短波理疗仪联合精准强脉冲光修复面部敏感性皮肤的疗效观察
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摘要
目的评价短波理疗仪联合精准强脉冲光(delicate pulse light, DPL)在修复面部敏感性皮肤的有效性及安全性。方法将2017年4月—10月就诊于解放军总医院皮肤科的108例(均为女性)诊断为敏感性皮肤综合征患者纳入研究,年龄为17～54岁,随机分为A、B、C 3组,每组36例。A组使用DPL每4周1次,共3次,短波理疗仪每周1次,共12次,每次20 min;B组使用DPL每4周1次,共3次;C组使用短波理疗仪每周1次,共12次,每次20 min。分别于基线、第4周、第8周、第12周进行照片采集,并在第4周、第8周及第12周进行主观症状、客观体征及安全性评价,记录每组患者的评分。结果面部敏感性皮肤综合征患者共108例,治疗第4周3组的治疗方法有效率差异无统计学意义(P> 0.05);治疗第8周和12周A组治疗有效率与B组、C组比较差异有统计学意义(P <0.05),而B组与C组之间比较差异无统计学意义(P> 0.05)。结论 DPL联合短波理疗仪治疗敏感性皮肤综合征的效果在治疗第8周和12周优于单独使用DPL和短波理疗仪治疗组,两者联合使用对皮肤屏障功能恢复、降低皮肤敏感性及炎症反应、提高皮肤耐受性有促进作用,效果明确且安全。
Objective To evaluate the efficacy and safety of short wave physiotherapy combined with delicate pulse light(DPL) in repairing sensitive skin on the face. Methods A total of 108 patients(all female) with sensitive skin syndrome diagnosed in dermatology department of PLA General Hospital from April to October 2017 were randomly divided into groups A, B and C with 36 cases in each group. For group A, DPL was applied once every four weeks, 3 times in total, and the short wave physiotherapy was applied once per week, 12 times in total, 20 minutes for each time. For group B and group C, the patients were respectively treated with DPL or short wave physiotherapy according to the above regimens. Photographs were collected at baseline, 4 th, 8 th and 12 th weeks of the treatment respectively and the subjective symptoms, objective signs and safety were evaluated at the same time. The scores of each group were recorded. Results There was no significant difference in the effective rate of treatment among the three groups at the 4 th week of the treatment(P>0.05); at the 8 th and 12 th weeks of the treatment, the therapeutic efficiency of group A was significant higher than that of group B or group C(P<0.05), but there was no significant difference between group B and group C(P>0.05). Conclusion The efficacy of DPL combined with short wave physiotherapy in the treatment of sensitive skin syndrome is better than that of DPL or short wave physiotherapy applied alone at the 8 th and 12 th weeks of the treatment. The combined use of DPL and short-wave physiotherapy can promote the recovery of skin barrier function, reduce skin sensitivity and inflammatory reaction, and improve skin tolerance, at the same time, this combination therapy has high safety.
Objective To evaluate the efficacy and safety of short wave physiotherapy combined with delicate pulse light(DPL) in repairing sensitive skin on the face. Methods A total of 108 patients(all female) with sensitive skin syndrome diagnosed in dermatology department of PLA General Hospital from April to October 2017 were randomly divided into groups A, B and C with 36 cases in each group. For group A, DPL was applied once every four weeks, 3 times in total, and the short wave physiotherapy was applied once per week, 12 times in total, 20 minutes for each time. For group B and group C, the patients were respectively treated with DPL or short wave physiotherapy according to the above regimens. Photographs were collected at baseline, 4 th, 8 th and 12 th weeks of the treatment respectively and the subjective symptoms, objective signs and safety were evaluated at the same time. The scores of each group were recorded. Results There was no significant difference in the effective rate of treatment among the three groups at the 4 th week of the treatment(P>0.05); at the 8 th and 12 th weeks of the treatment, the therapeutic efficiency of group A was significant higher than that of group B or group C(P<0.05), but there was no significant difference between group B and group C(P>0.05). Conclusion The efficacy of DPL combined with short wave physiotherapy in the treatment of sensitive skin syndrome is better than that of DPL or short wave physiotherapy applied alone at the 8 th and 12 th weeks of the treatment. The combined use of DPL and short-wave physiotherapy can promote the recovery of skin barrier function, reduce skin sensitivity and inflammatory reaction, and improve skin tolerance, at the same time, this combination therapy has high safety.
引文
[1]Berardesca E,Farage M,Maibach H.Sensitive skin:an overview[J].Int J Cosmet Sci,2013,35(1):2-8.
[2]透明质酸修护生物膜与舒敏保湿修复霜辅助治疗敏感性皮肤随机对照观察[J].临床皮肤科杂志,2013,42(12):735-738.
[3]Farage MA,Katsarou A,Maibach HI.Sensitive skin.Sensory,clinical,and physiological factors[J].Contact Dermatitis,2006,55(1):1-14.
[4]Maibach HI.The cosmetic intolerance syndrome[J].Ear Nose Throat J,1987,66(1):29-33.
[5]Fisher AA."Status cosmeticus":a cosmetic intolerance syndrome[J].Cutis,1990,46(2):109-110.
[6]Lev-Tov H,Maibach HI.The sensitive skin syndrome[J].Indian JDermatol,2012,57(6):419-423.
[7]余玲玲,王学民.上海地区敏感性皮肤的流行病学调查[J].临床皮肤科杂志,2011,40(7):403-406.
[8]Misery L,Jean-Decoster C,Mery S,et al.A new ten-item questionnaire for assessing sensitive skin:the sensitive scale-10[J].Acta Derm Venereol,2014,94(6):635-639.
[9]Kim YR,Cheon HI,L Misery,et al.Sensitive skin in Korean population:An epidemiological approach[J].Skin Res Technol,2018,24(2):229-234.
[10]Duarte L,Silveira JEPS,Hafner MFS,et al.Sensitive skin:review of an ascending concept[J].An Bras Dermatol,2017,92(4):521-525.
[11]An S,Lee E,Kim S,et al.Comparison and correlation between stinging responses to lactic acid and bioengineering parameters[J].Contact Dermatitis,2007,57(3):158-162.
[12]Seidenari S,Francomano M,Mantavoni L.Baseline biophysical parameters in subjects with sensitive skin[J].Contact Dermatol,1998,38(6):311-315.
[13]Lee BH,Park CK,Kim HO,et al.The skin irritations of corrosive and non-corrosive irritants in patients with sensitive skin[J].Korean JDermatol,2007,426:551-559.
[14]苏伟,朱威,连石,等.强脉冲光治疗皮肤光老化疗效评估方法讨论[J].实用皮肤病学杂志,2008,1(1):45-47.
[15]Ciocon DH,Boker A,Goldberg DJ.Intense pulsed light:what works,what's new,what's next[J].Facial Plast Surg,2009,25(5):290-300.
[16]王玮蓁,黄海,吴纪园,等.低能量强脉冲光治疗104例面部敏感性皮肤病的疗效观察[J].中华皮肤科杂志,2009,42(9):607-609.
[17]Negishi K,Wakamatsu S,Kushikata N,et a1.Full-face photorejuvenation of photodamaged skin by intense pulsed light with integrated contact cooling initial experiences in Asian patients[J].Laser Sung Med,2002,30(4):298-305.
[18]Sun W,Wu J,Qian H,et al.Objective evaluation of the effects of intense pulsed light treatment on Asian skin by reflectance confocal microscopy analysis[J].Laser Med Sci,2018,33(4):779-784.
[19]Zhong H,Weiyuan M,Daxing C,et al.A comparison of Q-switched1064 nm Nd:YAG laser and intense pulsed light in the nonablative rejuvenation on rat model[J].J Cosmet Laser Ther,2013,15(3):126-132.
[20]Wong WR,Shyu WL,Hsu KH,et al.Intense pulsed light modulates the expressions of MMP-2,MMP-14 and MMP-2 in skin dermal fibroblasts cultured within contracted collagen lattices[J].J Dermatol Sci,2008,51(1):70-73.
[21]何黎,温海,徐丽敏,等.含马齿览及甘草提取物护肤品对敏感性皮肤辅助治疗作用的临床观察[J].临床皮肤科杂志,2009,38(6):364-366.
[2]透明质酸修护生物膜与舒敏保湿修复霜辅助治疗敏感性皮肤随机对照观察[J].临床皮肤科杂志,2013,42(12):735-738.
[3]Farage MA,Katsarou A,Maibach HI.Sensitive skin.Sensory,clinical,and physiological factors[J].Contact Dermatitis,2006,55(1):1-14.
[4]Maibach HI.The cosmetic intolerance syndrome[J].Ear Nose Throat J,1987,66(1):29-33.
[5]Fisher AA."Status cosmeticus":a cosmetic intolerance syndrome[J].Cutis,1990,46(2):109-110.
[6]Lev-Tov H,Maibach HI.The sensitive skin syndrome[J].Indian JDermatol,2012,57(6):419-423.
[7]余玲玲,王学民.上海地区敏感性皮肤的流行病学调查[J].临床皮肤科杂志,2011,40(7):403-406.
[8]Misery L,Jean-Decoster C,Mery S,et al.A new ten-item questionnaire for assessing sensitive skin:the sensitive scale-10[J].Acta Derm Venereol,2014,94(6):635-639.
[9]Kim YR,Cheon HI,L Misery,et al.Sensitive skin in Korean population:An epidemiological approach[J].Skin Res Technol,2018,24(2):229-234.
[10]Duarte L,Silveira JEPS,Hafner MFS,et al.Sensitive skin:review of an ascending concept[J].An Bras Dermatol,2017,92(4):521-525.
[11]An S,Lee E,Kim S,et al.Comparison and correlation between stinging responses to lactic acid and bioengineering parameters[J].Contact Dermatitis,2007,57(3):158-162.
[12]Seidenari S,Francomano M,Mantavoni L.Baseline biophysical parameters in subjects with sensitive skin[J].Contact Dermatol,1998,38(6):311-315.
[13]Lee BH,Park CK,Kim HO,et al.The skin irritations of corrosive and non-corrosive irritants in patients with sensitive skin[J].Korean JDermatol,2007,426:551-559.
[14]苏伟,朱威,连石,等.强脉冲光治疗皮肤光老化疗效评估方法讨论[J].实用皮肤病学杂志,2008,1(1):45-47.
[15]Ciocon DH,Boker A,Goldberg DJ.Intense pulsed light:what works,what's new,what's next[J].Facial Plast Surg,2009,25(5):290-300.
[16]王玮蓁,黄海,吴纪园,等.低能量强脉冲光治疗104例面部敏感性皮肤病的疗效观察[J].中华皮肤科杂志,2009,42(9):607-609.
[17]Negishi K,Wakamatsu S,Kushikata N,et a1.Full-face photorejuvenation of photodamaged skin by intense pulsed light with integrated contact cooling initial experiences in Asian patients[J].Laser Sung Med,2002,30(4):298-305.
[18]Sun W,Wu J,Qian H,et al.Objective evaluation of the effects of intense pulsed light treatment on Asian skin by reflectance confocal microscopy analysis[J].Laser Med Sci,2018,33(4):779-784.
[19]Zhong H,Weiyuan M,Daxing C,et al.A comparison of Q-switched1064 nm Nd:YAG laser and intense pulsed light in the nonablative rejuvenation on rat model[J].J Cosmet Laser Ther,2013,15(3):126-132.
[20]Wong WR,Shyu WL,Hsu KH,et al.Intense pulsed light modulates the expressions of MMP-2,MMP-14 and MMP-2 in skin dermal fibroblasts cultured within contracted collagen lattices[J].J Dermatol Sci,2008,51(1):70-73.
[21]何黎,温海,徐丽敏,等.含马齿览及甘草提取物护肤品对敏感性皮肤辅助治疗作用的临床观察[J].临床皮肤科杂志,2009,38(6):364-366.
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