秦巴山区野生连翘产地加工方法研究
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摘要
目的:研究秦巴山区野生连翘产地加工方法,用于指导当地药农正确的加工青翘,确保临床用药质量的稳定性。方法:模仿产地药农传统加工工艺设计单因素试验,对水煮烘干工艺采用L9(34)正交设计试验,以连翘苷、连翘酯苷A、总黄酮含量为指标,用AHP法确定3种成分权重系数分别为0.429、0.429、0.143,加权综合分析,考察加水量、水煮时间、烘干温度3个因素对野生连翘青翘质量的影响。结果:单因素试验中水煮烘干工艺3种成分的综合评分最高达97.16,正交试验优选的最佳条件为A_2B_2C_3。结论:水煮烘干工艺优于其他产地加工方法,确定最佳水煮烘干工艺为青翘采收后采用3倍量的水,煮制10 min,70℃烘干。
Objective To study the processing methods of wild Forsythia in Qinba Mountains for guiding local pharmacists to process Forsythia correctly and ensuring the quality of clinical medication. Methods Through simulating the single factor experiment of traditional processing technology design of local medicinal farmer,the orthogonal design experiment of L9( 34)was adopted in the boiling and drying process. With the content of forsythiaside,forsythiaside A and total flavonoids as the index,the weight coefficients of three components determined by AHP method were 0.429,0.429 and 0.143,respectively.The weighted comprehensive analysis was conducted to investigate the effects of water addition,boiling time and drying temperature on the quality of wild forsythia suspensa. Results In the single factor test,the comprehensive score of the three components in the hydro-boiling drying process was up to 97. 16,and the optimum condition for the orthogonal test was A2 B2 C3. Conclusion Boiling and drying process is superior to other origin processing methods. The best boiling and drying process is to use 3 times the amount of water after harvesting forsythia,boiling for 10 minutes and drying at 70 ℃.
Objective To study the processing methods of wild Forsythia in Qinba Mountains for guiding local pharmacists to process Forsythia correctly and ensuring the quality of clinical medication. Methods Through simulating the single factor experiment of traditional processing technology design of local medicinal farmer,the orthogonal design experiment of L9( 34)was adopted in the boiling and drying process. With the content of forsythiaside,forsythiaside A and total flavonoids as the index,the weight coefficients of three components determined by AHP method were 0.429,0.429 and 0.143,respectively.The weighted comprehensive analysis was conducted to investigate the effects of water addition,boiling time and drying temperature on the quality of wild forsythia suspensa. Results In the single factor test,the comprehensive score of the three components in the hydro-boiling drying process was up to 97. 16,and the optimum condition for the orthogonal test was A2 B2 C3. Conclusion Boiling and drying process is superior to other origin processing methods. The best boiling and drying process is to use 3 times the amount of water after harvesting forsythia,boiling for 10 minutes and drying at 70 ℃.
引文
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[9]李坚,陈作环,王玉紫,等.RP-HPLC法测定上清丸中连翘苷的含量[J].湖北医药学院学报,2012,31(4):317-319.
[2]江苏新医学院.中药大辞典[M].上海:上海人民出版社,1977:2 270.
[3]雷建林,李艳桃,聂会生,等.HPLC法测定不同产地连翘药材中连翘苷的含量[J].中华中医药学刊,2012,30(1):202-204.
[4]胡静,马琳,张坚,等.连翘的研究进展[J].中南药学,2012,10(10):760-764.
[5]邓雪,李家铭,曾浩健,等.层次分析法权重计算方法分析及其应用研究[J].数学的实践与认识,2012,42(7):93-100.
[6]白吉庆,王小平,曹林林,等.产地加工方法对青翘中连翘苷、连翘酯苷A的影响[J].中国中药杂志,2011,36(3):2 358-2 361.
[7]张天锡,史磊,刘雯,等.连翘化学成分、药理活性现代研究[J].辽宁中医药大学学报,2016,18(12):222.
[8]陈瑾,谭丽媛,张淑蓉,等.不同产地连翘主要成分分析及抗菌作用研究[J].时珍国医国药,2018,29(2):427-430.
[9]李坚,陈作环,王玉紫,等.RP-HPLC法测定上清丸中连翘苷的含量[J].湖北医药学院学报,2012,31(4):317-319.