大黄黄连泻心汤治疗慢性胃病研究进展与声动力疗法展望
|
摘要
慢性胃病是常见的消化性系统疾病。据统计,慢性胃病在人群中的发病率高达80%,若不及时治疗则可发展为癌前病变,不仅给社会带来巨大的经济负担,也给患者带来精神与身体上的痛苦。大黄黄连泻心汤作为经方被各医家传承与沿用,临床多用于胃炎、胃及十二指肠溃疡的治疗,效果显著,其作用机制与调节胃部炎性因子、杀灭幽门螺杆菌与保护胃黏膜有关。基于大黄黄连泻心汤对慢性胃病治愈周期长的弱势,寻求一种辅助疗法用以增强其疗效应受到重视。对大黄黄连泻心汤治疗慢性胃病的作用机制进行综合阐述,并展望利用声动力疗法可杀灭病原微生物的潜在优势以此拓宽该方剂的现代化研究,为以该方为基础方的新药研究提供理论和实践依据。
Chronic gastric disease is a common digestive system disease.According to the statistics,the incidence of chronic gastric disease in the population is as high as 80%,which not only brings a huge economic burden to the society,but also brings mental and physical pain to patients.Dahuang Huanglian Xiexin decoction has been passed down and followed by all doctors as a classical prescription.It could be used in the treatment of gastritis,stomach and duodenal ulcer,which the effect is remarkable.The mechanism of its action is thought to be related to the regulation of gastric inflammatory factors,the killing of Helicobacter pylori and the protection of gastric mucosa.Based on the long period of treatment using Dahuang Huanglian decoction,seeking a kind of adjuvant therapy to enhance its effect is important.In this article,the mechanism of Dahuang Huanglian Xiexin decoction in treating chronic gastric diseases was comprehensively expounded and looked forward to broadening the modern research of this prescription by using the potential advantages of sonodynamic therapy which can kill pathogenic microorganism.
Chronic gastric disease is a common digestive system disease.According to the statistics,the incidence of chronic gastric disease in the population is as high as 80%,which not only brings a huge economic burden to the society,but also brings mental and physical pain to patients.Dahuang Huanglian Xiexin decoction has been passed down and followed by all doctors as a classical prescription.It could be used in the treatment of gastritis,stomach and duodenal ulcer,which the effect is remarkable.The mechanism of its action is thought to be related to the regulation of gastric inflammatory factors,the killing of Helicobacter pylori and the protection of gastric mucosa.Based on the long period of treatment using Dahuang Huanglian decoction,seeking a kind of adjuvant therapy to enhance its effect is important.In this article,the mechanism of Dahuang Huanglian Xiexin decoction in treating chronic gastric diseases was comprehensively expounded and looked forward to broadening the modern research of this prescription by using the potential advantages of sonodynamic therapy which can kill pathogenic microorganism.
引文
[1]秦福云.大黄黄连泻心汤的临床应用[J].内蒙古中医药,2012,31(17):74.
[2]宫庆东,张沁园,王洪海,等.大黄黄连泻心汤历史源流及古今应用[J].山东中医药大学学报,2014(1):5-7.
[3]王国斌.大黄黄连泻心汤煎服法探析[J].国医论坛,2010,25(2):2-3.
[4]姚茹冰,赵智明,蔡辉,等.活血化瘀中药三七抗炎及免疫调节作用研究进展[J].中西医结合心脑血管病杂志,2009,7(6):720-721.
[5]鲁恒心,方肇勤.清热解毒治法的现代研究进展及其在肝癌中的应用概况[J].江苏中医药,2001,22(4):43-45.
[6]马世堂,刘培勋,龙伟,等.血必净抗炎作用药效物质基础和多靶点作用效应[J].物理化学学报,2009,25(10):2080-2086.
[7]姜志昂.大黄黄连泻心汤治疗胃幽门螺杆菌相关性胃病68例[J].实用中医内科杂志,1998(1):6.
[8]李冬寒,宋丹,岳琦,等.声动力疗法诱导肿瘤细胞内源性凋亡[J].现代肿瘤医学,2017,25(15):2499-2501.
[9]侯春艳,毕良佳.以光动力理论为基础的声动力抗菌化学疗法展望[J].中国实用口腔科杂志,2014,7(4):200-203.
[10]张万岱,徐智民.幽门螺杆菌研究现状及共识[J].世界华人消化杂志,2000,8(10):1084-1088.
[11]盛涛,张建中.幽门螺杆菌尿素酶研究现状[J].世界华人消化杂志,1999,7(10):881-884.
[12]张琳,杨连文.幽门螺旋菌与慢性萎缩性胃炎发病关系及防治研究[J].中国中西医结合杂志,1992(9):521-523.
[13]唐庆芝,魏长志.清热解毒药与抗菌、抗病毒药的抗感染作用分析[J].河北中医,2013,35(6):910-911.
[14]包雨晴,凌云,石银龙,等.不同浸渍条件下大黄黄连泻心汤对大鼠胃溃疡的疗效及胃组织PGE2含量的影响[J].中华中医药杂志,2018(1):291-293.
[15]高青竹.大黄黄连泻心汤、理中丸对幽门结扎型胃溃疡模型大鼠药效学及作用机理研究[D].哈尔滨:黑龙江中医药大学,2009:37-40.
[16]李冀,谢田,毕珺辉,等.大黄黄连泻心汤、理中丸对消炎痛型胃溃疡寒热证模型大鼠脑组织5-HT和NE含量的影响[J].辽宁中医杂志,2011(1):7-9.
[17]蒋蕾.大黄黄连泻心汤、理中丸(汤)对水浸应激型胃溃疡寒热证模型大鼠影响的研究[D].哈尔滨:黑龙江中医药大学,2010:12-15.
[18]高秀凤.大黄黄连泻心汤治疗幽门螺杆菌阳性慢性胃炎的效果观察[J].世界最新医学信息文摘,2016,16(27):182-183.
[19]汪新荣,廖永平,朱维,等.光声敏化剂在光动力疗法与声动力疗法中的作用研究[J].中国激光医学杂志,2016(5):254.
[20]MARUANI A,BOUCAUD A,PERRODEAU E,et al.Lowfrequency ultrasound sonophoresis to increase the efficiency of topical steroids:apilot randomized study of humans[J].International Journal of Pharmaceutics,2010,395(1):84-90.
[21]TSIVGOULIS G,EGGERS J,RIBO M,et al.Safety and efficacy of ultrasound-enhanced thrombolysis:a comprehensive review and meta-analysis of randomized and nonrandomized studies[J].Stroke,2010,41(2):280-287.
[22]杨力明,梁会娟,彭成海,等.羟基乙酰化姜黄素诱导的声动力治疗对巨噬细胞凋亡与坏死的影响[J].中国应用生理学杂志,2015,31(2):102-106.
[23]刘韧耕,李黎波.声动力治疗的研究进展[J].中国激光医学杂志,2015(3):151-157.
[24]付玉凤,刘晓燕.中药声敏剂的研究进展[J].吉林中医药,2016,36(10):1078-1080.
[25]寇佳媛,姜月晴,田野,等.中药提取物声敏剂在声动力治疗动脉粥样硬化中的应用[J].上海大学学报:自然科学版,2016,22(3):318-325.
[26]WEN KUN,SHEN BING.Induction of the apoptosis of cancer cell by sonodynamic therapy:a review[J].中国癌症研究:英文版,2012,24(4):368-373.
[27]PECHA R,B GOMPF.Microimplosions:cavitation collapse and shock wave emission on a nanosecond time scale[J].Physical Review Letters,2000,84(6):1328-1330.
[28]CHEN H,ZHOU X,GAO Y,et al.Recent progress in development of new sonosensitizers for sonodynamic cancer therapy[J].Drug Discovery Today,2014,19(4):502-509.
[29]WU J,W L NYBORG.Ultrasound,cavitation bubbles and their interaction with cells[J].Advanced Drug Delivery Reviews,2008,60(10):1103-1116.
[30]NOGUEIRA D R,C M ROLIM,A A FAROOQI,et al.Nanoparticle induced oxidative stress in cancer cells:adding new pieces to an incomplete jigsaw puzzle[J].Asian Pac J Cancer Prev,2014,15(12):4739-4743.
[31]SONG W,CUI H,ZHANG R,et al.Apoptosis of SAS cells induced by sonodynamic therapy using 5-aminolevulinic acid sonosensitizer[J].Anticancer Research,2011,31(1):39-45.
[32]KOU J Y,LI Y,ZHONG Z Y,et al.Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage[J].Cell Death&Disease,2017,8(1):e2558.
[33]Z PING,Q LIU,W PAN,et al.Autophagic and apoptotic response to sonodynamic therapy induced cell damage in leukemia l1210cells in vitro[J].Cancer Biotherapy&Radiopharmaceuticals,2011,26(2):209-218.
[34]X WANG,D XIONG,J WANG,et al.Investigation on damage of DNA molecules under irradiation of low frequency ultrasound in the presence of hematoporphyrin-gallium(HP-Ga)complex[J].Ultrasonics Sonochemistry,2008,15(5):761-767.
[35]QIAN J,Q GAO.Sonodynamic Therapy Mediated by Emodin Induces the Oxidation of Microtubules to Facilitate the Sonodynamic Effect[J].Ultrasound in Medicine&Biology,2018,44(4):853-860.
[2]宫庆东,张沁园,王洪海,等.大黄黄连泻心汤历史源流及古今应用[J].山东中医药大学学报,2014(1):5-7.
[3]王国斌.大黄黄连泻心汤煎服法探析[J].国医论坛,2010,25(2):2-3.
[4]姚茹冰,赵智明,蔡辉,等.活血化瘀中药三七抗炎及免疫调节作用研究进展[J].中西医结合心脑血管病杂志,2009,7(6):720-721.
[5]鲁恒心,方肇勤.清热解毒治法的现代研究进展及其在肝癌中的应用概况[J].江苏中医药,2001,22(4):43-45.
[6]马世堂,刘培勋,龙伟,等.血必净抗炎作用药效物质基础和多靶点作用效应[J].物理化学学报,2009,25(10):2080-2086.
[7]姜志昂.大黄黄连泻心汤治疗胃幽门螺杆菌相关性胃病68例[J].实用中医内科杂志,1998(1):6.
[8]李冬寒,宋丹,岳琦,等.声动力疗法诱导肿瘤细胞内源性凋亡[J].现代肿瘤医学,2017,25(15):2499-2501.
[9]侯春艳,毕良佳.以光动力理论为基础的声动力抗菌化学疗法展望[J].中国实用口腔科杂志,2014,7(4):200-203.
[10]张万岱,徐智民.幽门螺杆菌研究现状及共识[J].世界华人消化杂志,2000,8(10):1084-1088.
[11]盛涛,张建中.幽门螺杆菌尿素酶研究现状[J].世界华人消化杂志,1999,7(10):881-884.
[12]张琳,杨连文.幽门螺旋菌与慢性萎缩性胃炎发病关系及防治研究[J].中国中西医结合杂志,1992(9):521-523.
[13]唐庆芝,魏长志.清热解毒药与抗菌、抗病毒药的抗感染作用分析[J].河北中医,2013,35(6):910-911.
[14]包雨晴,凌云,石银龙,等.不同浸渍条件下大黄黄连泻心汤对大鼠胃溃疡的疗效及胃组织PGE2含量的影响[J].中华中医药杂志,2018(1):291-293.
[15]高青竹.大黄黄连泻心汤、理中丸对幽门结扎型胃溃疡模型大鼠药效学及作用机理研究[D].哈尔滨:黑龙江中医药大学,2009:37-40.
[16]李冀,谢田,毕珺辉,等.大黄黄连泻心汤、理中丸对消炎痛型胃溃疡寒热证模型大鼠脑组织5-HT和NE含量的影响[J].辽宁中医杂志,2011(1):7-9.
[17]蒋蕾.大黄黄连泻心汤、理中丸(汤)对水浸应激型胃溃疡寒热证模型大鼠影响的研究[D].哈尔滨:黑龙江中医药大学,2010:12-15.
[18]高秀凤.大黄黄连泻心汤治疗幽门螺杆菌阳性慢性胃炎的效果观察[J].世界最新医学信息文摘,2016,16(27):182-183.
[19]汪新荣,廖永平,朱维,等.光声敏化剂在光动力疗法与声动力疗法中的作用研究[J].中国激光医学杂志,2016(5):254.
[20]MARUANI A,BOUCAUD A,PERRODEAU E,et al.Lowfrequency ultrasound sonophoresis to increase the efficiency of topical steroids:apilot randomized study of humans[J].International Journal of Pharmaceutics,2010,395(1):84-90.
[21]TSIVGOULIS G,EGGERS J,RIBO M,et al.Safety and efficacy of ultrasound-enhanced thrombolysis:a comprehensive review and meta-analysis of randomized and nonrandomized studies[J].Stroke,2010,41(2):280-287.
[22]杨力明,梁会娟,彭成海,等.羟基乙酰化姜黄素诱导的声动力治疗对巨噬细胞凋亡与坏死的影响[J].中国应用生理学杂志,2015,31(2):102-106.
[23]刘韧耕,李黎波.声动力治疗的研究进展[J].中国激光医学杂志,2015(3):151-157.
[24]付玉凤,刘晓燕.中药声敏剂的研究进展[J].吉林中医药,2016,36(10):1078-1080.
[25]寇佳媛,姜月晴,田野,等.中药提取物声敏剂在声动力治疗动脉粥样硬化中的应用[J].上海大学学报:自然科学版,2016,22(3):318-325.
[26]WEN KUN,SHEN BING.Induction of the apoptosis of cancer cell by sonodynamic therapy:a review[J].中国癌症研究:英文版,2012,24(4):368-373.
[27]PECHA R,B GOMPF.Microimplosions:cavitation collapse and shock wave emission on a nanosecond time scale[J].Physical Review Letters,2000,84(6):1328-1330.
[28]CHEN H,ZHOU X,GAO Y,et al.Recent progress in development of new sonosensitizers for sonodynamic cancer therapy[J].Drug Discovery Today,2014,19(4):502-509.
[29]WU J,W L NYBORG.Ultrasound,cavitation bubbles and their interaction with cells[J].Advanced Drug Delivery Reviews,2008,60(10):1103-1116.
[30]NOGUEIRA D R,C M ROLIM,A A FAROOQI,et al.Nanoparticle induced oxidative stress in cancer cells:adding new pieces to an incomplete jigsaw puzzle[J].Asian Pac J Cancer Prev,2014,15(12):4739-4743.
[31]SONG W,CUI H,ZHANG R,et al.Apoptosis of SAS cells induced by sonodynamic therapy using 5-aminolevulinic acid sonosensitizer[J].Anticancer Research,2011,31(1):39-45.
[32]KOU J Y,LI Y,ZHONG Z Y,et al.Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage[J].Cell Death&Disease,2017,8(1):e2558.
[33]Z PING,Q LIU,W PAN,et al.Autophagic and apoptotic response to sonodynamic therapy induced cell damage in leukemia l1210cells in vitro[J].Cancer Biotherapy&Radiopharmaceuticals,2011,26(2):209-218.
[34]X WANG,D XIONG,J WANG,et al.Investigation on damage of DNA molecules under irradiation of low frequency ultrasound in the presence of hematoporphyrin-gallium(HP-Ga)complex[J].Ultrasonics Sonochemistry,2008,15(5):761-767.
[35]QIAN J,Q GAO.Sonodynamic Therapy Mediated by Emodin Induces the Oxidation of Microtubules to Facilitate the Sonodynamic Effect[J].Ultrasound in Medicine&Biology,2018,44(4):853-860.