阴虚血瘀型慢性咽炎经玄麦柑桔汤加减联合耳穴贴压治疗的效果分析
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摘要
目的分析阴虚血瘀型慢性咽炎经玄麦柑桔汤加减联合耳穴贴压治疗的效果。方法采用前瞻性研究,根据本研究相关标准于2015年12月～2016年12月在我院纳入120例慢性咽炎(阴虚血瘀型)患者,根据随机数字表法分为观察组和对照组,对照组给予西医常规治疗,观察组在此基础上使用玄麦柑桔汤加减和耳穴贴压。比较两组治疗前中医症状体征总分及各项积分;统计两组治疗总有效率、不良反应发生率、6个月复发率及1年复发率。结果治疗后,观察组中医症状及体征积分降低且低于对照组,治疗前后中医症状及体征积分差值大于对照组;治疗后,观察组除咽部灼热感,症状及体征其余指标积分均低于对照组。观察组治疗总有效率(91.67%)高于对照组(75.00%),1年复发率(30.00%)低于对照组(46.67%),差异均有统计学意义(P<0.05)。两组不良反应发生率、6个月复发率比较差异无统计学意义(P>0.05)。结论在常规西医治疗基础上采用玄麦柑桔汤加减和耳穴贴治疗能提高阴虚血瘀型慢性咽炎疗效,缓解症状,改善体征,减低远期复发率,用药安全,值得推广。
Objective To analyze the effect of Xuanmai Ganju decoction addition and subtraction combined with auricular pressure in the treatment of yin deficiency and blood stasis type chronic pharyngitis. Methods A prospective study was conducted. According to the relevant criteria of this study, 120 patients with chronic pharyngitis(yin deficiency and blood stasis type)in the hospital from December 2015 to December 2016 were enrolled. The patients were divided into observation group and control group according to random number table method. The control group was given conventional treatment by Western medicine, and the observation group was treated with Xuanmai Ganju decoction addition and subtraction combined with auricular pressure on the above basis. The total scores and scores of TCM symptoms and signs before and after treatment were compared between the two groups. The total effective rate, adverse reaction rate,6-month recurrence rate and 1-year recurrence rate were compared between the two groups. Results After treatment,the scores of TCM symptoms and signs in the observation group decreased and were lower than those of the control group. The difference of TCM symptoms and signs scores before and after treatment was larger than that of the control group. After treatment, the remaining indicators of symptoms and signs in the observation group were lower than those of the control group, except for the pharyngeal burning sensation.The total effective rate of treatment in the observation group(91.67%) was higher than that of the control group(75.00%), and the 1-year recurrence rate(30.00%) in the observation group was lower than that of the control group(46.67%), the differeces were satistically significant(P<0.05).There were no significant differences in adverse reations and 6-month recurrence between the two groups(P>0.05).Conclusion On the basis of conventional western medicine treatment, the use of Xuanmai Ganju decoction addition and subtraction combined with auricular pressure can improve the curative effect of yin deficiency and blood stasis type chronic pharyngitis, relieve symptoms, improve physical signs, reduce long-term recurrence rate, safe medication, and it is worth promoting.
Objective To analyze the effect of Xuanmai Ganju decoction addition and subtraction combined with auricular pressure in the treatment of yin deficiency and blood stasis type chronic pharyngitis. Methods A prospective study was conducted. According to the relevant criteria of this study, 120 patients with chronic pharyngitis(yin deficiency and blood stasis type)in the hospital from December 2015 to December 2016 were enrolled. The patients were divided into observation group and control group according to random number table method. The control group was given conventional treatment by Western medicine, and the observation group was treated with Xuanmai Ganju decoction addition and subtraction combined with auricular pressure on the above basis. The total scores and scores of TCM symptoms and signs before and after treatment were compared between the two groups. The total effective rate, adverse reaction rate,6-month recurrence rate and 1-year recurrence rate were compared between the two groups. Results After treatment,the scores of TCM symptoms and signs in the observation group decreased and were lower than those of the control group. The difference of TCM symptoms and signs scores before and after treatment was larger than that of the control group. After treatment, the remaining indicators of symptoms and signs in the observation group were lower than those of the control group, except for the pharyngeal burning sensation.The total effective rate of treatment in the observation group(91.67%) was higher than that of the control group(75.00%), and the 1-year recurrence rate(30.00%) in the observation group was lower than that of the control group(46.67%), the differeces were satistically significant(P<0.05).There were no significant differences in adverse reations and 6-month recurrence between the two groups(P>0.05).Conclusion On the basis of conventional western medicine treatment, the use of Xuanmai Ganju decoction addition and subtraction combined with auricular pressure can improve the curative effect of yin deficiency and blood stasis type chronic pharyngitis, relieve symptoms, improve physical signs, reduce long-term recurrence rate, safe medication, and it is worth promoting.
引文
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[14]李一圣,李文周,卫平,等.咽喉清口含片治疗急性咽炎外感风热证的Ⅲ期临床试验[J].中成药,2017,39(2):266-272.
[15]Badran Hatem,Salah Mohamad,Fawzy Mohamed,et al.Detection of bacterial biofilms in chronic pharyngitis resistant to medical treatment[J].The Annals of Otology,Rhinology,and Laryngology,2015,124(7):567-571.
[16]韦榕飒,潘冬梅,廖金莲,等.放射性口腔黏膜炎患者医护一体化疼痛护理干预[J].护理学杂志,2015,30(6):7-10.
[17]苗壮,姜丹泉.慢性咽炎与心血管危险因素的关系[J].实用医学杂志,2015,31(16):2672-2674.
[18]苗壮.不良生活方式和肥胖与慢性咽炎的关系研究[J].天津医药,2017,45(2):200-204.
[19]胡北,姚东,王琳琳,等.咽炎糖浆质量控制[J].医药导报,2016,19(3):285-288.
[20]O'Meara Wendy P,Mott Joshua A,Laktabai Jeremiah,et al Etiology of pediatric fever in western Kenya:A casecontrol study of falciparum malaria,respiratory viruses,and streptococcal pharyngitis[J].The American Journal of Tropical Medicine and Hygiene,2015,92(5):1030-1037.
[21]朱建明.HPLC法测定咽炎含片中橙皮苷的含量[J].西部中医药,2015,28(6):22-24.
[2]陈华,于波涛,金伟华,等.咽炎灵颗粒中药材的薄层色谱鉴别和甘草酸铵的测定[J].华西药学杂志,2016,31(1):79-81.
[3]汪宇,杨光照,崔思娇,等.咽炎灵分散片中药材提取工艺考察[J].中国药师,2017,20(6):1123-1125.
[4]安静娟,朱春晖.“利咽止敏方”治疗过敏性咽炎30例临床研究[J].江苏中医药,2017,49(4):46-47.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:392.
[6]王德鉴,千祖望.中医耳鼻咽喉科学[M].上海:上海科学技术出版社,1984.
[7]国家中医药管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:47-48.
[8]叶再青.肿痛安胶囊联合阿莫西林治疗急性咽炎43例临床观察[J].河北中医,2016,38(4):607-608.
[9]高秀芹,肖建彪,张旭,等.中医穴位贴敷联合超短波治疗慢性咽炎的临床疗效评价[J].临床和实验医学杂志,2015,15(11):922-924.
[10]肖伊,闫占峰,刘真,等.慢性咽炎患者中医体质及治疗特点研究[J].现代中医临床,2015,22(5):31-34.
[11]杜晓轲,陈文勇,李云英,等.基于方证信息采集探索李云英教授治疗慢性咽炎经验的研究[J].西部中医药,2017,30(6):50-51.
[12]熊俊伟,李兵,周维康,等.孟鲁司特钠联合养阴合剂治疗过敏性咽炎疗效分析[J].中国临床研究,2015,28(7):941-943.
[13]Elisabeth Holden,Hirminder Ubhi,Mitul Patel,et al.Scarlet fever:Acute management and infection control[J].Clinical pharmacist,2015,7(3):68-70.
[14]李一圣,李文周,卫平,等.咽喉清口含片治疗急性咽炎外感风热证的Ⅲ期临床试验[J].中成药,2017,39(2):266-272.
[15]Badran Hatem,Salah Mohamad,Fawzy Mohamed,et al.Detection of bacterial biofilms in chronic pharyngitis resistant to medical treatment[J].The Annals of Otology,Rhinology,and Laryngology,2015,124(7):567-571.
[16]韦榕飒,潘冬梅,廖金莲,等.放射性口腔黏膜炎患者医护一体化疼痛护理干预[J].护理学杂志,2015,30(6):7-10.
[17]苗壮,姜丹泉.慢性咽炎与心血管危险因素的关系[J].实用医学杂志,2015,31(16):2672-2674.
[18]苗壮.不良生活方式和肥胖与慢性咽炎的关系研究[J].天津医药,2017,45(2):200-204.
[19]胡北,姚东,王琳琳,等.咽炎糖浆质量控制[J].医药导报,2016,19(3):285-288.
[20]O'Meara Wendy P,Mott Joshua A,Laktabai Jeremiah,et al Etiology of pediatric fever in western Kenya:A casecontrol study of falciparum malaria,respiratory viruses,and streptococcal pharyngitis[J].The American Journal of Tropical Medicine and Hygiene,2015,92(5):1030-1037.
[21]朱建明.HPLC法测定咽炎含片中橙皮苷的含量[J].西部中医药,2015,28(6):22-24.
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