基于电化学生物传感器检测食源性致病菌及其毒素的研究进展
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摘要
食源性致病菌是危害食品安全的主要因素,食品中的致病菌是影响人类健康和公共安全的重要方面,因此建立一种简单、快速、经济的检测技术体系可以极大地提高检测效率,缩短检测时限。相比于传统的检测方法,电化学生物传感器具有灵敏度高、稳定性强、检测重复性好和便于微型化等优势,被广泛应用于分析领域。该文综述电化学生物传感器检测食源性致病菌及其毒素的基本工作原理和简单分类,及其最新研究进展,总结存在的发展瓶颈并对其应用前景进行展望。
Foodborne pathogenic bacteria are the main factors endangering food safety. Food pathogens are important aspects of human health and public safety. Therefore,the establishment of a simple,rapid and economical detection technology system can greatly improve the detection efficiency,the test time limit was shortened. Compared with the traditional detection methods,electrochemical biosensor has the advantages of high sensitivity,strong stability,good repeatability and easy miniaturization. So it is always utilized in the field of analysis. This review summarized the basic principle and classification of electrochemical biosensor for the detection of foodborne pathogenic bacteria and toxins,and its latest research progress,the existing development bottlenecks are summarized and the application of electrochemical biosensor is prospected.
Foodborne pathogenic bacteria are the main factors endangering food safety. Food pathogens are important aspects of human health and public safety. Therefore,the establishment of a simple,rapid and economical detection technology system can greatly improve the detection efficiency,the test time limit was shortened. Compared with the traditional detection methods,electrochemical biosensor has the advantages of high sensitivity,strong stability,good repeatability and easy miniaturization. So it is always utilized in the field of analysis. This review summarized the basic principle and classification of electrochemical biosensor for the detection of foodborne pathogenic bacteria and toxins,and its latest research progress,the existing development bottlenecks are summarized and the application of electrochemical biosensor is prospected.
引文
[1]董秀秀,王宇,沈玉栋,等.基于新型纳米材料的电化学免疫传感器及其在食品安全检测中的应用进展[J].中国食品学报,2015,15(4):136-146
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[10]郭燕,窦文超,赵广英.便携式电流型葡萄糖传感器快速检测致奶牛乳腺炎金黄色葡萄球菌的研究[J].中国预防兽医学报,2015,37(10):780-785
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[13]Shiqiang Chen,Y Frank Cheng,Gerrit Voordouw.Three-dimensional graphene nanosheet doped with gold nanoparticles as electrochemical DNA biosensor for bacterial detection[J].Sensors&Actuators:B.Chemical,2018,262:860-868
[14]朱丹,李强强,逄秀梅,等.阻抗光谱在电化学生物传感器中的应用[J].化学传感器,2016,36(1):42-47
[15]张爱萍,唐佳妮,孟瑞锋,等.电化学法快速检测微生物的发展现状及趋势[J].生物技术进展,2011,1(5):342-346
[16]Marta Sánchez-Paniagua López,Beatriz López-Ruiz.Electrochemical biosensor based on ionic liquid polymeric microparticles.An analytical platform for catechol[J].Microchemical Journal,2018,138:173-179
[17]Materon EM,Huang JPJ,Wong A,et al.Glutathione-s-transferase modified electrodes for detecting anticancer drugs[J].Biosensors and Bioelectronics,2014,58:232-236
[18]Wu D,Guo AP,Guo ZK,et al.Simultaneous electrochemical detection of cervical cancer markers using reduced graphene oxide-tetraethylene pentamine as electrode materials and distinguishable redox probes as labels[J].Biosensors and Bioelectronics,2014,54:634-639
[19]Kara P,Meric B,Ozsoz M.Application of Impedimetric and Voltammetric Genosensor for Detection of a Biological Warfare:Anthrax[J].Electroanalysis,2010,20(24):2629-2634
[20]Shabani A,Zourob M,Allain B,et al.Bacteriophage-modified microarrays for the direct impedimetric detection of bacteria[J].Analytical Chemistry,2008,80(24):9475-9482
[21]Gamella M,Campuzano S,Parrado C,et al.Microorganisms recognition and quantification by lectin adsorptive affinity impedance[J].Talanta,2009,78(4):1303-1309
[22]Umer Farooq,Qiaoli Yang,Muhammad Wajid Ullah,et al.Bacterial biosensing:Recent advances in phage-based bioassays and biosensors[J].Biosensors and Bioelectronics,2018,118:204-216
[23]Hoda Ilkhani,Siamak Farhad.A novel electrochemical DNA biosensor for Ebola virus detection[J].Analytical Biochemistry,2018,557:151-155
[24]C Day,S S覬pstad,H Ma,et al.Impedance-based sensor for potassium ions[J].Analytica Chimica Acta,2018,1034(30):39-45
[25]E Fazio,S G Leonardi,M Santoro,et al.Synthesis,characterization and hydrogen sensing properties of nanosized colloidal rhodium oxides prepared by Pulsed Laser Ablation in water[J].Sensors&Actuators:B.Chemical,2018,262:79-85
[26]Jia XL,Liu ZM,Liu N,et al.A label-free immunosensor based on graphene nanocomposites for simultaneous multiplexed electrochemical determination of tumor markers[J].Biosensors and Bioelectronics,2014,53:160-166
[27]O O Soldatkin,O S Burdak,T A Sergeyeva,et al.Acetylcholinesterase-based conductometric biosensor for determination of aflatoxin B1[J].Sensors&Actuators:B.Chemical,2013,188:999-1003
[28]周从燕,李丽蓉,刘入源.纳米基电分析生物传感器在食品兽药残留检测中的研究与应用进展[J].食品安全质量检测学报,2017,8(1):150-155
[29]Steffen Rameil,Peter Schubert,Peter Grundmann,et al.Use of 3-(4-hydroxyphenyl)propionic acid as electron donating com-pound in a potentiometric aflatoxin M1-immunosensor[J].Analytica Chimica Acta,2009,661(1):122-127
[30]Evangelia Larou,Iakovos Yiakoumettis,Grigoris Kaltsas,et al.High throughput cellular biosensor for the ultra-sensitive,ultra-rapid detection of aflatoxin M1[J].Food Control,2013,29(1):208-212
[2]王延新,谢书宇,陈冬梅,等.电化学免疫传感器在食品安全检测中的研究进展[J].畜牧兽医学报,2018,49(7):1334-1342
[3]谢银侠.电化学功能核酸生物传感器在转基因食品检测中的发展现状[J].食品安全导刊,2018(10):25-27
[4]储嫣红,邹彬,陈学珊,等.酶电极传感器在食品安全检测中的研究进展[J].食品工业科技,2017,38(17):335-340
[5]Hélder da Silva,Joo G Pacheco,Júlia McS Magalh觔es,et al.MIP-graphene-modified glassy carbon electrode for the determination of trimethoprim[J].Biosensors and Bioelectronics,2014,52:56-61
[6]董世彪,赵荣涛,李杨,等.DNA电化学生物传感器检测病原微生物的应用研究进展[J].军事医学,2015,39(6):480-483
[7]Mead MI,Popoola OAM,Stewart GB,et al.The use of electrochemical sensors for monitoring urban air quality in low-cost,high-density networks[J].Atmospheric Environment,2013,70:186-203
[8]张金玲,杜祎,高广恒,等.酶电极法测定玉米中黄曲霉毒素B1含量[J].山东科学,2018,31(1):60-64
[9]王泽华,曾冬冬,张欢,等.电沉积纳米金修饰的16通道电流型PSA免疫传感器的制备[J].中国生物医学工程学报,2015,34(1):55-61
[10]郭燕,窦文超,赵广英.便携式电流型葡萄糖传感器快速检测致奶牛乳腺炎金黄色葡萄球菌的研究[J].中国预防兽医学报,2015,37(10):780-785
[11]马海华,张元,甄彤,等.电化学生物传感器在黄曲霉毒素检测中的研究进展[J].中国粮油学报,2016,31(2):132-140
[12]Larou E,Yiakoumettis I,Kaltsas G,et al.High throughput cellular biosensor for the ultra-sensitive,ultra-rapid de-tection of aflatoxin M1[J].Food Control,2013,29(1):208-212
[13]Shiqiang Chen,Y Frank Cheng,Gerrit Voordouw.Three-dimensional graphene nanosheet doped with gold nanoparticles as electrochemical DNA biosensor for bacterial detection[J].Sensors&Actuators:B.Chemical,2018,262:860-868
[14]朱丹,李强强,逄秀梅,等.阻抗光谱在电化学生物传感器中的应用[J].化学传感器,2016,36(1):42-47
[15]张爱萍,唐佳妮,孟瑞锋,等.电化学法快速检测微生物的发展现状及趋势[J].生物技术进展,2011,1(5):342-346
[16]Marta Sánchez-Paniagua López,Beatriz López-Ruiz.Electrochemical biosensor based on ionic liquid polymeric microparticles.An analytical platform for catechol[J].Microchemical Journal,2018,138:173-179
[17]Materon EM,Huang JPJ,Wong A,et al.Glutathione-s-transferase modified electrodes for detecting anticancer drugs[J].Biosensors and Bioelectronics,2014,58:232-236
[18]Wu D,Guo AP,Guo ZK,et al.Simultaneous electrochemical detection of cervical cancer markers using reduced graphene oxide-tetraethylene pentamine as electrode materials and distinguishable redox probes as labels[J].Biosensors and Bioelectronics,2014,54:634-639
[19]Kara P,Meric B,Ozsoz M.Application of Impedimetric and Voltammetric Genosensor for Detection of a Biological Warfare:Anthrax[J].Electroanalysis,2010,20(24):2629-2634
[20]Shabani A,Zourob M,Allain B,et al.Bacteriophage-modified microarrays for the direct impedimetric detection of bacteria[J].Analytical Chemistry,2008,80(24):9475-9482
[21]Gamella M,Campuzano S,Parrado C,et al.Microorganisms recognition and quantification by lectin adsorptive affinity impedance[J].Talanta,2009,78(4):1303-1309
[22]Umer Farooq,Qiaoli Yang,Muhammad Wajid Ullah,et al.Bacterial biosensing:Recent advances in phage-based bioassays and biosensors[J].Biosensors and Bioelectronics,2018,118:204-216
[23]Hoda Ilkhani,Siamak Farhad.A novel electrochemical DNA biosensor for Ebola virus detection[J].Analytical Biochemistry,2018,557:151-155
[24]C Day,S S覬pstad,H Ma,et al.Impedance-based sensor for potassium ions[J].Analytica Chimica Acta,2018,1034(30):39-45
[25]E Fazio,S G Leonardi,M Santoro,et al.Synthesis,characterization and hydrogen sensing properties of nanosized colloidal rhodium oxides prepared by Pulsed Laser Ablation in water[J].Sensors&Actuators:B.Chemical,2018,262:79-85
[26]Jia XL,Liu ZM,Liu N,et al.A label-free immunosensor based on graphene nanocomposites for simultaneous multiplexed electrochemical determination of tumor markers[J].Biosensors and Bioelectronics,2014,53:160-166
[27]O O Soldatkin,O S Burdak,T A Sergeyeva,et al.Acetylcholinesterase-based conductometric biosensor for determination of aflatoxin B1[J].Sensors&Actuators:B.Chemical,2013,188:999-1003
[28]周从燕,李丽蓉,刘入源.纳米基电分析生物传感器在食品兽药残留检测中的研究与应用进展[J].食品安全质量检测学报,2017,8(1):150-155
[29]Steffen Rameil,Peter Schubert,Peter Grundmann,et al.Use of 3-(4-hydroxyphenyl)propionic acid as electron donating com-pound in a potentiometric aflatoxin M1-immunosensor[J].Analytica Chimica Acta,2009,661(1):122-127
[30]Evangelia Larou,Iakovos Yiakoumettis,Grigoris Kaltsas,et al.High throughput cellular biosensor for the ultra-sensitive,ultra-rapid detection of aflatoxin M1[J].Food Control,2013,29(1):208-212