布地奈德联合复方异丙托溴铵治疗小儿肺炎支原体感染后咳嗽临床疗效及咳嗽症状评分分析

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英文篇名：Clinical efficacy of budesonide combined with compound ipratropium bromide in the treatment of cough in children with mycoplasma pneumoniae infection and scoring of cough symptoms 作者：吴俊 ; 雷后兴 ; 雷文芬 ; 付小丽 英文作者：WU Jun;LEI Houxing;LEI Wenfen;FU Xiaoli;Department of Pediatrics, Lishui Hospital of Traditional Chinese Medicine in Zhejiang Province;Department of Pediatrics, Lishui People's Hospital in Zhejiang Province; 关键词：布地奈德 ; 复方异丙托溴铵 ; 小儿肺炎支原体感染 ; 咳嗽症状 英文关键词：Budesonide;;Compound ipratropium bromide;;Pediatric pneumonia mycoplasma infection;;Cough symptoms 中文刊名：ZDYS 英文刊名：China Modern Doctor 机构：浙江省丽水市中医院儿科;浙江省丽水市人民医院儿科; 出版日期：2019-03-28 出版单位：中国现代医生 年：2019 期：v.57 基金：浙江省医药卫生科技计划项目(2014KYB317) 语种：中文; 页：ZDYS201909016 页数：4 CN：09 ISSN：11-5603/R 分类号：58-61

摘要

目的分析布地奈德联合复方异丙托溴铵对小儿肺炎支原体感染后咳嗽的临床治疗效果。方法选取2016年1月～2018年8月到我院治疗的80例小儿肺炎支原体感染患者作为研究对象,将患者进行随机分组,分为对照组和观察组,每组40例。对照组患者采用氨溴索进行治疗,观察组患者采用布地奈德联合复方异丙托溴铵治疗,比较两组患者肺炎支原体感染后咳嗽治疗的有效率,对患者咳嗽症状症状及生活质量进行评分,比较治疗前后肺炎支原体感染后咳嗽血嗜酸粒细胞阳离子蛋白(eosinophil cationic protein)和嗜酸性粒细胞水平(eosinophil)的变化。结果观察组患者在肺炎支原体感染后咳嗽治疗的总有效率高于对照组,差异有统计学意义(P<0.05);治疗前后观察组患者的咳嗽症状及生活质量评分改善程度高于对照组,差异有统计学意义(P<0.05)。观察组的ECP、EOS均明显低于对照组,差异有统计学意义(P<0.05)。结论布地奈德与复方异丙托溴铵联合治疗对小儿肺炎支原体感染后咳嗽具有确切的临床治疗效果,对小儿咳嗽情况具有显著改善的效果,值得在临床进行推广。
        Objective To analyze the clinical effect of budesonide combined with ipratropium bromide on cough in children with mycoplasma pneumoniae infection. Methods Eighty children with mycoplasma pneumoniae infection who were treated in our hospital from January 2016 to August 2018 were enrolled. The patients were randomly divided into control group and observation group, 40 patients in each group. The patients in the control group were treated with ambroxol. The patients in the observation group were treated with budesonide and compound ipratropium bromide. The effective rate of cough treatment after pneumoniae infection was compared between the two groups. The symptoms of cough and quality of life of patients were scored, and the changes of blood eosinophil cationic protein and eosinophils were compared before and after treatment. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). The improvement of cough symptoms and quality of life scores in the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). The ECP and EOS of the observation group were significantly lower than those of the control group, which was statistically significant(P<0.05). Conclusion The combination of budesonide and compound ipratropium bromide has a definite clinical effect on cough in children with mycoplasma pneumoniae infection, and can significantly relieve cough in children, which is worthy of clinical promotion.

引文

[1]董汉权.小儿肺炎支原体感染合并肺外消化系统损害的临床特征及影响因素分析[J].中国妇幼保健,2015,30(22):3821-3823.
    [2]楼兰芳,李小兵,张兰青.小儿肺炎支原体感染后血清免疫球蛋白、红细胞免疫及外周血T淋巴细胞亚群的变化情况分析[J].中国妇幼保健,2015,30(3):385-387.
    [3]崔明姬.阿奇霉素在小儿肺炎支原体感染的应用效果探讨[J].河北医学,2014,20(1):156-158.
    [4]Luo Z,Luo J,Liu E,et al.Effects of prednisolone on refractory mycoplasma pneumoniae pneumonia in children[J].Pediatric Pulmonology,2014,49(4):377-380.
    [5]陈正荣,严永东.小儿肺炎支原体感染流行病学特征[J]中国实用儿科杂志,2015,30(3):180-183.
    [6]艾景芳.146例小儿肺炎支原体感染临床分析[J].中国民康医学,2014,26(1):56-57.
    [7]You SY,Jwa HJ,Yang E,et al.Effects of methylprednisolone pulse therapy on refractory Mycoplasma pneumoniae pneumonia in children[J].Allergy,Asthma&Immunology Research,2014,6(1):22-26.
    [8]艾莉莉.小儿肺炎支原体感染特点及其相关危险因素[J].中国妇幼保健,2016,31(17):3556-3557.
    [9]陈璐,陈艳萍,黄建宝,等.布地奈德联合盐酸氨溴索雾化吸入对小儿肺炎支原体感染所致慢性咳嗽的影响[J].实用临床医药杂志,2014,18(3):66-68.
    [10]Ma YJ,Wang SM,Cho YH,et al.Clinical and epidemiological characteristics in children with community-acquired mycoplasma pneumonia in Taiwan:A nationwide surveillance[J].Journal of Microbiology,Immunology and Infection,2015,48(6):632-638.
    [11]王艳敏.小儿肺炎支原体感染行快速血清学检验与微生物培养检测的价值比较[J].中国现代药物应用,2015,9(19):29-30.
    [12]张林.超敏C反应蛋白及血常规对小儿肺炎支原体感染的临床诊断价值分析[J].临床和实验医学杂志,2014,13(10):840-842.
    [13]Chen K,Jia R,Li L,et al.The aetiology of community associated pneumonia in children in Nanjing,China and aetiological patterns associated with age and season[J].BMC Public Health,2015,15(1):113.
    [14]陈兰举.小儿肺炎支原体肺及肺外感染的诊断和治疗[J].中华全科医学,2016,14(3):344-345.
    [15]Shin JE,Cheon BR,Shim JW,et al.Increased risk of refractory Mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma[J].Korean Journal of Pediatrics,2014,57(6):271-277.
    [16]陈花莲.快速血清学和微生物培养检测对小儿肺炎支原体感染的诊断价值[J].临床输血与检验,2016,18(2):131-133.
    [17]章礼真.孟鲁司特钠联合布地奈德雾化吸入佐治小儿肺炎支原体肺炎30例疗效观察[J].中国中西医结合儿科学,2014,6(1):74-75.
    [18]Wang L,Wei B.Effect of serum High sensitive C reactive protein level on the curative effect of Azithromycin in treatment of Mycoplasma pneumonia in children[J].Journal of Medical Research,2017,46(9):181-184.
    [19]黄丽娜.脾氨肽口服冻干粉对小儿肺炎支原体感染的临床疗效及对免疫的影响观察[J].临床医学工程,2016,23(3):317-318.
    [20]Zhang Y,Zhou Y,Li S,et al.The clinical characteristics and predictors of refractory Mycoplasma pneumoniae pneumonia in children[J].PLo S One,2016,11(5):e0156465.
    [21]王忠涛,王燕,马允东.阿奇霉素序贯联合多药治疗小儿肺炎支原体感染致过敏性紫癜的临床研究[J].临床肺科杂志,2017,22(12):2208-2211.