关元和足三里穴位埋线对海洛因成瘾患者周围血中DNA拷贝数影响的研究
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摘要
目的探讨关元和足三里穴位埋线对海洛因成瘾患者周围血中DNA拷贝数影响的研究。方法将符合标准的70例海洛因成瘾者随机分成2组,治疗组(40例)采用穴位埋线治疗,对照组(30例)采用美沙酮治疗。观察穴位埋线对海洛因成瘾患者周围血中DNA拷贝数的影响。结果穴位埋线能明显增加海洛因成瘾患者周围血中DNA的拷贝数(p <0.05),具有统计学意义。结论与服用美沙酮相比,穴位埋线更能明显提高海洛因成瘾患者周围血中DNA的拷贝数,为临床提高戒毒效率提供治疗方法及依据。
Objective To investigate the effects of Guanyuan(CV 4) and Zusanli(ST 36) points thread burial therapy on the number of DNA copies in peripheral blood of heroin addicts. Methods 70 heroin addicts who fit the criteria were randomly divided into two groups. The treatment group(40 cases) was treated with thread burial therapy, and the control group(30 cases) was treated with methadone. To observe the effect of thread burial therapy on the number of DNA copies in peripheral blood heroin addicts. Results Thread burial therapy could significantly increase the copy number of DNA in the peripheral blood of heroin addicts(P < 0.05) with statistical significance.Conclusion Compared with methadone, thread burial therapy can significantly increase the number of copies of DNA in the peripheral blood of heroin addicts, and provide a treatment method and basis for improving the efficiency of detoxification in clinic.
Objective To investigate the effects of Guanyuan(CV 4) and Zusanli(ST 36) points thread burial therapy on the number of DNA copies in peripheral blood of heroin addicts. Methods 70 heroin addicts who fit the criteria were randomly divided into two groups. The treatment group(40 cases) was treated with thread burial therapy, and the control group(30 cases) was treated with methadone. To observe the effect of thread burial therapy on the number of DNA copies in peripheral blood heroin addicts. Results Thread burial therapy could significantly increase the copy number of DNA in the peripheral blood of heroin addicts(P < 0.05) with statistical significance.Conclusion Compared with methadone, thread burial therapy can significantly increase the number of copies of DNA in the peripheral blood of heroin addicts, and provide a treatment method and basis for improving the efficiency of detoxification in clinic.
引文
[1]泰伯益.戒毒药物的现状及研究进展[J].医药导报,2002,21(8):467-468.
[2]宋小鸽,吕航,蔡兴慧,等.近10年针灸戒毒研究概况[J].中国针灸,2012, 32(7):669-672.
[3]周雨青,刘星,马兰.药物成瘾的神经生物学机制研究[J].生命科学,2014, 26(6):593-602.
[4]和晓明,王晓琴,王功伍.阻断阿片受体可改变吗啡成瘾大鼠下边缘皮质脑电功率谱成分[J]. Journal of biology,2015, 32(5):15-18.
[5]BRIZ V,HSU Y T,LI Y,et al. Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation ofdendritic protein synthesis[J]. Neurosci, 2013(33):4317-4328.
[6]秦妍滨,陈琨,蒋满,等.多种脑功能成像技术的临床应用[J].中国临床康复,2006, 10(18):132-134.
[7] BINGOL B, SHENG M. Deconstruction for reconstruction:the role of proteolysis in neural plasticity and disease[J].Neuron, 2011, 69(1):22-32.
[8]赵竞,金可可,吴亮,等.银杏叶提取物对糖尿病大鼠学习记忆能力及海马神经元NGF、NT-3表达的影响[J].中国应用生理学杂志,2012, 28(5):467-471.
[9]杨桦,高玉杰,杨丽美.针刺治疗海洛因依赖者稽延性戒断症状的临床观察[J].时珍国医国药,2007, 18(4):947-948.
[10]侯文光,梁艳,李煜,等.针刺夹脊穴对海洛因依赖者稽延性戒断症状疗效观察[J].上海针灸杂志,2011, 30(6):357-359.
[11]吴俊梅,魏东焰,罗永芬,等.针刺对海洛因依赖的脱毒疗效及其防复吸潜力的临床研究[J].中西医结合学报,2003, 1(4):268-272.
[12]魏东焰,吴俊梅,罗永芬.针刺脱毒对海洛因依赖者短时记忆量及大脑工作能力的影响[J].成都中医药大学学报,2010, 33(4):33-35.
[13]张荣军,宋小鸽,蔡兴慧.针灸对海洛因复吸大鼠条件性位置偏爱及脑前额叶皮质超微结构的影响[J].针刺研究,2009, 34(2):97-100.
[14]宋小鸽,李传富,胡玲,等.针刺对海洛因线索诱发成瘾者磁共振脑功能成像的影响[J].针刺研究,2011, 36(2):121-127.
[15]ROTHFUSS O, GASSER T,PATENGE N. Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach[J].Nucleic Acids Research, 2010, 38(4):e24.
[16] CHENG G L,ZENG H,LEUNG M,et al.Heroin abuse accelerates biological aging:a novel insight from telomerase and brain imaging interaction[J]. Transl Psychiatry, 2013(3):e260.
[17] QIU Y W, HAN L J, LYU X F, et al. Regional homogeneity changes in heroin-dependent individuals:resting-state functional MR imaging study[J]. Radiology, 2011, 261(2):551-559.
[18] QIU Y W,JIANG G H,SU H H,et al. The impulsivity behavior is correlated with prefrontal cortex gray matter volume reduction in heroin-dependent individuals[J].Neuroscience Letters, 2013, 538(3):43-48.
[19]徐美林,陈崇宏.药物依赖性的神经递质-信号传导机制的研究进展[J].海峡药学,2004, 16(3):1-6.
[20]王桂华,潘虹,王敏,等.针刺对吗啡戒断大鼠情绪及氨基酸水平的影响[J].滨州医学院学报,2008, 31(3):182-184.
[2]宋小鸽,吕航,蔡兴慧,等.近10年针灸戒毒研究概况[J].中国针灸,2012, 32(7):669-672.
[3]周雨青,刘星,马兰.药物成瘾的神经生物学机制研究[J].生命科学,2014, 26(6):593-602.
[4]和晓明,王晓琴,王功伍.阻断阿片受体可改变吗啡成瘾大鼠下边缘皮质脑电功率谱成分[J]. Journal of biology,2015, 32(5):15-18.
[5]BRIZ V,HSU Y T,LI Y,et al. Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation ofdendritic protein synthesis[J]. Neurosci, 2013(33):4317-4328.
[6]秦妍滨,陈琨,蒋满,等.多种脑功能成像技术的临床应用[J].中国临床康复,2006, 10(18):132-134.
[7] BINGOL B, SHENG M. Deconstruction for reconstruction:the role of proteolysis in neural plasticity and disease[J].Neuron, 2011, 69(1):22-32.
[8]赵竞,金可可,吴亮,等.银杏叶提取物对糖尿病大鼠学习记忆能力及海马神经元NGF、NT-3表达的影响[J].中国应用生理学杂志,2012, 28(5):467-471.
[9]杨桦,高玉杰,杨丽美.针刺治疗海洛因依赖者稽延性戒断症状的临床观察[J].时珍国医国药,2007, 18(4):947-948.
[10]侯文光,梁艳,李煜,等.针刺夹脊穴对海洛因依赖者稽延性戒断症状疗效观察[J].上海针灸杂志,2011, 30(6):357-359.
[11]吴俊梅,魏东焰,罗永芬,等.针刺对海洛因依赖的脱毒疗效及其防复吸潜力的临床研究[J].中西医结合学报,2003, 1(4):268-272.
[12]魏东焰,吴俊梅,罗永芬.针刺脱毒对海洛因依赖者短时记忆量及大脑工作能力的影响[J].成都中医药大学学报,2010, 33(4):33-35.
[13]张荣军,宋小鸽,蔡兴慧.针灸对海洛因复吸大鼠条件性位置偏爱及脑前额叶皮质超微结构的影响[J].针刺研究,2009, 34(2):97-100.
[14]宋小鸽,李传富,胡玲,等.针刺对海洛因线索诱发成瘾者磁共振脑功能成像的影响[J].针刺研究,2011, 36(2):121-127.
[15]ROTHFUSS O, GASSER T,PATENGE N. Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach[J].Nucleic Acids Research, 2010, 38(4):e24.
[16] CHENG G L,ZENG H,LEUNG M,et al.Heroin abuse accelerates biological aging:a novel insight from telomerase and brain imaging interaction[J]. Transl Psychiatry, 2013(3):e260.
[17] QIU Y W, HAN L J, LYU X F, et al. Regional homogeneity changes in heroin-dependent individuals:resting-state functional MR imaging study[J]. Radiology, 2011, 261(2):551-559.
[18] QIU Y W,JIANG G H,SU H H,et al. The impulsivity behavior is correlated with prefrontal cortex gray matter volume reduction in heroin-dependent individuals[J].Neuroscience Letters, 2013, 538(3):43-48.
[19]徐美林,陈崇宏.药物依赖性的神经递质-信号传导机制的研究进展[J].海峡药学,2004, 16(3):1-6.
[20]王桂华,潘虹,王敏,等.针刺对吗啡戒断大鼠情绪及氨基酸水平的影响[J].滨州医学院学报,2008, 31(3):182-184.