低聚物对左旋聚乳酸水解性能的影响
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摘要
左旋聚乳酸(PLLA)在可植入生物全降解材料中具有极其重要的地位。然而,在对力学强度有一定要求的条件下降解速度慢的问题始终存在。为了探究促进左旋聚乳酸降解的方法,采用溶液共混和热压成型的方式制备了左旋聚乳酸与左旋乳酸低聚物的混合物。并进一步对其力学、热力学、质量损失和降解速率进行了研究。结果表明,加入适量的低聚物可以保持较高的力学强度;共混后结晶峰值温度(T_c)、玻璃化转变温度(T_g)降低、无相分离出现,说明低聚物共混有很好的相容性;质量损失表明,低聚物能加快左旋聚乳酸降解;降解速率模型分析表明,5%低聚物含量的共混物可以实现左旋聚乳酸3倍的降解速率。
Poly( L-lactic acid) expressed an extremely important role in implantable biodegradable materials. However, under the condition of certain requirements on mechanics, the problem of slow degradation still exists. In order to study the methods to improve the degradation properties of PLLA,the mixtures of poly( L-lactic acid) and oligomer were prepared by solution blending and hot compression molding. The mechanics,thermodynamics,mass loss and degradation rate were studied. The results show that the addition of oligomer could maintain the mechanical properties of the composites. The peak crystallizing temperature and glass transiting temperature of the blend could decrease and there is no phase separation,which indicates that the blend has good compatibility. The mass loss shows that oligomer could effectively accelerate the hydrolysis rate. And the degradation rate model analysis indicates that 5% of the oligomer blending could achieve 3 times degradation rate of Poly( L-lactic acid).
Poly( L-lactic acid) expressed an extremely important role in implantable biodegradable materials. However, under the condition of certain requirements on mechanics, the problem of slow degradation still exists. In order to study the methods to improve the degradation properties of PLLA,the mixtures of poly( L-lactic acid) and oligomer were prepared by solution blending and hot compression molding. The mechanics,thermodynamics,mass loss and degradation rate were studied. The results show that the addition of oligomer could maintain the mechanical properties of the composites. The peak crystallizing temperature and glass transiting temperature of the blend could decrease and there is no phase separation,which indicates that the blend has good compatibility. The mass loss shows that oligomer could effectively accelerate the hydrolysis rate. And the degradation rate model analysis indicates that 5% of the oligomer blending could achieve 3 times degradation rate of Poly( L-lactic acid).
引文
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[3]SHARMA U,CONCAGH D,CORE L,et al.The development of bioresorbable composite polymeric implants with high mechanical strength[J].Nature Mater,2018,17(1):96-104.
[4]ELOMAR M M,DANGAS G,IAKOVOU I,et a1.Update on in-stent restenosis[J].Curr Interv Cardiol Rep,2001,3(4):296-305.
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[6]沈莹冉,周永新.生物可降解冠状动脉支架的研究进展[J].外科研究与新技术,2014(4):267-274.
[7]王云兵,马晓.降解速率可调的聚(L-丙交酯)支架的制造方法:102892442B[P].2015-06-10.
[8]章培标,武汉,王新,等.可降解高分子丙交酯-乙交酯共聚物(PLGA)三维支架的细胞相容性和鼻软骨组织工程[J].组织工程与重建外科,2006,2(2):88-91.
[9]施纯朝,赵晓飞,吴晓峰.聚丙交酯/乙交酯胆道支架生物降解及与宿主的相容性[J].中国组织工程研究,2015,19(25):4002-4006.
[10]MAGNUSSON I,BATICH C,COLLINS B R.New attachment formation following controlled tissue regeneration using biodegradable membranes[J].J Periodontol,1988,59:l-8.
[11]NARDO T,CHIONO V,GENTILE P,etal.Poly(DL-lactide-co-ε-caprolactone)and poly(DL-lactide-co-glycolide)blends for biomedical application:Physical properties,cell compatibility,and in vitro degradation behavior[J].Int J Polym Mater,2016,65(14):741-750.
[12]ZHANG J M,TASHIRO K,TSUJI H,et al.Disorder-toorder phase transition and multiple melting behavior of poly(L-lactide)investigated by simultaneous measurements of WAXD and DSC[J].Macromolecules,2008,41:1352-1357.
[13]李琦,熊祖江,王锐,等.右旋聚乳酸-己内酯无规共聚物改性左旋聚乳酸的结构与性能[J].高分子材料科学与工程,2018,53(3):43-47.
[14]王硕,王敏丽,刘培智,等.酸碱和湿热条件对聚乳酸纤维强伸性能的影响[J].青岛大学学报:工程技术版,2015,30(4):82-85.
[15]REED A M,GILDING D K.Biodegradable polymers for use in surgery-poly(glycolic)/poly(lactic acid)homo and copolymers:2.In vitro degradation[J].Polymer,1981,22:342-346.
[16]ELSAWY M A,KIM K H,PARK J W,et al.Hydrolytic degradation of polylactic acid(PLA)and its composites[J].Renew Sust Energy Rev,2017,79:1346-1352.
[17]WEIR N A,BUCHANAN F J,ORR J F,et al.Degradation of poly(lactic acid)Part 2:Increased temperature accelerated degradation[J].Proc Inst Mech Eng Part H J Eng Med,2004,218(5):321-330.