视频头脉冲试验正常人群增益值年龄稳定性的临床研究
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摘要
目的:探讨视频头脉冲试验(vHIT)在正常人群中年龄的稳定性。方法:前瞻性分析经健康体检的无眩晕病史、颈部活动度好且无眼部和颈部疾患的21～80岁体检者180例的临床资料,应用vHIT对体检人群进行高频前庭功能检查,以vHIT的增益值为检查指标,并分析其与年龄的关系。结果:入选研究的180例体检者均完成了vHIT检查,其左侧水平半规管、后半规管及前半规管的前庭眼反射(VOR)增益值分别为1.02±0.12、1.04±0.15、0.94±0.16,右侧水平半规管、后半规管及前半规管的VOR增益值分别是1.05±0.14、1.00±0.16、0.97±0.15,左右两侧相对应半规管间VOR增益值的差异无统计学意义(P>0.05)。体检者中,男性的水平及前后半规管的VOR增益值分别是1.05±0.13、1.02±0.16、0.99±0.16,女性的水平及前后半规管的VOR增益值分别是1.05±0.13、1.01±0.16、0.97±0.16,男女之间3个半规管的VOR增益值的差异无统计学意义(P>0.05)。180例体检者的年龄与其水平、后及前3个半规管VOR的增益值分别进行线性回归分析,建立的线性回归方程的斜率分别为0.001 8、0.000 2、0.000 3。对不同年龄组3个半规管的VOR增益值采用单因素方差分析,各年龄组之间3个半规管VOR增益值差异无统计学意义(P>0.05)。结论:正常人群vHIT 6个半规管VOR的增益值在不同性别间的差异并不显著,且vHIT 6个半规管VOR的增益值具有良好的年龄稳定性,年龄差异不会对vHIT结果造成影响。
Objective:To explore the age stability of the video head impulse test(vHIT)in healthy subjects.Method:This was a prospective study on healthy subjects referred to our department.One hundred and eighty healthy subjects(age range 21-80)without any current or previous history of brain disorder,vertigo,neck stiffness or eye diseases participated in this study and the vHIT was carried out in all 180 cases.The relationship between VOR gain and age was analysed using univariate regression model and one-way ANOVA for subjects.Result:The VOR gains of the left horizontal semicircular canal,posterior semicircular canal and anterior semicircular canal were 1.02±0.12,1.04±0.15 and 0.94±0.16 respectively.The VOR gains of the right horizontal semicircular canal,posterior semicircular canal and anterior semicircular canal were 1.05±0.14,1.00±0.16,0.97±0.15 respectively.The difference of VOR gain between left and right corresponding semicircular canals was not statistically significant(P>0.05).For male subjects,the VOR gains of horizontal,anterior and posterior semicircular canal were 1.05±0.13,1.02±0.16,0.99±0.16 respectively,and for female subjects,the VOR gains of horizontal,anterior and posterior semicircular canal were 1.05±0.13,1.01±0.16,0.97±0.16 respectively.There was no significant difference in VOR gain of three semicircular canals between male and female(P>0.05).The VOR gain in different age groups was analyzed by one-way ANOVA.There was no significant difference in the VOR gain among different age groups(P>0.05).Univariate linear regression analysis was performed between the age and the VOR gain of the three semicircular canals.The slopes of the regression equations were 0.001 8,0.000 2 and 0.000 3,respectively.Conclusion:The VOR gain of the six semicircular canals in healthy subjects is not significantly influenced by gender,and it varies slightly with age without requirement for adjustment with age.
Objective:To explore the age stability of the video head impulse test(vHIT)in healthy subjects.Method:This was a prospective study on healthy subjects referred to our department.One hundred and eighty healthy subjects(age range 21-80)without any current or previous history of brain disorder,vertigo,neck stiffness or eye diseases participated in this study and the vHIT was carried out in all 180 cases.The relationship between VOR gain and age was analysed using univariate regression model and one-way ANOVA for subjects.Result:The VOR gains of the left horizontal semicircular canal,posterior semicircular canal and anterior semicircular canal were 1.02±0.12,1.04±0.15 and 0.94±0.16 respectively.The VOR gains of the right horizontal semicircular canal,posterior semicircular canal and anterior semicircular canal were 1.05±0.14,1.00±0.16,0.97±0.15 respectively.The difference of VOR gain between left and right corresponding semicircular canals was not statistically significant(P>0.05).For male subjects,the VOR gains of horizontal,anterior and posterior semicircular canal were 1.05±0.13,1.02±0.16,0.99±0.16 respectively,and for female subjects,the VOR gains of horizontal,anterior and posterior semicircular canal were 1.05±0.13,1.01±0.16,0.97±0.16 respectively.There was no significant difference in VOR gain of three semicircular canals between male and female(P>0.05).The VOR gain in different age groups was analyzed by one-way ANOVA.There was no significant difference in the VOR gain among different age groups(P>0.05).Univariate linear regression analysis was performed between the age and the VOR gain of the three semicircular canals.The slopes of the regression equations were 0.001 8,0.000 2 and 0.000 3,respectively.Conclusion:The VOR gain of the six semicircular canals in healthy subjects is not significantly influenced by gender,and it varies slightly with age without requirement for adjustment with age.
引文
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[9]MACDOUGALL H G,MCGARVIE L A,HAL-MAGYI G M,et al.Application of the video head impulse test to detect vertical semicircular canal dysfunction[J].Otol Neurotol,2013,34:974-979.
[10]WUYTS F L,FURMAN J,VANSPAUWEN R,et al.Vestibular function testing[J].Curr Opin Neurol,2007,20:19-24.
[11]HALMAGYI G M,CHEN L,MACDOUGALL H G,et al.The Video Head Impulse Test[J].Front Neurol,2017,8:258.
[2]LEE S K,CHA C I,JUNG T S,et al.Age-related differences in parameters of vestibular evoked myogenic potentials[J].Acta Otolaryngol,2008,128:66-72.
[3]HONG S M,YEO S G,KIM S W,et al.The results of vestibular evoked myogenic potentials,with consideration of age-related changes,in vestibular neuritis,benign paroxysmal positional vertigo,and Meniere's disease[J].Acta Otolaryngol,2008,128:861-865.
[4]MCGARVIE L A,MACDOUGALL H G,HAL-MAGYI G M,et al.The Video Head Impulse Test(vHIT)of Semicircular Canal Function-Age-Dependent Normative Values of VOR Gain in Healthy Subjects[J].Front Neurol,2015,6:154-154.
[5]HALMAGYI G M,CURTHOYS I S.A clinical sign of canal paresis[J].Arch Neurol,1988,45:737-739.
[6]PARK H K,KIM J S,STRUPP M,et al.Isolated floccular infarction:impaired vestibular responses to horizontal head impulse[J].J Neurol,2013,260:1576-1582.
[7]WEBER K P,MACDOUGALL H G,HALMAGYI GM,et al.Impulsive testing of semicircular-canal function using video-oculography[J].Ann N Y Acad Sci,2009,1164:486-491.
[8]ALHABIB S F,SALIBA I.Video head impulse test:a review of the literature[J].Eur Arch Otorhinolaryngol,2017,274:1215-1222.
[9]MACDOUGALL H G,MCGARVIE L A,HAL-MAGYI G M,et al.Application of the video head impulse test to detect vertical semicircular canal dysfunction[J].Otol Neurotol,2013,34:974-979.
[10]WUYTS F L,FURMAN J,VANSPAUWEN R,et al.Vestibular function testing[J].Curr Opin Neurol,2007,20:19-24.
[11]HALMAGYI G M,CHEN L,MACDOUGALL H G,et al.The Video Head Impulse Test[J].Front Neurol,2017,8:258.