椎间盘源性腰痛疼痛机制的研究进展
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摘要
盘源性腰痛严重影响人们的健康和生活质量,其机制仍未明确,因而逐渐受到人们重视。目前研究显示,盘源性腰痛的疼痛机制按照起因可大致分为压力改变、神经因素以及化学因子等。本文就盘源性腰痛的疼痛机制的研究进展进行综述。
Discogenic low back pain considerably deteriorates human healthy and quality of life,which draws attention more and more in recent years.However,the pain mechanism is not clear completely.The present researches reveal that the pain mechanism of discogenic low back pain may be divided into three factors,including pressure changes,neural factors and chemical factor.This article makes a review on the research progress about the pain mechanism of the discogenic low back pain.
Discogenic low back pain considerably deteriorates human healthy and quality of life,which draws attention more and more in recent years.However,the pain mechanism is not clear completely.The present researches reveal that the pain mechanism of discogenic low back pain may be divided into three factors,including pressure changes,neural factors and chemical factor.This article makes a review on the research progress about the pain mechanism of the discogenic low back pain.
引文
[1]Monfett M,Harrison J,Boachie-Adjei K,et al.Intradiscal plateletrich plasma(PRP)injections for discogenic low back pain:an update[J].Int Orthop,2016,40(6):1321-1328.
[2]Wilson DH,Maccarty WC.Discography:its role in the diagnosis of lumbar disc protrusion[J].J Neurosurg,1969,31(5):520-523.
[3]Crock HV.Internal disc disruption.A challenge to disc prolapse fifty years on[J].Spine(Phila Pa 1976),1986,11(6):650-653.
[4]Goodkin R.The textbook of spinal surgery[J].JAMA,1997,(18)1-10.
[5]Peng BG.Pathophysiology,diagnosis,and treatment of discogenic low back pain[J].World J Orthop,2013,4(2):42-52.
[6]Bogduk N.The innervation of the lumbar spine[J].Spine(Philadelphia,1976),1983,8(3):286-293.
[7]Fukui D,Kawakami M,Matsumoto T,et al.Stress enhances gait disturbance induced by lumbar disc degeneration in rat[J].Eur Spine J,2017,27(8):1-9.
[8]Sivan SS,Wachtel E,Roughley P.Structure,function,aging and turnover of aggrecan in the intervertebral disc[J].BBA General Subjects,2014,1840(10):3181-3189.
[9]Cavanaugh JM,Chen C,Kallakuri S.Thoracolumbar pain:neural mechanisms and biomechanics[J].2015:581-609.
[10]Garcia-Cosamalon J,Del Valle ME,Calavia MG,et al.Intervertebral disc,sensory nerves and neurotrophins:who is who in discogenic pain[J].J Anat,2010,217(1):1-15.
[11]Freemont AJ,Peacock TE,Goupille P,et al.Nerve ingrowth into diseased intervertebral disc in chronic back pain[J].Lancet,1997,350(9072):178-181.
[12]张辉,刘林,薛文.退变和健康椎间盘组织提取细胞外基质诱导背根神经节轴突生长的差异[J].中国组织工程研究,2014,18(7):1039-1044.
[13]Molinos M,Almeida CR,Caldeira J,et al.Inflammation in intervertebral disc degeneration and regeneration[J].J Royal Soc Interface,2015,12(104):20141191.
[14]Yang J,Kang J,Feng D,et al.Increased IL-1 and IL-6 expressions are negatively correlated with modified Japanese Orthopedic Association(mJOA)scores of discogenic low back pain[J].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi,2016,32(1):88-91.
[15]Kang JD,Georgescu HI,Mcintyre-Larkin L,et al.Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases,nitric oxide,interleukin-6,and prostaglandin E2[J].Spine(Phila Pa 1976),1996,21(3):271-277.
[16]Burke JG,Watson RW,Mccormack D,et al.Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators[J].J Bone Joint Surg Br,2002,84(2):196-201.
[17]魏远福.不同分型腰椎间盘突出症患者血清IL-1、IL-6的表达及临床意义[J].现代仪器与医疗,2015,21(3):64-65.
[18]Cohen SP,Mao J.Neuropathic pain:mechanisms and their clinical implications[J].BMJ,2014,348(feb05 6):f7656.
[19]Saal JS,Franson RC,Dobrow R,et al.High levels of inflammatory phospholipase A2 activity in lumbar disc herniations[J].Spine(Phila Pa 1976),1990,15(7):674-678.
[20]郭刚,王文辉.腰椎间盘组织髓核内TNF-α、PGE2、PLA2表达与神经根性疼痛的相关性[J].实用疼痛学杂志,2016,12(6):402-405.
[21]Freemont AJ,Watkins A,Maitre CL,et al.Nerve growth factor epression and innervation of the painful intervertebral disc[J].JPathol,2002,197(3):286-292.
[22]Tian L,Prabhakaran MP,Ramakrishna S.Strategies for regeneration of components of nervous system:scaffolds,cells and biomolecules[J].Regenerative Biomater,2015,2(1):31.2018-07-26
[2]Wilson DH,Maccarty WC.Discography:its role in the diagnosis of lumbar disc protrusion[J].J Neurosurg,1969,31(5):520-523.
[3]Crock HV.Internal disc disruption.A challenge to disc prolapse fifty years on[J].Spine(Phila Pa 1976),1986,11(6):650-653.
[4]Goodkin R.The textbook of spinal surgery[J].JAMA,1997,(18)1-10.
[5]Peng BG.Pathophysiology,diagnosis,and treatment of discogenic low back pain[J].World J Orthop,2013,4(2):42-52.
[6]Bogduk N.The innervation of the lumbar spine[J].Spine(Philadelphia,1976),1983,8(3):286-293.
[7]Fukui D,Kawakami M,Matsumoto T,et al.Stress enhances gait disturbance induced by lumbar disc degeneration in rat[J].Eur Spine J,2017,27(8):1-9.
[8]Sivan SS,Wachtel E,Roughley P.Structure,function,aging and turnover of aggrecan in the intervertebral disc[J].BBA General Subjects,2014,1840(10):3181-3189.
[9]Cavanaugh JM,Chen C,Kallakuri S.Thoracolumbar pain:neural mechanisms and biomechanics[J].2015:581-609.
[10]Garcia-Cosamalon J,Del Valle ME,Calavia MG,et al.Intervertebral disc,sensory nerves and neurotrophins:who is who in discogenic pain[J].J Anat,2010,217(1):1-15.
[11]Freemont AJ,Peacock TE,Goupille P,et al.Nerve ingrowth into diseased intervertebral disc in chronic back pain[J].Lancet,1997,350(9072):178-181.
[12]张辉,刘林,薛文.退变和健康椎间盘组织提取细胞外基质诱导背根神经节轴突生长的差异[J].中国组织工程研究,2014,18(7):1039-1044.
[13]Molinos M,Almeida CR,Caldeira J,et al.Inflammation in intervertebral disc degeneration and regeneration[J].J Royal Soc Interface,2015,12(104):20141191.
[14]Yang J,Kang J,Feng D,et al.Increased IL-1 and IL-6 expressions are negatively correlated with modified Japanese Orthopedic Association(mJOA)scores of discogenic low back pain[J].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi,2016,32(1):88-91.
[15]Kang JD,Georgescu HI,Mcintyre-Larkin L,et al.Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases,nitric oxide,interleukin-6,and prostaglandin E2[J].Spine(Phila Pa 1976),1996,21(3):271-277.
[16]Burke JG,Watson RW,Mccormack D,et al.Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators[J].J Bone Joint Surg Br,2002,84(2):196-201.
[17]魏远福.不同分型腰椎间盘突出症患者血清IL-1、IL-6的表达及临床意义[J].现代仪器与医疗,2015,21(3):64-65.
[18]Cohen SP,Mao J.Neuropathic pain:mechanisms and their clinical implications[J].BMJ,2014,348(feb05 6):f7656.
[19]Saal JS,Franson RC,Dobrow R,et al.High levels of inflammatory phospholipase A2 activity in lumbar disc herniations[J].Spine(Phila Pa 1976),1990,15(7):674-678.
[20]郭刚,王文辉.腰椎间盘组织髓核内TNF-α、PGE2、PLA2表达与神经根性疼痛的相关性[J].实用疼痛学杂志,2016,12(6):402-405.
[21]Freemont AJ,Watkins A,Maitre CL,et al.Nerve growth factor epression and innervation of the painful intervertebral disc[J].JPathol,2002,197(3):286-292.
[22]Tian L,Prabhakaran MP,Ramakrishna S.Strategies for regeneration of components of nervous system:scaffolds,cells and biomolecules[J].Regenerative Biomater,2015,2(1):31.2018-07-26
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