细胞焦亡在肾脏疾病中的作用
摘要
细胞焦亡是一种依赖于半胱天冬氨酸蛋白酶caspase-1/4/5/11且由GSDMD介导并伴有炎性介质释放的程序性细胞死亡。NLRP3炎性小体调控细胞焦亡并促使炎性因子的活化与释放。NLRP3炎性小体调控的细胞焦亡参与多种肾脏疾病的病理生理过程。本文就NLRP3-caspase-1介导的细胞焦亡在肾脏疾病中的作用研究进展做一简述。
引文
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22 Zhuang Y,Zhao F,Liang J,et al. Activation of COX-2/m PGES-1 /PGE2 Cascade via NLRP3 inflammasome contributes to albumininduced proximal tubule cell injury[J]. Cell Physiol Biochem,2017,42(2):797-807
23 Gong W,Mao S,Yu J,et al. NLRP3 deletion protects against renal fibrosis and attenuates mitochondrial abnormality in mouse with 5/6nephrectomy[J]. Am J Physiol Renal Physiol,2016,310(10):F1081-F1088
24 Guo H,Bi X,Zhou P,et al. NLRP3 deficiency attenuates renal fibrosis and ameliorates mitochondrial dysfunction in a mouse unilateral ureteral obstruction model of chronic kidney disease[J]. Mediators Inflamm,2017,2017:8316560
25 Pulskens WP,Butter LM,Teske GJ,et al. Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction[J]. PLo S One,2014,9(1):e85775
26 Zhao J,Wang H,Dai C,et al. P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1pathway[J]. Arthr Rheum,2013,65(12):3176-3185
27 Tran TA. Muckle-Wells syndrome:clinical perspectives[J]. Open Access Rheumatol,2017,9:123-129
28 Haque S,Lan X,Wen H,et al. HIV promotes NLRP3 inflammasome complex activation in murine HIV-associated nephropathy[J]. Am J Pathol,2016,186(2):347-358
2 Broderick L,De Nardo D,Franklin BS,et al. The inflammasomes and autoinflammatory syndromes[J]. Annu Rev Pathol,2015,10:395-424
3 He WT,Wan H,Hu L,et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1 beta secretion[J]. Cell Res,2015,25(12):1285-1298
4 Ding J,Wang K,Liu W,et al. Pore-forming activity and structural autoinhibition of the gasdermin family[J]. Nature, 2016, 535(7610):111-116
5 Yang JR,Yao FH,Zhang JG,et al. Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway[J]. Am J Physiol Renal Physiol,2014,306(1):F75-F84
6 Cao Y,Fei D,Chen M,et al. Role of the nucleotide-binding domain-like receptor protein 3 inflammasome in acute kidney injury[J]. FEBS J,2015,282(19):3799-3807
7 Tan X,Zheng X,Huang Z,et al. Involvement of S100A8/A9-TLR4-NLRP3 Inflammasome Pathway in Contrast-Induced Acute Kidney Injury[J]. Cell Physiol Biochem,2017,43(1):209-222
8 Komada T,Usui F,Kawashima A,et al. Role of NLRP3 inflammasomes for rhabdomyolysis-induced acute kidney injury[J]. Sci Rep,2015,5:10901
9 Yuan X,Zheng Y,Chen C,et al. Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury[J]. Apoptosis,2017,22(12):1524-1531
10 Shahzad K,Bock F,Dong W,et al. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy[J].Kidney Int,2015,87(1):74-84
11 Larsen CM,Faulenbach M,Vaag A,et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus[J]. N Engl J Med,2007,356(15):1517-1526
12 Yi H,Peng R,Zhang LY,et al. LincRNA-Gm4419 knockdown ameliorates NF-kappaB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy[J]. Cell Death Dis,2017,8(2):e2583
13 Wang S,Li Y,Fan J,et al. Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation[J]. Cell Death Dis,2017,8(7):e2937
14 Lu M,Yin N,Liu W,et al. Curcumin ameliorates diabetic nephropathy by suppressing NLRP3 inflammasome signaling[J]. Biomed Res Int,2017,2017:1516985
15 Shahzad K,Bock F,Al-Dabet MM,et al. Caspase-1,but not caspase-3,promotes diabetic nephropathy[J]. J Am Soc Nephrol,2016,27(8):2270-2275
16 Mulay SR,Kulkarni OP,Rupanagudi KV,et al. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1beta secretion[J]. J Clin Invest,2013,123(1):236-246
17 Knauf F,Asplin JR,Granja I,et al. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy[J]. Kidney Int,2013,84(5):895-901
18 Ludwig-Portugall I,Bartok E,Dhana E,et al. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice[J]. Kidney Int,2016,90(3):525-539
19 Conley SM,Abais JM,Boini KM,et al. Inflammasome activation in chronic glomerular diseases[J]. Curr Drug Targets,2017,18(9):1019-1029
20 Bai M,Chen Y,Zhao M,et al. NLRP3 inflammasome activation contributes to aldosterone-induced podocyte injury[J]. Am J Physiol Renal Physiol,2017,312(4):F556-F564
21 Vilaysane A,Chun J,Seamone M E,et al. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD[J]. J Am Soc Nephrol,2010,21(10):1732-1744
22 Zhuang Y,Zhao F,Liang J,et al. Activation of COX-2/m PGES-1 /PGE2 Cascade via NLRP3 inflammasome contributes to albumininduced proximal tubule cell injury[J]. Cell Physiol Biochem,2017,42(2):797-807
23 Gong W,Mao S,Yu J,et al. NLRP3 deletion protects against renal fibrosis and attenuates mitochondrial abnormality in mouse with 5/6nephrectomy[J]. Am J Physiol Renal Physiol,2016,310(10):F1081-F1088
24 Guo H,Bi X,Zhou P,et al. NLRP3 deficiency attenuates renal fibrosis and ameliorates mitochondrial dysfunction in a mouse unilateral ureteral obstruction model of chronic kidney disease[J]. Mediators Inflamm,2017,2017:8316560
25 Pulskens WP,Butter LM,Teske GJ,et al. Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction[J]. PLo S One,2014,9(1):e85775
26 Zhao J,Wang H,Dai C,et al. P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1pathway[J]. Arthr Rheum,2013,65(12):3176-3185
27 Tran TA. Muckle-Wells syndrome:clinical perspectives[J]. Open Access Rheumatol,2017,9:123-129
28 Haque S,Lan X,Wen H,et al. HIV promotes NLRP3 inflammasome complex activation in murine HIV-associated nephropathy[J]. Am J Pathol,2016,186(2):347-358