情绪异常大鼠模型的旷场行为实验在中医药领域的研究进展
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摘要
大鼠是较为常用的实验动物,旷场行为实验是检测动物情绪行为的一种常用的经典实验方法。涉及大鼠旷场行为实验的研究是这些年的热点,并呈上升趋势。旷场行为实验的条件会引起大鼠生理心理状态改变,影响大鼠行为的解读,从而影响疾病模型的判定。文章通过梳理近5年涉及大鼠旷场行为实验的研究文献,为选择较为合适大鼠旷场行为实验的条件以及合理的行为解读和模型判定作一综述。
Rat is a commonly used experimental animal. The open-field behavior test is one of the most commonly used methods to detect emotional behavior in animals,particularly for rats in recent years. The conditions of the open-field behavior test can cause changes in the physiological and psychological state of rats,affecting the interpretation of rat behavior,and thus affecting the determination of the rat model of diseases. To select suitable experimental conditions and achieve reasonable interpretation of behavior and an appropriate model,this article presents a review of the research literature on the open-field behavior test of rats published in the last 5 years.
Rat is a commonly used experimental animal. The open-field behavior test is one of the most commonly used methods to detect emotional behavior in animals,particularly for rats in recent years. The conditions of the open-field behavior test can cause changes in the physiological and psychological state of rats,affecting the interpretation of rat behavior,and thus affecting the determination of the rat model of diseases. To select suitable experimental conditions and achieve reasonable interpretation of behavior and an appropriate model,this article presents a review of the research literature on the open-field behavior test of rats published in the last 5 years.
引文
[1]ParéWP.Open field,learned helplessness,conditioned defensive burying,and forced-swim tests in WKY rats[J].Physiol Behav,1994,55(3):433-439.
[2]易丽莎,陈莹,孙会会,等.精神应激致内脏高敏感大鼠的心理行为学变化[J].中国现代医学杂志,2013,23(35):1-6.
[3]欧阳俊彦,胡卓炎,褚玥,等.γ-氨基丁酸对情绪应激大鼠额叶皮质一氧化氮合酶和一氧化氮水平的影响[J].第三军医大学学报,2013,35(5):385-389.
[4]余庆,蒋雪,李琴.焦虑模型大鼠下丘脑-垂体-肾上腺轴高反应性与糖皮质激素受体蛋白表达降低相关[J].第三军医大学学报,2017,39(14):1464-1468.
[5]郑伟男,赵建军,胡志英,等.创伤后应激障碍海马Beclin-1/Bcl-2自噬标记变化[J].解剖学杂志,2015,38(5):560-563.
[6]刘莹,赵宏艳,于峥,等.补肝益肾法对更年期模型大鼠行为变化的调节作用[J].中国中医基础医学杂志,2013,19(4):397-399.
[7]吴天添,朱江,毛翔宇,等.亮氨酸对肠道术后大鼠中枢神经递质和外周炎性因子的影响[J].肠外与肠内营养,2014,21(3):167-171.
[8]王雯龙,唐启盛,赵瑞珍,等.丹栀逍遥散对饮水冲突天敌暴露模型大鼠行为学影响[J].北京中医药大学学报,2014,37(7):486-489.
[9]蒲蜀湘,吴培基,饶从磊,等.丰富环境对局灶性脑梗死大鼠旷场和水迷宫行为学及Nogo-A蛋白表达的影响[J].广东医学,2013,34(16):2437-2440.
[10]杨丽萍,李改,万海娇,等.恐伤孕鼠对其21日龄子代情绪的影响[J].中华中医药杂志,2018,33(1):62-64.
[11]李力卓,何松柏.大鼠创伤性脑损伤后精神障碍的精神行为学改变[J].中国医科大学学报,2016,45(8):708-710,714.
[12]朱孝苍,黄荟杰,韩秋琴,等.电针不同穴位对慢性应激抑郁大鼠的抗抑郁作用及对血浆胃饥饿素的影响[J].针刺研究,2015,40(4):283-289.
[13]吴媛媛,蒋永亮,邵晓梅,等.痛抑郁二联征模型大鼠中缝背核不同水平5羟色胺表达差异[J].解剖学报,2015,46(2):170-174.
[14]方锦颖,陈光耀,李龙梅,等.孤养对单次延长应激建立的创伤后应激障碍模型大鼠行为学的影响[J].中国比较医学杂志,2018,28(3):32-35.
[15]费鹏鸽,赵琳,任慧聪,等.重复经颅磁刺激对抑郁模型大鼠行为学及海马BDNF表达的影响[J].中国神经精神疾病杂志,2016,42(10):591-595.
[16]赵荣华,谢鸣,刘进娜,等.肝郁、脾虚和肝郁脾虚证模型大鼠行为学变化及柴疏四君子汤对其作用的比较[J].北京中医药大学学报,2015,38(8):515-518,528.
[17]Luo J,Wang T,Liang S,et al.Experimental gastritis leads to anxiety-and depression-like behaviors in female but not male rats[J].Behav Brain Funct,2013,9:46.
[18]Bai M,Zhu X,Zhang Y,et al.Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life[J].PLo S One,2012,7(10):e46921.
[19]王慧霞,詹向红,李伟,等.负性情绪应激大鼠模型的建立与评价[J].中国老年学杂志,2015,35(15):4140-4142.
[20]胡海燕,徐志伟,敖海清,等.四逆散影响慢性应激抑郁模型大鼠行为学研究[J].中华中医药杂志,2016,31(1):271-274.
[21]沙中玮,王国华,李志敏,等.香萱解郁方对焦虑大鼠血清单胺类神经递质及BDNF水平的影响[J].中成药,2018,40(1):191-194.
[22]宗绍波,朱德豪,魏盛.白香丹胶囊对经前期综合征肝气逆证模型大鼠学习记忆功能的影响[J].中国药理学通报,2015,31(2):284-289.
[23]刘旭东,刘文俊,孙大宇,等.脾气虚证模型大鼠神疲乏力的客观化评价[J].中华中医药杂志,2015,30(3):699-701.
[24]魏盛,宗绍波,乔明琦.愤怒、郁怒反应模型大鼠不同脑区5-羟色胺含量分析[J].中华中医药杂志,2013,28(5):1423-1426.
[25]陈锦锋,王爱成,王玉来,等.肝气郁结证诊断的必备症状以及与抑郁状态的关系探讨[J].辽宁中医杂志,2005,32(1):19-22.
[2]易丽莎,陈莹,孙会会,等.精神应激致内脏高敏感大鼠的心理行为学变化[J].中国现代医学杂志,2013,23(35):1-6.
[3]欧阳俊彦,胡卓炎,褚玥,等.γ-氨基丁酸对情绪应激大鼠额叶皮质一氧化氮合酶和一氧化氮水平的影响[J].第三军医大学学报,2013,35(5):385-389.
[4]余庆,蒋雪,李琴.焦虑模型大鼠下丘脑-垂体-肾上腺轴高反应性与糖皮质激素受体蛋白表达降低相关[J].第三军医大学学报,2017,39(14):1464-1468.
[5]郑伟男,赵建军,胡志英,等.创伤后应激障碍海马Beclin-1/Bcl-2自噬标记变化[J].解剖学杂志,2015,38(5):560-563.
[6]刘莹,赵宏艳,于峥,等.补肝益肾法对更年期模型大鼠行为变化的调节作用[J].中国中医基础医学杂志,2013,19(4):397-399.
[7]吴天添,朱江,毛翔宇,等.亮氨酸对肠道术后大鼠中枢神经递质和外周炎性因子的影响[J].肠外与肠内营养,2014,21(3):167-171.
[8]王雯龙,唐启盛,赵瑞珍,等.丹栀逍遥散对饮水冲突天敌暴露模型大鼠行为学影响[J].北京中医药大学学报,2014,37(7):486-489.
[9]蒲蜀湘,吴培基,饶从磊,等.丰富环境对局灶性脑梗死大鼠旷场和水迷宫行为学及Nogo-A蛋白表达的影响[J].广东医学,2013,34(16):2437-2440.
[10]杨丽萍,李改,万海娇,等.恐伤孕鼠对其21日龄子代情绪的影响[J].中华中医药杂志,2018,33(1):62-64.
[11]李力卓,何松柏.大鼠创伤性脑损伤后精神障碍的精神行为学改变[J].中国医科大学学报,2016,45(8):708-710,714.
[12]朱孝苍,黄荟杰,韩秋琴,等.电针不同穴位对慢性应激抑郁大鼠的抗抑郁作用及对血浆胃饥饿素的影响[J].针刺研究,2015,40(4):283-289.
[13]吴媛媛,蒋永亮,邵晓梅,等.痛抑郁二联征模型大鼠中缝背核不同水平5羟色胺表达差异[J].解剖学报,2015,46(2):170-174.
[14]方锦颖,陈光耀,李龙梅,等.孤养对单次延长应激建立的创伤后应激障碍模型大鼠行为学的影响[J].中国比较医学杂志,2018,28(3):32-35.
[15]费鹏鸽,赵琳,任慧聪,等.重复经颅磁刺激对抑郁模型大鼠行为学及海马BDNF表达的影响[J].中国神经精神疾病杂志,2016,42(10):591-595.
[16]赵荣华,谢鸣,刘进娜,等.肝郁、脾虚和肝郁脾虚证模型大鼠行为学变化及柴疏四君子汤对其作用的比较[J].北京中医药大学学报,2015,38(8):515-518,528.
[17]Luo J,Wang T,Liang S,et al.Experimental gastritis leads to anxiety-and depression-like behaviors in female but not male rats[J].Behav Brain Funct,2013,9:46.
[18]Bai M,Zhu X,Zhang Y,et al.Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life[J].PLo S One,2012,7(10):e46921.
[19]王慧霞,詹向红,李伟,等.负性情绪应激大鼠模型的建立与评价[J].中国老年学杂志,2015,35(15):4140-4142.
[20]胡海燕,徐志伟,敖海清,等.四逆散影响慢性应激抑郁模型大鼠行为学研究[J].中华中医药杂志,2016,31(1):271-274.
[21]沙中玮,王国华,李志敏,等.香萱解郁方对焦虑大鼠血清单胺类神经递质及BDNF水平的影响[J].中成药,2018,40(1):191-194.
[22]宗绍波,朱德豪,魏盛.白香丹胶囊对经前期综合征肝气逆证模型大鼠学习记忆功能的影响[J].中国药理学通报,2015,31(2):284-289.
[23]刘旭东,刘文俊,孙大宇,等.脾气虚证模型大鼠神疲乏力的客观化评价[J].中华中医药杂志,2015,30(3):699-701.
[24]魏盛,宗绍波,乔明琦.愤怒、郁怒反应模型大鼠不同脑区5-羟色胺含量分析[J].中华中医药杂志,2013,28(5):1423-1426.
[25]陈锦锋,王爱成,王玉来,等.肝气郁结证诊断的必备症状以及与抑郁状态的关系探讨[J].辽宁中医杂志,2005,32(1):19-22.