丹蛭降糖胶囊治疗早期糖尿病肾脏疾病
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摘要
目的观察纯中药制剂丹蛭降糖胶囊(Danzhijiangtang Capcule,DJC)对早期糖尿病肾脏疾病(Diabetic kidney disease,DKD)的疗效。方法选取2016年1月-2017年6月期间我院内分泌科住院的早期糖尿病肾脏疾病患者40例,随机分为治疗组及对照组,均给予常规基础治疗,治疗组在此基础上加用丹蛭降糖胶囊,治疗时间为20周,观察治疗前后患者血糖、糖化血红蛋白、尿白蛋白/肌酐等指标及中医症状量化积分变化的情况。结果经过20周治疗,早期DKD患者中医症状量化积分明显减少,临床症状明显改善(P<0.05);空腹血糖及餐后2 h血糖、糖化血红蛋白、尿白蛋白肌酐比值较治疗前亦明显降低(P<0.05)。结论丹蛭降糖胶囊能显著改善早期DKD患者的临床症状,降低尿白蛋白/肌酐比值,有效预防临床白蛋白尿及终末期肾病的发生发展。
Objective To observe the curative effect of Danzhi Jiangtang capsule on early diabetic kidney disease. Methods From January 2016 to June 2017, 40 patients with early diabetic kidney disease were randomly divided into treatment group and control group, all of them were treated with routine basic treatment, and the treatment group was treated with Danzhi Jiangtang capsule on this basis. The treatment time was 20 weeks. The changes of blood glucose, glycosylated hemoglobin, urinary albumin/creatinine and the quantitative integral of TCM symptoms were observed before and after treatment. Results After 20 weeks of treatment, the quantitative scores of TCM symptoms and clinical symptoms of early DKD patients were significantly decreased(P < 0.05), and the fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin and urinary albumin creatinine ratio were significantly decreased than those before treatment(P < 0.05). Conclusion Danzhi Jiangtang capsule can significantly improve the clinical symptoms of early DKD patients, reduce the urinary albumin/creatinine ratio, so as to effectively prevent the occurrence and development of clinical albuminuria and end-stage nephropathy.
Objective To observe the curative effect of Danzhi Jiangtang capsule on early diabetic kidney disease. Methods From January 2016 to June 2017, 40 patients with early diabetic kidney disease were randomly divided into treatment group and control group, all of them were treated with routine basic treatment, and the treatment group was treated with Danzhi Jiangtang capsule on this basis. The treatment time was 20 weeks. The changes of blood glucose, glycosylated hemoglobin, urinary albumin/creatinine and the quantitative integral of TCM symptoms were observed before and after treatment. Results After 20 weeks of treatment, the quantitative scores of TCM symptoms and clinical symptoms of early DKD patients were significantly decreased(P < 0.05), and the fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin and urinary albumin creatinine ratio were significantly decreased than those before treatment(P < 0.05). Conclusion Danzhi Jiangtang capsule can significantly improve the clinical symptoms of early DKD patients, reduce the urinary albumin/creatinine ratio, so as to effectively prevent the occurrence and development of clinical albuminuria and end-stage nephropathy.
引文
[1]中华医学会糖尿病学分会微血管并发症学组.糖尿病肾病防治专家共识(2014年版)[J].中华糖尿病杂志,2014,6(11):792-901.
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[3]吴吉萍,方朝晖,倪英群.益气养阴活血中药对2型糖尿病合并血管病变的干预研究[J].安徽医药,2014,18(4):735-737.
[4]李艳,卜文婕,朱建梁,等.丹蛭降糖胶囊对糖尿病大鼠肾脏的保护作用[J].中国药学杂志,2015,50(10):857-862.
[5]方朝晖,赵进东,鲍陶陶,等.丹蛭降糖胶囊对2型糖尿病患者FINS和IRI作用有效性的系统评价[J].世界中医药,2014,9(12):1679-1681.
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[8]蔡文娟,李洋,门岚,等.尿微量白蛋白/肌酐比值对糖尿病肾病早期诊断价值[J].中国实验诊断学,2013,17(9):1650-1653.
[9]吴敏华,王新月.中医内科学[M].北京:中国中医药出版社,2012:383-390.
[10]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:117-119.
[11]中华中医药学会糖尿病分会糖尿病肾脏疾病中医诊疗标准[J].世界中西医结合杂志,2011,6(6):548-552.
[12]赵进喜,邓德强,李靖.糖尿病肾病相关中医病名考辨[J].南京中医药大学学报,2005,21(5):288-289.
[13]甘洪桥.从湿瘀论治糖尿病肾病浅析[J].四川中医,2015,33(1):42-43.
[14]黎晶晶,汪悦.糖尿病肾病中医病因病机[J].长春中医药大学学报,2013,29(3):449-450.
[15]褚书豪,汪小彩,冯良.太子参化学成分及其药理作用研究进展[J].光明中医,2016,31(7):1047-1048.
[16]郭琳,苗明三.生(鲜)地黄的化学、药理与应用特点[J].中医学报,2014,190(29):375-377.
[17]徐先祥,李道中,彭代银,等.菟丝子多糖改善糖尿病大鼠糖脂代谢作用[J].中国实验方剂学杂志,2011,17(18):232-234.
[18]汪旻晖,单娇娇,李浣钧,等.丹参素对异丙肾上腺素损伤大鼠内皮血管活性的保护作用及机制研究[J].中草药,2013,44(1):59-64.
[19]郭晓庆,孙佳明,张辉.水蛭的化学成分与药理作用[J].吉林中医药,2015,35(1):47-50.
[20]陈旺,曾宇,邢增智.泽泻的化学成分与药理作用研究进展[J].中医药导报,2017,23(15):75-78.
[2]倪英群,谢峰涛,方朝晖.基于Wnt/β-链蛋白表达评价丹蛭降糖胶囊对2型糖尿病患者血管的保护作用[J].中国临床药理学与治疗学,2017,22(5):531-537.
[3]吴吉萍,方朝晖,倪英群.益气养阴活血中药对2型糖尿病合并血管病变的干预研究[J].安徽医药,2014,18(4):735-737.
[4]李艳,卜文婕,朱建梁,等.丹蛭降糖胶囊对糖尿病大鼠肾脏的保护作用[J].中国药学杂志,2015,50(10):857-862.
[5]方朝晖,赵进东,鲍陶陶,等.丹蛭降糖胶囊对2型糖尿病患者FINS和IRI作用有效性的系统评价[J].世界中医药,2014,9(12):1679-1681.
[6]倪英群,方朝晖.不同强度运动联合中药对葡萄糖耐量减退大鼠血管内皮功能的影响[J].中国中医药信息杂志,2016,23(4):54-57.
[7]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[8]蔡文娟,李洋,门岚,等.尿微量白蛋白/肌酐比值对糖尿病肾病早期诊断价值[J].中国实验诊断学,2013,17(9):1650-1653.
[9]吴敏华,王新月.中医内科学[M].北京:中国中医药出版社,2012:383-390.
[10]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:117-119.
[11]中华中医药学会糖尿病分会糖尿病肾脏疾病中医诊疗标准[J].世界中西医结合杂志,2011,6(6):548-552.
[12]赵进喜,邓德强,李靖.糖尿病肾病相关中医病名考辨[J].南京中医药大学学报,2005,21(5):288-289.
[13]甘洪桥.从湿瘀论治糖尿病肾病浅析[J].四川中医,2015,33(1):42-43.
[14]黎晶晶,汪悦.糖尿病肾病中医病因病机[J].长春中医药大学学报,2013,29(3):449-450.
[15]褚书豪,汪小彩,冯良.太子参化学成分及其药理作用研究进展[J].光明中医,2016,31(7):1047-1048.
[16]郭琳,苗明三.生(鲜)地黄的化学、药理与应用特点[J].中医学报,2014,190(29):375-377.
[17]徐先祥,李道中,彭代银,等.菟丝子多糖改善糖尿病大鼠糖脂代谢作用[J].中国实验方剂学杂志,2011,17(18):232-234.
[18]汪旻晖,单娇娇,李浣钧,等.丹参素对异丙肾上腺素损伤大鼠内皮血管活性的保护作用及机制研究[J].中草药,2013,44(1):59-64.
[19]郭晓庆,孙佳明,张辉.水蛭的化学成分与药理作用[J].吉林中医药,2015,35(1):47-50.
[20]陈旺,曾宇,邢增智.泽泻的化学成分与药理作用研究进展[J].中医药导报,2017,23(15):75-78.