2016-2018年自贡市丙型肝炎感染者基因型分布
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摘要
目的调查自贡市丙肝病毒基因型分布状况,为不同人群丙肝防治提供数据参考。方法对2016-2018年自贡市医院及美沙酮门诊HCV初筛为阳性的186份标本通过HCV-RNA检测,其结果大于1.0×10~3IU/ml的阳性138例标本再进行基因分型试验。结果 186份抗-HCV阳性的标本中,HCV-RNA>1.0×10~3IU/ml核酸阳性标本为138份,共发现5种基因亚型,占比最多的为1b型(50例,36.23%),其次为6a型(41例,29.71%)和3b型(19.57%)。普通人群HCV感染以1b型(55.26%)为主,其次为6a型(23.68%),吸毒人群HCV感染以6a型(38.71%)为主,其次为3b型(25.81%)。结论自贡地区丙肝病毒基因型流行株普通人群为1b、6a型,尤以1b为主,吸毒人群为6a、3b型,尤以6a为主。
Objective To investigate the genotype distribution of hepatitis C in Zigong City so as to provide reference for the prevention and treatment of hepatitis in different populations. Methods One hundred and eighty six HCV-positive specimens found in preliminary screening in Zigong Hospital and Methadone Clinic in 2016 to 2018 were assayed for HCV-RNA, and 138 positive specimens with results greater than 1.0×10~3 IU/ml were further genotyped. Results Among the 186 anti-HCVpositive specimens,138 specimens with HCV-RNA>1.0×10~3 IU/ml nucleic acid were found. A total of five genotypes were discovered. Type 1b accounted for the largest proportion(n=50,36.23%),followed by type 6a(n=41,29.71%) and type 3b(19.57%). In the general population,type 1b was the predominant HCV genotype(55.26%), followed by type 6a(23.68%). In drug addicts,type 6a was the predominant HCV genotype(38.71%),followed by type 3b(25.81%). Conclusion Prevalent strains of hepatitis C virus are types 1b and 6a, the former in particular, in the general population and types 6a and 3b, the former in particular,in drug addicts in Zigong.
Objective To investigate the genotype distribution of hepatitis C in Zigong City so as to provide reference for the prevention and treatment of hepatitis in different populations. Methods One hundred and eighty six HCV-positive specimens found in preliminary screening in Zigong Hospital and Methadone Clinic in 2016 to 2018 were assayed for HCV-RNA, and 138 positive specimens with results greater than 1.0×10~3 IU/ml were further genotyped. Results Among the 186 anti-HCVpositive specimens,138 specimens with HCV-RNA>1.0×10~3 IU/ml nucleic acid were found. A total of five genotypes were discovered. Type 1b accounted for the largest proportion(n=50,36.23%),followed by type 6a(n=41,29.71%) and type 3b(19.57%). In the general population,type 1b was the predominant HCV genotype(55.26%), followed by type 6a(23.68%). In drug addicts,type 6a was the predominant HCV genotype(38.71%),followed by type 3b(25.81%). Conclusion Prevalent strains of hepatitis C virus are types 1b and 6a, the former in particular, in the general population and types 6a and 3b, the former in particular,in drug addicts in Zigong.
引文
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[15]彭瑾瑜,贺健梅,郑军,等.湖南省107例HIV和HCV双重感染者HCV基因型分布[J].中华实验和临床病毒学杂志,2017,4(31):127-130.
[16]杨兰辉,陈梅,霍松,等.红河州HIV/HCV合并感染者HCV基因亚型多样性及种系进化研究[J].分子诊断与治疗杂志,2018,10(1):17-24.
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[3]尹秀华.丙型肝炎检测方法的研究进展[J].医学伦理与实践2013,26(2):171-173.
[4]武海波,周紫霄,黄奕祥.2004-2011年中国丙型病毒性肝炎流行病学特征分析[J].现代预防医学,2015,42(7):1173-1175.
[5]杨银辉.病毒基因分型方法的研究进展及应用[J].中华检验医学杂志,2005,28(10):1102-1104.
[6]刘娜,徐光华,李春霞,等.影响丙型肝炎抗病毒疗效因素的研究进展[J].医药综述,2015,21(17):3082-3084.
[7]李伟琴,袁致海,徐光华,等.丙型肝炎基因分型进展及临床意义[J].世界华人消化杂志,2009,17(6):549-554.
[8]Duan Z,Jia JD,Hou J,et al.Current challenges and the management of chronic hepatitis C in mainland China[J].Journal of Clinical Gastroenterology,2014,48(8):679-686.
[9]赵璐,冯悦,夏雪山.HCV基因型的差异性流行与进化[J].遗传,2012,34(6):666-672.
[10]刘剑荣,黄永建.丙型肝炎基因型分布特点及流行分析[J].国际检验学杂志,2010,31(12):1347-1348.
[11]刘丽君,张瑞.中国南部和西部地区HCV感染的基因型分布特征[J].中国现代医学杂志,2007,17(19):2337-2340.
[12]龚卫锋,张养民,郭晓波,等.陕西地区丙肝患者分型与疗效分析[J].昆明医科大学学报,2018,39(8):64-68.
[13]林江,温先勇,唐敏.川南地区丙型肝炎病毒基因型的特征及其临床价值[J].四川医学,2016,37(12):1348-1351.
[14]陶钧,刘勇,童毅,等.贵州吸毒人群丙型肝炎病毒感染者的基因分型研究[J].中国病毒病杂志,2012,2(2):117-122.
[15]彭瑾瑜,贺健梅,郑军,等.湖南省107例HIV和HCV双重感染者HCV基因型分布[J].中华实验和临床病毒学杂志,2017,4(31):127-130.
[16]杨兰辉,陈梅,霍松,等.红河州HIV/HCV合并感染者HCV基因亚型多样性及种系进化研究[J].分子诊断与治疗杂志,2018,10(1):17-24.