探讨绝经前良性乳腺疾病血清性激素水平的改变
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摘要
目的分析绝经前良性乳腺疾病患者血清性激素水平的改变情况。方法选取2017年04月~2018年05月我院收治的绝经前良性乳腺疾病患者100例作为研究对象,根据术后病理检查诊断结果将其分为乳腺增生组53例与乳腺纤维腺瘤组47例,同时选取同期一般资料相吻合的体检健康女性患者51例作为对照组。应用电化学发光方法测定血清性激素水平,分析各组患者的血清性激素水平的变化情况。结果乳腺纤维腺瘤组、乳腺增生组的垂体泌乳素(183.50±12.02)IU/L、睾酮(1.14±0.24)nmol/L,垂体泌乳素(146.23±10.88)IU/L、睾酮(1.03±0.23)nmol/L显著低于对照组,乳腺纤维腺瘤组的孕酮(33.50±5.20)nmol/L、雌二醇(783.20±10.20)pmol/L显著高于乳腺增生组、对照组,乳腺纤维腺瘤组促卵泡生成素(2.64±0.34)IU/L、黄体生成素(4.35±0.67)IU/L显著低于乳腺增生组,乳腺增生组的孕酮(15.08±3.70)nmol/L、雌二醇(530.02±12.24)pmol/L显著低于对照组,乳腺增生组的促卵泡生成素(4.51±0.28)IU/L、黄体生成素(5.71±0.72)IU/L显著高于对照组,差异有统计学意义(P<0.05)。结论绝经前良性乳腺疾病患者的血清性激素水平有所改变,尤其垂体泌乳素、睾酮,在乳腺疾病的发生、发展中起一定的作用。
Objective To analyze the changes of serum sex hormone levels in premenopausal patients with benign breast diseases.Methods From 04 months to 05 months from 2017 to 05 months,100 patients with premenopausal benign breast diseases were selected to be studied.According to the postoperative pathological examination,the results were divided into groups of mammary gland hyperplasia(53 cases) and breast fibroadenoma group(47 cases).At the same time, the general data were selected to match the health examination health.51 cases of female patients were used as the control group. The levels of serum sex hormones were measured by electrochemiluminescence and the changes of serum sex hormone levels were analyzed.Results The pituitary prolactin(183.50±12.02) IU/L, testosterone(1.14±0.24) nmol/L, pituitary prolactin(146.23±10.88) IU/L and testosterone(1.03±0.23) nmol/L were significantly lower than that of the control group.The progesterone(33.50±5.20) nmol/L and estradiol(783.20±10.20) pmol/L in the breast fibroadenoma group were significantly lower than those in the control group.In the breast fibroadenoma group, the follicle stimulating hormone(2.64±0.34) IU/L and luteinizing hormone(4.35±0.67) IU/L were significantly lower than those in the breast hyperplasia group. The progesterone(15.08±3.70) nmol/L and the estradiol(530.02±12.24) pmol/L were significantly lower than those in the control group. The level of progesterone(4.51±0.28) IU/L and luteinizing hormone(5.71±0.72) IU/L was significantly higher than that of the control group(P<0.05).Conclusion The serum sex hormone levels of the patients with premenopausal benign breast disease have changed,especially the pituitary prolactin and testosterone,which play a certain role in the occurrence and development of breast disease.
Objective To analyze the changes of serum sex hormone levels in premenopausal patients with benign breast diseases.Methods From 04 months to 05 months from 2017 to 05 months,100 patients with premenopausal benign breast diseases were selected to be studied.According to the postoperative pathological examination,the results were divided into groups of mammary gland hyperplasia(53 cases) and breast fibroadenoma group(47 cases).At the same time, the general data were selected to match the health examination health.51 cases of female patients were used as the control group. The levels of serum sex hormones were measured by electrochemiluminescence and the changes of serum sex hormone levels were analyzed.Results The pituitary prolactin(183.50±12.02) IU/L, testosterone(1.14±0.24) nmol/L, pituitary prolactin(146.23±10.88) IU/L and testosterone(1.03±0.23) nmol/L were significantly lower than that of the control group.The progesterone(33.50±5.20) nmol/L and estradiol(783.20±10.20) pmol/L in the breast fibroadenoma group were significantly lower than those in the control group.In the breast fibroadenoma group, the follicle stimulating hormone(2.64±0.34) IU/L and luteinizing hormone(4.35±0.67) IU/L were significantly lower than those in the breast hyperplasia group. The progesterone(15.08±3.70) nmol/L and the estradiol(530.02±12.24) pmol/L were significantly lower than those in the control group. The level of progesterone(4.51±0.28) IU/L and luteinizing hormone(5.71±0.72) IU/L was significantly higher than that of the control group(P<0.05).Conclusion The serum sex hormone levels of the patients with premenopausal benign breast disease have changed,especially the pituitary prolactin and testosterone,which play a certain role in the occurrence and development of breast disease.
引文
[1]徐虓,王霞,曹明芹.女性乳腺疼痛症患者血清甲状腺激素水平变化的临床意义[J].新疆医科大学学报,2016,39(3):334-337.
[2]贾杰,王姗,刘显阳.血清甲状腺激素与抑郁障碍的相关性分析[J].精神医学杂志,2015,28(3):171-174.
[3]袁帅,江璐,朱力.上海地区6112例健康体检者血清甲状腺激素和甲状腺自身抗体检测结果分析[J].检验医学,2015,30(3):219-223.
[4]马素珍,石宁,刘丹丹,等.人CREB1基因及蛋白的生物信息学分析[J].生物技术,2016(6):557-565.
[5]庄海慧,王雪,王萍.转录因子环腺苷酸反应元件结合蛋白在肿瘤转移中的作用及其分子机制[J].解剖学报,2015,46(01):138-143.
[6]Mitton B,Chae H-D,Hsu K,etal.Small Molecule Inhibitionofc AMP Response Element Binding Protein in Human Acute Myeloid Leukemia Cells[J].Leukemia,2016,30(12):2302-2311.
[7]戎荣,吴妍,宋国新,等.磷酸化CREB蛋白在肝内胆管癌组织中的表达及临床意义[J].江苏医药,2014,40(19):2293-2295+2381.
[8]唐海斌,马越云,苏明权,等.CREB及p-CREB在前列腺癌细胞增殖中的作用[J].中国肿瘤生物治疗杂志,2016,23(02):223-229.
[9]何佩娜,窦拉加,盛捡云.microRNA-21在乳腺浸润性导管癌患者血清中的表达及临床意义.医学研究杂志,2014,43(6):97-100.
[10]王雷,马菲.microRNA在三阴型乳腺癌中的研究进展.中国普外科杂志,2013,22(11):1490-1494.
[2]贾杰,王姗,刘显阳.血清甲状腺激素与抑郁障碍的相关性分析[J].精神医学杂志,2015,28(3):171-174.
[3]袁帅,江璐,朱力.上海地区6112例健康体检者血清甲状腺激素和甲状腺自身抗体检测结果分析[J].检验医学,2015,30(3):219-223.
[4]马素珍,石宁,刘丹丹,等.人CREB1基因及蛋白的生物信息学分析[J].生物技术,2016(6):557-565.
[5]庄海慧,王雪,王萍.转录因子环腺苷酸反应元件结合蛋白在肿瘤转移中的作用及其分子机制[J].解剖学报,2015,46(01):138-143.
[6]Mitton B,Chae H-D,Hsu K,etal.Small Molecule Inhibitionofc AMP Response Element Binding Protein in Human Acute Myeloid Leukemia Cells[J].Leukemia,2016,30(12):2302-2311.
[7]戎荣,吴妍,宋国新,等.磷酸化CREB蛋白在肝内胆管癌组织中的表达及临床意义[J].江苏医药,2014,40(19):2293-2295+2381.
[8]唐海斌,马越云,苏明权,等.CREB及p-CREB在前列腺癌细胞增殖中的作用[J].中国肿瘤生物治疗杂志,2016,23(02):223-229.
[9]何佩娜,窦拉加,盛捡云.microRNA-21在乳腺浸润性导管癌患者血清中的表达及临床意义.医学研究杂志,2014,43(6):97-100.
[10]王雷,马菲.microRNA在三阴型乳腺癌中的研究进展.中国普外科杂志,2013,22(11):1490-1494.