脑卒中患者内分泌代谢改变
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摘要
脑卒中(stroke),又称"中风""脑血管意外",包括缺血性和出血性卒中,是由于脑血管阻塞或脑血管突然破裂导致血液不能流入大脑而引起脑组织缺血或坏死的一组疾病。特点为高发病率,高致残率和高死亡率,城乡合计脑卒中已成为我国第一位死亡原因,也是中国成年人残疾的首要原因,因此,早期准确评估脑卒中患者预后,有助于患者早期功能康复、心理辅导,还能更好的开放治疗新策略及优化医疗资源的利用。近年脑血管病的神经内分泌变化日益受到业界重视,研究发现卒中后患者内分泌代谢紊乱可造成神经细胞凋亡、脑水肿或血管痉挛等,加重神经系统损伤,影响患者预后。本文对脑卒中患者内分泌代谢改变做一综述。
引文
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[3]Christensen H,Boysen G,Johannesen HH.Serum-cortisol reflects severity and mortality in acute stroke[J].J Neurol Sci.,2004,217(2):175-180.
[4]Anne M,Juha K,Timo M,et al.Neurohormonal activation in ischemic stroke:effects of acute phase disturbances on long-term mortality[J].Curr Neurovasc Res,2007,4(3):170-175.
[5]Alhazzani W,Alenezi F,jaeschke RZ,et al.Proton pumpinhibitors versus histamine 2 receptor antagonists forstress ulcer prophulaxis in critically ill patients:asystematic review and teta-analysis[J].Crit CareMed,2013,41(3):693-705.
[6]钮优生,李坤正,肖宗宇.丘脑出血后肾上腺皮质激素变化的最新研究进展[J].影像研究与医学应用,2017,1(4):2-4.
[7]Mancini A,Di Segni C,Raimondo S,et al.Thyroid hormones,oxidative stress,and inflammation[J].Mediators Inflamm,2016:6757154.
[8]高春林,郭学英,张雅丽,等.氟西汀对卒中后抑郁患者下丘脑-垂体-甲状腺轴功能低下的干预作用[J].中华行为医学与脑科学杂志,2012,21(1):50-52.
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[10]Suda S,Muraga K,Kanamaru T,et al.Low free triiodothyonine predicts poor functional outcome after actue ischemic stroke[J].JNeurol Sci,2016,68(3):89-93.
[11]付学锋,吕云利,路逵,等.急性脑卒中患者血浆胰岛素样生长因子1与胰岛素抵抗的关系[J].中华医学杂志,2002,82(6):410-412.
[12]杜小平,杨期东,刘运海,等.脑梗塞患者肿瘤坏死因子与胰岛素抵抗关系的研究[J].中华医学杂志,2000,80:105-106.
[13]Kaneda Y,Ishikawa S,Sadakane A,et al.Insulin resistance and risk of cerebral infarction in a Japanese general population:the Jichi Medical School Cohort Study[J].Asia Pac J Public Health,2015,27(2):572-579.
[14]王晓鹏,李春岩,耿连霞,等.脑梗死患者性激素水平的测定及分析[J].中国神经精神疾病杂志,2003,29(6):456-457.
[15]肖丽,邵蓓,蒋慧刚,等.雌激素对脑卒中后抑郁大鼠行为学和神经再生的剂量相关性研究[J].中国临床神经科学,2014,22(2):154-159.
[16]Canonico M,Carcalon L,Plu Bureau G,et a1.Postmenopausa Ihormone therapy and risk of stroke:impact of the route of estrogen administration and type of progestogen[J].stroke,2016,47(7):1734-1741.