参茯五味芍药汤对突发性耳聋治疗前后信噪比的影响
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摘要
目的探讨畸变产物耳声发射(DPOAE)中信噪比的变化,评价参茯五味芍药汤治疗突发性耳聋的疗效。方法 120例突发性耳聋患者,随机分为治疗组(60例)和对照组(60例),前者采用参茯五味芍药汤结合综合治疗的方法,后者仅采用综合方法治疗,疗程2周,治疗前后观察2组的临床疗效。结果治疗组治疗前的耳声发射通过率为36.7%,治疗后提高到71.7%;对照组治疗前的耳声发射通过率为43.3%,治疗后提高到58.3%。治疗组对耳声发射通过率的提高明显优于对照组(P<0.01)。比较各频率点信噪比(SNR),治疗组能有效提高0.5、1、2、8 k Hz频率点的SNR,且优于对照组(P<<0.05)。结论参茯五味芍药汤治疗突发性耳聋的疗效明显,耳声发射对于评价突发性耳聋的临床疗效具有重要的意义。
Objective To investigate the effect of the change of the noise ratio of distortion product otoacoustic emissions(DPOAE) on sudden deafness. Methods 120 patients with sudden deafness were randomly divided into two groups, 60 cases were treated with Shenfu Wuwei Shaoyao decoction as treating group and 60 were cases treated with chemical drugs as control group. The therapies were all lasted for two weeks for the patients in the two groups. The therapeutic effects were then evaluated by the end of therapy.Results In the treatment group, the rate of otoacoustic emission before treatment was 35%, which was increased to 70% after treatment, the rate of otoacoustic emission the control group before treatment was 45%, and the improvement to 56.7% after treatment. In the treatment group, the improvement of the passing rate of the otoacoustic emission was significantly better than that of the control group(P<0.01). Compared with the control group(P<0.05), the signal to noise ratio(SNR) of each frequency point could be improved by 0.5, 1, 2 and 8 kHz. Conclusion Shenfu Wuwei Shaoyao decoction is very effective on sudden deafness. Distortion product otoacoustic emission has important significance for the evaluation of the clinical efficacy of sudden deafness.
Objective To investigate the effect of the change of the noise ratio of distortion product otoacoustic emissions(DPOAE) on sudden deafness. Methods 120 patients with sudden deafness were randomly divided into two groups, 60 cases were treated with Shenfu Wuwei Shaoyao decoction as treating group and 60 were cases treated with chemical drugs as control group. The therapies were all lasted for two weeks for the patients in the two groups. The therapeutic effects were then evaluated by the end of therapy.Results In the treatment group, the rate of otoacoustic emission before treatment was 35%, which was increased to 70% after treatment, the rate of otoacoustic emission the control group before treatment was 45%, and the improvement to 56.7% after treatment. In the treatment group, the improvement of the passing rate of the otoacoustic emission was significantly better than that of the control group(P<0.01). Compared with the control group(P<0.05), the signal to noise ratio(SNR) of each frequency point could be improved by 0.5, 1, 2 and 8 kHz. Conclusion Shenfu Wuwei Shaoyao decoction is very effective on sudden deafness. Distortion product otoacoustic emission has important significance for the evaluation of the clinical efficacy of sudden deafness.
引文
[1]张静,周慧芳.耳声发射的临床应用[J].国外医学·耳鼻咽喉科学分册,2005(6):28-31.
[2]郑雅丽,李永新,于子龙,等.突发性聋预后影响因素[J].中国耳鼻咽喉头颈外科,2008(8):451-453.
[3] Salvi R J,Ding D,Wang J,et al. A review of the effects of selective inner hair cell lesions on distortion product otoacoustic emissions,cochlear function and auditory evoked potentials[J]. Noise Health,2000,2(6):9-26.
[4] Kemp D T. Otoacoustic emissions,their origin in cochlear function,and use[J]. Br Med Bull,2002,63:223-241.
[5] Mauermann M,Kollmeier B. Distortion product otoacoustic emission(DPOAE)input/output functions and the influence of the second DPOAE source[J]. J Acoust Soc Am,2004,116(4 Pt 1):2199-2212.
[6] Uchida Y,Ando F,Shimokata H,et al. The effects of aging on distortionproduct otoacoustic emissions in adults with normal hearing[J]. Ear Hear,2008,29(2):176-184.
[7] Ueberfuhr M A,Fehlberg H,Goodman S S,et al. A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss[J].Hear Res,2016,332:137-150.
[8]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.耳突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006(8):569.
[9] Chen Y S,Emmerling Q,Ilgner J,et al. Idiopathic sudden sensorineural hearing loss in children[J]. Int J Pediatr Otorhinolaryngol,2005,69:817.
[10] Teranishi M,Katayama N,Uchida Y,et al. Thirty-year trends in sudden deafness from four nationwide epidemiological surveys in Japan[J]. Acm Otohryngol,2007,127:1259.
[11] Klemm E,Deutscher A,Mosses R. A present investigation of the epidemiology in idiopathic sudden sensorineural hearing loss[J]. Laryngorhinootologie,2009,88:524.
[12]张晓彤,许珉,段茂利,等.突发性聋临床流行病学分析[J].中华耳科学杂志,2009,7(2):152-156.
[13]张晟.突发性耳聋的病因和诊疗进展[J].继续医学教育,2015,29(4):65-66.
[14] Merchant S N,Durand ML,Adams J C. Sudden deafness:is it viral[J].ORL J Otorinolaryngol Relat Spec,2008,70:52.
[15] Shimada A,Ebisu M,Morita T,et al. Age-related changes in the cochlea and cochlear nuclei of dogs[J]. J Vet Med Sci,1998,60(1):41-48.
[16]韩国英,接惠群,殷善开.老年性聋防治的研究进展[J].听力学及言语疾病杂志,2014,22(5):464-467.
[17]谌晶晶,郑芸,李刚,等.耳声发射与纯音听阈之间关系的研究[J].临床耳鼻咽喉头颈外科杂志,2015(18):1591-1597.
[18]许珊,姜学钧,田颖,等.畸变产物耳声发射早期监测老年性耳聋的临床价值[J].中国老年保健医学,2011,9(1):8-10.
[19]唐俊翔,刘博,陈秀伍,等.突发性耳聋伴眩晕患者临床特点分析[J].中国耳鼻咽喉头颈外科,2010,17(10):507-510.
[20]陈银忠,郭清华,俞德顺.突发性聋疗效及预后相关因素分析[J].中国耳鼻咽喉头颈外科,2012,19(11):605-608.
[21] Mori T,Suzuki H,Hiraki N,et al. Prediction of hearing outcomes by distortion product otoacoustic emissions in patients with idiopathic sudden sensorineural hearing loss[J]. Auris Nasus Larynx,2011,38:564-569.
[22]忻耀杰,滕磊,高旭青.《素灵微蕴》学术思想对治疗突发性耳聋的指导意义[J].上海中医药杂志,2011,45(8):15-16.
[23]滕磊,袁波,忻耀杰,等.《四圣心源》辨治耳聋的学术思想探析[J].中医药信息,2016,33(1):67-68.
[24]王海妹,黄继红,周小柳.不同年龄段突发性耳聋临床分析[J].第四军医大学学报,2008(18):1721.
[2]郑雅丽,李永新,于子龙,等.突发性聋预后影响因素[J].中国耳鼻咽喉头颈外科,2008(8):451-453.
[3] Salvi R J,Ding D,Wang J,et al. A review of the effects of selective inner hair cell lesions on distortion product otoacoustic emissions,cochlear function and auditory evoked potentials[J]. Noise Health,2000,2(6):9-26.
[4] Kemp D T. Otoacoustic emissions,their origin in cochlear function,and use[J]. Br Med Bull,2002,63:223-241.
[5] Mauermann M,Kollmeier B. Distortion product otoacoustic emission(DPOAE)input/output functions and the influence of the second DPOAE source[J]. J Acoust Soc Am,2004,116(4 Pt 1):2199-2212.
[6] Uchida Y,Ando F,Shimokata H,et al. The effects of aging on distortionproduct otoacoustic emissions in adults with normal hearing[J]. Ear Hear,2008,29(2):176-184.
[7] Ueberfuhr M A,Fehlberg H,Goodman S S,et al. A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss[J].Hear Res,2016,332:137-150.
[8]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.耳突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006(8):569.
[9] Chen Y S,Emmerling Q,Ilgner J,et al. Idiopathic sudden sensorineural hearing loss in children[J]. Int J Pediatr Otorhinolaryngol,2005,69:817.
[10] Teranishi M,Katayama N,Uchida Y,et al. Thirty-year trends in sudden deafness from four nationwide epidemiological surveys in Japan[J]. Acm Otohryngol,2007,127:1259.
[11] Klemm E,Deutscher A,Mosses R. A present investigation of the epidemiology in idiopathic sudden sensorineural hearing loss[J]. Laryngorhinootologie,2009,88:524.
[12]张晓彤,许珉,段茂利,等.突发性聋临床流行病学分析[J].中华耳科学杂志,2009,7(2):152-156.
[13]张晟.突发性耳聋的病因和诊疗进展[J].继续医学教育,2015,29(4):65-66.
[14] Merchant S N,Durand ML,Adams J C. Sudden deafness:is it viral[J].ORL J Otorinolaryngol Relat Spec,2008,70:52.
[15] Shimada A,Ebisu M,Morita T,et al. Age-related changes in the cochlea and cochlear nuclei of dogs[J]. J Vet Med Sci,1998,60(1):41-48.
[16]韩国英,接惠群,殷善开.老年性聋防治的研究进展[J].听力学及言语疾病杂志,2014,22(5):464-467.
[17]谌晶晶,郑芸,李刚,等.耳声发射与纯音听阈之间关系的研究[J].临床耳鼻咽喉头颈外科杂志,2015(18):1591-1597.
[18]许珊,姜学钧,田颖,等.畸变产物耳声发射早期监测老年性耳聋的临床价值[J].中国老年保健医学,2011,9(1):8-10.
[19]唐俊翔,刘博,陈秀伍,等.突发性耳聋伴眩晕患者临床特点分析[J].中国耳鼻咽喉头颈外科,2010,17(10):507-510.
[20]陈银忠,郭清华,俞德顺.突发性聋疗效及预后相关因素分析[J].中国耳鼻咽喉头颈外科,2012,19(11):605-608.
[21] Mori T,Suzuki H,Hiraki N,et al. Prediction of hearing outcomes by distortion product otoacoustic emissions in patients with idiopathic sudden sensorineural hearing loss[J]. Auris Nasus Larynx,2011,38:564-569.
[22]忻耀杰,滕磊,高旭青.《素灵微蕴》学术思想对治疗突发性耳聋的指导意义[J].上海中医药杂志,2011,45(8):15-16.
[23]滕磊,袁波,忻耀杰,等.《四圣心源》辨治耳聋的学术思想探析[J].中医药信息,2016,33(1):67-68.
[24]王海妹,黄继红,周小柳.不同年龄段突发性耳聋临床分析[J].第四军医大学学报,2008(18):1721.
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