生物支架材料在骨组织工程中的研究进展
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摘要
骨缺损修复尤其是大段骨缺损的修复一直是骨科临床急需解决的问题,目前组织工程用于骨缺损的修复已成为研究热点,随着组织工程的快速发展,骨修复支架材料的研究也越来越多。本文就近年来组织工程支架材料的发展分类做简要综述。
The repair of bone defects, especially the repair of large bone defects, has been an urgent problem in orthopedics.At present, tissue engineering for the repair of bone defects has become a research hotspot. With the rapid development of tissue engineering, the research of bone repair scaffold materials More and more. This paper briefly summarizes the development classification of tissue engineering scaffold materials in recent years.
The repair of bone defects, especially the repair of large bone defects, has been an urgent problem in orthopedics.At present, tissue engineering for the repair of bone defects has become a research hotspot. With the rapid development of tissue engineering, the research of bone repair scaffold materials More and more. This paper briefly summarizes the development classification of tissue engineering scaffold materials in recent years.
引文
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[15]Rizzi SC,Heath DJ,Coombes AG,et al.Biodegradablepolymer/hydroxyapatite composites:surface analysis andinitial attachment of human osteoblasts[J].Biomed MaterRes,2001,55(4):475-486.
[16]宋鑫月,朱光明,王宗瑶,等.聚己内酯的制备及改性研究进展[J].中国胶粘剂,2016,13(04):52-56.
[17]曲文强,夏文龙,孙斌,等.生物降解材料聚羟基乙酸及其共聚物研究进展[J].山东化工,2014,14(03):34-36.
[18]刘璐,黄天意,史金先,等.聚乳酸-羟基乙酸在骨组织工程材料支架中的应用[J].口腔医学,2019,39(2):167-170.
[19]李涛,杨述华,刘国辉,等.钛网植骨侧前路钉棒系统内固定治疗脊柱结核伴截瘫[J].中国矫形外科杂志,2007,15(5):340-343.
[20]马信龙.人工骨修复材料及金属钛材料在骨组织工程中的应用[J].中国组织工程研究,2012,16(12):2229-2232.
[21]Niinomi M.Recent metallic materials for biomedical applications[J].Metall and Mat Trans A,2002,33:477-486.
[22]Staiger MP,Pietak AM,Huadmai J,et al.Magnesium and its alloys as orthopedic biomaterials:a review[J].Biomaterials,2006,27(9):1728-34.
[23]柴乐,全仁夫,黄小龙.羟基磷灰石构建组织工程骨支架的研究进展[J].中医正骨,2018,30(01),44-46+50.
[24]Ito M,Yamagishi T,Yagasaki H,et al.In vitro properties of a chitosanbonded bone-filling paste:studies on solubility of calcium phosphate compounds[J].J Biomed Mater Res,1996,32(1):95-98.
[25]徐海星,刘慧,许沛虎,等.聚乳酸/β-磷酸三钙/透明质酸/壳聚糖神经支架的制备工艺研究[J].武汉理工大学学报,2014,36(01):58-61+78.
[26]王鹏飞,阮孝慈,杨富帮.纳米羟基磷灰石/胶原复合材料的研究进展[J].杭州化工,2017,47(2):10-13.
[27]Kunert-Keil C,Scholz F,Gedrange T,et al.Comparative study of biphasic calcium phosphate with beta-tricalcium phosphate in rat cranial defects--Amolecular-biological and histological study[J].Ann Anat,2015,199(12):79-84.
[28]潘福勤,刘建辉,庞胤,等.胶原-生物活性玻璃-聚己内酯复合材料促进人牙髓细胞的增殖、迁移和分化[J].中国组织工程研究,2018,22(14):2168-2173.
[29]He F,Chen Y,Li J,et al.Improving bone repair of femoral and radial defects in rabbit by incorporating PRP into PLGA/CPC composite scaffold with unidirectional pore structure[J].Biomed Mater Res A,2015,103(4):1312-1324.
[30]朱淑倩,何家才.人工骨替代材料修复种植体周围骨缺损的研究进展[J].医学综述,2010,16(6):863-865
[31]Dalgic AD,Alshemary AZ,Tezcaner A,et al.Silicate-doped nanohydroxyapatite/graphene oxide composite reinforced fibrous scaffolds for bone tissue engineering[J].Journal of Biomaterials Applications,201832(10):1392-1405.
[32]张迪峰,余霄,庞清江.骨组织工程支架及骨修补材料:复合型骨移植材料的前景更好[J].中国组织工程研究,2018,22(26):4253-4258.
[2]李瑞瑞,戴传波.骨修复材料的研究进展[J].化学工程与装备,2018,105(09):265-266.
[3]俞兰.钛表面磷酸钙/Ⅰ型胶原涂层成骨效应的体内研究[D].浙江大学,2014.
[4]许晨辉,何阿祥,谢栋,等.介孔钙硅酸盐改性硫酸钙骨水泥的体内降解及成骨性能[J].中国矫形外科杂志,2016,24(6):544-551.
[5]Pang L.,Hu Y.,Yan Y.,et al.Surface modification of PLGA/β-TCP scaffold for bone tissue engineering:Hybridization with collagen and apatite[J].Surface and Coatings Technology,2007,201(24):9549-57.
[6]Younes I,Rinaudo M.Chitin and chitosan preparation from marine sources:structure,properties and applications[J].Mar Drugs,2015,13(3):1133-1174.
[7]Venkatesan J,Kim SK.Chitosan composites for bone tissue engineering:an overview[J].Mar Drugs,2010,8(8):2252-2266.
[8]Aam BB,Heggset EB,Norberg AL,et al.Production of chitooligosaccharides and their potential applications in medicine[J].Mar Drugs,2010,8(5):1482-1517.
[9]陆遥,尹庆水,夏虹.壳聚糖复合材料在骨修复领域的研究进展[J].中国骨科临床与基础研究杂志,2018,10(01):46-52.
[10]帅亚俊,王捷,张青,等.丝蛋白在生物材料领域的最新研究进展[J].蚕业科学,2017,43(06),889-897.
[11]Partlow BP,Hanna CW,Rnjak-Kovacin J,et al.Highly tunable elastomeric silk biomaterials[J].Adv Funct Mater,2014,24(29):4615-4624.
[12]Liu B,Song YW,Jin L,et al.Silk structure and degradation[J].Colloids Surf B Biointerfaces,2015,(131):122-128.
[13]盛敏刚,张金花,李延红.环境友好新型聚乳酸复合材料的研究及应用[J].资源开发与市场,2007,23(11):1012-1014,1028.
[14]李亚儒,陈康.聚乳酸基生物医用复合材料研究进展[J].山东化工,2018,47(16),60-61+63.
[15]Rizzi SC,Heath DJ,Coombes AG,et al.Biodegradablepolymer/hydroxyapatite composites:surface analysis andinitial attachment of human osteoblasts[J].Biomed MaterRes,2001,55(4):475-486.
[16]宋鑫月,朱光明,王宗瑶,等.聚己内酯的制备及改性研究进展[J].中国胶粘剂,2016,13(04):52-56.
[17]曲文强,夏文龙,孙斌,等.生物降解材料聚羟基乙酸及其共聚物研究进展[J].山东化工,2014,14(03):34-36.
[18]刘璐,黄天意,史金先,等.聚乳酸-羟基乙酸在骨组织工程材料支架中的应用[J].口腔医学,2019,39(2):167-170.
[19]李涛,杨述华,刘国辉,等.钛网植骨侧前路钉棒系统内固定治疗脊柱结核伴截瘫[J].中国矫形外科杂志,2007,15(5):340-343.
[20]马信龙.人工骨修复材料及金属钛材料在骨组织工程中的应用[J].中国组织工程研究,2012,16(12):2229-2232.
[21]Niinomi M.Recent metallic materials for biomedical applications[J].Metall and Mat Trans A,2002,33:477-486.
[22]Staiger MP,Pietak AM,Huadmai J,et al.Magnesium and its alloys as orthopedic biomaterials:a review[J].Biomaterials,2006,27(9):1728-34.
[23]柴乐,全仁夫,黄小龙.羟基磷灰石构建组织工程骨支架的研究进展[J].中医正骨,2018,30(01),44-46+50.
[24]Ito M,Yamagishi T,Yagasaki H,et al.In vitro properties of a chitosanbonded bone-filling paste:studies on solubility of calcium phosphate compounds[J].J Biomed Mater Res,1996,32(1):95-98.
[25]徐海星,刘慧,许沛虎,等.聚乳酸/β-磷酸三钙/透明质酸/壳聚糖神经支架的制备工艺研究[J].武汉理工大学学报,2014,36(01):58-61+78.
[26]王鹏飞,阮孝慈,杨富帮.纳米羟基磷灰石/胶原复合材料的研究进展[J].杭州化工,2017,47(2):10-13.
[27]Kunert-Keil C,Scholz F,Gedrange T,et al.Comparative study of biphasic calcium phosphate with beta-tricalcium phosphate in rat cranial defects--Amolecular-biological and histological study[J].Ann Anat,2015,199(12):79-84.
[28]潘福勤,刘建辉,庞胤,等.胶原-生物活性玻璃-聚己内酯复合材料促进人牙髓细胞的增殖、迁移和分化[J].中国组织工程研究,2018,22(14):2168-2173.
[29]He F,Chen Y,Li J,et al.Improving bone repair of femoral and radial defects in rabbit by incorporating PRP into PLGA/CPC composite scaffold with unidirectional pore structure[J].Biomed Mater Res A,2015,103(4):1312-1324.
[30]朱淑倩,何家才.人工骨替代材料修复种植体周围骨缺损的研究进展[J].医学综述,2010,16(6):863-865
[31]Dalgic AD,Alshemary AZ,Tezcaner A,et al.Silicate-doped nanohydroxyapatite/graphene oxide composite reinforced fibrous scaffolds for bone tissue engineering[J].Journal of Biomaterials Applications,201832(10):1392-1405.
[32]张迪峰,余霄,庞清江.骨组织工程支架及骨修补材料:复合型骨移植材料的前景更好[J].中国组织工程研究,2018,22(26):4253-4258.
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