窄谱强脉冲光联合舒敏保湿特护霜治疗敏感性皮肤面部红斑的效果观察
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摘要
目的观察窄谱强脉冲光联合舒敏保湿特护霜治疗敏感性皮肤面部红斑的效果。方法选取敏感性皮肤、表现为持续性面部红斑的患者80例为研究对象。其中40例患者采用窄谱强脉冲光联合舒敏保湿特护霜治疗,为观察组;另40例患者单用窄谱强脉冲光治疗,为对照组。两组患者均接受窄谱强脉冲光治疗,共4次,每次间隔3～4周,疗程持续约4个月,另观察组患者外用舒敏保湿特护霜,2次/d。观察并比较两组患者治疗前后皮肤状态参数(红斑面积、血红素指数、凹陷指数、最大深度)与皮肤屏障参数(治疗区经表皮失水量、角质层含水量),比较两组患者临床疗效与不良反应发生率。结果无论是观察组还是对照组,治疗后皮肤状态参数与皮肤屏障参数均优于治疗前(均P<0.05)。两组患者治疗前皮肤状态参数与皮肤屏障参数比较差异均无统计学意义(均P>0.05),观察组治疗后皮肤状态参数与皮肤屏障参数均优于对照组(均P<0.05)。观察组患者治疗有效率高于对照组(95.0%vs 75.0%,P<0.05),不良反应发生率低于对照组(0.0%vs 22.5%,P<0.05)。结论窄谱强脉冲光联合舒敏保湿特护霜治疗敏感性皮肤面部红斑临床效果确切,同时可以减少皮肤水分流失,增加角质层含水量,修复皮肤屏障功能,不良反应发生率低,值得临床推广应用。
Objective To evaluate the efficacy of narrow-spectrum intense pulse light combined with soothing moisturizing care cream to treat persistent facial redness of sensitive skin. Methods Eighty patients with persistent facial redness of sensitive skin and positive lactic acid test were enrolled in the study. Among them, 40 patients were treated with narrow-spectrum intense pulse light combined with soothing moisturizing care cream(study group), and other 40 patients were treated with narrow-spectrum intense pulse light only(control group).The pulse light treatment was performed with a interval of 3-4 weeks for 4 sessions in both groups, and patients in study group were topically treated with soothing moisturizing care cream twice daily. The therapeutic parameters(erythema area, erythema chroma, indentation index and maximum depth), and the skin barrier parameters(erythema percentile, transepidermal water loss, stratum corneum) were observed in two groups before and after treatment. The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results After treatment, the therapeutic effect and skin barrier parameters were better than those before treatment in both groups(P <0.05). There was no significant difference in the therapeutic effect parameters and the skin barrier parameters between the two groups before treatment(P >0.05);after treatment, the therapeutic effect parameters and skin barrier parameters were better in the study group than those in the control group. The total effective rate of the study group was significantly higher than that of the control group(95.0% vs 75.0%, P<0.05). The study group showed the lower rate of side effects than control group(0.0% vs 22.5%, P<0.05). Conclusion The narrow-spectrum intense pulse light combined with soothing moisturizing care cream is more effective than light therapy alone in treatment of persistent facial redness in the sensitive skin and it is thereby worthy for being promoted in clinical application.
Objective To evaluate the efficacy of narrow-spectrum intense pulse light combined with soothing moisturizing care cream to treat persistent facial redness of sensitive skin. Methods Eighty patients with persistent facial redness of sensitive skin and positive lactic acid test were enrolled in the study. Among them, 40 patients were treated with narrow-spectrum intense pulse light combined with soothing moisturizing care cream(study group), and other 40 patients were treated with narrow-spectrum intense pulse light only(control group).The pulse light treatment was performed with a interval of 3-4 weeks for 4 sessions in both groups, and patients in study group were topically treated with soothing moisturizing care cream twice daily. The therapeutic parameters(erythema area, erythema chroma, indentation index and maximum depth), and the skin barrier parameters(erythema percentile, transepidermal water loss, stratum corneum) were observed in two groups before and after treatment. The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results After treatment, the therapeutic effect and skin barrier parameters were better than those before treatment in both groups(P <0.05). There was no significant difference in the therapeutic effect parameters and the skin barrier parameters between the two groups before treatment(P >0.05);after treatment, the therapeutic effect parameters and skin barrier parameters were better in the study group than those in the control group. The total effective rate of the study group was significantly higher than that of the control group(95.0% vs 75.0%, P<0.05). The study group showed the lower rate of side effects than control group(0.0% vs 22.5%, P<0.05). Conclusion The narrow-spectrum intense pulse light combined with soothing moisturizing care cream is more effective than light therapy alone in treatment of persistent facial redness in the sensitive skin and it is thereby worthy for being promoted in clinical application.
引文
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[3]中国医师协会皮肤科医师分会皮肤激光与理疗亚专业委员会.强脉冲光临床应用专家共识(2017)[J].中华皮肤科杂志,2017,50(10):701.
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[5]Wu Y,Wang X,Zhou Y,et al.Correlation between stinging,TEWL and capacitance[J].Skin Res Technol,2010,9(2):90-93.
[6]Matias AR,Ferreira M,Costa P,et al.Skin colour,skin redness and melanin biometric measurements:comparison study between Antera((R))3D,Mexameter((R))and Colorimeter((R))[J].Skin Res Technol,2015,21(3):346-362.doi:10.1111/srt.12199.
[7]Linming F,Wei H,Anqi L,et al.Comparison of two skin imaging analysis instruments:The VISIA((R))from Canfield vs the ANTERA 3D((R))CS from Miravex[J].Skin Res Technol,2018,24(1):3-8.doi:10.1111/srt.12381.
[8]Pinto P,Rosado C,Parreirao C,et al.Is there any barrier impairment in sensitive skin?:a quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves[J].Skin Res Technol,2011,17(2):181-185.
[9]Issachar N,Gall Y,Borrel MT,et al.Correlation between percutaneous penetration of methyl nicotinate and sensitive skin,using laser Doppler imaging[J].Contact Dermatitis,2010,39(4):182-186.
[10]Jeong S,Lee SH,Park BD,et al.Comparison of the Efficacy of Atopalm((R))Multi-Lamellar Emulsion Cream and Physiogel((R))Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin[J].Dermatol Ther(Heidelb),2016,6(1):47-56.
[11]Fodor L,Ramon Y,Fodor A,et al.A side-by-side prospective study of intense pulsed light and Nd:YAG laser treatment for vascular lesions[J].Ann Plast Surg,2006,56(2):164-170.
[12]Moy WJ,Yakel JD,Osorio OC,et al.Targeted narrowband intense pulsed light on cutaneous vasculature[J].Lasers Surg Med,2015,47(8):651-657.
[13]黄惠娟,马宝林.强脉冲光配合除红血丝美容仪治疗面部毛细血管扩张的疗效观察[J].中国皮肤性病学杂志,2009,23(9):577-578.
[14]何黎,温海,徐丽敏,等.含马齿苋及甘草提取物护肤品对敏感性皮肤辅助治疗作用的临床观察[J].临床皮肤科杂志,2009,38(6):364-366.
[15]Zhao H,Shuang LI,Luo F,et al.Portulaca oleracea L.aids calcipotriol in reversing keratinocyte differentiation and skin barrier dysfunction in psoriasis through inhibition of the nuclear factorκB signaling pathway[J].Exp Ther Med,2015,9(2):303-310.
[16]起珏,庞勤,涂颖,等.含1%青刺果油、10%马齿苋提取物的护肤品对糖皮质激素依赖性皮炎患者皮肤屏障恢复的临床观察[J].临床皮肤科杂志,2012,41(2):119-121.
[2]蔄茂强,Jeong SK,Park BD,et al.敏感性皮肤及其处理对策[J].中华皮肤科杂志,2016,49(12):899-902.
[3]中国医师协会皮肤科医师分会皮肤激光与理疗亚专业委员会.强脉冲光临床应用专家共识(2017)[J].中华皮肤科杂志,2017,50(10):701.
[4]Gan H,Yue B,Wang Y,et al.Treatment of facial telangiectasia with narrow-band intense pulsed light in Chinese patients[J].J Cosmet Laser Ther,2018(9):1-5.
[5]Wu Y,Wang X,Zhou Y,et al.Correlation between stinging,TEWL and capacitance[J].Skin Res Technol,2010,9(2):90-93.
[6]Matias AR,Ferreira M,Costa P,et al.Skin colour,skin redness and melanin biometric measurements:comparison study between Antera((R))3D,Mexameter((R))and Colorimeter((R))[J].Skin Res Technol,2015,21(3):346-362.doi:10.1111/srt.12199.
[7]Linming F,Wei H,Anqi L,et al.Comparison of two skin imaging analysis instruments:The VISIA((R))from Canfield vs the ANTERA 3D((R))CS from Miravex[J].Skin Res Technol,2018,24(1):3-8.doi:10.1111/srt.12381.
[8]Pinto P,Rosado C,Parreirao C,et al.Is there any barrier impairment in sensitive skin?:a quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves[J].Skin Res Technol,2011,17(2):181-185.
[9]Issachar N,Gall Y,Borrel MT,et al.Correlation between percutaneous penetration of methyl nicotinate and sensitive skin,using laser Doppler imaging[J].Contact Dermatitis,2010,39(4):182-186.
[10]Jeong S,Lee SH,Park BD,et al.Comparison of the Efficacy of Atopalm((R))Multi-Lamellar Emulsion Cream and Physiogel((R))Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin[J].Dermatol Ther(Heidelb),2016,6(1):47-56.
[11]Fodor L,Ramon Y,Fodor A,et al.A side-by-side prospective study of intense pulsed light and Nd:YAG laser treatment for vascular lesions[J].Ann Plast Surg,2006,56(2):164-170.
[12]Moy WJ,Yakel JD,Osorio OC,et al.Targeted narrowband intense pulsed light on cutaneous vasculature[J].Lasers Surg Med,2015,47(8):651-657.
[13]黄惠娟,马宝林.强脉冲光配合除红血丝美容仪治疗面部毛细血管扩张的疗效观察[J].中国皮肤性病学杂志,2009,23(9):577-578.
[14]何黎,温海,徐丽敏,等.含马齿苋及甘草提取物护肤品对敏感性皮肤辅助治疗作用的临床观察[J].临床皮肤科杂志,2009,38(6):364-366.
[15]Zhao H,Shuang LI,Luo F,et al.Portulaca oleracea L.aids calcipotriol in reversing keratinocyte differentiation and skin barrier dysfunction in psoriasis through inhibition of the nuclear factorκB signaling pathway[J].Exp Ther Med,2015,9(2):303-310.
[16]起珏,庞勤,涂颖,等.含1%青刺果油、10%马齿苋提取物的护肤品对糖皮质激素依赖性皮炎患者皮肤屏障恢复的临床观察[J].临床皮肤科杂志,2012,41(2):119-121.
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