DRD3基因Ser9Gly多态性与中国帕金森病抑郁的关系
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摘要
目的探讨多巴胺D3受体(DRD3)基因Ser9Gly多态性与中国帕金森病抑郁的相关性。方法 2016年6月至2018年6月,散发帕金森病患者312例根据汉密尔顿抑郁量表评分分为抑郁组(n=132)和非抑郁组(n=180)。同时招募性别和年龄匹配的健康体检者252例为对照组。留取外周血提取基因组DNA,采用限制性片段长度多态性-聚合酶链反应和限制性酶切方法检测DRD3基因Ser9Gly多态位点。结果三组DRD3基因Ser9Gly位点基因型和等位基因型分布无显著性差异(χ~2=3.095,χ~2=2.627, P> 0.05)。结论 DRD3基因Ser9Gly多态性并非中国帕金森病抑郁人群的遗传易感因素。
Objectives To explore the relationship between the dopamine D3 receptor(DRD3) polymorphism on Ser9 Gly and depression in Parkinson's disease(PD).Methods From June, 2016 to June, 2018, 312 Chinese patients with PD were divided into depression group(n = 132)and non-depression group(n = 180) according to scores of Hamilton Depression Scale. A total of 252 age-and gender-matched healthy subjects were recruited as control group. Their blood samples were collected. Genotyping of Ser9 Gly polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism.Results No statistical difference was identified in Ser9 Gly polymorphism among three groups in both gene types and allel(χ~2 = 3.095, χ~2 = 2.627, P > 0.05).Conclusion Ser9 Gly polymorphism in DRD3 gene may not be a susceptible factor for depression in PD in China.
Objectives To explore the relationship between the dopamine D3 receptor(DRD3) polymorphism on Ser9 Gly and depression in Parkinson's disease(PD).Methods From June, 2016 to June, 2018, 312 Chinese patients with PD were divided into depression group(n = 132)and non-depression group(n = 180) according to scores of Hamilton Depression Scale. A total of 252 age-and gender-matched healthy subjects were recruited as control group. Their blood samples were collected. Genotyping of Ser9 Gly polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism.Results No statistical difference was identified in Ser9 Gly polymorphism among three groups in both gene types and allel(χ~2 = 3.095, χ~2 = 2.627, P > 0.05).Conclusion Ser9 Gly polymorphism in DRD3 gene may not be a susceptible factor for depression in PD in China.
引文
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[5]Zhuo C,Xue R,Luo L,et al.Efficacy of antidepressive medication for depression in Parkinson disease:a network meta-analysis[J].Medicine(Baltimore),2017,96(22):e6698.
[6]Aarsland D,P?hlhagen S,Ballard C G,et al.Depression in Parkinson disease-epidemiology,mechanisms and management[J].Nat Rev Neurol,2011,8(1):35-47.
[7]Moraga-Amaro R,Gonzalez H,Pacheco R,et al.Dopamine receptor D3 deficiency results in chronic depression and anxiety[J].Behav Brain Res,2014,274:186-193.
[8]Chang T T,Chen S L,Chang Y H,et al.The DRD3 Ser9Gly polymorphism predicted metabolic change in drug-naive patients with bipolar II disorder[J].Medicine(Baltimore),2016,95(24):e3488.
[9]Tee S,Tang P,Loh H.Genetic association analysis of dopamine DRD3 Ser9Gly polymorphism and schizophrenia in Malay population[J].Iran J Public Health,2011,40(2):6-10.
[10]Godlewska B R,Olajossy-Hilkesberger L,Limon J,et al.Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients[J].Psychiatry Res,2010,177(1-2):266-267.
[11]Kim B,Choi E Y,Kim C Y,et al.Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia?Results from treatment responses to risperidone in a naturalistic setting[J].Hum Psychopharmacol,2008,23(1):61-67.
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[13]Malhotra A K,Goldman D,Buchanan R W,et al.The dopamine D3 receptor(DRD3)Ser9Gly polymorphism and schizophrenia:a haplotype relative risk study and association with clozapine response[J].Mol Psychiatry,1998,3(1):72-75.
[14]Postuma R B,Berg D,Stern M,et al.MDS clinical diagnostic criteria for Parkinson's disease[J].Mov Disord,2015,30(12):1591-1601.
[15]Chaudhuri K R,Healy D G,Schapira A H.Non-motor symptoms of Parkinson's disease:diagnosis and management[J].Lancet Neurol,2006,5(3):235-245.
[16]Even C,Weintraub D.Is depression in Parkinson's disease(PD)a specific entity[J].J Affect Disord,2012,139(2):103-112.
[17]Lundstrom K,Turpin M P.Proposed schizophrenia-related gene polymorphism:expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system[J].Biochem Biophys Res Commun,1996,225(3):1068-1072.
[18]Paus S,Gadow F,Kaut O,et al.Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism[J].Parkinsonism Relat Disord,2010,16(6):381-383.
[19]Xu S,Liu J,Yang X,et al.Association of the DRD2 CAnSTR and DRD3 Ser9Gly polymorphisms with Parkinson's disease and response to dopamine agonists[J].J Neurol Sci,2017,372:433-438.
[20]Lucotte G,Lagarde J P,Funalot B,et al.Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families[J].Clin Genet,2006,69(5):437-440.
[21]王雪梅,冯涛,陈慧敏,等.帕金森病抑郁与运动障碍的相关性分析[J].中国医药导报,2017,14(35):4-7,24.
[2]Müller B,Assmus J,Herlofson K,et al.Importance of motor vs.non-motor symptoms for health-related quality of life in early Parkinson's disease[J].Parkinsonism Relat Disord,2013,19(11):1027-1032.
[3]Qin Z,Zhang L,Sun F,et al.Depressive symptoms impacting on health-related quality of life in early Parkinson's disease:results from Chinese L-dopa exposed cohort[J].Clin Neurol Neurosurg,2009,111(9):733-737.
[4]Reijnders J S,Ehrt U,Weber W E,et al.A systematic review of prevalence studies of depression in Parkinson's disease[J].Mov Disord,2008,23(2):183-189,quiz 313.
[5]Zhuo C,Xue R,Luo L,et al.Efficacy of antidepressive medication for depression in Parkinson disease:a network meta-analysis[J].Medicine(Baltimore),2017,96(22):e6698.
[6]Aarsland D,P?hlhagen S,Ballard C G,et al.Depression in Parkinson disease-epidemiology,mechanisms and management[J].Nat Rev Neurol,2011,8(1):35-47.
[7]Moraga-Amaro R,Gonzalez H,Pacheco R,et al.Dopamine receptor D3 deficiency results in chronic depression and anxiety[J].Behav Brain Res,2014,274:186-193.
[8]Chang T T,Chen S L,Chang Y H,et al.The DRD3 Ser9Gly polymorphism predicted metabolic change in drug-naive patients with bipolar II disorder[J].Medicine(Baltimore),2016,95(24):e3488.
[9]Tee S,Tang P,Loh H.Genetic association analysis of dopamine DRD3 Ser9Gly polymorphism and schizophrenia in Malay population[J].Iran J Public Health,2011,40(2):6-10.
[10]Godlewska B R,Olajossy-Hilkesberger L,Limon J,et al.Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients[J].Psychiatry Res,2010,177(1-2):266-267.
[11]Kim B,Choi E Y,Kim C Y,et al.Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia?Results from treatment responses to risperidone in a naturalistic setting[J].Hum Psychopharmacol,2008,23(1):61-67.
[12]Spurlock G,Williams J,McGuffin P,et al.European Multicentre Association Study of Schizophrenia:a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms[J].Am J Med Genet,1998,81(1):24-28.
[13]Malhotra A K,Goldman D,Buchanan R W,et al.The dopamine D3 receptor(DRD3)Ser9Gly polymorphism and schizophrenia:a haplotype relative risk study and association with clozapine response[J].Mol Psychiatry,1998,3(1):72-75.
[14]Postuma R B,Berg D,Stern M,et al.MDS clinical diagnostic criteria for Parkinson's disease[J].Mov Disord,2015,30(12):1591-1601.
[15]Chaudhuri K R,Healy D G,Schapira A H.Non-motor symptoms of Parkinson's disease:diagnosis and management[J].Lancet Neurol,2006,5(3):235-245.
[16]Even C,Weintraub D.Is depression in Parkinson's disease(PD)a specific entity[J].J Affect Disord,2012,139(2):103-112.
[17]Lundstrom K,Turpin M P.Proposed schizophrenia-related gene polymorphism:expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki Forest virus system[J].Biochem Biophys Res Commun,1996,225(3):1068-1072.
[18]Paus S,Gadow F,Kaut O,et al.Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism[J].Parkinsonism Relat Disord,2010,16(6):381-383.
[19]Xu S,Liu J,Yang X,et al.Association of the DRD2 CAnSTR and DRD3 Ser9Gly polymorphisms with Parkinson's disease and response to dopamine agonists[J].J Neurol Sci,2017,372:433-438.
[20]Lucotte G,Lagarde J P,Funalot B,et al.Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families[J].Clin Genet,2006,69(5):437-440.
[21]王雪梅,冯涛,陈慧敏,等.帕金森病抑郁与运动障碍的相关性分析[J].中国医药导报,2017,14(35):4-7,24.