微波辐射下以马尿酸缩合产物为底物合成系列含氮杂环化合物研究

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英文篇名：Microwave-assisted Synthesis of Heterocyclic Compounds Containing Nitrogen Atom with Unsolid Acid Condensation Products as Substrates 作者：贾润红 ; 焦锐 英文作者：JIA Runhong;JIAO Rui;School of Elementary Education,Lianyungang Normal College; 关键词：微波辐射 ; 有机合成 ; 含氮杂环化合物 英文关键词：microwave irradiation;;organic synthesis;;heterocyclic compounds containing nitrogen atom 中文刊名：LYGJ 英文刊名：Journal of Lianyungang Normal College 机构：连云港师范高等专科学校初等教育学院; 出版日期：2018-03-25 出版单位：连云港师范高等专科学校学报 年：2018 期：v.35;No.121 基金：连云港师范高等专科学校科研课题“微波辐射下以马尿酸为底物合成系列含氮杂环化合物的研究方法”(项目编号:LYGSZ16005);连云港师范高等专科学校高级别科研培育课题“多组分反应在构筑氮氧杂环骨架中的应用”(项目编号:LYGSZ 201706) 语种：中文; 页：LYGJ201801026 页数：6 CN：01 ISSN：32-1618/G4 分类号：109-114

摘要

利用微波技术合成五元含氮杂环化合物、六元含氮杂环化合物的研究越来越受到学界重视。在微波辐射下,通过各种胺类与4-芳亚甲基-2-苯基恶唑-5(4H)-酮的反应,合成具有潜在生物活性的一系列含氮杂环化合物。该方法产率高,反应时间短,操作简便,适用范围广。产物的结构经红外光谱以及核磁共振谱证实,部分产物的结构经元素分析和单晶X-射线衍射确证。
        The application of microwave irradiation in the synthesis of five and six-member heterocyclic compounds containing nitrogen atom has aroused more and more concern from the academic circles. We study the synthesis of a series of nitrogen-containing heterocyclic compounds of biological importance via the reaction of 4-arylidene-3-methylisoxazol-5(4 H)-one with various amines under microwave irradiation. Particularly valuable features of this method include the short reaction time,high yield,and broad substrate scope,as well as convenient operation. All the products are conformed by their IR and 1 H NMR. The structures of some products are determined by elemental analysis and X-ray diffraction.

引文

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