电休克疗法敏感的非人灵长类动物认知量表评估健康受试者认知功能的重测信度
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摘要
目的哥伦比亚大学非人灵长类动物认知(CUPCB)量表对电休克疗法(ECT)引起的认知损伤非常敏感,本研究初步将CUPCB转化应用于健康人,为建立一个适合中国人的ECT认知损伤相关的量表提供基础。方法对CUPCB重新修订,选取100名健康受试者完成CUPCB评定,利用t检验和Pearson相关分析评估CUPCB的性能;间隔2 w后,对受试者进行CUPCB重测,检测其重测信度。结果基于健康受试者,CUPCB成套量表能评估认知的不同领域;CUPCB的测试结果不受性别和种族的影响(P>0.05),但与年龄、受教育程度和智商显著相关(P<0.05);CUPCB成套量表的5个测试任务有充分的重测信度。结论可以将CUPCB进一步用于评估接受ECT治疗的患者的认知功能,监测ECT治疗效果。
Objective To study an innovative translational project that has examined the psychometric properties of computerized experimental neurocognitive tests developed for nonhuman primate models in healthy humans. Methods The CUPCB parameters were modified. 100 healthy control subjects completed the five CUPCB subtests(Target Identification, Target Tracking, Target Sequencing, Spatial Configuration, and Serial Probe Recognition), and t-test and Pearson correlation coefficient analysis had been conducted. The subjects were retested 2 weeks later to obtain the test-retest reliability. Results Based on healthy subjects, five cognitive tests of CUPCB evaluated different aspects of cognition; the performance on the CUPCB might not be influenced by gender or race,but it was related to age, level of education and intelligence; and five cognitive tests of CUPCB had high test-retest reliability.Conclusions CUPCB could be further used for cognitive assessment in patients undergoing ECT and monitoring the efficacy of treatment.
Objective To study an innovative translational project that has examined the psychometric properties of computerized experimental neurocognitive tests developed for nonhuman primate models in healthy humans. Methods The CUPCB parameters were modified. 100 healthy control subjects completed the five CUPCB subtests(Target Identification, Target Tracking, Target Sequencing, Spatial Configuration, and Serial Probe Recognition), and t-test and Pearson correlation coefficient analysis had been conducted. The subjects were retested 2 weeks later to obtain the test-retest reliability. Results Based on healthy subjects, five cognitive tests of CUPCB evaluated different aspects of cognition; the performance on the CUPCB might not be influenced by gender or race,but it was related to age, level of education and intelligence; and five cognitive tests of CUPCB had high test-retest reliability.Conclusions CUPCB could be further used for cognitive assessment in patients undergoing ECT and monitoring the efficacy of treatment.
引文
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2 Chatwin H,Stapleton P,Porter B,et al.The effectiveness of cognitive behavioral therapy and emotional freedom techniques in reducing depression and anxiety among adults:a pilot study[J].Integr Med(Encinitas),2016;15(2):27-34.
3 Ferrari AJ,Somerville AJ,Baxter AJ,et al.Global variation in the prevalence and incidence of major depressive disorder:a systematic review of the epidemiological literature[J].Psychol Med,2013;43(3):471-81.
4 Karyotaki E,Smit Y,Holdt Henningsen K,et al.Combining pharmacotherapy and psychotherapy or monotherapy for major depression? A meta-analysis on the long-term effects[J].J Affect Disord,2016;194:144-52.
5 Carvalho AF,Berk M,Hyphantis TN,et al.The integrative management of treatment-resistant depression:a comprehensive review and perspectives[J].Psychother Psychosom,2014;83(2):70-88.
6 McCall WV.Finally,evidence for continuation electroconvulsive therapy in major depressive disorder[J].J ECT,2016;32(4):221.
7 Dybedal GS,Tanum L,Sundet K,et al.The role of baseline cognitive function in the neurocognitive effects of electroconvulsive therapy in depressed elderly patients[J].Clin Neuropsychol,2015;29(4):487-508.
8 Bodnar A,Krzywotulski M,Lewandowska A,et al.Electroconvulsive therapy and cognitive functions in treatment-resistant depression[J].World J Biol Psychiatry,2016;17(2):159-64.
9 Boere E,Kamperman AM,van′t Hoog AE,et al.Anterograde amnesia during electroconvulsive therapy:a prospective pilot-study in patients with major depressive disorder[J].PLoS One,2016;11(10):e0165392.
10 Semkovska M,McLoughlin DM.Measuring retrograde autobiographical amnesia following electroconvulsive therapy:historical perspective and current issues[J].J ECT,2013;29(2):127-33.
11 McElhiney MC,Moody BJ,Sackeim HA.The autobiographical memory interview short form:manual for administration and scoring[M].New York:Department of Psychiatry,New York State Psychiatric Institute,2001:37.
12 Semkovska M,Noone M,Carton M,et al.Measuring consistency of autobiographical memory recall in depression[J].Psychiatry Res,2012;197(1-2):41-8.
13 Martin DM,Gálvez V,Loo CK.Predicting retrograde autobiographical memory changes following electroconvulsive therapy:relationships between individual,treatment,and early clinical factors[J].Int J Neuropsychopharmacol,2015;18(12):pyv067.
14 Moscrip TD,Terrace HS,Sackeim HA,et al.A primate model of anterograde and retrograde amnesia produced by convulsive treatment[J].J ECT,2004;20(1):26-36.
15 Moscrip TD,Terrace HS,Sackeim HA,et al.Randomized controlled trial of the cognitive side-effects of magnetic seizure therapy(MST) and electroconvulsive shock(ECS)[J].Int J Neuropsychopharmacol,2006;9(1):1-11.
16 Spellman T,McClintock SM,Terrace H,et al.Differential effects of high-dose magnetic seizure therapy and electroconvulsive shock on cognitive function[J].Biol Psychiatry,2008;63(12):1163-70.
17 Sarter M.Animal cognition:defining the issues[J].Neurosci Biobehav Rev,2004;28(7):645-50.