地衣芽胞杆菌活菌制剂的临床应用进展
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摘要
整肠生是应用二十多年的地衣芽胞杆菌活菌制剂,已有大量的研究报道其临床有效性和安全性。地衣芽胞杆菌大量分泌种类丰富的消化酶,通过抑制肠道有害菌生长和促进有益菌增殖调节肠道菌群,并产生杆菌肽、地衣素和乙酸等生物活性物质发挥益生作用。本文总结了益生菌的益生特点,并重点分析了芽胞杆菌的益生特点,归纳了整肠生的作用机制与临床研究现状,揭示了其在肝脏疾病、溃疡性结肠炎、肠易激综合征、幽门螺旋杆菌感染以及病毒感染等疾病中的治疗作用,并对整肠生未来的临床应用方向进行了展望。
Zheng Chang Sheng,a live Bacillus licheniformis preparation,is a kind of probiotics which has been used in clinical practice for more than twenty years.Its clinical efficacy and safety have been well-documented.By secreting various digestive enzymes,improving the balance of intestinal flora,and producing many types of bioactive substances such as bacitracin,zearin and acetic acid,the live Bacillus licheniformis preparation plays a probiotic role for the host.This review analysed the probiotic characteristics of probiotics,revealed the characteristics of Bacillus species,summarized the effects of Zheng Chang Sheng in the treatment of liver diseases,ulcerative colitis,irritable bowel syndrome,Helicobacter pylori infection,and virus infection.
Zheng Chang Sheng,a live Bacillus licheniformis preparation,is a kind of probiotics which has been used in clinical practice for more than twenty years.Its clinical efficacy and safety have been well-documented.By secreting various digestive enzymes,improving the balance of intestinal flora,and producing many types of bioactive substances such as bacitracin,zearin and acetic acid,the live Bacillus licheniformis preparation plays a probiotic role for the host.This review analysed the probiotic characteristics of probiotics,revealed the characteristics of Bacillus species,summarized the effects of Zheng Chang Sheng in the treatment of liver diseases,ulcerative colitis,irritable bowel syndrome,Helicobacter pylori infection,and virus infection.
引文
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[12]刘巍,史娇.参苓白术散联合整肠生治疗腹泻型肠易激综合征的疗效观察[J].临床医药文献杂志,2015,2(20):4255-4256.
[13]杨黎黎.联合地衣芽孢杆菌的三联疗法根治幽门螺杆菌的疗效观察[J].临床医药文献杂志,2016,3(17):3463-3464.
[14]JIANG Yongai,OU Xilong,Wang Jianning.Efficacy of Bacillus licheniformis combined with PPI triple therapy in eradication of Helicobacter pylori[J].World Chin J Digestol,2013,21(9):840-844.(in Chinese)蒋永爱,欧希龙,王建宁.地衣芽孢杆菌联合PPI三联疗法根除幽门螺杆菌的临床疗效[J].世界华人消化杂志,2013,21(9):840-844.
[15]林慈升,陈汉武,林海涵.整肠生联合参苓白术散加减治疗小儿病毒性肠炎40例临床观察[J].中国民族民间医药,2015,24(16):103-104.
[16]CHEN Biquan,CHEN Xiaofeng,YUAN Ziqing,et al.Clinical effect of Bacillus licheniformis granules in treating infantile hand-foot-and-mouth disease(ordinary)[J].Chin J Microecol,2016,28(3):305-308.(in Chinese)陈必全,陈晓枫,袁子清,等.地衣芽孢杆菌颗粒治疗小儿手足口病(普通型)的临床疗效[J].中国微生态学杂志,2016,28(3):305-308.
[17]Natarajan N,Hori D,Flavahan S,et al.Microbial short chain fatty acid metabolites lower blood pressure via endothelial G-protein coupled receptor 41[J].Physiol Genomics,2016,48(11):826-834.
[18]Ferro S,Azevedo-Silva J,Casal M,et al.Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications[J].Oncotarget,2016,doi:10.18632/oncotarget.12156.
[2]Gao K,Wang C,Liu L,et al.Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide[J].J Microbiol Immunol Infect,2015:pii:S1684-1182(15)00748-3.Doi:10.1016/j.jmii.2015.05.002.
[3]Sivan A,Corrales L,Hubert N,et al.Commensal Bifidobacteriumpromotes antitumor immunity and facilitates anti-PD-L1efficacy[J].Science,2015,350(6264):1084-1089.
[4]Vétizou M,Pitt JM,Daillère R,et al.Anticancer immunotherapy by CTLA-4blockade relies on the gut microbiota[J].Science,2015,350(6264):1079-1084.
[5]Browne HP,Forster SC,Anonye BO,et al.Culturing of′unculturable′human microbiota reveals novel taxa and extensive sporulation[J].Nature,2016,533(7604):543-546.
[6]Huang JM,La Ragione RM,Nunez A,et al.Immunostimulatory activity of Bacillus spores[J].FEMS Immunol Med Microbiol,2008,53(2):195-203.
[7]Ren NG,Chen W,Peng B,et al.Mechanism and clinical application of live Bacillus licheniformis preparation[J].Chin JClin Pharmacol,2013,29(9):716-717+720.(in Chinese)任乃刚,陈伟,彭勃,等.整肠生的作用机制及临床应用[J].中国临床药理学杂志,2013,29(9):716-717+720.
[8]YANG Junjie,ZHANG Haiyan,LIU Lixin.Improvement on liver fibrosis in experimentally fibrotic rats treated with Bacillus licheniformis[J].Chin J Digest Med Imageol(Electronic),2012,2(2):154-159.(in Chinese)杨俊杰,张海燕,刘立新.整肠生改善大鼠肝纤维化程度的实验研究[J].中华消化病与影像杂志(电子版),2012,2(2):154-159.
[9]WU Yingwen,JIANG Hongwei.Influence of Bacillus Licheniformis Capsules on serum endotoxin,high-sensitivity C-reactive protein and procalcitonin levels of patients with posthepatitic cirrhosis[J].Chin J Microecol,2014,26(9):1046-1048.(in Chinese)吴莹雯,姜宏伟.地衣芽胞杆菌活菌胶囊对肝炎后肝硬化患者血清内毒素、超敏C反应蛋白及前降钙素水平的影响[J].中国微生态学杂志,2014,26(9):1046-1048.
[10]CAI Lirong,WANG Wen.Clinical efficacy of Bacillus licheniformis in treatment of spontaneous bacterial peritonitis in patients with liver cirrhosis[J].Chin J Microecol,2012,24(1):49-51.(in Chinese)蔡丽蓉,王雯.地衣芽胞杆菌治疗肝硬化并自发性细菌性腹膜炎的临床疗效研究[J].中国微生态学杂志,2012,24(1):49-51.
[11]朱伟青.整肠生联合美沙拉嗪治疗溃疡性结肠炎临床疗效观察[J].中国乡村医药,2013,20(12):24-25.
[12]刘巍,史娇.参苓白术散联合整肠生治疗腹泻型肠易激综合征的疗效观察[J].临床医药文献杂志,2015,2(20):4255-4256.
[13]杨黎黎.联合地衣芽孢杆菌的三联疗法根治幽门螺杆菌的疗效观察[J].临床医药文献杂志,2016,3(17):3463-3464.
[14]JIANG Yongai,OU Xilong,Wang Jianning.Efficacy of Bacillus licheniformis combined with PPI triple therapy in eradication of Helicobacter pylori[J].World Chin J Digestol,2013,21(9):840-844.(in Chinese)蒋永爱,欧希龙,王建宁.地衣芽孢杆菌联合PPI三联疗法根除幽门螺杆菌的临床疗效[J].世界华人消化杂志,2013,21(9):840-844.
[15]林慈升,陈汉武,林海涵.整肠生联合参苓白术散加减治疗小儿病毒性肠炎40例临床观察[J].中国民族民间医药,2015,24(16):103-104.
[16]CHEN Biquan,CHEN Xiaofeng,YUAN Ziqing,et al.Clinical effect of Bacillus licheniformis granules in treating infantile hand-foot-and-mouth disease(ordinary)[J].Chin J Microecol,2016,28(3):305-308.(in Chinese)陈必全,陈晓枫,袁子清,等.地衣芽孢杆菌颗粒治疗小儿手足口病(普通型)的临床疗效[J].中国微生态学杂志,2016,28(3):305-308.
[17]Natarajan N,Hori D,Flavahan S,et al.Microbial short chain fatty acid metabolites lower blood pressure via endothelial G-protein coupled receptor 41[J].Physiol Genomics,2016,48(11):826-834.
[18]Ferro S,Azevedo-Silva J,Casal M,et al.Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications[J].Oncotarget,2016,doi:10.18632/oncotarget.12156.