水凝胶支架材料在牙髓再生中的研究进展
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摘要
近年来用于牙髓再生的支架材料逐渐被重视,并成为研究热点。其中水凝胶凭借一定的韧性、流变性、良好的生物相容性和可降解性等优势,被越来越广泛地应用于牙髓再生的研究中。水凝胶在调控干细胞命运、调节生长因子释放、装载抗菌抗炎药物等方面都发挥着重要作用。该文就水凝胶支架材料在牙髓再生中的研究进展作一综述。
Scaffolds for dental pulp regeneration have been gradually attached importance to and become research hotspots in recent years. Hydrogel, with the advantages of toughness, rheology, good bio-compatibility and biodegradability, has been more and more widely used in dental pulp regeneration. Hydrogel plays an important role in control of stem cell fate, control of growth factor release and delivery of anti-inflammation and anti-bacteria drugs. This article reviewed the research progress of hydrogel in dental pulp regeneration.
Scaffolds for dental pulp regeneration have been gradually attached importance to and become research hotspots in recent years. Hydrogel, with the advantages of toughness, rheology, good bio-compatibility and biodegradability, has been more and more widely used in dental pulp regeneration. Hydrogel plays an important role in control of stem cell fate, control of growth factor release and delivery of anti-inflammation and anti-bacteria drugs. This article reviewed the research progress of hydrogel in dental pulp regeneration.
引文
[1] Galler KM,D'Souza RN,Hartgerink JD,et al.Scaffolds for dental pulp tissue engineering[J].Adv Dent Res,2011,23(3):333-339.
[2] 雷鸣,高丽娜,陈发明,等.牙髓组织工程和再生中生物支架材料的进展[J].牙体牙髓牙周病学杂志,2013,23(1):51-56.
[3] Van Vlierberghe S,Dubruel P,Schacht E.Biopolymer-based hydrogels as scaffolds for tissue engineering applications:A review[J].Biomacromolecules,2011,12(5):1387-1408.
[4] Zhu J,Marchant RE.Design properties of hydrogel tissue-engineering scaffolds[J].Expert Rev Med Devices,2011,8(5):607-626.
[5] Galler KM,Brandl FP,Kirchhof S,et al.Suitability of different natural and synthetic biomaterials for dental pulp tissue engineering[J].Tissue Eng Part A,2018,24(3/4):234-244.
[6] Fakhari A,Berkland C.Applications and emerging trends of hyaluronic acid in tissue engineering,as a dermal filler,and in osteoarthritis treatment[J].Acta Biomaterialia,2013,9(7):7081-7092.
[7] Lee KY,Mooney DJ.Hydrogels for tissue engineering[J].Chem Rev,2001,101(7):1869-1879.
[8] Tan H,Marra KG.Injectable,biodegradable hydrogels for tissue engineering applications[J].Materials,2010,3(3):1746-1767.
[9] Galler KM,Cavender A,Yuwono V,et al.Self-assembling pepti-de amphiphile nanofibers as a scaffold for dental stem cells[J].Tissue Eng Part A,2008,14(12):2051-2058.
[10] Galler KM,Aulisa L,Regan KR,et al.Self-assembling multidomain peptide hydrogels:Designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading[J].J Am Chem Soc,2010,132(9):3217-3223.
[11] Rosa V,Zhang Z,Grande RH,et al.Dental pulp tissue engineering in full-length human root canals[J].J Dent Res,2013,92(11):970-975.
[12] Dissanayaka WL,Hargreaves KM,Jin L,et al.The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo[J].Tissue Eng Part A,2015,21(3/4):550-563.
[13] Galler KM,Hartgerink JD,Cavender AC,et al.A customized self-assembling peptide hydrogel for dental pulp tissue engineering[J].Tissue Eng Part A,2012,18(1/2):176-184.
[14] Gong T,Heng BC,Lo EC,et al.Current advance and future prospects of tissue engineering approach to dentin/pulp regenerative therapy[J].Stem Cells Int,2016,2016:9204574.
[15] Frasca S,Norol F,Le Visage C,et al.Calcium-phosphate ceramics and polysaccharide-based hydrogel scaffolds combined with mesenchymal stem cell differently support bone repair in rats[J].J Mater Sci Mater Med,2017,28(2):35.
[16] Wolf MT,Daly KA,Brennanpierce EP,et al.A hydrogel derived from decellularized dermal extracellular matrix[J].Biomaterials,2012,33(29):7028-7038.
[17] Song JS,Takimoto K,Jeon M,et al.Decellularized human dental pulp as a scaffold for regenerative endodontics[J].J Dent Res,2017,96(6):640-646.
[18] Alqahtani Q,Zaky SH,Patil A,et al.Decellularized swine dental pulp tissue for regenerative root canal therapy[J].J Dent Res,2018:22034518785124.
[19] Murphy WL,McDevitt TC,Engler AJ.Materials as stem cell regulators[J].Nat Mater,2014,13(6):547-557.
[20] Lutolf MP,Gilbert PM,Blau HM.Designing materials to direct stem-cell fate[J].Nature,2009,462(7272):433-441.
[21] Kolind K,Kraft D,Boggild T,et al.Control of proliferation and osteogenic differentiation of human dental-pulp-derived stem cells by distinct surface structures[J].Acta Biomater,2014,10(2):641-650.
[22] Hata M,Naruse K,Ozawa S,et al.Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells[J].Tissue Eng Part A,2013,19(5/6):625-633.
[23] Erisken C,Kalyon DM,Zhou J,et al.Viscoelastic properties of dental pulp tissue and ramifications on biomaterial development for pulp regeneration[J].J Endod,2015,41(10):1711-1717.
[24] Piva E,Silva AF,Nor JE.Functionalized scaffolds to control dental pulp stem cell fate[J].J Endod,2014,40(4 Suppl):S33-40.
[25] Dissanayaka WL,Zhang C.The role of vasculature engineering in dental pulp regeneration[J].J Endod,2017,43(9s):S102-106.
[26] Rombouts C,Giraud T,Jeanneau C,et al.Pulp vascularization during tooth development,regeneration,and therapy[J].J Dent Res,2017,96(2):137-144.
[27] Li X,Ma C,Xie X,et al.Pulp regeneration in a full-length human tooth root using a hierarchical nanofibrous microsphere system[J].Acta Biomater,2016,35:57-67.
[28] 杨懋彬,曾倩.再生牙髓病学——牙髓再生的新方向[J].国际口腔医学杂志,2016,43(5):495-499.
[29] Lin CC,Metters AT.Hydrogels in controlled release formulations:Network design and mathematical modeling[J].Adv Drug Deliv Rev,2006,58(12/13):1379-1408.
[30] Cooper PR,Chicca IJ,Holder MJ,et al.Inflammation and regeneration in the dentin-pulp complex:Net gain or net loss?[J].J Endod,2017,43(9s):S87-s94.
[31] Goldberg M,Njeh A,Uzunoglu E.Is pulp inflammation a prerequisite for pulp healing and regeneration?[J].Mediators Inflamm,2015,2015:347649.
[32] Dondoni L,Scarparo RK,Kantarci A,et al.Effect of the pro-resolution lipid mediator resolvin e1(rve1) on pulp tissues exposed to the oral environment[J].Int Endod J,2014,47(9):827-834.
[33] Scarparo RK,Dondoni L,Bottcher DE,et al.Intracanal delivery of resolvin e1 controls inflammation in necrotic immature rat teeth[J].J Endod,2014,40(5):678-682.夏鹍,等.水凝胶支架材料在牙髓再生中的研究进展
[34] Colombo JS,Moore AN,Hartgerink JD,et al.Scaffolds to control inflammation and facilitate dental pulp regeneration[J].J Endod,2014,40(4 Suppl):S6-12.
[35] Kim SG,Malek M,Sigurdsson A,et al.Regenerative endodon-tics:A comprehensive review[J].Int Endod J,2018,51(12):1367-1388.
[36] Bottino MC,Kamocki K,Yassen GH,et al.Bioactive nanofibrous scaffolds for regenerative endodontics[J].J Dent Res,2013,92(11):963-969.
[37] Albuquerque MT,Valera MC,Nakashima M,et al.Tissue-engineering-based strategies for regenerative endodontics[J].J Dent Res,2014,93(12):1222-1231.
[38] Bottino MC,Pankajakshan D,Nor JE.Advanced scaffolds for dental pulp and periodontal regeneration[J].Dent Clin North Am,2017,61(4):689-711.
[39] Palasuk J,Kamocki K,Hippenmeyer L,et al.Bimix antimicrobial scaffolds for regenerative endodontics[J].J Endod,2014,40(11):1879-1884.
[40] Karczewski A,Feitosa SA,Hamer EI,et al.Clindamycin-modified triple antibiotic nanofibers:A stain-free antimicrobial intracanal drug delivery system[J].J Endod,2018,44(1):155-162.
[41] Pankajakshan D,Albuquerque MT,Evans JD,et al.Triple antibiotic polymer nanofibers for intracanal drug delivery:Effects on dual species biofilm and cell function[J].J Endod,2016,42(10):1490-1495.
[2] 雷鸣,高丽娜,陈发明,等.牙髓组织工程和再生中生物支架材料的进展[J].牙体牙髓牙周病学杂志,2013,23(1):51-56.
[3] Van Vlierberghe S,Dubruel P,Schacht E.Biopolymer-based hydrogels as scaffolds for tissue engineering applications:A review[J].Biomacromolecules,2011,12(5):1387-1408.
[4] Zhu J,Marchant RE.Design properties of hydrogel tissue-engineering scaffolds[J].Expert Rev Med Devices,2011,8(5):607-626.
[5] Galler KM,Brandl FP,Kirchhof S,et al.Suitability of different natural and synthetic biomaterials for dental pulp tissue engineering[J].Tissue Eng Part A,2018,24(3/4):234-244.
[6] Fakhari A,Berkland C.Applications and emerging trends of hyaluronic acid in tissue engineering,as a dermal filler,and in osteoarthritis treatment[J].Acta Biomaterialia,2013,9(7):7081-7092.
[7] Lee KY,Mooney DJ.Hydrogels for tissue engineering[J].Chem Rev,2001,101(7):1869-1879.
[8] Tan H,Marra KG.Injectable,biodegradable hydrogels for tissue engineering applications[J].Materials,2010,3(3):1746-1767.
[9] Galler KM,Cavender A,Yuwono V,et al.Self-assembling pepti-de amphiphile nanofibers as a scaffold for dental stem cells[J].Tissue Eng Part A,2008,14(12):2051-2058.
[10] Galler KM,Aulisa L,Regan KR,et al.Self-assembling multidomain peptide hydrogels:Designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading[J].J Am Chem Soc,2010,132(9):3217-3223.
[11] Rosa V,Zhang Z,Grande RH,et al.Dental pulp tissue engineering in full-length human root canals[J].J Dent Res,2013,92(11):970-975.
[12] Dissanayaka WL,Hargreaves KM,Jin L,et al.The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo[J].Tissue Eng Part A,2015,21(3/4):550-563.
[13] Galler KM,Hartgerink JD,Cavender AC,et al.A customized self-assembling peptide hydrogel for dental pulp tissue engineering[J].Tissue Eng Part A,2012,18(1/2):176-184.
[14] Gong T,Heng BC,Lo EC,et al.Current advance and future prospects of tissue engineering approach to dentin/pulp regenerative therapy[J].Stem Cells Int,2016,2016:9204574.
[15] Frasca S,Norol F,Le Visage C,et al.Calcium-phosphate ceramics and polysaccharide-based hydrogel scaffolds combined with mesenchymal stem cell differently support bone repair in rats[J].J Mater Sci Mater Med,2017,28(2):35.
[16] Wolf MT,Daly KA,Brennanpierce EP,et al.A hydrogel derived from decellularized dermal extracellular matrix[J].Biomaterials,2012,33(29):7028-7038.
[17] Song JS,Takimoto K,Jeon M,et al.Decellularized human dental pulp as a scaffold for regenerative endodontics[J].J Dent Res,2017,96(6):640-646.
[18] Alqahtani Q,Zaky SH,Patil A,et al.Decellularized swine dental pulp tissue for regenerative root canal therapy[J].J Dent Res,2018:22034518785124.
[19] Murphy WL,McDevitt TC,Engler AJ.Materials as stem cell regulators[J].Nat Mater,2014,13(6):547-557.
[20] Lutolf MP,Gilbert PM,Blau HM.Designing materials to direct stem-cell fate[J].Nature,2009,462(7272):433-441.
[21] Kolind K,Kraft D,Boggild T,et al.Control of proliferation and osteogenic differentiation of human dental-pulp-derived stem cells by distinct surface structures[J].Acta Biomater,2014,10(2):641-650.
[22] Hata M,Naruse K,Ozawa S,et al.Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells[J].Tissue Eng Part A,2013,19(5/6):625-633.
[23] Erisken C,Kalyon DM,Zhou J,et al.Viscoelastic properties of dental pulp tissue and ramifications on biomaterial development for pulp regeneration[J].J Endod,2015,41(10):1711-1717.
[24] Piva E,Silva AF,Nor JE.Functionalized scaffolds to control dental pulp stem cell fate[J].J Endod,2014,40(4 Suppl):S33-40.
[25] Dissanayaka WL,Zhang C.The role of vasculature engineering in dental pulp regeneration[J].J Endod,2017,43(9s):S102-106.
[26] Rombouts C,Giraud T,Jeanneau C,et al.Pulp vascularization during tooth development,regeneration,and therapy[J].J Dent Res,2017,96(2):137-144.
[27] Li X,Ma C,Xie X,et al.Pulp regeneration in a full-length human tooth root using a hierarchical nanofibrous microsphere system[J].Acta Biomater,2016,35:57-67.
[28] 杨懋彬,曾倩.再生牙髓病学——牙髓再生的新方向[J].国际口腔医学杂志,2016,43(5):495-499.
[29] Lin CC,Metters AT.Hydrogels in controlled release formulations:Network design and mathematical modeling[J].Adv Drug Deliv Rev,2006,58(12/13):1379-1408.
[30] Cooper PR,Chicca IJ,Holder MJ,et al.Inflammation and regeneration in the dentin-pulp complex:Net gain or net loss?[J].J Endod,2017,43(9s):S87-s94.
[31] Goldberg M,Njeh A,Uzunoglu E.Is pulp inflammation a prerequisite for pulp healing and regeneration?[J].Mediators Inflamm,2015,2015:347649.
[32] Dondoni L,Scarparo RK,Kantarci A,et al.Effect of the pro-resolution lipid mediator resolvin e1(rve1) on pulp tissues exposed to the oral environment[J].Int Endod J,2014,47(9):827-834.
[33] Scarparo RK,Dondoni L,Bottcher DE,et al.Intracanal delivery of resolvin e1 controls inflammation in necrotic immature rat teeth[J].J Endod,2014,40(5):678-682.夏鹍,等.水凝胶支架材料在牙髓再生中的研究进展
[34] Colombo JS,Moore AN,Hartgerink JD,et al.Scaffolds to control inflammation and facilitate dental pulp regeneration[J].J Endod,2014,40(4 Suppl):S6-12.
[35] Kim SG,Malek M,Sigurdsson A,et al.Regenerative endodon-tics:A comprehensive review[J].Int Endod J,2018,51(12):1367-1388.
[36] Bottino MC,Kamocki K,Yassen GH,et al.Bioactive nanofibrous scaffolds for regenerative endodontics[J].J Dent Res,2013,92(11):963-969.
[37] Albuquerque MT,Valera MC,Nakashima M,et al.Tissue-engineering-based strategies for regenerative endodontics[J].J Dent Res,2014,93(12):1222-1231.
[38] Bottino MC,Pankajakshan D,Nor JE.Advanced scaffolds for dental pulp and periodontal regeneration[J].Dent Clin North Am,2017,61(4):689-711.
[39] Palasuk J,Kamocki K,Hippenmeyer L,et al.Bimix antimicrobial scaffolds for regenerative endodontics[J].J Endod,2014,40(11):1879-1884.
[40] Karczewski A,Feitosa SA,Hamer EI,et al.Clindamycin-modified triple antibiotic nanofibers:A stain-free antimicrobial intracanal drug delivery system[J].J Endod,2018,44(1):155-162.
[41] Pankajakshan D,Albuquerque MT,Evans JD,et al.Triple antibiotic polymer nanofibers for intracanal drug delivery:Effects on dual species biofilm and cell function[J].J Endod,2016,42(10):1490-1495.
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