毛细支气管炎Th17/Treg失衡和潮气呼吸肺功能变化及其相关性研究进展
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摘要
毛细支气管炎是婴幼儿中最常见的下呼吸道感染性疾病,部分婴幼儿感染经过治疗后急性期痊愈,但其后不久反复发生喘息并有1/3左右演变为哮喘,目前文献认为两者在发病机制上均存在辅助性细胞Th1/辅助性细胞Th2和辅助性细胞Th17/调节性细胞Treg的失衡现象,而潮气呼吸肺功能是婴幼儿呼吸系统疾病必备检查之一,现对毛细支气管炎潮气呼吸肺功能中相关变化相关性做一综述。
Bronchiolitis is the most common lower respiratory tract infectious disease in infants and young children. Some infants and young children are cured in the acute stage after treatment. However,shortly afterwards,wheezing occurs repeatedly and about one third of them develop into asthma. Currently,it is believed that there are imbalances between Th1/Th2 and Th17/Treg in the pathogenesis of both diseases. Tidal respiratory and pulmonary function is one of the necessary examinations for infants with respiratory diseases. This article reviews the correlation of changes in tidal respiratory and pulmonary function in bronchiolitis.
Bronchiolitis is the most common lower respiratory tract infectious disease in infants and young children. Some infants and young children are cured in the acute stage after treatment. However,shortly afterwards,wheezing occurs repeatedly and about one third of them develop into asthma. Currently,it is believed that there are imbalances between Th1/Th2 and Th17/Treg in the pathogenesis of both diseases. Tidal respiratory and pulmonary function is one of the necessary examinations for infants with respiratory diseases. This article reviews the correlation of changes in tidal respiratory and pulmonary function in bronchiolitis.
引文
1.张国辉,吴福玲.Thl7与毛细支气管炎的研究进展.国际儿科学杂志,2013,40:18-21.
2.中华医学会儿科学分会呼吸学组肺功能协作组,《中华实用儿科临床杂志》编辑委员会.儿童肺功能系列指南(四):潮气呼吸肺功能.中华实用儿科临床杂志,2016,31:1617-1621.
3.鲍一笑.婴幼儿喘息诊治进展.临床儿科杂志,2008,26:1-4.
4.岳丽杰,傅文永.呼吸道合胞病毒性毛细支气管炎远期随访观察.中华儿科杂志,1990,28:82-84.
5.Harrington LE,Mangan PR,Weaver CT.Expanding the effector CD4 T-cell repertoire:the Thl7 lineage.Curr Opin Immunol,2006,18:349-356.
6.Sakaguchi S,Sakagllm N,Asano M,et al.Pillar article:immunologic self-tolerante maintained by activated T cells expressing IL-2 receptor alpha-chains(CD25).Breakdown of asingle mechanism of self-tolerance causes various autoimmune disease.J.Immunol.1995.J Immunol,186:3808-3821.
7.陈凌,张建华.Th17细胞的分化调控机制及其在支气管哮喘呼吸道炎症中的作用.中国实用儿科临床杂志,2016,31:1275-1277.
8.姚圣连,徐美玉,钱金强,等.辅助性T细胞17及白介素-17在呼吸道合胞病毒毛细支气管炎的表达及作用.临床儿科杂志,2013,31:850-853.
9.朱亚非,蔡晓红,朱建央,等.毛细支气管炎CD4+CD25+调节性T细胞和FoxP3mRNA表达与激素调控.中华医学杂志,2009,89:1563-1566.
10.李茂兴,王静.RSV毛细支气管炎患儿外周血Treg细胞及IL-4、IFN‐r、IL-17的水平及意义.山东医学高等专科学校学报,2017,89:135-138.
11.高萌,吴福玲.毛细支气管炎与间充质干细胞的相关性研究.国际儿科学杂志,2015,42:135-138.
12.聂晖,韦红.潮气肺功能测定在婴幼儿喘息性疾病中的应用及意义.国际呼吸杂志,2016,
13.Manczur T,Greenough A,Hooper R,et al.Tidal breathing parameters in young children:comparison of measurement by respiratory inductance plethysmography to a facemask pneumotachograph system.Pediatr Pulmonol,1999,28:436-441.
14.李睿,王吉安,许家增,等.毛细支气管炎患儿单次潮气肺功能测定的临床意义.临床儿科杂志,2014,32:1057-1059.
15.丁明杰,韩玉玲,程璐,等.毛细支气管炎患儿潮气肺功能动态变化的研究.中国医药,2013,8:323-326.
16.张丽敏,乔俊英,栾斌.儿童肺功能临床研究和应用进展.国际儿科学杂志,2016,43:456-461.
17.白翠芬.脉冲振荡肺功能检查对哮喘儿童病情评估的价值及与血清指标的相关性分析.海南医学院学报,2016,22:1016-1019.
18.梁粤.肺炎支原体肺炎患儿外周血IL-10/IL-17表达与肺功能变化的相关性研究.临床儿科杂志,2015,33:686-689.
19.黄坤玲,刘建华,帅金凤,等.喘息婴幼儿Th17/Treg免疫平衡和肺功能变化及其相关性研究.检验医学与临床,2017,14:2435-2437.
2.中华医学会儿科学分会呼吸学组肺功能协作组,《中华实用儿科临床杂志》编辑委员会.儿童肺功能系列指南(四):潮气呼吸肺功能.中华实用儿科临床杂志,2016,31:1617-1621.
3.鲍一笑.婴幼儿喘息诊治进展.临床儿科杂志,2008,26:1-4.
4.岳丽杰,傅文永.呼吸道合胞病毒性毛细支气管炎远期随访观察.中华儿科杂志,1990,28:82-84.
5.Harrington LE,Mangan PR,Weaver CT.Expanding the effector CD4 T-cell repertoire:the Thl7 lineage.Curr Opin Immunol,2006,18:349-356.
6.Sakaguchi S,Sakagllm N,Asano M,et al.Pillar article:immunologic self-tolerante maintained by activated T cells expressing IL-2 receptor alpha-chains(CD25).Breakdown of asingle mechanism of self-tolerance causes various autoimmune disease.J.Immunol.1995.J Immunol,186:3808-3821.
7.陈凌,张建华.Th17细胞的分化调控机制及其在支气管哮喘呼吸道炎症中的作用.中国实用儿科临床杂志,2016,31:1275-1277.
8.姚圣连,徐美玉,钱金强,等.辅助性T细胞17及白介素-17在呼吸道合胞病毒毛细支气管炎的表达及作用.临床儿科杂志,2013,31:850-853.
9.朱亚非,蔡晓红,朱建央,等.毛细支气管炎CD4+CD25+调节性T细胞和FoxP3mRNA表达与激素调控.中华医学杂志,2009,89:1563-1566.
10.李茂兴,王静.RSV毛细支气管炎患儿外周血Treg细胞及IL-4、IFN‐r、IL-17的水平及意义.山东医学高等专科学校学报,2017,89:135-138.
11.高萌,吴福玲.毛细支气管炎与间充质干细胞的相关性研究.国际儿科学杂志,2015,42:135-138.
12.聂晖,韦红.潮气肺功能测定在婴幼儿喘息性疾病中的应用及意义.国际呼吸杂志,2016,
13.Manczur T,Greenough A,Hooper R,et al.Tidal breathing parameters in young children:comparison of measurement by respiratory inductance plethysmography to a facemask pneumotachograph system.Pediatr Pulmonol,1999,28:436-441.
14.李睿,王吉安,许家增,等.毛细支气管炎患儿单次潮气肺功能测定的临床意义.临床儿科杂志,2014,32:1057-1059.
15.丁明杰,韩玉玲,程璐,等.毛细支气管炎患儿潮气肺功能动态变化的研究.中国医药,2013,8:323-326.
16.张丽敏,乔俊英,栾斌.儿童肺功能临床研究和应用进展.国际儿科学杂志,2016,43:456-461.
17.白翠芬.脉冲振荡肺功能检查对哮喘儿童病情评估的价值及与血清指标的相关性分析.海南医学院学报,2016,22:1016-1019.
18.梁粤.肺炎支原体肺炎患儿外周血IL-10/IL-17表达与肺功能变化的相关性研究.临床儿科杂志,2015,33:686-689.
19.黄坤玲,刘建华,帅金凤,等.喘息婴幼儿Th17/Treg免疫平衡和肺功能变化及其相关性研究.检验医学与临床,2017,14:2435-2437.