小儿咽扁颗粒抗急性咽炎药理作用研究

详细信息    查看全文 | 推荐本文 |

英文篇名：Study on the Pharmacological Effects of Xiaoer Yanbian Granules in the Acute Pharyngitis 作者：张可可 ; 陈建新 ; 张芬 ; 段娟慧 ; 代耀兰 ; 杨若聪 ; 吴传鸿 ; 段飞鹏 ; 李京忠 ; 赵慧辉 ; 李韶菁 英文作者：Zhang Keke;Chen Jianxin;Zhang Fen;Duan Juanhui;Dai Yaolan;Yang Ruocong;Wu Chuanhong;Duan Feipeng;Li Jingzhong;Zhao Huihui;Li Shaojing;Beijing University of Chinese Medicine;Huarun Sanjiu Medical & Pharmaceutical Co.,Ltd.;School of Life Science and Engineering,Southwest Jiaotong University;University of Macau;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences; 关键词：小儿咽扁颗粒 ; 急性咽炎 ; 氨水喷雾 ; 抗炎 ; 药理 ; 大鼠 ; 免疫 英文关键词：Xiaoer Yanbian Granules;;Acute pharyngitis;;Ammonia spraying;;Anti-inflammatory;;Pharmacology;;Rats;;Immunity 中文刊名：SJZA 英文刊名：World Chinese Medicine 机构：北京中医药大学;华润三九医药股份有限公司;西南交通大学生命科学与工程学院;澳门大学;中国中医科学院中药研究所; 出版日期：2019-06-12 13:38 出版单位：世界中医药 年：2019 期：v.14 基金：国家自然科学基金面上项目(81274133);; 中国中医科学院“自主选题”项目(ZXKT17040) 语种：中文; 页：SJZA201905022 页数：5 CN：05 ISSN：11-5529/R 分类号：107-111

摘要

目的:根据小儿咽扁颗粒的临床适应证,研究小儿咽扁颗粒对于急性咽炎的治疗作用,证明其疗效,并初步分析其作用环节。方法:采用咽部氨水喷雾的方法,诱发大鼠急性咽炎(Acute Pharyngitis),观察小儿咽扁颗粒对急性咽炎大鼠免疫功能、血清炎性反应因子的影响以及对咽部黏膜的保护作用。结果:连续给药7 d后,模型组与正常组比较,大鼠表观指标评分比较,差异有统计学意义(P <0. 05);小儿咽扁颗粒低剂量组可显著性降低表观指标评分。连续给药7 d后,病理学指标结果显示小儿咽扁颗粒低、中、高剂量组可不同程度改善咽部炎性反应情况。血清炎性因子检测结果显示,小儿咽扁颗粒不同剂量组可不同程度降低血清炎性因子TNF-α浓度(P <0. 05; P <0. 01)。结论:小儿咽扁颗粒对急性咽炎大鼠有增强免疫功能、降低血清炎性反应因子的作用,对咽部黏膜有一定保护作用。
        Objective: To study the therapeutic effects of Xiaoer Yanbian Granules on acute pharyngitis according to its clinical indications. Methods: Acute pharyngitis in rats was induced by pharyngeal ammonia spray to observe the effects of Xiaoer Yanbian Granules on the immune function and serum inflammatory factors,and the protective effect in pharynx mucosa. Results: After 7 days of continuous administration,there was a significant difference in the apparent index score between the model group and the normal group( P < 0. 05). The low dose of Xiaoer Yanbian Granules significantly reduced the apparent index score. After 7 days of continuous administration,the pathological results showed that the low,medium and high doses of Xiaoer Yanbian Granules could improve the pharyngeal inflammation to different degrees. The results of serum inflammatory factor test showed that the concentration of serum inflammatory factor TNF-α was decreased to different degrees in different dosage groups of Xiaoer Yanbian Granules( P < 0. 05;P < 0. 01). Conclusion: Xiaoer Yanbian Granules could improve immune function,reduce serum inflammatory factors of rats with acute pharyngitis and protect the pharynx mucosa to some extent.

引文

[1]田勇泉.耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2013:128.
    [2]漆浩,张瑞贤,王发渭,等.二十世纪中医药最佳处方(五官科卷)[M].北京:人民卫生出版社,2003:138.
    [3]姚冰,潘洁,王远光,等.儿科用药现状与分析[J].中国医院用药评价与分析,2011,11(1):41-44.
    [4]郑天瑛,杨小琼,蓝丹,等.中药方剂联合超声波雾化治疗慢性咽炎的临床观察[J].中国医药科学,2015,5(12):38-39.
    [5]国家药典编委会.中华人民共和国药典临床用药须知--中药成方制剂卷[M].北京:中国医药科技出版社,2010:774.
    [6]Ma WW,Zhang AH,Sun H,et al.Metabolomics Deciphering Therapeutic Effects and Mechanism of Traditional Chinese Medicines[J].World J Tradit Chin Med,2016,2(3):17-24.
    [7]于兴娟.清凉消暑金银花[N].中国中医药报,2018-7-23(7).
    [8]马云,王尧尧,王蕾,等.忍冬花发育期间形态与13种活性成分含量变化[J].中药材,2018,41(7):1559-1565.
    [9]覃文格,罗试计,杨文进,等.西名壮医杨顺发应用金果榄治疗疾病经验[J].中国民族医药杂志,2017,23(7):12-14.
    [10]胡奇志,贾宪生,胡成刚.金果榄质量评价[J].中国实验方剂学杂志,2015,21(15):57-60.
    [11]许福泉,旭东,陈士林.玄参化学成分及药理活性研究进展[J].中国现代中药,2013,15(9):753-759.
    [12]刘芳,周小江,袁志鹰,等.玄参药材等级质量标准研究(Ⅰ)-基于肉桂酸含量的差异性[J].湖南中医杂志,2018,34(7):181-185.
    [13]童菊华,庞小存,王威,等.杭麦冬与川麦冬中高异黄酮类成分和抗氧化活性的比较[J].中草药,2015,46(20):3091-3095.
    [14]谭玲玲,侯晓敏,胡正海,等.不同产地桔梗药材中桔梗总皂苷和桔梗皂苷D的测定[J].中草药,2015,46(11):1682-1684.
    [15]张宇静,夏晶,仇佳思,等.牛黄中胆汁酸的药理作用及定量分析方法研究进展[J].国际药学研究杂志,2016,43(2):268-274.
    [16]滕毅,杨海玲.冰片在药代动力学方面的研究进展[J].中国临床药理学与治疗学,2015,20(4):469-475.
    [17]急性咽炎动物模型制备规范(草案).中华中医药学会.中药实验药理专业委员会[J].中药药理与临床,2018,34(1):175-178.
    [18]张凯,杨晓瑞.小儿喉痹方治疗急性咽炎药理作用研究[J].亚太传统医药,2017,13(8):6-9.
    [19]Masters SL,Simon A,Aksentijevich I,et al.Horror autoinflammaticus:the molecular pathophysiology of autoinflammatory disease[J].Annu Rev Immunol,2009,27:621-668.
    [20]Walsh LJ,Trinchieri G,Waldorf HA,etc.Human dermal mast cells contain and release tumor necrosis factor alpha,which induces endothelial leukocyte adhesion molecule 1[J].Proc Natl Acad Sci USA,1991,88(10):4220-4424.
    [21]Banks WA,Kastin AJ,Gutierrez EG.Penetration of interleukin-6across the murine blood-brain barrier[J].Neurosci Lett,1994,179(1-2):53-56.
    [22]梁璐,朴晋华,马建丽.急性和慢性咽炎的发病机制与动物模型建立的研究现状[J].临床医药实践,2012,21(7):540-542.