帕金森病合并阻塞性睡眠呼吸暂停低通气综合征患者血清胱抑素C水平与事件相关电位P300的关系
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摘要
目的初步探讨合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)帕金森病(PD)患者血清胱抑素(cys) C水平及其与事件相关电位P300相关认知指标的关系。方法采集90例PD患者的一般资料和病史情况,完善相关化验指标、P300测评等,并依据呼吸暂停低通气指数(AHI)分为PD合并OSAHS组和PD不合并OSAHS组,同时随机选取90例健康中老年人为对照组。结果 PD患者OSAHS的发生率显著高于对照组(P<0. 05); PD合并OSAHS组较PD不合并OSAHS组N2、P3潜伏期明显延长,cys C水平显著升高,且cys C水平与N2、P3潜伏期呈正相关(均P<0. 05)。结论 cys C、事件相关电位P300可以作为评价PD合并OSAHS患者认知功能障碍的相关指标。
引文
1 Nakamura Y,Takeda M,Suzuki H,et al.Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease[J].Neurosci Lett,1991;130(2):195-8.
2 Bever CT Jr,Garver DW.Increased cathepsin B activity in multiple sclerosis brain[J].J Neurol Sci,1995;131(1):71-3.
3 Palm DE,Knuckey NW,Primiano MJ,et al.Cystatin C,a protease inhibitor,in degenerating rat hippocampal neurons following transient forebrain ischemia[J].Brain Res,1995;691(1):1-8.
4 Lukasiuk K,Pirttila TJ,Pitkanen A.Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy[J].Epilepsia,2002;43(Suppl 5):137-45.
5徐金敏,陈静,毛成洁,等.血清胱抑素C的水平变化与帕金森病的关系[J].中华医学杂志,2014;94(11):804-7.
6叶海程,姜财,黄佳,等.事件相关单位P300在认知功能障碍评测中的应用价值[J].中国康复杂志,2014;29(6):468-70.
7中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病的诊断标准[J].中华神经科杂志,2016;49(4):268-71.
8中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002;25(4):195-8.
9谢娜,邓建中,齐进兴,等.神经心理测试及P300对皮质下缺血性脑血管病伴认知功能障碍患者评估研究[J].中国实用神经疾病杂志,2015;18(1):69-70.
10 Pal PK,Thennarasu K,Fleming J,et al.Nocturnal sleep disturbances and daytime dysfunction in patients with Parkinson's disease and in their caregivers[J].Parkinsonism Relat Disord,2014;10(3):157-68.
11 Noradina AT,Karim NA,Hamidon BB,et al.Sleep-disordered breathing in patients with Parkinson's disease[J].Singapore Med J,2010;51(1):60-4.
12 Cochen DCV,Abouda M,Leu S,et al.Is obstructive sleep apnea a problem in Parkinson's disease[J]?Sleep Med,2010;11(3):247-52.
13 Dalrymple-Alford JC,Livingston L,Macaskill MR,et al.Characterizing mild cognitive impairment in Parkinson's disease[J].Mov Disord,2011;26(4):629-36.
14 Xu L,Sheng J,Tang Z,et al.Cystatin C prevents degeneration of rat nigral dopaminergic neurons:in vitro and in vivo studies[J].Neurobiol Dis,2005;18(1):152-65.
15 Dutta G,Barber DS,Zhang P,et al.Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity[J].J Neurochem,2012;122(4):752-63.
16刘娟子,石玉玲,李林海,等.血清胱抑素C对帕金森病的临床诊断价值[J].生物技术通讯,2011;23(1):115-9.
17 Kato K,Takata Y,Usui Y,et al.Severe obstructive sleep apnea increases cystatin C in clinically latent renal dysfunction[J].Respir Med,2011;105(4):643-9.
18 Zhang XB,Lin QC,Deng CS,et al.Elevated serum cystatin C in severe OSA younger men without complications[J].Sleep Breath,2013;17(1):235-41.
19 Liu Y,Li J,Wang Z,et al.Attenuation of early brain injury and learning deficits following experimental subarachnoid hemorrhage secondary to cystatin C possible involvement of the autophagy pathway[J].Mol Neurobiol,2014;49(2):1043-54.
20马灿灿,陈蓓蕾,徐俊,等.血清胱抑素C对初诊帕金森病患者轻度认知损害的早期诊断价值[J].中国现代神经疾病杂志,2015;15(8):638-44.
2 Bever CT Jr,Garver DW.Increased cathepsin B activity in multiple sclerosis brain[J].J Neurol Sci,1995;131(1):71-3.
3 Palm DE,Knuckey NW,Primiano MJ,et al.Cystatin C,a protease inhibitor,in degenerating rat hippocampal neurons following transient forebrain ischemia[J].Brain Res,1995;691(1):1-8.
4 Lukasiuk K,Pirttila TJ,Pitkanen A.Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy[J].Epilepsia,2002;43(Suppl 5):137-45.
5徐金敏,陈静,毛成洁,等.血清胱抑素C的水平变化与帕金森病的关系[J].中华医学杂志,2014;94(11):804-7.
6叶海程,姜财,黄佳,等.事件相关单位P300在认知功能障碍评测中的应用价值[J].中国康复杂志,2014;29(6):468-70.
7中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病的诊断标准[J].中华神经科杂志,2016;49(4):268-71.
8中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002;25(4):195-8.
9谢娜,邓建中,齐进兴,等.神经心理测试及P300对皮质下缺血性脑血管病伴认知功能障碍患者评估研究[J].中国实用神经疾病杂志,2015;18(1):69-70.
10 Pal PK,Thennarasu K,Fleming J,et al.Nocturnal sleep disturbances and daytime dysfunction in patients with Parkinson's disease and in their caregivers[J].Parkinsonism Relat Disord,2014;10(3):157-68.
11 Noradina AT,Karim NA,Hamidon BB,et al.Sleep-disordered breathing in patients with Parkinson's disease[J].Singapore Med J,2010;51(1):60-4.
12 Cochen DCV,Abouda M,Leu S,et al.Is obstructive sleep apnea a problem in Parkinson's disease[J]?Sleep Med,2010;11(3):247-52.
13 Dalrymple-Alford JC,Livingston L,Macaskill MR,et al.Characterizing mild cognitive impairment in Parkinson's disease[J].Mov Disord,2011;26(4):629-36.
14 Xu L,Sheng J,Tang Z,et al.Cystatin C prevents degeneration of rat nigral dopaminergic neurons:in vitro and in vivo studies[J].Neurobiol Dis,2005;18(1):152-65.
15 Dutta G,Barber DS,Zhang P,et al.Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity[J].J Neurochem,2012;122(4):752-63.
16刘娟子,石玉玲,李林海,等.血清胱抑素C对帕金森病的临床诊断价值[J].生物技术通讯,2011;23(1):115-9.
17 Kato K,Takata Y,Usui Y,et al.Severe obstructive sleep apnea increases cystatin C in clinically latent renal dysfunction[J].Respir Med,2011;105(4):643-9.
18 Zhang XB,Lin QC,Deng CS,et al.Elevated serum cystatin C in severe OSA younger men without complications[J].Sleep Breath,2013;17(1):235-41.
19 Liu Y,Li J,Wang Z,et al.Attenuation of early brain injury and learning deficits following experimental subarachnoid hemorrhage secondary to cystatin C possible involvement of the autophagy pathway[J].Mol Neurobiol,2014;49(2):1043-54.
20马灿灿,陈蓓蕾,徐俊,等.血清胱抑素C对初诊帕金森病患者轻度认知损害的早期诊断价值[J].中国现代神经疾病杂志,2015;15(8):638-44.