摘要
间质细胞瘤是睾丸最常见的性索-间质肿瘤,但恶性间质细胞瘤极为罕见,且术前影像学检查常难以明确其性质,确诊需要依靠术后病理,本文报道1例老年男性睾丸恶性间质细胞瘤,复习其组织学和免疫组织化学特点,以提高对本病的认识。
Leydig cell tumors are the most common sex cord-stromal tumor of testis,while malignant leydig cell tumors are rare.In virtue of the limitation of preoperative radiological image,the correct diagnosis depends on pathological examination with operative specimen. In order to improve the understanding of this disease,this report presents one case of malignant testicular leydig cell tumor in an elderly old man,reviewing the histological and immunohistological characteristics.
引文
[1]哈英娣,董亮,钱震,等.睾丸间质细胞瘤的电镜观察和分析[J].电子显微学报,1999,18(3):367-370.
[2]蔡林,邵光军,何群,等.成人睾丸间质细胞瘤:单中心17例报告[J].中华泌尿外科杂志,2014,35(2):111-114.
[3]Kim I,Young R H,Scully R E.Leydig cell tumors of the testis.Aclinicopathological analysis of 40 cases and review of the literature[J].Am JSurg Pathol,1985,9(3):177-192.
[4]Mccluggage W G,Shanks J H,Arthur K,et al.Cellular proliferation and nuclear ploidy assessments augment established prognostic factors in predicting malignancy in testicular Leydig cell tumours[J].Histopatholo gy,1998,33(4):361-368.
[5]Hendry J,Fraser S,White J,et al.Retroperitoneal lymph node dissection(RPLND)for malignant phenotype Leydig cell tumours of the testis:a 10-year experience[J].Springerplus,2015,4:20.
[6]Abiuso A,Varela M L,Haro D L,et al.Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys[J].Eur J Cancer,2018,91:125-135.