人核仁磷酸化蛋白1(NOLC1)影响禽流感病毒感染过程研究进展
|
摘要
禽流感是由A型流感病毒引起的家禽类传染病,能够引发从呼吸系统病变到全身性败血症等多种症状。禽流感病毒的传播给养殖业带来巨大经济损失,同时对人类健康也造成威胁。研究表明,禽流感病毒非结构蛋白NS1通过与宿主细胞内多种蛋白相互作用影响了病毒的感染进程,人核仁磷酸化蛋白即是其中之一,该蛋白参与核仁组装、细胞生长发育及肿瘤发生等过程,还能与禽流感病毒的非结构蛋白NS1发生相互作用,影响禽流感病毒感染过程。本文对NOLC1蛋白的结构、功能及如何影响禽流感病毒的感染等相关研究进展进行综述。
Avian influenza is a poultry infectious disease caused by the influenza A virus, which can cause various symptoms from the respiratory system to systemic sepsis. The spread of avian influenza virus has brought huge economic losses to the poultry industry, and it also poses a threat to human health.Studies have shown that the virus' non-structural protein 1(NS1) affects the infection process by interacting with various proteins in the host cell. One of them is NOLC1, which is involved in nucleolar assembly, cell growth and development, tumor growth, and interacting with the NS1 protein, which affect the infection process of the avian influenza virus.This article reviews the research progress on the structure and function of NOLC1 and how it affects the infection of avian influenza virus.
Avian influenza is a poultry infectious disease caused by the influenza A virus, which can cause various symptoms from the respiratory system to systemic sepsis. The spread of avian influenza virus has brought huge economic losses to the poultry industry, and it also poses a threat to human health.Studies have shown that the virus' non-structural protein 1(NS1) affects the infection process by interacting with various proteins in the host cell. One of them is NOLC1, which is involved in nucleolar assembly, cell growth and development, tumor growth, and interacting with the NS1 protein, which affect the infection process of the avian influenza virus.This article reviews the research progress on the structure and function of NOLC1 and how it affects the infection of avian influenza virus.
引文
[1] Takeyama N,Minari K,Kajihara M,et al.Detection of highly pathogenic avian influenza virus infection in vaccinated chicken flocks by monitoring antibodies against non-structural protein 1 (NS1)[J].Veterinary Microbiology,2011,147(3-4):283-291.
[2] Zhang W,Wang CY,Yang ST,et al.Inhibition of highly pathogenic avian influenza virus H5N1 replication by the small interfering RNA targeting polymerase A gene[J].Biochemical & Biophysical Research Communications,2009,390(3):421-426.
[3] Ma W,Brenner D,Wang Z,et al.The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency,cell tropism,and host range of an H7N1 HPAIV[J].Journal of Virology,2010,84(4):2122-2133.
[4] Duan XF,Zhang JQ,Liu SN,et al.Methylation of nucleolar and coiled-body phosphoprotein 1 is associated with the mechanism of tumorigenesis in hepatocellular carcinoma[J].Oncology Reports,2013,30(5):2220-2228.
[5] Li D,Meier UT,Dobrowolska G,et al.Specific interaction between casein kinase 2 and the nucleolar protein nopp140[J].Journal of Biological Chemistry,1997,272(6):3773-3779.
[6] Meier UT,Blobel G.Nopp140 shuttles on tracks between nucleolus and cytoplasm[J].Cell,1992,70(1):127-138.
[7] Meier UT.Comparison of the rat nucleolar protein nopp140 with its yeast homolog srp40 differential phosphorylation in vertebrates and yeast[J].Journal of Biological Chemistry,1996,271(32):19376-19384.
[8] Kim YK,Lee WK,Jin Y,et al.Doxorubicin binds to un-phosphorylated form of hNopp140 and reduces protein kinase CK2-dependent phosphorylation of hNopp140[J].Journal of Biochemistry & Molecular Biology,2006,39(6):774-781.
[9] Pai CY,Chen HK,Sheu HL,et al.Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis[J].Journal of Cell Science,1995,108(5):1911-1920.
[10] Kim YK,Lee KJ,Jeon H,et al.Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner[J].Journal of Biological Chemistry,2006,281(48):36752-36757.
[11] Gao X,Wang Q,Li W,et al.Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB[J].Bmb Reports,2011,44(1):70-75.
[12] Yang Y,Isaac C,Wang C,et al.Conserved composition of mammalian Box H/ACA and Box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor nopp140[J].Molecular Biology of the Cell,2000,11(2):567-577.
[13] He F,James A,Raje H,et al.Deletion of drosophila Nopp140 induces subcellular ribosomopathies[J].Chromosoma,2015,124(2):191-208.
[14] Lee CC,Tsai YT,Kao CW,et al.Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C.elegans[J].Cell Death and Disease,2014,5(4):e1158.
[15] Hwang YC,Lu TY,Huang DY,et al.NOLC1,an enhancer of nasopharyngeal carcinoma progression,is essential for TP53 to regulate MDM2 expression[J].American Journal of Pathology,2009,175(1):342-354.
[16] Pikarsky E,Porat RM,Stein I,et al.NF-kB functions as a tumour promoter in inflammation-associated cancer[J].Nature,2004,431(7007):461-466.
[17] Abramovitch R,Tavor E,Jacob-Hirsch J,et al.A pivotal role of cyclic amp-responsive element binding protein in tumor progression[J].Cancer Research,2004,64(4):1338-1346.
[18] Yao Y,Fan Y,Wu J,et al.Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis[J].Biochemical and Biophysical Research Communications,2012,423(3):613-619.
[19] Krastev DB,Slabicki M,Paszkowski-Rogacz M,et al.A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly[J].Nature Cell Biology,2011,13(7):809-818.
[20] 彭欠欠,孙王杨吉,石磊,等.A型流感病毒NS1蛋白的研究进展[J].畜牧与兽医,2016,48(7):132-135.
[21] 刘宏生,赵丹,段艳婷.禽流感病毒H5N1亚型NS1蛋白的研究进展[J].微生物学杂志,2013,33(5):1-3.
[22] Zhu C,Sun T,Zhao J,et al.Screening of proteins interacting with nonstructural 1 protein of H5N1 avian influenza virus from T7-phage display library[J].Chemical research in chinese universites,2012,28(1):103-107.
[23] Zhu C,Zheng F,Sun T,et al.Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1[J].Virus Genes,2013,46(2):287-292.
[24] Zhu C,Zheng F,She X,et al.Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein[J].Virus genes,2015,50(2):238-244.
[25] Lee WK,Son SH,Jin BS,et al.Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140[J].Proceedings of the National Academy of Sciences,2013,110(48):19360-19365.
[26] Wen X,Huang X,Mok WY,et al.NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells[J].The Journal of Immunology,2014,192(8):3753-3764.
[27] Kochs G,Garcia-Sastre A,Martinez-Sobrido L.Multiple anti-interferon actions of the influenza a virus NS1 protein[J].Journal of Virology,2007,81(13):7011-7021.
[28] Hale BG,Randall RE,Ortin J,et al.The multifunctional NS1 protein of influenza A viruses[J].Journal of General Virology,2008,89(10):2359-2376.
[29] Stasakova J,Ferko B,Kittel C,et al.Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages,resulting in fast apoptosis and release of high levels of interleukins 1beta and 18.[J].Journal of General Virology,2005,86(1):185-195.
[30] Hale BG,Kerry PS,Jackson D,et al.Structural insights into phosphoinositide 3-Kinase activation by the influenza a virus NS1 protein[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(5):1954-1959.
[31] Matsuoka Y,Matsumae H,Katoh M,et al.A comprehensive map of the influenza a virus replication cycle[J].BMC Systems Biology,2013,7(1):97.
[2] Zhang W,Wang CY,Yang ST,et al.Inhibition of highly pathogenic avian influenza virus H5N1 replication by the small interfering RNA targeting polymerase A gene[J].Biochemical & Biophysical Research Communications,2009,390(3):421-426.
[3] Ma W,Brenner D,Wang Z,et al.The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency,cell tropism,and host range of an H7N1 HPAIV[J].Journal of Virology,2010,84(4):2122-2133.
[4] Duan XF,Zhang JQ,Liu SN,et al.Methylation of nucleolar and coiled-body phosphoprotein 1 is associated with the mechanism of tumorigenesis in hepatocellular carcinoma[J].Oncology Reports,2013,30(5):2220-2228.
[5] Li D,Meier UT,Dobrowolska G,et al.Specific interaction between casein kinase 2 and the nucleolar protein nopp140[J].Journal of Biological Chemistry,1997,272(6):3773-3779.
[6] Meier UT,Blobel G.Nopp140 shuttles on tracks between nucleolus and cytoplasm[J].Cell,1992,70(1):127-138.
[7] Meier UT.Comparison of the rat nucleolar protein nopp140 with its yeast homolog srp40 differential phosphorylation in vertebrates and yeast[J].Journal of Biological Chemistry,1996,271(32):19376-19384.
[8] Kim YK,Lee WK,Jin Y,et al.Doxorubicin binds to un-phosphorylated form of hNopp140 and reduces protein kinase CK2-dependent phosphorylation of hNopp140[J].Journal of Biochemistry & Molecular Biology,2006,39(6):774-781.
[9] Pai CY,Chen HK,Sheu HL,et al.Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis[J].Journal of Cell Science,1995,108(5):1911-1920.
[10] Kim YK,Lee KJ,Jeon H,et al.Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner[J].Journal of Biological Chemistry,2006,281(48):36752-36757.
[11] Gao X,Wang Q,Li W,et al.Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB[J].Bmb Reports,2011,44(1):70-75.
[12] Yang Y,Isaac C,Wang C,et al.Conserved composition of mammalian Box H/ACA and Box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor nopp140[J].Molecular Biology of the Cell,2000,11(2):567-577.
[13] He F,James A,Raje H,et al.Deletion of drosophila Nopp140 induces subcellular ribosomopathies[J].Chromosoma,2015,124(2):191-208.
[14] Lee CC,Tsai YT,Kao CW,et al.Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C.elegans[J].Cell Death and Disease,2014,5(4):e1158.
[15] Hwang YC,Lu TY,Huang DY,et al.NOLC1,an enhancer of nasopharyngeal carcinoma progression,is essential for TP53 to regulate MDM2 expression[J].American Journal of Pathology,2009,175(1):342-354.
[16] Pikarsky E,Porat RM,Stein I,et al.NF-kB functions as a tumour promoter in inflammation-associated cancer[J].Nature,2004,431(7007):461-466.
[17] Abramovitch R,Tavor E,Jacob-Hirsch J,et al.A pivotal role of cyclic amp-responsive element binding protein in tumor progression[J].Cancer Research,2004,64(4):1338-1346.
[18] Yao Y,Fan Y,Wu J,et al.Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis[J].Biochemical and Biophysical Research Communications,2012,423(3):613-619.
[19] Krastev DB,Slabicki M,Paszkowski-Rogacz M,et al.A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly[J].Nature Cell Biology,2011,13(7):809-818.
[20] 彭欠欠,孙王杨吉,石磊,等.A型流感病毒NS1蛋白的研究进展[J].畜牧与兽医,2016,48(7):132-135.
[21] 刘宏生,赵丹,段艳婷.禽流感病毒H5N1亚型NS1蛋白的研究进展[J].微生物学杂志,2013,33(5):1-3.
[22] Zhu C,Sun T,Zhao J,et al.Screening of proteins interacting with nonstructural 1 protein of H5N1 avian influenza virus from T7-phage display library[J].Chemical research in chinese universites,2012,28(1):103-107.
[23] Zhu C,Zheng F,Sun T,et al.Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1[J].Virus Genes,2013,46(2):287-292.
[24] Zhu C,Zheng F,She X,et al.Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein[J].Virus genes,2015,50(2):238-244.
[25] Lee WK,Son SH,Jin BS,et al.Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140[J].Proceedings of the National Academy of Sciences,2013,110(48):19360-19365.
[26] Wen X,Huang X,Mok WY,et al.NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells[J].The Journal of Immunology,2014,192(8):3753-3764.
[27] Kochs G,Garcia-Sastre A,Martinez-Sobrido L.Multiple anti-interferon actions of the influenza a virus NS1 protein[J].Journal of Virology,2007,81(13):7011-7021.
[28] Hale BG,Randall RE,Ortin J,et al.The multifunctional NS1 protein of influenza A viruses[J].Journal of General Virology,2008,89(10):2359-2376.
[29] Stasakova J,Ferko B,Kittel C,et al.Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages,resulting in fast apoptosis and release of high levels of interleukins 1beta and 18.[J].Journal of General Virology,2005,86(1):185-195.
[30] Hale BG,Kerry PS,Jackson D,et al.Structural insights into phosphoinositide 3-Kinase activation by the influenza a virus NS1 protein[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(5):1954-1959.
[31] Matsuoka Y,Matsumae H,Katoh M,et al.A comprehensive map of the influenza a virus replication cycle[J].BMC Systems Biology,2013,7(1):97.