,278(2):323-335.
12 Kelly OG,Pinson KI,Skarnes WC.The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice[J].Development,2004,131(12):2803-2815.
13 Brennan J,Lu CC,Norris DP,et al.Nodal signalling in the epiblast patterns the early mouse embryo[J].Nature,2001,411(6840):965-969.
14 Vincent SD,Dunn NR,Hayashi S,et al.Cell fate decisions within the mouse organizer are governed by graded Nodal signals[J].Genes Dev,2003,17(13):1646-1662.
15 de Caestecker M.The transforming growth factor-beta superfamily of receptors[J].Cytokine Growth Factor Rev,2004,15(1):1-11.
16 Lu CC,Brennan J,Robertson EJ.From fertilization to gastrulation:axis formation in the mouse embryo[J].Curr Opin Genet Dev,2001,11(4):384-392.
17 Sulzbacher S,Schroeder IS,Truong TT,et al.Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions[J].Stem Cell Rev,2009,5(2):159-173.
18 Bingham EL,Cheng SP,Woods Ignatoski KM,et al.Differentiation of Human Embryonic Stem Cells to a Parathyroid-Like Phenotype[J].Stem Cells Dev,2009,18(7):1071-1080.
19 Woods Ignatoski KM,Bingham EL,Frome LK,et al.Differentiation of precursors into parathyroid-like cells for treatment of hypoparathyroidism[J].Surgery,2010,148(6):1186-1190.
20 D'Amour KA,Agulnick AD,Eliazer S,et al.Effi cient differentiation of human embryonic stem cells to defi nitive endoderm[J].Nat Biotechnol,2005,23(12):1534-1541.
21 Woods Ignatoski KM,Bingham EL,Frome LK,et al.Directed TransDifferentiation of Thymus Cells into Parathyroid-Like Cells Without Genetic[J].Tissue Eng Part C Methods,2011,17(11):1051-1059.
22 Mouiseddine M,Mathieu N,Stefani J,et al.Characterization and histological localization of multipotent mesenchymal stromal cells in the human postnatal thymus[J].Stem Cells Dev,2008,17(6):1165-1174.
23 Ryu KH,Cho KA,Park HS,et al.Tonsil-derived mesenchymal stromal cells:evaluation of biologic,immunologic and genetic factors for successful banking[J].Cytotherapy,2012,14(10):1193-1202.
24 Park YS,Kim HS,Jin YM,et al.Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy[J].Biomaterials,2015,65:140-152.
25 Lee Y,Bae JW,Oh DH,et al.In situ forming gelatin-based tissue adhesives and their phenolic content-driven properties[J].J Mater Chem B,2013,1:2407-2414.
26 Park YS,Lee Y,Jin YM,et al.Sustained release of parathyroid hormone via in situ cross-linking gelatin hydrogels improves the therapeutic potential of tonsil-derived mesenchymal stem cells for hypoparathyroidism[J].J Tissue Eng Regen Med,2018,12(3):e1747-e1756.
27 Choi YY,Chung BG,Lee DH,et al.Controlled-size embryoid body formation in concave microwell arrays[J].Biomaterials,2010,31(15):4296-4303.
28 Park JY,Lee DH,Lee EJ,et al.Study of cellular behaviors on concave and convex microstructures fabricated from elastic PDMSmembranes[J].Lab Chip,2009,9(14):2043-2049.
29 Park YS,Hwang JY,Jun Y,et al.Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells[J].Acta Biomater,2016,35:215-227.
30 Zhou Y,Lv BJ,Xu P,etal.Optimising gene therapy of hypoparathyroidism with hematopoietic stem cells[J].Chin Med J,2005,118(3):204-209.
31 ZhaoY,Luo B.Adipose-derived stem cells:A novel source of parathyroid cells for treatment of hypoparathyroidism[J].Med Hypotheses,2016,93:143-145.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |