原发性高血压及左室肥厚患者外周血儿茶酚抑素、脑钠肽及同型半胱氨酸检测的临床意义
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摘要
目的探讨原发性高血压(EH)及左室肥厚(LVH)患者检测儿茶酚抑素(CST)、脑钠肽(BNP)、同型半胱氨酸(Hcy)的临床意义。方法选取2017年8月-2018年7月收治的EH患者120例纳入研究,其中LVH组53例、非LVH(NLVH)组67例,1级高血压48例、2级高血压52例、3级高血压20例,另选取同期健康体检者50例为对照组。所有受试者于晨起安静状态下采用超声心动仪测定左室重量指数(LVMI),于晨起空腹抽取静脉血,测定血浆CST,血清BNP及Hcy水平。结果 NLVH和LVH组LVMI、GST、BNP、Hcy均高于对照组(P均<0.01);NLVH组LVMI、GST、BNP均高于LVH组(P均<0.01)。1级高血压LVMI、BNP均高于对照组(P均<0.05),2级高血压、3级高血压LVMI、GST、BNP、Hcy均高于对照组(P均<0.01);1级高血压、2级高血压、3级高血压间LVMI、GST、BNP、Hcy比较差异有统计学意义(P均<0.01)。结论 EH患者外周血中GST、BNP、Hcy水平检测可用于判断LVH严重程度。
Objective To explore the correlation of catechostatin(CST),brain natriuretic peptide(BNP),and(Homocysteine)Hcy with the essential hypertension(EH) and left ventricle hypertrophy(LVH).Methods A total of 120 patients with EH who were admitted in our hospital from August,2017 to July,2018 were included in the study,among which 53 cases in LVH group,67 cases in NLVH group;48 had grade 1 hypertension,52 had grade 2 hypertension,and 20 had grade 3 hypertension. Moreover,50 healthy individuals who came for physical examination were served as the control group. Under the rest state in the morning,the ultrasound cardiotachograph was used to detect LVMI. The morning fasting venous blood was collected to detect the plasma CST,BNP and Hcy. Results LVMI,CST,BNP,and Hcy in NLVH and LVH groups were significantly higher than those in the control group(P all <0.01). LVMI,CST,and BNP in NLVH group were significantly higher than those in LVH group(P all < 0.01). LVMI and BNP in grade 1 hypertension group were significantly higher than those in the control group(P all < 0.05). LVMI,CST,BNP,and Hcy in hypertension 2 and 3 groups were significantly higher than those in the control group(P all < 0.01). The comparison of LVMI,CST,BNP,and Hcy among grade 1,2,and 3 hypertension groups was statistically significant(P all <0.01). Conclusion The peripheral blood CST,BNP,and Hcy levels in EH patients are significantly higher than those in the healthy individuals,whose level can reflect the severity degree of LVH.
Objective To explore the correlation of catechostatin(CST),brain natriuretic peptide(BNP),and(Homocysteine)Hcy with the essential hypertension(EH) and left ventricle hypertrophy(LVH).Methods A total of 120 patients with EH who were admitted in our hospital from August,2017 to July,2018 were included in the study,among which 53 cases in LVH group,67 cases in NLVH group;48 had grade 1 hypertension,52 had grade 2 hypertension,and 20 had grade 3 hypertension. Moreover,50 healthy individuals who came for physical examination were served as the control group. Under the rest state in the morning,the ultrasound cardiotachograph was used to detect LVMI. The morning fasting venous blood was collected to detect the plasma CST,BNP and Hcy. Results LVMI,CST,BNP,and Hcy in NLVH and LVH groups were significantly higher than those in the control group(P all <0.01). LVMI,CST,and BNP in NLVH group were significantly higher than those in LVH group(P all < 0.01). LVMI and BNP in grade 1 hypertension group were significantly higher than those in the control group(P all < 0.05). LVMI,CST,BNP,and Hcy in hypertension 2 and 3 groups were significantly higher than those in the control group(P all < 0.01). The comparison of LVMI,CST,BNP,and Hcy among grade 1,2,and 3 hypertension groups was statistically significant(P all <0.01). Conclusion The peripheral blood CST,BNP,and Hcy levels in EH patients are significantly higher than those in the healthy individuals,whose level can reflect the severity degree of LVH.
引文
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[11]吴斌,顾菊红,耿海华,等.左房容积指数与血清氨基末端脑钠肽前体在评价原发性高血压左室舒张功能不全中的作用[J].南通大学学报(医学版),2015,35(4):269-273.
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[13]荣爱国.原发性高血压患者血同型半胱氨酸、颈动脉粥样硬化与24h血压变异性的关系[J].血栓与止血学,2017,23(6):924-926.
[14]陈小龙,丁春丽,王璐.原发性高血压合并左心室肥厚与血浆同型半胱氨酸水平的相关性研究[J].中国循证心血管医学杂志,2017,9(6):742-744.
[15]刁杰,夏豪.原发性高血压病人同型半胱氨酸水平与动脉病变及左心室肥厚的关系探讨[J].中西医结合心脑血管病杂志,2016,14(11):1197-1200.
[16]刘傲亚,朱永芳,王宁.原发性高血压患者动态血压参数与左心室肥厚的相关性研究[J].中国康复理论与实践,2016,22(6):724-728.
[17]郑雯,荣阳,马殿忠,等.原发性高血压患者左心室肥厚对预后的影响与临床研究[J].中国医药指南,2016,14(27):131-132.
[2]黄菊香,聂连涛,李中健.原发性高血压患者心电图改变与自主神经功能关系研究[J].中国全科医学,2016,19(20):2423-2425.
[3]杨祥,龚剑锋,向镜芬,等.儿茶酚抑素水平与慢性心力衰竭病人预后的相关性[J].蚌埠医学院学报,2017,42(4):447-450.
[4]王蕾,熊声贺,张俊,等.同型半胱氨酸、血脂、肾功能指标及颈动脉超声在H型高血压中的临床应用价值[J].检验医学,2017,32(12):1109-1113.
[5]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616.
[6]邓阳生,刘全未,赵增光.原发性高血压患者心血管风险水平分层研究[J].中国现代医学杂志,2016,26(4):133-137.
[7]吴振东,高伟勤,孔繁和,等.血浆儿茶酚抑素水平与原发性高血压的相关性研究[J].黑龙江医药科学,2014,37(1):56-57.
[8]李洁,荆忱,刘义欣,等.儿茶酚抑素在急性冠状动脉综合征患者中的检测价值[J].临床心血管病杂志,2016,32(6):566-569.
[9]许涛,王慧莹,李莉,等.血浆儿茶酚抑素水平与急性心肌梗死预后的相关性研究[J].河北医科大学学报,2016,37(5):579-582.
[10]任雪丽,谭仕芸,陈海波,等.高血压伴心功能不全患者的BNP、Hcy和hs-CRP表达及临床意义[J].解放军医药杂志,2016,28(12):73-76.
[11]吴斌,顾菊红,耿海华,等.左房容积指数与血清氨基末端脑钠肽前体在评价原发性高血压左室舒张功能不全中的作用[J].南通大学学报(医学版),2015,35(4):269-273.
[12]吴曼,刘铁楠,郑德清,等.原发性高血压患者不同左室舒张功能状态与脑钠肽的相关性分析[J].河北联合大学学报(医学版),2015,17(6):194-196.
[13]荣爱国.原发性高血压患者血同型半胱氨酸、颈动脉粥样硬化与24h血压变异性的关系[J].血栓与止血学,2017,23(6):924-926.
[14]陈小龙,丁春丽,王璐.原发性高血压合并左心室肥厚与血浆同型半胱氨酸水平的相关性研究[J].中国循证心血管医学杂志,2017,9(6):742-744.
[15]刁杰,夏豪.原发性高血压病人同型半胱氨酸水平与动脉病变及左心室肥厚的关系探讨[J].中西医结合心脑血管病杂志,2016,14(11):1197-1200.
[16]刘傲亚,朱永芳,王宁.原发性高血压患者动态血压参数与左心室肥厚的相关性研究[J].中国康复理论与实践,2016,22(6):724-728.
[17]郑雯,荣阳,马殿忠,等.原发性高血压患者左心室肥厚对预后的影响与临床研究[J].中国医药指南,2016,14(27):131-132.