不同方案治疗多囊卵巢综合征的疗效观察
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摘要
目的探讨不同治疗方案对多囊卵巢综合征的治疗效果。方法选择多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)患者60例作为研究对象,随机分为二甲双胍组和罗格列酮组,各30例。二甲双胍组给予环丙孕酮炔雌醇(达英-35)及二甲双胍治疗,罗格列酮组给予达英-35和罗格列酮治疗,比较两组的临床疗效及不良反应。结果二甲双胍组的体质量指数降低更明显(P <0. 05),罗格列酮组的稳态模型IR指数(HOMA-IR)、黄体生成素(LH)、卵泡刺激素(FSH)、血清睾酮(T)降低更明显,排卵率更高(P <0. 05)。两组的不良反应无明显差异(P> 0. 05)。结论达英-35联合罗格列酮能显著提高PCOS患者临床疗效,改善患者的LH、FSH、T、HOMA-IR及排卵率,而达英-35联合二甲双胍对于肥胖的PCOS疗效更好,应该给予患者个体化的治疗方案。
Objective To explore the effects of different treatments for polycystic ovary syndrome. Methods Sixty patients of PCOS were randomly divided into Metformin group and Rosiglitazone group,with 30 cases in each group. Metformin group wastreated by diane-35 and metformin,while Rosiglitazone group was treated with diane-35 and rosiglitazone.The clinical effects and side effects were compared between two groups. Results After treatment,body mass index in the patients of Metformin group was significantly decreased compared with Rosiglitazone group( P < 0. 05). While homeostasis model assessment insulin resistance index,luteinizing hormone,follicule-stimulating hormone,testosterone in Rosiglitazone group were decreased significantly( P < 0. 05). And the ovulation rate was increased significantly( P < 0. 05). There were no statistically significant differences in the side effects between the two groups. Conclusion Diane-35 and rosiglitazone can significantly improve the clinical effect of patients with PCOS,and can improve LH,FSH,T,HOMA-IR,the ovulation rate. Diane-35 and metformin are good for fat patients with PCOS. Individualized treatment methods should be given to patients.
Objective To explore the effects of different treatments for polycystic ovary syndrome. Methods Sixty patients of PCOS were randomly divided into Metformin group and Rosiglitazone group,with 30 cases in each group. Metformin group wastreated by diane-35 and metformin,while Rosiglitazone group was treated with diane-35 and rosiglitazone.The clinical effects and side effects were compared between two groups. Results After treatment,body mass index in the patients of Metformin group was significantly decreased compared with Rosiglitazone group( P < 0. 05). While homeostasis model assessment insulin resistance index,luteinizing hormone,follicule-stimulating hormone,testosterone in Rosiglitazone group were decreased significantly( P < 0. 05). And the ovulation rate was increased significantly( P < 0. 05). There were no statistically significant differences in the side effects between the two groups. Conclusion Diane-35 and rosiglitazone can significantly improve the clinical effect of patients with PCOS,and can improve LH,FSH,T,HOMA-IR,the ovulation rate. Diane-35 and metformin are good for fat patients with PCOS. Individualized treatment methods should be given to patients.
引文
[1]余慧.采用不同方案治疗多囊卵巢综合征的疗效观察[J].临床合理用药,2018,11(3):83-84.
[2]江雪.罗格列酮对多囊卵巢综合征的治疗疗效分析[J].大家健康,2016,10(14):108.
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[4]田润芝,徐燕颖.二甲双胍联合达英-35治疗肥胖型多囊卵巢综合征合并胰岛素抵抗的疗效分析[J].基层医学论坛,2018,22(19):2640-2643.
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[7]马玮,戴峻,吴相思.地塞米松联合氯米芬治疗多囊卵巢综合征对患者血清性激素水平的影响[J].国际医药卫生导报,2018,24(7):981-983,994.
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[9]刘世雄,赵丽,周芸,等.二甲双胍联合埃索美拉唑对老年2型糖尿病患者血清胃泌素和血糖的影响[J].中华老年医学杂志,2016,35(4):405-408.
[10]邓清华,李仁河,林还珠,等.达英-35与二甲双胍联合治疗多囊卵巢综合征的临床疗效观察[J].中国实用医药,2017,12(35):115-117.
[11]杨志平.达英-35联合二甲双胍治疗多囊卵巢综合征对激素、胰岛素抵抗的影响[J].中国妇幼保健,2016,31(5):1015-1017.
[12]刘素萍.二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征的临床研究[J].中外医学研究,2017,15(35):168-169.
[13] BERGER J,BAILEY P,BISWAS C,et al. Thiazolidinedionges producea conformational change in peroxisomal proliferator-activated receptor-gamma:binding and activation correlate with antidiabetic actions in db/db mice[J]. Endocrinology,1996,137:4189-4195.
[14]刘春喜,田作荣.二甲双胍和罗格列酮治疗多囊卵巢综合征的临床价值体会[J].实用妇科内分泌杂志,2016,3(7):18-19.
[15]翟振远.肥胖型多囊卵巢综合征不孕症应用二甲双胍联合针灸治疗的疗效[J].国际医药卫生导报,2017,23(15):2403-2405.
[16]吴晓明.来曲唑联合中医针灸促排卵治疗克罗米芬抵抗的多囊卵巢综合征的临床应用[J].中国医药科学,2018,8(8):49-51.
[17]黄定芳.苍附导痰汤联合二甲双胍治疗肥胖型多囊卵巢综合征的临床效果[J].中国当代医药,2018,25(6):34-36.
[2]江雪.罗格列酮对多囊卵巢综合征的治疗疗效分析[J].大家健康,2016,10(14):108.
[3]乔杰.多囊卵巢综合征[M].北京:北京大学医学出版社,2010:10.
[4]田润芝,徐燕颖.二甲双胍联合达英-35治疗肥胖型多囊卵巢综合征合并胰岛素抵抗的疗效分析[J].基层医学论坛,2018,22(19):2640-2643.
[5]谢幸,苟文丽.妇产科学[M]. 8版.北京:人民卫生出版社,2013:359-362.
[6]武红琴,阮祥燕,卢永军,等.多囊卵巢综合征患者合并代谢综合征的患病率和预测指标[J].首都医科大学学报,2015,36(4):553-558.
[7]马玮,戴峻,吴相思.地塞米松联合氯米芬治疗多囊卵巢综合征对患者血清性激素水平的影响[J].国际医药卫生导报,2018,24(7):981-983,994.
[8]乔杰.多囊卵巢综合征[M].北京:北京大学医学出版社,2010:40-41.
[9]刘世雄,赵丽,周芸,等.二甲双胍联合埃索美拉唑对老年2型糖尿病患者血清胃泌素和血糖的影响[J].中华老年医学杂志,2016,35(4):405-408.
[10]邓清华,李仁河,林还珠,等.达英-35与二甲双胍联合治疗多囊卵巢综合征的临床疗效观察[J].中国实用医药,2017,12(35):115-117.
[11]杨志平.达英-35联合二甲双胍治疗多囊卵巢综合征对激素、胰岛素抵抗的影响[J].中国妇幼保健,2016,31(5):1015-1017.
[12]刘素萍.二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征的临床研究[J].中外医学研究,2017,15(35):168-169.
[13] BERGER J,BAILEY P,BISWAS C,et al. Thiazolidinedionges producea conformational change in peroxisomal proliferator-activated receptor-gamma:binding and activation correlate with antidiabetic actions in db/db mice[J]. Endocrinology,1996,137:4189-4195.
[14]刘春喜,田作荣.二甲双胍和罗格列酮治疗多囊卵巢综合征的临床价值体会[J].实用妇科内分泌杂志,2016,3(7):18-19.
[15]翟振远.肥胖型多囊卵巢综合征不孕症应用二甲双胍联合针灸治疗的疗效[J].国际医药卫生导报,2017,23(15):2403-2405.
[16]吴晓明.来曲唑联合中医针灸促排卵治疗克罗米芬抵抗的多囊卵巢综合征的临床应用[J].中国医药科学,2018,8(8):49-51.
[17]黄定芳.苍附导痰汤联合二甲双胍治疗肥胖型多囊卵巢综合征的临床效果[J].中国当代医药,2018,25(6):34-36.