无创呼吸机治疗特发性肺间质纤维化合并呼吸衰竭患者的临床效果
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摘要
目的探讨无创呼吸机治疗特发性肺间质纤维化合并呼吸衰竭患者的临床效果。方法选取160例特发性肺间质纤维化合并呼吸衰竭患者,随机分为参照组与研究组,每组80例。参照组采用常规治疗,研究组采用无创呼吸机治疗。治疗2个月后比较2组疗效,包括并发症发生情况、治疗总有效率及治疗前后二氧化碳分压[p(CO_2)]、氧分压[p(O_2)]、第1秒用力肺活量(FEV1)、呼气流量峰值(PEF)、最大通气量(MVV)、呼吸困难评分变化。结果研究组并发症发生率显著低于参照组(P <0. 05)。研究组治疗总有效率显著高于参照组(P <0. 05)。治疗前,2组p(CO_2)、p(O_2)、FEV1、PEF、MVV等指标及呼吸困难评分比较无显著差异(P> 0. 05)。治疗后,研究组p(CO_2)、p(O_2)、FEV1、PEF、MVV等肺功能指标均显著高于参照组,呼吸功能评分显著低于参照组(P <0. 05)。结论无创呼吸机治疗特发性肺间质纤维化合并呼吸衰竭患者的临床效果显著,能够改善其肺功能,降低并发症发生风险。
Objective To explore the clinical efficiency of non-invasive ventilator in the treatment of patients with idiopathic pulmonary interstitial fibrosis complicated with respiratory failure.Methods A total of 160 patients with idiopathic pulmonary interstitial fibrosis complicated with respiratory failure were selected and randomly divided into reference group and research group,with 80 cases in each group. The reference group was treated with conventional therapy,while the research group was treated with non-invasive ventilator. Efficacy was compared after 2 months of treatment between two groups,including complications,total effective rate,partial pressure of carbon dioxide[p( CO_2) ],partial pressure of oxygen [p( O_2) ],the forced expiratory volume in first second( FEV1),peak expiratory flow( PEF),maximal ventilatory volume( MVV) and dyspnea score. Results The incidence rate of complications in the research group was significantly lower than that in the control group( P < 0. 05). The total effective rate in the research group was significantly higher than that in the control group( P < 0. 05). Before treatment,there were no significant differences in p( CO_2),p( O_2),FEV1,PEF,MVV and dyspnea score between the two groups( P > 0. 05). After treatment,p( CO_2),p( O_2),FEV1,PEF and MVV in the research group were significantly higher than those in the reference group,while the respiratory function score was significantly lower than the reference group( P < 0. 05). Conclusion Non-invasive ventilator is effective in treating patients with idiopathic pulmonary interstitial fibrosis complicated with respiratory failure,which can improve lung function and reduce the risk of complications.
Objective To explore the clinical efficiency of non-invasive ventilator in the treatment of patients with idiopathic pulmonary interstitial fibrosis complicated with respiratory failure.Methods A total of 160 patients with idiopathic pulmonary interstitial fibrosis complicated with respiratory failure were selected and randomly divided into reference group and research group,with 80 cases in each group. The reference group was treated with conventional therapy,while the research group was treated with non-invasive ventilator. Efficacy was compared after 2 months of treatment between two groups,including complications,total effective rate,partial pressure of carbon dioxide[p( CO_2) ],partial pressure of oxygen [p( O_2) ],the forced expiratory volume in first second( FEV1),peak expiratory flow( PEF),maximal ventilatory volume( MVV) and dyspnea score. Results The incidence rate of complications in the research group was significantly lower than that in the control group( P < 0. 05). The total effective rate in the research group was significantly higher than that in the control group( P < 0. 05). Before treatment,there were no significant differences in p( CO_2),p( O_2),FEV1,PEF,MVV and dyspnea score between the two groups( P > 0. 05). After treatment,p( CO_2),p( O_2),FEV1,PEF and MVV in the research group were significantly higher than those in the reference group,while the respiratory function score was significantly lower than the reference group( P < 0. 05). Conclusion Non-invasive ventilator is effective in treating patients with idiopathic pulmonary interstitial fibrosis complicated with respiratory failure,which can improve lung function and reduce the risk of complications.
引文
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[6]包鹤龄,方利文,王临虹. 1990-2014年中国40岁及以上人群慢性阻塞性肺疾病患病率Meta分析[J].中华流行病学杂志,2016,37(1):119-125.
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[8]王瑞,王建华,何积银.无创呼吸机对特发性肺间质纤维化合并感染患者的临床治疗效果分析[J].四川医学,2018,39(4):408-411.
[9]赵娟.无创呼吸机治疗特发性肺间质纤维化合并感染的临床疗效[J].中国医药指南,2015,13(35):149-149.
[10]章德军.特发性肺间质纤维化合并感染患者应用无创呼吸机治疗的临床效果观察[J].现代实用医学,2016,28(12):1589-1590.
[11]周倜,朱煜明,张秋娣,等.不同给氧方式对特发性肺间质纤维化急性加重期的疗效观察[J].西部医学,2013,25(5):749-751.
[2]谢荣华,杨西超,庞琳烜,等.结缔组织病相关肺纤维化、未分化结缔组织病相关肺纤维化和特发性肺纤维化特征分析[J].山西医科大学学报,2016,47(8):737-741.
[3] White E S,Xia M,Murray S,et al. Plasma Surfactant Protein-D,Matrix Metalloproteinase-7,and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis From Other Idiopathic Interstitial Pneumonias[J]. American Journal of Respiratory&Critical Care Medicine,2016,194(10):1242-1249.
[4]梁丽娟,梁立荣,代华平.特发性肺间质纤维化患者生活质量评价量表研制[J].中国中西医结合杂志,2016,36(6):668-673.
[5]祝莉娜.汉防己甲素联合虫草菌粉和胸腺肽治疗特发性肺间质纤维化的临床疗效比较[J].社区医学杂志,2017,15(5):39-41.
[6]包鹤龄,方利文,王临虹. 1990-2014年中国40岁及以上人群慢性阻塞性肺疾病患病率Meta分析[J].中华流行病学杂志,2016,37(1):119-125.
[7]李冰冰,许涵,李维.无创呼吸机在肺间质纤维化伴呼吸衰竭患者临床治疗中的应用研究[J].中国医疗器械信息,2017,23(6):56-57.
[8]王瑞,王建华,何积银.无创呼吸机对特发性肺间质纤维化合并感染患者的临床治疗效果分析[J].四川医学,2018,39(4):408-411.
[9]赵娟.无创呼吸机治疗特发性肺间质纤维化合并感染的临床疗效[J].中国医药指南,2015,13(35):149-149.
[10]章德军.特发性肺间质纤维化合并感染患者应用无创呼吸机治疗的临床效果观察[J].现代实用医学,2016,28(12):1589-1590.
[11]周倜,朱煜明,张秋娣,等.不同给氧方式对特发性肺间质纤维化急性加重期的疗效观察[J].西部医学,2013,25(5):749-751.
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