竞争性内源RNA调控网络在心血管疾病中的研究进展
摘要
竞争性内源RNA(ceRNA)作为生物标志物、潜在的治疗靶点和强有力的预后指标,在心肌肥厚、心肌梗死以及动脉粥样硬化等心血管疾病中均表现出了巨大的研究价值及临床应用前景。该文主要介绍了ceRNA调控网络在心血管疾病(CVDs)中的最新研究成果及其调控机制。
引文
[1]Salmena L,Poliseno L,Tay Y,et al.A ceRNA hypothesis:the Rosetta Stone of a hidden RNA language?[J].Cell,2011,146(3):353-358.
[2]Tay Y,Rinn J,Pandolfi PP.The multilayered complexity of ceRNA crosstalk and competition [J].Nature,2014,505(7483):344-352.
[3]Bartel DP.MicroRNAs:target recognition and regulatory functions [J].Cell,2009,136(2):215-233.
[4]Thomson DW,Dinger ME.Endogenous microRNA sponges:evidence and controversy [J].Nat Rev Genet,2016,17(5):272-283.
[5]Lauressergues D,Couzigou JM,Clemente HS,et al.Primary transcripts of microRNAs encode regulatory peptides[J].Nature,2015,520(7545):90-93.
[6]Bak RO,Mikkelsen JG.MiRNA sponges:soaking up miRNAs for regulation of gene expression[J].Wiley Interdiscip Rev RNA,2014,5(3):317-333.
[7]Marian AJ,Braunwald E.Hypertrophic cardiomyopathy:genetics,patho-genesis,clinical manifestations,diagnosis,and therapy[J].Circ Res,2017,121(7):749-770.
[8]Wang K,Liu F,Zhou LY,et al.The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489[J].Circ Res,2014,114(9):1377-1388.
[9]Lai Y,He S,Ma L,et al.HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy[J].Mol Cell Biochem,2017,432(1-2):179-187.
[10]Jiang F,Zhou X,Huang J.Long noncoding RNA-ROR mediates the reprogramming in cardiac hypertrophy[J].PLoS One,2016,11(4):e0152767.
[11]Li W,Zhai L,Wang H,et al.Downregulation of lncRNA GAS5 causes trastuzumab resistance in breast cancer[J].Oncotarget,2016,7(19):27778-27786.
[12]Zhang Z,Zhu Z,Watabe K,et al.Negative regulation of lncRNA GAS5 by miR-21[J].Cell Death Differ,2013,20(11):1558-1568.
[13]Wei W,Chen Y,Gao J,et al.The lncRNA-GAS5/miR-23a/Foxo3a axis regulates cardiac hypertrophy by Wnt/β-catenin signal pathway[J].Biochem Biophys Res Commun,2017,494(1-2):424.
[14]Anderson JL,Morrow DA.Acute myocardial infarction[J].N Engl J Med,2017,376:(21):2053-2064.
[15]Liang H,Pan Z,Zhao X,et al.LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d[J].Theranos-tics,2018,8(4):1180-1194.
[16]Wang K,Liu CY,Zhou LY,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].Nat Comm,2015,6:6779.
[17]Zhao ZH,Hao W,Meng QT,et al.Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocar-dial ischemia-reperfusion injury[J].Cell Biol Int,2017,41(1):62-70.
[18]Wu T,Wu D,Wu Q,et al.Knockdown of long noncoding RNA-ZFAS1 protects cardiomyocytes against acute myocardial infarction via antiapoptosis by regulating miR-150/CRP[J].J Cell Biochem,2017,118(10):3281-3289.
[19]Kim JY,Shim SH.Medicinal herbs effective against atherosclerosis:classification according to mechanism of action[J].Biomol Ther (Seou-l),2019,27(3):254-264.
[20]Zhang F,Zhang R,Zhang X,et al.Comprehensive analysis of circ-RNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits[J].Aging(Albany NY),2018,10(9):2266-2283.
[21]Chen C,Cheng G,Yang X,et al.Tanshinol suppresses endothelial cells apoptosis in mice with atherosclerosis via lncRNA TUG1 up regula-ting the expression of miR-26a[J].Am J Transl Res,2016,8(7),2981-2991.
[22]Lin ZW,Ge JF,Wang Z,et al.Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk[J].Sci Rep,2017,7:42498.
[23]Shan K,Jiang Q,Wang XQ,et al.Role of long non-coding RNA RNCR3 in atherosclerosis-related vascular dysfunction[J].Cell Death Dis,2016,7(6):e2248.
[24]Kotecha D,Piccini JP.Atrial fibrillation in heart failure:what should we do?[J].Eur Heart J,2015,36(46):3250-3257.
[25]Li Z,Wang X,Wang W,et al.Altered long non-coding RNA expression profile in rabbit atrial fibrillation:TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C[J].J Mol Cell Cardiol,2017,108:73-85.
[26]Pan RY,Liu P,Zhou HT,et al.Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients[J].Oncotarget,2017,8(36):60280-60290.
[27]Huang ZW,Tian LH,Yang B.Long noncoding RNA H19 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-455 in cardiac fibrosis[J].DNA Cell Biol,2017,36(9):1-8.
[2]Tay Y,Rinn J,Pandolfi PP.The multilayered complexity of ceRNA crosstalk and competition [J].Nature,2014,505(7483):344-352.
[3]Bartel DP.MicroRNAs:target recognition and regulatory functions [J].Cell,2009,136(2):215-233.
[4]Thomson DW,Dinger ME.Endogenous microRNA sponges:evidence and controversy [J].Nat Rev Genet,2016,17(5):272-283.
[5]Lauressergues D,Couzigou JM,Clemente HS,et al.Primary transcripts of microRNAs encode regulatory peptides[J].Nature,2015,520(7545):90-93.
[6]Bak RO,Mikkelsen JG.MiRNA sponges:soaking up miRNAs for regulation of gene expression[J].Wiley Interdiscip Rev RNA,2014,5(3):317-333.
[7]Marian AJ,Braunwald E.Hypertrophic cardiomyopathy:genetics,patho-genesis,clinical manifestations,diagnosis,and therapy[J].Circ Res,2017,121(7):749-770.
[8]Wang K,Liu F,Zhou LY,et al.The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489[J].Circ Res,2014,114(9):1377-1388.
[9]Lai Y,He S,Ma L,et al.HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy[J].Mol Cell Biochem,2017,432(1-2):179-187.
[10]Jiang F,Zhou X,Huang J.Long noncoding RNA-ROR mediates the reprogramming in cardiac hypertrophy[J].PLoS One,2016,11(4):e0152767.
[11]Li W,Zhai L,Wang H,et al.Downregulation of lncRNA GAS5 causes trastuzumab resistance in breast cancer[J].Oncotarget,2016,7(19):27778-27786.
[12]Zhang Z,Zhu Z,Watabe K,et al.Negative regulation of lncRNA GAS5 by miR-21[J].Cell Death Differ,2013,20(11):1558-1568.
[13]Wei W,Chen Y,Gao J,et al.The lncRNA-GAS5/miR-23a/Foxo3a axis regulates cardiac hypertrophy by Wnt/β-catenin signal pathway[J].Biochem Biophys Res Commun,2017,494(1-2):424.
[14]Anderson JL,Morrow DA.Acute myocardial infarction[J].N Engl J Med,2017,376:(21):2053-2064.
[15]Liang H,Pan Z,Zhao X,et al.LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d[J].Theranos-tics,2018,8(4):1180-1194.
[16]Wang K,Liu CY,Zhou LY,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].Nat Comm,2015,6:6779.
[17]Zhao ZH,Hao W,Meng QT,et al.Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocar-dial ischemia-reperfusion injury[J].Cell Biol Int,2017,41(1):62-70.
[18]Wu T,Wu D,Wu Q,et al.Knockdown of long noncoding RNA-ZFAS1 protects cardiomyocytes against acute myocardial infarction via antiapoptosis by regulating miR-150/CRP[J].J Cell Biochem,2017,118(10):3281-3289.
[19]Kim JY,Shim SH.Medicinal herbs effective against atherosclerosis:classification according to mechanism of action[J].Biomol Ther (Seou-l),2019,27(3):254-264.
[20]Zhang F,Zhang R,Zhang X,et al.Comprehensive analysis of circ-RNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits[J].Aging(Albany NY),2018,10(9):2266-2283.
[21]Chen C,Cheng G,Yang X,et al.Tanshinol suppresses endothelial cells apoptosis in mice with atherosclerosis via lncRNA TUG1 up regula-ting the expression of miR-26a[J].Am J Transl Res,2016,8(7),2981-2991.
[22]Lin ZW,Ge JF,Wang Z,et al.Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk[J].Sci Rep,2017,7:42498.
[23]Shan K,Jiang Q,Wang XQ,et al.Role of long non-coding RNA RNCR3 in atherosclerosis-related vascular dysfunction[J].Cell Death Dis,2016,7(6):e2248.
[24]Kotecha D,Piccini JP.Atrial fibrillation in heart failure:what should we do?[J].Eur Heart J,2015,36(46):3250-3257.
[25]Li Z,Wang X,Wang W,et al.Altered long non-coding RNA expression profile in rabbit atrial fibrillation:TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C[J].J Mol Cell Cardiol,2017,108:73-85.
[26]Pan RY,Liu P,Zhou HT,et al.Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients[J].Oncotarget,2017,8(36):60280-60290.
[27]Huang ZW,Tian LH,Yang B.Long noncoding RNA H19 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-455 in cardiac fibrosis[J].DNA Cell Biol,2017,36(9):1-8.