加味防己黄芪汤治疗原发性肾病综合征50例
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摘要
目的:观察加味防己黄芪汤治疗原发性肾病综合征的临床疗效。方法:将100例原发性肾病综合征患者随机分为观察组和对照组,每组各50例。对照组给予西医常规治疗,观察组在对照组的基础上给予加味防己黄芪汤口服。比较两组患者的临床疗效,检测两组患者治疗前后24 h尿蛋白定量、血清白蛋白(albumin,Alb)、总胆固醇(total cholesterol,TC)含量、凝血酶原时间(prothrombin time,PT)、血小板计数(platelet,PLT)、超敏C反应蛋白(hs-C reactive protein,hsCRP)及白细胞介素-10(interleukin-10,IL-10)含量。结果:观察组有效率为84. 00%,对照组有效率为66. 00%,两组患者临床疗效比较,差异具有统计学意义(P <0. 05)。两组患者治疗后24 h尿蛋白、TC、PT、PLT低于治疗前,Alb高于治疗前,差异具有统计学意义(P <0. 05);观察组治疗后24 h尿蛋白、TC、PT低于对照组,Alb高于对照组,差异具有统计学意义(P <0. 05)。两组患者治疗后hs-CRP、IL-8水平及血管生成素样蛋白3(Angiopoietin-like protein 3,ANGPTL3)免疫组织化学指数均低于治疗前,且观察组低于对照组,差异具有统计学意义(P <0. 05)。结论:加味防己黄芪汤治疗原发性肾病综合征能有效缓解患者临床症状,其作用机制可能与改善患者微炎症状态、凝血状态和ANGPTL3有关。
Objective: To observe the clinical curative effect of Supplemented Stephania Root and Astragalus Decoction on primary nephrotic syndrome( PNS). Methods: A total of 100 patients with PNS were randomly divided into the observation group and the control group,with 50 cases in each group. The control group was given routine Western medicine treatment,while the observation group was given Supplemented Stephania Root and Astragalus Decoction on the basis of the control group. Results: The effective rate was 84. 00% in the observation group and 66. 00% in the control group. The difference between the two groups was statistically significant( P < 0. 05). After the treatment,24 hours' urinary protein,TC,PT and PLT in the two groups were lower than those before the treatment,and Alb was higher than that before the treatment,with statistical significance( P < 0. 05). And24 hours' urinary protein,TC,PT in the observation group were lower than those in the control group,and Alb was higher than that in the control group,with statistical significance( P < 0. 05). After the treatment,the levels of Hs-CRP and IL-8 in both groups were lower than those before the treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant( P < 0. 05). The ANGPTL3 immunohistochemical indexes of the two groups after the treatment were lower than those before the treatment,and the observation group was lower than that of the control group,and the difference was statistically significant( P < 0. 05). Conclusion: Supplemented Stephania Root and Astragalus Decoction has a remarkable efficacy on PNS,can effectively alleviate the clinical symptoms of patients,and its mechanism may be related to the improvement of microinflammation,coagulation and angiopoietin-like protein 3( ANGPTL3).
Objective: To observe the clinical curative effect of Supplemented Stephania Root and Astragalus Decoction on primary nephrotic syndrome( PNS). Methods: A total of 100 patients with PNS were randomly divided into the observation group and the control group,with 50 cases in each group. The control group was given routine Western medicine treatment,while the observation group was given Supplemented Stephania Root and Astragalus Decoction on the basis of the control group. Results: The effective rate was 84. 00% in the observation group and 66. 00% in the control group. The difference between the two groups was statistically significant( P < 0. 05). After the treatment,24 hours' urinary protein,TC,PT and PLT in the two groups were lower than those before the treatment,and Alb was higher than that before the treatment,with statistical significance( P < 0. 05). And24 hours' urinary protein,TC,PT in the observation group were lower than those in the control group,and Alb was higher than that in the control group,with statistical significance( P < 0. 05). After the treatment,the levels of Hs-CRP and IL-8 in both groups were lower than those before the treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant( P < 0. 05). The ANGPTL3 immunohistochemical indexes of the two groups after the treatment were lower than those before the treatment,and the observation group was lower than that of the control group,and the difference was statistically significant( P < 0. 05). Conclusion: Supplemented Stephania Root and Astragalus Decoction has a remarkable efficacy on PNS,can effectively alleviate the clinical symptoms of patients,and its mechanism may be related to the improvement of microinflammation,coagulation and angiopoietin-like protein 3( ANGPTL3).
引文
[1]何丽杰.防己黄芪汤加减治疗原发性肾病综合征水肿期的疗效分析[J].医学信息,2018,31(12):151-152.
[2]毛仁丽,陈丽,秦盼盼.加味防己黄芪汤对原发性肾病综合征微炎症状态及血管生成素样蛋白3的影响[J].世界中医药,2018,13(3):624-627,631.
[3]李新民.防己黄芪汤加减在原发性肾病综合征水肿期患者治疗中的应用价值[J].全科口腔医学电子杂志,2017,4(13):54-55.
[4]卢国军.防己黄芪汤加减在原发性肾病综合征水肿期患者治疗中的应用研究[J].中国实用医药,2017,12(11):151-152.
[5]张琨,董鹏达,戚聿霞,等.加味防己黄芪汤治疗成人原发性肾病综合征的临床效果观察[J].中国卫生标准管理,2017,8(2):118-119.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:163.
[7]聂静涛.防己黄芪汤对原发性肾病综合征水肿期患者的疗效及对24h尿蛋白、血清白蛋白、血脂的影响[J].实用临床医药杂志,2017,21(1):48-51.
[8]杜卫军,占爱君.防己黄芪汤对原发性肾病综合征患者血清TNF-α、IL-6的影响[J].河南中医,2014,34(5):805-806.
[9]王岚,范尧夫,魏睦新.防己黄芪汤加味治疗原发性肾病综合征疗效分析[J].辽宁中医药大学学报,2013,15(3):111-112.
[10]徐燕舞.防己黄芪汤治疗原发性肾病综合征的临床疗效研究[J].中国医药指南,2012,10(22):286-288.
[11]覃正壮.防己黄芪汤治疗原发性肾病综合征水肿期疗效观察[J].吉林中医药,2010,30(7):582-583.
[12]林杰.防己黄芪汤治疗原发性肾病综合征水肿期疗效观察[J].中国现代药物应用,2017,11(19):119-120.
[13]钱阳晶.防己黄芪汤联合通因通用法治疗脾虚湿困型原发性肾病综合征疗效及对血清IL-8和IL-13水平的影响[J].现代中西医结合杂志,2017,26(20):2217-2219.
[14]徐江维,张永芳.防己黄芪汤加味联合西药治疗小儿肾病综合征疗效观察[J].现代中西医结合杂志,2017,26(17):1920-1922.
[15]陆海霞.防己黄芪汤治疗原发性肾病综合征水肿期疗效观察[J].内蒙古中医药,2016,35(14):38-39.
[16]陈肖蓉.加味防己黄芪汤治疗原发性肾病综合征的临床疗效观察及其对血清IL-10、TNF-α的影响[J].中国中医药科技,2016,23(4):393-395.
[2]毛仁丽,陈丽,秦盼盼.加味防己黄芪汤对原发性肾病综合征微炎症状态及血管生成素样蛋白3的影响[J].世界中医药,2018,13(3):624-627,631.
[3]李新民.防己黄芪汤加减在原发性肾病综合征水肿期患者治疗中的应用价值[J].全科口腔医学电子杂志,2017,4(13):54-55.
[4]卢国军.防己黄芪汤加减在原发性肾病综合征水肿期患者治疗中的应用研究[J].中国实用医药,2017,12(11):151-152.
[5]张琨,董鹏达,戚聿霞,等.加味防己黄芪汤治疗成人原发性肾病综合征的临床效果观察[J].中国卫生标准管理,2017,8(2):118-119.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:163.
[7]聂静涛.防己黄芪汤对原发性肾病综合征水肿期患者的疗效及对24h尿蛋白、血清白蛋白、血脂的影响[J].实用临床医药杂志,2017,21(1):48-51.
[8]杜卫军,占爱君.防己黄芪汤对原发性肾病综合征患者血清TNF-α、IL-6的影响[J].河南中医,2014,34(5):805-806.
[9]王岚,范尧夫,魏睦新.防己黄芪汤加味治疗原发性肾病综合征疗效分析[J].辽宁中医药大学学报,2013,15(3):111-112.
[10]徐燕舞.防己黄芪汤治疗原发性肾病综合征的临床疗效研究[J].中国医药指南,2012,10(22):286-288.
[11]覃正壮.防己黄芪汤治疗原发性肾病综合征水肿期疗效观察[J].吉林中医药,2010,30(7):582-583.
[12]林杰.防己黄芪汤治疗原发性肾病综合征水肿期疗效观察[J].中国现代药物应用,2017,11(19):119-120.
[13]钱阳晶.防己黄芪汤联合通因通用法治疗脾虚湿困型原发性肾病综合征疗效及对血清IL-8和IL-13水平的影响[J].现代中西医结合杂志,2017,26(20):2217-2219.
[14]徐江维,张永芳.防己黄芪汤加味联合西药治疗小儿肾病综合征疗效观察[J].现代中西医结合杂志,2017,26(17):1920-1922.
[15]陆海霞.防己黄芪汤治疗原发性肾病综合征水肿期疗效观察[J].内蒙古中医药,2016,35(14):38-39.
[16]陈肖蓉.加味防己黄芪汤治疗原发性肾病综合征的临床疗效观察及其对血清IL-10、TNF-α的影响[J].中国中医药科技,2016,23(4):393-395.