茵栀黄口服液联合布拉酵母对新生儿黄疸的治疗
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摘要
目的探讨茵栀黄口服液联合布拉酵母治疗新生儿黄疸的效果。方法回顾性分析2012年5月至2016年2月我院收治的108例新生儿黄疸患儿的临床资料,根据治疗方法的不同将患儿分为对照组(50例)和观察组(58例)。两组患儿均给予蓝光处理,对照组同时给予布拉酵母治疗,观察组在对照组的基础上联用茵栀黄口服液进行治疗。比较两组患儿凝血指数、血气指标、生化指标及治疗效果。结果观察组患儿治疗后有效率高于对照组(98.28%vs 90.00%,χ~2=24.92,P<0.05)。观察组患儿治疗后PaCO_2、pH、BE及Ca~(2+)和Mg~(2+)水平均低于对照组,差异有统计学意义(均P<0.05)。观察组患儿治疗后PT、APTT、FIB、TT异常发生率与对照组比较差异无统计学意义(均P>0.05)。观察组患儿治疗后血清总胆红素水平低于对照组,住院时间及黄疸消退时间均短于对照组,差异有统计学意义(均P<0.05)。结论茵栀黄口服液联合布拉酵母治疗新生儿黄疸效果显著,能够明显缩短黄疸消退时间,改善血气分析指标及生化指标水平,安全有效。
Objective To investigate the efficacy of Yin-zhi-huang oral liquid combined with Saccharomyces brasiliensis in treatment of neonatal jaundice. Methods The clinical data of 108 neonatal jaundice patients admitted to our hospital from May 2012 to February 2016 were retrospectively analyzed. According to the treatment, all the infants were divided into the control group(50 cases) or the observation group(58 cases). Both groups were treated with blue light and Saccharomyces brasiliensis. The observation group was additionally given Yin-zhi-huang oral liquid. The coagulation index, blood gas index, biochemical index and therapeutic effect of the two groups were compared. Results The efficiency rate in the observation group was higher than that in control group(98.28% vs 90.00%, χ~2=24.92, P<0.05). After treatment, the levels of PaCO_2, pH, BE, Ca~(2+) and Mg~(2+) in the observation group were lower than those in the control group, with significant differences(all P<0.05). There were no significant differences in the incidence rates of abnormal PT, APTT, FIB and TT between the two groups(all P>0.05). After treatment, the serum level of total bilirubin in the observation group was lower than that in the control group, and the days of hospitalization and time to dispearance of jaundice in the observation group were shorter than those in the control group respectively, with significant differences(all P<0.05). Conclusion Yin-zhi-huang oral liquid combined with Saccharomyces brasiliensis has a significant effect for the treatment of neonatal jaundice. It can significantly shorten the time to dispearance of jaundice and improve blood gas indexes and biochemical indicators with satisfactory safety and efficacy.
Objective To investigate the efficacy of Yin-zhi-huang oral liquid combined with Saccharomyces brasiliensis in treatment of neonatal jaundice. Methods The clinical data of 108 neonatal jaundice patients admitted to our hospital from May 2012 to February 2016 were retrospectively analyzed. According to the treatment, all the infants were divided into the control group(50 cases) or the observation group(58 cases). Both groups were treated with blue light and Saccharomyces brasiliensis. The observation group was additionally given Yin-zhi-huang oral liquid. The coagulation index, blood gas index, biochemical index and therapeutic effect of the two groups were compared. Results The efficiency rate in the observation group was higher than that in control group(98.28% vs 90.00%, χ~2=24.92, P<0.05). After treatment, the levels of PaCO_2, pH, BE, Ca~(2+) and Mg~(2+) in the observation group were lower than those in the control group, with significant differences(all P<0.05). There were no significant differences in the incidence rates of abnormal PT, APTT, FIB and TT between the two groups(all P>0.05). After treatment, the serum level of total bilirubin in the observation group was lower than that in the control group, and the days of hospitalization and time to dispearance of jaundice in the observation group were shorter than those in the control group respectively, with significant differences(all P<0.05). Conclusion Yin-zhi-huang oral liquid combined with Saccharomyces brasiliensis has a significant effect for the treatment of neonatal jaundice. It can significantly shorten the time to dispearance of jaundice and improve blood gas indexes and biochemical indicators with satisfactory safety and efficacy.
引文
[1] DENG Rong,LI Ying.Clinical effect of blue light therapy combined with Yinzhihuang oral solution in the treatment of neonatal pathologic jaundice[J].Chin J Clin Rational Drug Use,2018,11(9):9-10.(in Chinese) 邓荣,李迎.蓝光疗法联合茵栀黄口服液治疗新生儿病理性黄疸的临床疗效[J].临床合理用药杂志,2018,11(9):9-10.
[2] ZHU Yan.A prospective multicenter epidemiology investigation of premature newborn[D].Shanghai:Fudan University,2012.(in Chinese) 朱燕.出生早产儿流行病学特征的前瞻性多中心调查[D].上海:复旦大学,2012.
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[4] 赵红莉.茵栀黄口服液与蓝光照射法联合治疗新生儿黄疸中的应用[J].中国保健营养,2018,28(8):205.
[5] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2011:423-424.
[6] 国家中医药管理局.ZY/T001.1～001.9-94中医病证诊断疗效标准[S].南京:南京大学出版社,1994:301.
[7] CAO Qiaoling,ZHU Huijie.Yinzhihuang supplementary illumination analysis of humanized nursing in the treatment of neonatal jaundice[J].Chin J Biochem Pharm,2017,37(10):340-341.(in Chinese) 曹巧玲,朱惠洁.茵栀黄辅助光照治疗新生儿黄疸的人性化护理分析[J].中国生化药物志,2017,37(10):340-341.
[8] 李翠莲.茵栀黄口服液辅助治疗新生儿母乳性黄疸的疗效观察[J].实用中西医结合临床,2018,18(1):97-98.
[9] 高凤霞.茵栀黄口服液联合清蛋白治疗新生儿病理性黄疸疗效、安全性及可能机制分析[J].海峡药学,2018,30(5):205-206.
[10] 李晓云.口服亿活(布拉氏酵母菌)对新生儿高胆红素血症的疗效观察[J].贵阳中医学院学报,2013,35(2):85-87.
[11] QIN Liuju.Clinical observation on treating 44 cases of neonatal jaundice of the Shire Yuzheng type with the Yinzhihuang oral solution plus blue light phototherapy[J].Clin J Chin Med,2018,10(2):57-59.(in Chinese) 覃柳菊.茵栀黄联合蓝光照射治疗44例湿热郁蒸型新生儿黄疸的临床观察[J].中医临床研究,2018,10(2):57-59.
[12] 夏光平.茵栀黄口服液、布拉氏酵母菌散、双歧三联活菌胶囊治疗新生儿高胆红素血症的效果对比[J].中外医学研究,2018,16(11):121-122.
[13] HOU Zhifeng,YAN Haili.Effects and costs comparison of human blood albumin and Yinzhihuang oral liquid combined with blue light in the treatment of neonatal jaundice[J].Clin Res Pract,2017,2(33):107-108.(in Chinese) 侯志锋,闫海莉.人血白蛋白、茵栀黄口服液辅助蓝光照射治疗新生儿黄疸的疗效与治疗成本比较[J].临床医学研究与实践,2017,2(33):107-108.
[14] 李琼.茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸的临床效果观察[J].临床合理用药杂志,2017,10(2):61-62.
[15] LI Pengcheng,GUO Yuxiu,GUO Fei.Saccharomyces boulardii treatment of neonatal jaundice[J].Chin J Mod Drug Appl,2012,6(8):4-6.(in Chinese) 李鹏程,郭玉秀,郭飞.布拉氏酵母菌对治疗新生儿黄疸的促进作用[J].中国现代药物应用,2012,6(8):4-6.
[16] 汪芳华.茵桅黄辅治母乳性黄疸效果观察[J].中国乡村医药,2013,20(8):56-58.
[17] ZU Ting.The clinical effect of Yinzhihuang and Bifidobacterium triple viable in treatment of neonatal jaundice[J].Med Forum,2017,21(17):2175-2177.(in Chinese) 祖婷.茵栀黄口服液联合双歧杆菌三联活菌辅助冷光源照射治疗新生儿黄疸临床观察[J].基层医学论坛,2017,21(17):2175-2177.
[18] 徐睿霞,王甫琴,吴亚臻.茵栀黄口服液联合清蛋白治疗新生儿病理性黄疸疗效及安全性研究[J].重庆医学,2017,46(4):530-532.
[2] ZHU Yan.A prospective multicenter epidemiology investigation of premature newborn[D].Shanghai:Fudan University,2012.(in Chinese) 朱燕.出生早产儿流行病学特征的前瞻性多中心调查[D].上海:复旦大学,2012.
[3] 王卫平.儿科学[M].8版.北京:人民卫生出版社,2013:50.
[4] 赵红莉.茵栀黄口服液与蓝光照射法联合治疗新生儿黄疸中的应用[J].中国保健营养,2018,28(8):205.
[5] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2011:423-424.
[6] 国家中医药管理局.ZY/T001.1～001.9-94中医病证诊断疗效标准[S].南京:南京大学出版社,1994:301.
[7] CAO Qiaoling,ZHU Huijie.Yinzhihuang supplementary illumination analysis of humanized nursing in the treatment of neonatal jaundice[J].Chin J Biochem Pharm,2017,37(10):340-341.(in Chinese) 曹巧玲,朱惠洁.茵栀黄辅助光照治疗新生儿黄疸的人性化护理分析[J].中国生化药物志,2017,37(10):340-341.
[8] 李翠莲.茵栀黄口服液辅助治疗新生儿母乳性黄疸的疗效观察[J].实用中西医结合临床,2018,18(1):97-98.
[9] 高凤霞.茵栀黄口服液联合清蛋白治疗新生儿病理性黄疸疗效、安全性及可能机制分析[J].海峡药学,2018,30(5):205-206.
[10] 李晓云.口服亿活(布拉氏酵母菌)对新生儿高胆红素血症的疗效观察[J].贵阳中医学院学报,2013,35(2):85-87.
[11] QIN Liuju.Clinical observation on treating 44 cases of neonatal jaundice of the Shire Yuzheng type with the Yinzhihuang oral solution plus blue light phototherapy[J].Clin J Chin Med,2018,10(2):57-59.(in Chinese) 覃柳菊.茵栀黄联合蓝光照射治疗44例湿热郁蒸型新生儿黄疸的临床观察[J].中医临床研究,2018,10(2):57-59.
[12] 夏光平.茵栀黄口服液、布拉氏酵母菌散、双歧三联活菌胶囊治疗新生儿高胆红素血症的效果对比[J].中外医学研究,2018,16(11):121-122.
[13] HOU Zhifeng,YAN Haili.Effects and costs comparison of human blood albumin and Yinzhihuang oral liquid combined with blue light in the treatment of neonatal jaundice[J].Clin Res Pract,2017,2(33):107-108.(in Chinese) 侯志锋,闫海莉.人血白蛋白、茵栀黄口服液辅助蓝光照射治疗新生儿黄疸的疗效与治疗成本比较[J].临床医学研究与实践,2017,2(33):107-108.
[14] 李琼.茵栀黄口服液联合间隙蓝光照射佐以双歧杆菌三联活菌治疗新生儿黄疸的临床效果观察[J].临床合理用药杂志,2017,10(2):61-62.
[15] LI Pengcheng,GUO Yuxiu,GUO Fei.Saccharomyces boulardii treatment of neonatal jaundice[J].Chin J Mod Drug Appl,2012,6(8):4-6.(in Chinese) 李鹏程,郭玉秀,郭飞.布拉氏酵母菌对治疗新生儿黄疸的促进作用[J].中国现代药物应用,2012,6(8):4-6.
[16] 汪芳华.茵桅黄辅治母乳性黄疸效果观察[J].中国乡村医药,2013,20(8):56-58.
[17] ZU Ting.The clinical effect of Yinzhihuang and Bifidobacterium triple viable in treatment of neonatal jaundice[J].Med Forum,2017,21(17):2175-2177.(in Chinese) 祖婷.茵栀黄口服液联合双歧杆菌三联活菌辅助冷光源照射治疗新生儿黄疸临床观察[J].基层医学论坛,2017,21(17):2175-2177.
[18] 徐睿霞,王甫琴,吴亚臻.茵栀黄口服液联合清蛋白治疗新生儿病理性黄疸疗效及安全性研究[J].重庆医学,2017,46(4):530-532.