芪芍颗粒联合美沙拉嗪治疗溃疡性结肠炎临床疗效观察
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摘要
目的:探讨芪芍颗粒治疗溃疡性结肠炎(UC)的效果。方法:收治UC患者72例,随机平分为两组,试验组给予芪芍颗粒联合美沙拉嗪肠溶片口服,对照组给予美沙拉嗪肠溶片口服。连续用药8周后,观察两组患者临床症状、体征评分,血清白细胞介素6(IL-6)、血清白细胞介素10(IL-10)、肿瘤坏死因子α(TNF-α)水平及安全性。结果:试验组患者治疗总有效率91.6%,明显高于对照组的77.8%;两组治疗后临床症状、体征评分均低于治疗前;两组IL-6、TNF-α水平均较治疗前降低,IL-10较治疗前升高,试验组IL-6、TNF-α水平低于对照组,IL-10高于对照组,差异有统计学意义(P<0.05)。结论:芪芍颗粒联合美沙拉嗪治疗UC的效果显著。
Objective:To explore the efficacy of Qishao granula combined with mesalazine in the treatment of ulcerative colitis(UC).Methods:72 patients with ulcerative colitis were selected,they were divided into the two groups equally.The experimental group was treated with oral administration of Qishao granula and mesalazine,and the control group was treated with oral administration of mesalazine.After 8 weeks of continuous treatment,the clinical symptoms and signs scores,serum interleukin-6(IL-6),interleukin-10(IL-10),and tumor necrosis factor-alpha(TNF-alpha)levels and safety of the two groups were observed.Results:The total effective rate of the experimental group was 91.6%,which was significantly higher than that of the control group(77.8%).After treatment,the scores of signs and clinical symptoms in both groups were lower than those before treatment,the levels of IL-6 and TNF-alpha in both groups were lower than those before treatment,and IL-10 was higher than that before treatment.The levels of IL-6 and TNF-α in the experimental group were lower than those in the control group,and IL-10 was higher than the control group,the differences were statistically significant(P<0.05).Conclusion:Qishao granule combined with mesalazine has a significant effect on ulcerative colitis.
Objective:To explore the efficacy of Qishao granula combined with mesalazine in the treatment of ulcerative colitis(UC).Methods:72 patients with ulcerative colitis were selected,they were divided into the two groups equally.The experimental group was treated with oral administration of Qishao granula and mesalazine,and the control group was treated with oral administration of mesalazine.After 8 weeks of continuous treatment,the clinical symptoms and signs scores,serum interleukin-6(IL-6),interleukin-10(IL-10),and tumor necrosis factor-alpha(TNF-alpha)levels and safety of the two groups were observed.Results:The total effective rate of the experimental group was 91.6%,which was significantly higher than that of the control group(77.8%).After treatment,the scores of signs and clinical symptoms in both groups were lower than those before treatment,the levels of IL-6 and TNF-alpha in both groups were lower than those before treatment,and IL-10 was higher than that before treatment.The levels of IL-6 and TNF-α in the experimental group were lower than those in the control group,and IL-10 was higher than the control group,the differences were statistically significant(P<0.05).Conclusion:Qishao granule combined with mesalazine has a significant effect on ulcerative colitis.
引文
[1]Yang H,Li Y,Wu W,et al.The incidence of inflammatory bowel disease in northern china:A prospective population-based study[J].PloS one,2014,9(7):e101296.
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[4]刘宏晶.肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎的疗效研究[J].中医药学报,2014(4):142-145.
[5]翟登合,孙艳丽.肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎80例疗效观察[J].中西医结合研究,2015(3):144.
[2]Ouyang Q,Xue LY.Inflammatory bowel disease in the 21(st)century in china:Turning challenges into opportunities[J].J Dig Dis,2012,13(4):195-199.
[3]汪悦,查安生.中医药对溃疡性结肠炎作用机制的干预研究[J].中华中医药学刊,2015,(2):394-396.
[4]刘宏晶.肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎的疗效研究[J].中医药学报,2014(4):142-145.
[5]翟登合,孙艳丽.肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎80例疗效观察[J].中西医结合研究,2015(3):144.