补肾活血法治疗男性少弱精子症研究进展
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摘要
少弱精子症是男性不育的常见病因,因其发生机制不明,现代医学缺乏针对性的治疗方式。中医学在治疗少弱精子症方面具有明显优势。补肾活血法为辨证论治少弱精子症的法则之一,越来越多的基础及临床研究证实其在改善精子质量方面效果显著。文章就近期相关研究进行综述,旨在为临床上治疗本病提供新的思路。
Oligoasthenospermia is a common cause of male infertility.As the mechanism of male infertility is still unknown,modern medicine lacks targeted treatment to it.By contrast,Traditional Chinese Medicine has a significant advantages in the treatment of oligoasthenospermia. Kidney-tonifying and blood-activating method is one of the principles for treating Oligoasthenospermia based on syndrome differentiation and treatment,and more and more basic and clinical studies have supported its remarkable effect on improving sperm quality.This article reviews the recent studies in order to provide new ideas for the clinical treatment of this disease.
Oligoasthenospermia is a common cause of male infertility.As the mechanism of male infertility is still unknown,modern medicine lacks targeted treatment to it.By contrast,Traditional Chinese Medicine has a significant advantages in the treatment of oligoasthenospermia. Kidney-tonifying and blood-activating method is one of the principles for treating Oligoasthenospermia based on syndrome differentiation and treatment,and more and more basic and clinical studies have supported its remarkable effect on improving sperm quality.This article reviews the recent studies in order to provide new ideas for the clinical treatment of this disease.
引文
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[2]Check JH.Treatment of maleinfertility[J].Clin Exp Obstet Gynecol,2007,34(4):201-206.
[3]Sharlip ID,Jarow JP,Belker AM,et al.Best practice policies formale infertility[J].Fertil Steril,2002,77(5):873-882.
[4]郭军,耿强.少弱精子症的中医药治疗[J].江西中医药,2008,39(9):19-20.
[5]姜辉,邓春华.中国男科疾病诊断治疗指南与专家共识[M].北京:人民卫生社,2017:39.
[6]世界卫生组织.WHO人类精液及精子-宫颈粘液相互作用实验室检验手册[M].第5版,北京:人民卫生出版社,2010.
[7]Uqwa EA,Ashimi A,Abubakar M,et al.Poor semen parameters among inftertile couple presenting at a gynaecological clinic of Federal Medical Centre Birnin Kudu North-west Nigeria[J].Niger Med J.2015,56(4):283-286.
[8]Rajpert-De Meyts E,Leffers H,Petersen JH,et al.CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men[J].Lancet,2002,359(9300):44-46.
[9]Hopps CV,Mielnik A,Goldstein M,et al.Detection of sperm in men with Y chromosome microdeletions of the AZFa,AZFb,and AZFc regions[J].Hum Reprod,2003,18(8):1660-1665.
[10]汤尤怡,马艳华.肥胖与男性不育关系的研究进展[J].生殖医学杂志,2015,24(4):338-341.
[11]黄一亮,安黎明,李超.左卡尼汀联合他莫昔芬治疗少弱精症临床疗效观察[J].现代医药卫生,2013,29(23):3616-3617.
[12]苏迎春,孙莹璞,郭艺红,等.复方精氨酸胶囊治疗男性少弱精症疗效观察[J].郑州大学学报,2006,41(4):730-733.
[13]吴军,黄华武,黄勇平,等.他莫昔芬和枸椽酸氯米芬治疗少弱精症效果比较[J].中国计划生育学杂志,2013,21(6):407-408.
[14]孙建明,郝建国,杨振熙,等.补肾活血方对特发性少弱精子不育症的精子密度及成活率的影响[J].辽宁中医杂志,2012,39(11):2233-2234.
[15]耿强,郭军,张建,等.补肾法治疗男性不育症的Meta分析[J].中国计划生育杂志,2012,20(5):303-306.
[16]陈志强,江海平.男科专病中医临床诊治[M].北京:人民卫生出版社,2000:410.
[17]程亮亮.补肾活血法对子宫内膜容受性影响的研究进展[J].基层医学论坛,2014,18(1):105-107.
[18]赵玉,耿强.欧阳斌治疗少弱精子症经验[J].江西中医药,2014,45(382):15-16.
[19]王祖龙,马永,郑娟.孙自学教授治疗弱精子症用药经验分析[J].世界科学技术(中医药现代化),2013,15(6):1402-1405.
[20]倪凯,陈斌,李鹤,等.不同中医证型精索静脉曲张性不育症中西医治疗选择初探[J].中国中西医结合杂志,2013,33(3):326-331.
[21]袁启龙,陆杉,倪运萍,等.补肾活血方剂与迈之灵改善精索静脉曲张性精子异常的疗效对比研究[J].广州中医药大学学报,2015,32(5):838-842.
[22]刘建国,孙大林,金保方,等.补肾活血方治疗少弱精子症的临床研究.中国性科学,2015,24(11):85-88.
[23]谭迎春,陈子江.补肾活血中药对弱精子症大鼠抗氧化作用的研究[J].南京中医药大学学报,2006,22(4):231-233.
[24]张长城,周安方,张茂林,等.补肾活血方对实验性精索静脉曲张大鼠睾丸组织SOD、NOS、MDA水平的影响[J].中国实验方剂学杂志,2005,11(2):54-56.
[25]张长城,周安方,张茂林,等.补肾活血方对精索静脉曲张大鼠生精细胞凋亡的影[J].湖南中医学院学报,2005,25(4):10-12.
[26]管刚云,田斌群,郑新民,等.当归川芎水蛭合剂对精索静脉曲张大鼠睾丸抗氧化系统及精子质量的影响[J].医学新知杂志,2006,16(5):277-279.
[27]王志强,林树栋,张新东,等.补肾填精法治疗少弱精症的研究进展[J].世界中西医结合杂志,2013,8(5):521-524.
[28]王红全,裴鲜玲,张爱英,等.少弱精症中医辨治思路浅析[J].新中医,2011,43(7):159.
[29]郭军,王福,张强,等. 3种不同中医治则治疗少弱精子症患者的随机对照观察[J].中国中西医结合杂志,2013,33(9):1170-1173.
[2]Check JH.Treatment of maleinfertility[J].Clin Exp Obstet Gynecol,2007,34(4):201-206.
[3]Sharlip ID,Jarow JP,Belker AM,et al.Best practice policies formale infertility[J].Fertil Steril,2002,77(5):873-882.
[4]郭军,耿强.少弱精子症的中医药治疗[J].江西中医药,2008,39(9):19-20.
[5]姜辉,邓春华.中国男科疾病诊断治疗指南与专家共识[M].北京:人民卫生社,2017:39.
[6]世界卫生组织.WHO人类精液及精子-宫颈粘液相互作用实验室检验手册[M].第5版,北京:人民卫生出版社,2010.
[7]Uqwa EA,Ashimi A,Abubakar M,et al.Poor semen parameters among inftertile couple presenting at a gynaecological clinic of Federal Medical Centre Birnin Kudu North-west Nigeria[J].Niger Med J.2015,56(4):283-286.
[8]Rajpert-De Meyts E,Leffers H,Petersen JH,et al.CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men[J].Lancet,2002,359(9300):44-46.
[9]Hopps CV,Mielnik A,Goldstein M,et al.Detection of sperm in men with Y chromosome microdeletions of the AZFa,AZFb,and AZFc regions[J].Hum Reprod,2003,18(8):1660-1665.
[10]汤尤怡,马艳华.肥胖与男性不育关系的研究进展[J].生殖医学杂志,2015,24(4):338-341.
[11]黄一亮,安黎明,李超.左卡尼汀联合他莫昔芬治疗少弱精症临床疗效观察[J].现代医药卫生,2013,29(23):3616-3617.
[12]苏迎春,孙莹璞,郭艺红,等.复方精氨酸胶囊治疗男性少弱精症疗效观察[J].郑州大学学报,2006,41(4):730-733.
[13]吴军,黄华武,黄勇平,等.他莫昔芬和枸椽酸氯米芬治疗少弱精症效果比较[J].中国计划生育学杂志,2013,21(6):407-408.
[14]孙建明,郝建国,杨振熙,等.补肾活血方对特发性少弱精子不育症的精子密度及成活率的影响[J].辽宁中医杂志,2012,39(11):2233-2234.
[15]耿强,郭军,张建,等.补肾法治疗男性不育症的Meta分析[J].中国计划生育杂志,2012,20(5):303-306.
[16]陈志强,江海平.男科专病中医临床诊治[M].北京:人民卫生出版社,2000:410.
[17]程亮亮.补肾活血法对子宫内膜容受性影响的研究进展[J].基层医学论坛,2014,18(1):105-107.
[18]赵玉,耿强.欧阳斌治疗少弱精子症经验[J].江西中医药,2014,45(382):15-16.
[19]王祖龙,马永,郑娟.孙自学教授治疗弱精子症用药经验分析[J].世界科学技术(中医药现代化),2013,15(6):1402-1405.
[20]倪凯,陈斌,李鹤,等.不同中医证型精索静脉曲张性不育症中西医治疗选择初探[J].中国中西医结合杂志,2013,33(3):326-331.
[21]袁启龙,陆杉,倪运萍,等.补肾活血方剂与迈之灵改善精索静脉曲张性精子异常的疗效对比研究[J].广州中医药大学学报,2015,32(5):838-842.
[22]刘建国,孙大林,金保方,等.补肾活血方治疗少弱精子症的临床研究.中国性科学,2015,24(11):85-88.
[23]谭迎春,陈子江.补肾活血中药对弱精子症大鼠抗氧化作用的研究[J].南京中医药大学学报,2006,22(4):231-233.
[24]张长城,周安方,张茂林,等.补肾活血方对实验性精索静脉曲张大鼠睾丸组织SOD、NOS、MDA水平的影响[J].中国实验方剂学杂志,2005,11(2):54-56.
[25]张长城,周安方,张茂林,等.补肾活血方对精索静脉曲张大鼠生精细胞凋亡的影[J].湖南中医学院学报,2005,25(4):10-12.
[26]管刚云,田斌群,郑新民,等.当归川芎水蛭合剂对精索静脉曲张大鼠睾丸抗氧化系统及精子质量的影响[J].医学新知杂志,2006,16(5):277-279.
[27]王志强,林树栋,张新东,等.补肾填精法治疗少弱精症的研究进展[J].世界中西医结合杂志,2013,8(5):521-524.
[28]王红全,裴鲜玲,张爱英,等.少弱精症中医辨治思路浅析[J].新中医,2011,43(7):159.
[29]郭军,王福,张强,等. 3种不同中医治则治疗少弱精子症患者的随机对照观察[J].中国中西医结合杂志,2013,33(9):1170-1173.