痉病核心药证复杂网络分析

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英文篇名：Complex Network Analysis of Clinical Core Medicines and Syndromes Based on Association Rules in Convulsive Diseases 作者：陈延 ; 谭子虎 ; 吴永贵 ; 李贤炜 ; 柳弘汉 ; 梅应兵 ; 杨琼 英文作者：CHEN Yan;TAN Zihu;WU Yonggui;LI Xianwei;LIU Honghan;MEI Yingbing;YANG Qiong;Hubei Integrated Chinese and Western Medicine Hospital;Hubei Provincial Hospital of Chinese Medicine;Hubei University of Chinese Medicine; 关键词：痉病 ; 项背强直 ; 神疲 ; 不寐 ; 脉细 ; 关联规则 ; 复杂网络 英文关键词：convulsive disease;;back stiffness;;fatigue;;insomnia;;thin and weak pulse;;association rules;;complex network 中文刊名：HNZK 英文刊名：Acta Chinese Medicine 机构：湖北省中西医结合医院;湖北省中医院;湖北中医药大学; 出版日期：2019-01-29 09:29 出版单位：中医学报 年：2019 期：v.34;No.249 基金：国家中医药管理局标准化项目(2014238) 语种：中文; 页：HNZK201902052 页数：3 CN：02 ISSN：41-1411/R 分类号：220-222

摘要

目的:探讨痉病核心证候及药物应用规律。方法:通过病例调查表在全国11家单位收集病例资料237例,采用关联规则分析痉病证候与证候、药物与药物、药物与证候之间的关联规则,运用复杂网络分析建立网络模型。结果:利用关联规则选取置信度在60%以上证候关联项11条,中药关联项58条,中药与证候关联项20条,网络图显示痉病临床以项背强直、神疲、不寐、脉细为核心证候,芍药、甘草为核心药对,六味地黄丸、二陈汤等为核心方剂。结论:痉病证候和用药体现了痉病阴虚的基本病机,显示了痉病核心处方药物随临床常见气虚、痰浊、风动、气滞、血瘀等证候加减变化的规律。
        Objective:To explore the core syndromes of rickets and the application of drugs.Methods:A total of 237 cases of case data were collected from 11 units in the country through the case questionnaire.The association rules were used to analyze the association rules between syndromes and syndromes,drugs and drugs,drugs and syndromes,and complex network analysis was used to establish a network model.Results:Using association rules,11 related items with 60% confidence level,58 Chinese medicine related items,and 20 Chinese medicine and syndrome related items were selected.The network diagram shows that the rickets are clinically strong,scared,and uncomfortable.The pulse is the core syndrome,and the peony and licorice are the core drugs.Liu Wei Dihuang Pill and Erchen Decoction can be seen.Conclusion:The syndromes and medications of rickets reflect the basic pathogenesis of rickets yin deficiency,which shows the regularity of the core prescription drugs of rickets with the common Qi deficiency,turbidity,Wind,Qi stagnation,blood stasis and other syndromes.

引文

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