PTEN基因多态性与广西壮族食管癌发病风险的关系
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摘要
目的探讨第10号染色体缺失的磷酸酶和张力蛋白同源物基因(PTEN基因)多态性与广西壮族食管癌发病风险的关系。方法采用病例-对照研究,对比分析2015年1月至2016年10月在该院就诊且术前未经放化疗的来自广西壮族的80例食管癌患者(病例组)和100例健康对照者(对照组)的PTEN基因多态性。结果病例组与对照组基因型总体分布情况比较差异无统计学意义(χ~2=0.975,P=0.614)。ⅣS4~(+/+)基因型可显著降低食管癌的发病风险,校正年龄、性别、吸烟状况后的OR值为0.62(95%CI:0.41~0.92,P=0.08);而ⅣS4~(-/+)基因型确不影响食管癌的发病风险,校正OR值为0.77(95%CI:0.51~1.08,P=0.77)。结论 PTEN基因多态性与广西壮族食管癌的发病风险密切相关,PTENⅣS4~(+/+)基因型是广西壮族食管癌发生的保护因素。
Objective To explore the relationship between the PTEN polymorphism with the onset risk of esophageal cancer in Guangxi Zhuang nationality. Methods The case-control study was adopted to comparatively analyze the PTEN polymorphisms in 80 patients with esophageal cancer,who in the hospital visited and preoperative without radiotherapy and chemotherapy and 100 healthy controls from Guangxi Zhuang nationality between January 2015 and October 2016. Results There was no statistically significant difference in the total distribution of the PTEN ⅣS4 genotype between the esophageal cancer group and the control group(χ~2=0.975,P=0.614). PTEN ⅣS4~(+/+) genotype could significantly reduce the onset risk of esophageal cancer,after adjusting the age,gender and smoking status,the value of OR was 0.62(95%CI=0.41~0.92,P=0.08); while PTEN ⅣS4~(-/+)genotype did not affect the onset risk of esophageal cancer, the adjusted OR value was 0. 77(95%CI=0.51~1.08,P=0.77).Conclusion The polymorphism of PTEN is closely related to the onset risk of esophageal cancer in Guangxi Zhuang nationality,and the PTEN ⅣS4~(+/+) genotype is the protective factor for the occurrence of esophageal cancer in Guangxi Zhuang nationality.
Objective To explore the relationship between the PTEN polymorphism with the onset risk of esophageal cancer in Guangxi Zhuang nationality. Methods The case-control study was adopted to comparatively analyze the PTEN polymorphisms in 80 patients with esophageal cancer,who in the hospital visited and preoperative without radiotherapy and chemotherapy and 100 healthy controls from Guangxi Zhuang nationality between January 2015 and October 2016. Results There was no statistically significant difference in the total distribution of the PTEN ⅣS4 genotype between the esophageal cancer group and the control group(χ~2=0.975,P=0.614). PTEN ⅣS4~(+/+) genotype could significantly reduce the onset risk of esophageal cancer,after adjusting the age,gender and smoking status,the value of OR was 0.62(95%CI=0.41~0.92,P=0.08); while PTEN ⅣS4~(-/+)genotype did not affect the onset risk of esophageal cancer, the adjusted OR value was 0. 77(95%CI=0.51~1.08,P=0.77).Conclusion The polymorphism of PTEN is closely related to the onset risk of esophageal cancer in Guangxi Zhuang nationality,and the PTEN ⅣS4~(+/+) genotype is the protective factor for the occurrence of esophageal cancer in Guangxi Zhuang nationality.
引文
[1]陈万青,张思维,郑荣寿,等.中国肿瘤登记地区2007年肿瘤发病和死亡分析[J].中国肿瘤,2011,20(3):162-169.
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[11]詹树东,黄俊星.Cyclin A PTEN Survivin和p27与食管癌相关性的研究进展[J].现代肿瘤医学,2014,22(9):2245-2248.
[12]赵中华,朱琨,常东民,等.PTEN基因IVS4多态性与乳腺癌易感相关性分析[J].中华肿瘤防治杂志,2012,19(10):743-745.
[13]张晓燕,王红静,贾西彪.PTENVS4基因多态性与子宫内膜异位症发病风险的关系[J].第三军医大学学报,2010,32(9):979-981.
[14]张龙,蒋迎九.PTEN与肺癌的相关性研究进展[J].重庆医学,2015,44(21):3002-3004.
[15]刘南,徐昌青.MDM2和PTEN基因多态性与安阳地区食管鳞癌易感性的相关分析[J/CD].中华消化病与影像杂志:电子版,2015,5(5):223-228.
[16]莫赛军,柯少瑞,张佳彤,等.中国汉族人群食管癌遗传易感基因多态性的研究进展[J].世界华人消化杂志,2013,21(21):2045-2050.
[17]郭文佳,王洪江,李卉,等.PTEN基因在哈萨克族食管癌组织中的表达及意义[J].科技导报,2010,28(1):48-50.
[18]Bettstetter M,Berezowska S,Keller G,et al.Epidermal growth factor receptor,phosphatidylinositol-3-kinase catalytic subunit/PTEN,and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas:loss of PTEN is associated with worse clinical outcome[J].Hum Pathol,2013,44(5):829-836.
[2]Xu YW,Peng YH,Chen B,et al.Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma[J].Am J Gastroenterol,2014,109(1):36-45.
[3]王帅,王洲.抑癌基因PTEN与食管癌关系的研究进展[J].中华肿瘤防治杂志,2013,20(8):627-631.
[4]赫捷,邵康.中国食管癌流行病学现状、诊疗现状及未来对策[J].中国癌症杂志,2011,21(7):501-504.
[5]陈万青,张思维,郑荣寿,等.中国2009年恶性肿瘤发病与死亡[J].中国肿瘤,2013,22(1):2-12.
[6]陈万青,张思维,曾红梅,等.中国2010年恶性肿瘤发病与死亡[J].中国肿瘤,2014,23(1):1-10.
[7]陈万青,郑荣寿,曾红梅,等.2011年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2015,24(1):1-10.
[8]陈万青,郑荣寿,张思维,等.2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2016,25(1):1-8.
[9]陈万青,郑荣寿,张思维,等.2013年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2017,26(1):1-7.
[10]鲁建军,雷艺炎,潘游,等.PTEN和m TOR在食管鳞癌组织中的表达及意义[J].解剖学研究,2014,36(6):447-449.
[11]詹树东,黄俊星.Cyclin A PTEN Survivin和p27与食管癌相关性的研究进展[J].现代肿瘤医学,2014,22(9):2245-2248.
[12]赵中华,朱琨,常东民,等.PTEN基因IVS4多态性与乳腺癌易感相关性分析[J].中华肿瘤防治杂志,2012,19(10):743-745.
[13]张晓燕,王红静,贾西彪.PTENVS4基因多态性与子宫内膜异位症发病风险的关系[J].第三军医大学学报,2010,32(9):979-981.
[14]张龙,蒋迎九.PTEN与肺癌的相关性研究进展[J].重庆医学,2015,44(21):3002-3004.
[15]刘南,徐昌青.MDM2和PTEN基因多态性与安阳地区食管鳞癌易感性的相关分析[J/CD].中华消化病与影像杂志:电子版,2015,5(5):223-228.
[16]莫赛军,柯少瑞,张佳彤,等.中国汉族人群食管癌遗传易感基因多态性的研究进展[J].世界华人消化杂志,2013,21(21):2045-2050.
[17]郭文佳,王洪江,李卉,等.PTEN基因在哈萨克族食管癌组织中的表达及意义[J].科技导报,2010,28(1):48-50.
[18]Bettstetter M,Berezowska S,Keller G,et al.Epidermal growth factor receptor,phosphatidylinositol-3-kinase catalytic subunit/PTEN,and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas:loss of PTEN is associated with worse clinical outcome[J].Hum Pathol,2013,44(5):829-836.